Chief’s message: Welcome to our New Cardiology Fellows and Ongoing Work to do around Heart Disease.

As we approach the final month of the year, this week we were excited to welcome our next fellowship class to Duke.  These are the next generation of leaders that will help us continue to discover and deliver heart health.  We were also excited to have some end of year meetings with the CVCT (CardioVascular Clinical Trials) conference with several Duke Faculty and Fellows presenting.  Lots more work to do to ensure our evidence generation system improves to include more patients, work faster to get answer to patients and groups that need it the most.  It was again great to see some rising stars around the country in clinical research and heart from leaders like Dr. Califf from the FDA.

We also have had the start of the BacktoHeart22 Cardiology conference which is a Hybrid Medscape conference (in-person and Virtual) summarizing the years lessons in CV medicine.  This conference led by Bob Harrington and Fatima Rodriquez from Stanford and feature several interactive sessions.  The conference started this AM with a powerful survivor story from Bob Harper (Fitness Expert and Host of the Biggest Loser) who shared his near fatal Acute Heart Attack story.  He shared that bystander CPR and cardiac rehab after angioplasty and stent for his AMI saved his life.  He also shared the work he is doing to increase awareness around Lp(a) levels.

So through all our challenges and work to ensure access to healthcare, as the year comes to an end we are reminded about the significant work we still have to do to bend the curve on cardiovascular death and disability around the world and in our local communities.

Highlights of the week:

Incoming Cardiology Fellows Announced

We are excited to share with you the new members of our cardiology fellowship class starting in July, 2023. They are:

Jawan Abdulrahim     

Residency: Duke

Medical School: UAB

Aubrie Carroll

Residency: Duke

Medical School: University of Virginia

Jonathan Hanna

Residency: Yale

Medical School: Yale

Seamus Hughes

Residency: UTSW

Medical School:

John Hopkins

Damarcus Ingram

Residency: Duke

Medical School: Drexel

Ivan Nenadic Wood

Residency: Michigan

Medical School: Mayo

Josh Rushakoff

Residency: Cedars Sinai

Medical School: UC San Francisco

Husam Salah

Residency: Arkansas

Medical School: Jordan University

Aarti Thakkar

Residency: John Hopkins

Medical School: Duke

Eric Xie

Residency: Johns Hopkins

Medical School: John Hopkins

Anna Lisa Chamis would like to especially thank Manesh Patel, Camille Frazier Mills, Neha Pagidipati, Chris Holley, Rob Mentz and Chris Wrobel along with the fellowship recruitment committee, faculty interviewers and all the fellows for their time and efforts to recruit this amazing incoming class. In addition, Anna Lisa would like to thank Kayla Humphreys and Brianna Small for effectively and efficiently managing the administrative aspect of this virtual recruitment season.

We look forward to welcoming this outstanding team of fellows in July. Great job, everyone!

 

Shout-out: Outstanding Week for Duke EP Team

A big shout-out this week to Duke’s EP team. Way to go!

“I just wanted to recognize everyone on the invasive labs team (including Cath & CVSSU) for orchestrating the most number of cases completed in a single day ever by the DUH EP Lab!  Thank you for the Herculean effort by our incredible team,” Shawn Johnson, Assistant Nurse Manager, Adult Electrophysiology Lab.

On Dec. 1, the team completed 17 cases, including four Outpatient Tilt, seven Outpatient Devices, four Outpatient Ablations, one Inpatient Device, and 1 Inpatient Ablation.

“Sometimes we do special things and they go unnoticed. This should not. While the number of cases itself is not necessarily important, the cooperation, collaboration, and commitment required of the whole team to accomplish this milestone is truly impressive,” said Jonathan Piccini, MD, director of Cardiac Electrophysiology. “Thank you for your leadership and thanks to every member of the team that enabled this to happen – particularly on a day in which we were understaffed and short-handed. Our patients get the best because we have the best team.”

“Dr. Piccini said it so well. Kudos and thanks to the EP team for their tremendous dedication and talent, added Jill Engel, DNP, Service Line Vice President for Duke Heart. “We appreciate everything you do and are fortunate to have each of you on team Duke Heart!”

 

Scientific Sessions Twitter Space Link Now Available

As we mentioned previously in Pulse, Manesh Patel and Kelly Arps were the featured guests in a Twitter Space held Tuesday, Nov. 8 on Twitter. Patel and Arps did a recap of some of the most notable findings presented at Scientific Sessions. That link was made available to us this week. To check it out, please visit: https://duke.is/jq953.

 

Pickett Leaving as DUH CMO; Becoming Hospice & Palliative Care Fellow

Earlier this week we learned that Duke University Hospital Chief Medical Officer Lisa Pickett, MD will leave her role in 2023. She has been accepted into the Duke Hospice and Palliative Care Fellowship program. The announcement was made earlier this week by Tom Owens and Mary Martin:

It is with mixed emotions that we share the news that Dr. Lisa Pickett, FACS, has been accepted into the Duke Hospice and Palliative Care Fellowship program, beginning in July 2023. In pursuit of this next phase of her career, Lisa will step back from her current role as Chief Medical Officer for Duke University Hospital. The transition will take place in Spring 2023, and we will share more details as they are confirmed.

So many of us at Duke University Hospital, and across the entire Duke community, have been touched by Lisa’s compassionate care and servant leadership. As the hospital’s first female Chief Medical Officer, Lisa has shaped the role of hospital physicians at Duke and has supported our teams through more than ten years of transformational change.

As a member of the DUH Senior Leadership team, Lisa has helped develop the Health System Disruptive Patient and Visitor Policy, coordinated patient moves for both DMP and DCT, and worked to create an environment of gratitude and appreciation among our teams.

Throughout her career, Lisa’s passion for caring for our patients and families during their most difficult care journeys has always been evident. This will serve her very well in this next professional opportunity.

Lisa will join the Palliative Care Fellow class in July and so will continue her time with our Duke family. For those who may not know, Lisa began her career at Duke as an Intern and then a Resident in General Surgery in 1994. She subsequently completed a Fellowship in Critical Care and joined our faculty where she currently serves as Assistant Professor of Surgery and Critical Care.

Lisa also worked at Duke Regional Hospital, where she helped build a general surgery program and a 24/7 Critical Care service. She served as Chief Medical Officer at DRH for three years before beginning her current role as Duke University Hospital Chief Medical Officer in 2012.

We will share our plans for identifying our next Chief Medical Officer in the coming weeks. For now, please join us as we congratulate Lisa on this exciting new phase of her career and thank her for all she has done as a leader in our hospital and throughout the Duke community. Thank you, Lisa!

 

Reminder: ORA Holiday Deadlines

The Office of Research Administration (ORA) will operate with a reduced staff during the holiday season to allow team members time to recharge.  To help ORA respond as timely as possible to your needs, please plan in advance based on the following:

Last two weeks of December

For any transactions with due dates between December 19 – January 2, please have submitted in ready-form to ORA by Thursday, December 15 to ensure there is adequate time and staffing to respond to your needs.

Please note: the next NIH SBIR/STTR deadline is Jan. 5, 2023, and the internal deadline is 8 a.m. on Dec. 28, 2022. Because this deadline falls in the last two weeks in December when ORA will be operating with reduced staff and because these award mechanisms are usually complex and require careful institutional coordination before submission:

1. Please complete Intent to Submit for all planned SBIR/STTR applications no later than Dec. 5, 2022; and
2. Please plan to route a submission-ready application no later than Dec. 15, 2022; if more time is needed, please submit a late waiver request so that ORA can plan for appropriate coverage to support these applications.

For anything submitted in the last two weeks of December that can wait until after the holiday break, ORA will be back up to speed with a full team on Jan. 3, 2023 and will look forward to managing all pending issues at that time.

 

Additional Reminders:

• We’re seeing improvements with PPE throughout DUH – great job! It is vital that we all remain vigilant with masking, hand hygiene, PPE, and other safe behaviors to prevent the spread of infection. Please pay special attention to the proper wearing and securing of gowns and be mindful of PPE compliance. Thank you for all you do to keep everyone safe and healthy.

Upcoming Events & Opportunities

Cardiology Grand Rounds

Dec. 6: No CGR this week.

Dec. 13: Celebration for Dr. Tracy Wang. 5 p.m. Webex.

Dec. 20: Our featured speaker will be Dr. Michel Khouri. Webex.

Dec. 27: No CGR this week.

CME & Other Events

Dec. 19: PDC Annual Member Meeting. 5:30-6:30 p.m. Zoom.

The meeting will be recorded and posted the following day. Submit questions to: PDC-President@dm.duke.edu. Agenda items will include:

• Financial Year In Review
• Review of Retirement Portfolio Performance from CAPTRUST
• The Path Forward for 2023: Duke Health Integrated Practice
• Anticipated Member Asset Distribution Plan

 

Call for abstracts: 2023 Duke Health Quality and Safety Conference

The virtual poster submission period for the 2023 Duke Health Quality and Safety Conference is now open. The deadline for submission is Wednesday, Dec. 14. The 2023 Conference will be held the weeks of March 13 and 20, with an in-person event on Thursday, March 23.

For more information and to submit your abstract, please click here.

Have news to share?

If you have news to share with the Pulse readership, please contact Tracey Koepke, director of communications for Duke Heart at tracey.koepke@duke.edu. We would love to hear about your latest accomplishments, professional news, cool happenings, and any events or opportunities that may be of interest to our Duke Heart family. Please call with any questions: 919-681-2868. Feedback on Pulse is welcome and encouraged. Submissions by Noon, Wednesdays, to be considered for weekend inclusion.

Duke Heart in the News:

November 23 — Pamela Douglas

Healio

Health care industry struggles to keep pace with ‘tectonic shift’ in paid family leave

https://duke.is/najvu

November 23 — Ravi Karra and Navid Nafissi

Medscape

Test for ‘Concealed Cardiomyopathy’ After Sudden Unexplained Death

https://duke.is/btdbj

November 29 — Wayne Feng (neurology/Duke Stroke Center)

Neurology Live

Expanding the Capabilities of Treating Neuromuscular Poststroke Symptoms: Wayne Feng, MD, FAHA

https://duke.is/4rktq

Division of Cardiology Publications Indexed in PubMed November 19-30, 2022

Berwanger O, Pfeffer M, Claggett B, Jering KS, Maggioni AP, Steg PG, Mehran R, Lewis EF, Zhou Y, van der Meer P, De Pasquale C, Merkely B, Filippatos G, McMurray JJV, Granger CB, Solomon SD, Braunwald E. Sacubitril/valsartan versus ramipril for patients with acute myocardial infarction: win-ratio analysis of the PARADISE-MI trial. Eur J Heart Fail 2022 Oct;24(10):1918-1927. PM: 36054480.

Bonafiglia JT, Swinton PA, Ross R, Johannsen NM, Martin CK, Church TS, Slentz CA, Ross LM, Kraus WE, Walsh JJ, Kenny GP, Goldfield GS, Prud’homme D, Sigal RJ, Earnest CP, Gurd BJ. Interindividual Differences in Trainability and Moderators of Cardiorespiratory Fitness, Waist Circumference, and Body Mass Responses: A Large-Scale Individual Participant Data Meta-analysis. Sports Med 2022 Dec;52(12):2837-2851. PM: 35781787.

Brown LC, Halabi S, Somarelli JA, Humeniuk M, Wu Y, Oyekunle T, Howard L, Huang J, Anand M, Davies C, Patel P, Staats J, Weinhold KJ, Harrison MR, Zhang T, George DJ, Armstrong AJ. A phase 2 trial of avelumab in men with aggressive- variant or neuroendocrine prostate cancer. Prostate Cancer Prostatic Dis 2022 Apr;25(4):762-769. PM: 35292724.

Capodanno D, Baber U, Bhatt DL, Collet JP, Dangas G, Franchi F, Gibson CM, Gwon HC, Kastrati A, Kimura T, Lemos PA, Lopes RD, Mehran R, O’Donoghue ML, Rao SV, Rollini F, Serruys PW, Steg PG, Storey RF, Valgimigli M, Vranckx P, Watanabe H, Windecker S, Angiolillo DJ. P2Y inhibitor monotherapy in patients undergoing percutaneous coronary intervention. Nat Rev Cardiol 2022 Dec;19(12):829-844. PM: 35697777.

Chanfreau-Coffinier C, Tuteja S, Hull LE, MacDonald S, Efimova O, Bates J, Voora D, Oslin DW, DuVall SL, Lynch JA. Drug-drug-gene interaction risk among opioid users in the U.S. Department of Veterans Affairs. Pain 2022 Dec 1;163(12):2390-2397. PM: 35319502.

Doberne JW, Maisonave Y, DeVore A, Guinn N, Schroder JN. Bloodless HeartMate 3 explantation and orthotopic heart transplant in a heart failure patient refusing blood products. J Heart Lung Transplant 2022 Dec;41(12):1859-1860. PM: 36115786.

Fiorino C, Liu Y, Henao R, Ko ER, Burke TW, Ginsburg GS, McClain MT, Woods CW, Tsalik EL. Host Gene Expression to Predict Sepsis Progression. Crit Care Med 2022 Dec 1;50(12):1748-1756. PM: 36178298.

Greene SJ, Fonarow GC, Butler J. Sodium-glucose cotransporter 2 inhibitors for heart failure with mildly reduced or preserved ejection fraction: time to deliver implementation. Eur J Heart Fail 2022 Oct;24(10):1902-1905. PM: 36097872.

Inzucchi SE, Claggett BL, Vaduganathan M, Desai AS, Jhund PS, de Boer RA, Hernandez AF, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Verma S, Han Y, Kerr Saraiva JF, Bengtsson O, Petersson M, Langkilde AM, McMurray JJV, Solomon SD. Efficacy and safety of dapagliflozin in patients with heart failure with mildly reduced or preserved ejection fraction by baseline glycaemic status (DELIVER): a subgroup analysis from an international, multicentre, double-blind, randomised, placebo-controlled trial. Lancet Diabetes Endocrinol 2022 Dec;10(12):869-881. PM: 36372069.

Januzzi JL, Omar AMS, Liu Y, Murphy S, Butler J, Felker GM, Piña IL, Ward J, Solomon S, Contreras J. Association Between Sacubitril/Valsartan Initiation and Mitral Regurgitation Severity in Heart Failure With Reduced Ejection Fraction: The PROVE-HF Study. Circulation 2022 Nov 22;146(21):1638-1640. PM: 36183276.

Jollis JG, Granger CB, Zègre-Hemsey JK, Henry TD, Goyal A, Tamis-Holland JE, Roettig ML, Ali MJ, French WJ, Poudel R, Zhao J, Stone RH, Jacobs AK. Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021. JAMA 2022 Nov 22;328(20):2033-2040. PM: 36335474.

Karády J, Ferencik M, Mayrhofer T, Meyersohn NM, Bittner DO, Staziaki PV, Szilveszter B, Hallett TR, Lu MT, Puchner SB, Simon TG, Foldyna B, Ginsburg GS, McGarrah RW, Voora D, Shah SH, Douglas PS, Hoffmann U, Corey KE. Risk factors for cardiovascular disease among individuals with hepatic steatosis. Hepatol Commun 2022 Dec;6(12):3406-3420. PM: 36281983.

Karra R, Nafissi NA. Expanding the Molecular Autopsy to Uncover Occult Cardiomyopathy: Concealed to Revealed. J Am Coll Cardiol 2022 Nov 29;80(22):2069-2071. PM: 36423991.

Kern MJ, Cox D, Fearon W, Johnson N, Klein L, Krucoff M, Moses J, Naidu SS, Pinto D, Ramee S, Teirstein P, Yeung A. Is FFR dead? A conversation in cardiology. Catheter Cardiovasc Interv 2022Nov;100(6):1045-1050. PM: 36273434.

Liang J, Wang H, Cade BE, Kurniansyah N, He KY, Lee J, Sands SA, A Brody J, Chen H, Gottlieb DJ, Evans DS, Guo X, Gharib SA, Hale L, Hillman DR, Lutsey PL, Mukherjee S, Ochs-Balcom HM, Palmer LJ, Purcell S, Saxena R, Patel SR, Stone KL, Tranah GJ, Boerwinkle E, Lin X, Liu Y, et al. Targeted Genome Sequencing Identifies Multiple Rare Variants in Caveolin-1 Associated with Obstructive Sleep Apnea. Am J Respir Crit Care Med 2022 Nov15;206(10):1271-1280. PM: 35822943.

Long C, Tcheng JE, Marinac-Dabic D, Iorga A, Krucoff M, Fisher D. Developing minimum core data structure for the obesity devices Coordinated Registry Network (CRN). BMJ Surg Interv Health Technol 2022 Nov11;4(Suppl 1):e000118. PM: 36393892.

Navar AM, Fine LJ, Ambrosius WT, Brown A, Douglas PS, Johnson K, Khera AV, Lloyd-Jones D, Michos ED, Mujahid M, Muñoz D, Nasir K, Redmond N, Ridker PM, Robinson J, Schopfer D, Tate DF, Lewis CE. Earlier treatment in adults with high lifetime risk of cardiovascular diseases: What prevention trials are feasible and could change clinical practice? Report of a National Heart, Lung, and Blood Institute (NHLBI) Workshop. Am J Prev Cardiol 2022 Nov 13;12:100430. PM: 36439649.

Navar AM, Kolkailah AA, Overton R, Shah NP, Rousseau JF, Flaker GC, Pignone MP, Peterson ED. Trends in Oral Anticoagulant Use Among 436 864 Patients With Atrial Fibrillation in Community Practice, 2011 to 2020. J Am Heart Assoc 2022 Nov15;11(22):e026723. PM: 36346063.

Orvin NJ, Beavers JC, Russell SD. Acute Diuretic-Sparing Effects of Sacubitril-Valsartan: Staying in the Loop. J Pharm Pract 2022 Dec;35(6):859-863. PM: 33882753.

Ostrominski JW, Vaduganathan M, Claggett BL, de Boer RA, Desai AS, Dobreanu D, Hernandez AF, Inzucchi SE, Jhund PS, Kosiborod M, Lam CSP, Langkilde AM, Lindholm D, Martinez FA, O’Meara E, Petersson M, Shah SJ, Thierer J, McMurray JJV, Solomon SD. Dapagliflozin and New York Heart Association functional class in heart failure with mildly reduced or preserved ejection fraction: the DELIVER trial. Eur J Heart Fail 2022 Oct;24(10):1892-1901. PM: 36054231.

Patel D, Vatterott P, Piccini J, Epstein LM, Hakmi S, Syed I, Koweek LM, Bolen M, Schoenhagen P, Tarakji KG, Francis N, Shao M, Wilkoff BL. Prospective Evaluation of the Correlation Between Gated Cardiac Computed Tomography Detected Vascular Fibrosis and Ease of Transvenous Lead Extraction. Circ Arrhythm Electrophysiol 2022Nov;15(11):e010779. PM: 36306341.

Prabhakaran D, Singh K, Kondal D, Raspail L, Mohan B, Kato T, Sarrafzadegan N, Talukder SH, Akter S, Amin MR, Goma F, Gomez-Mesa J, Ntusi N, Inofomoh F, Deora S, Philippov E, Svarovskaya A, Konradi A, Puentes A, Ogah OS, Stanetic B, Issa A, Thienemann F, Juzar D, Zaidel E, et al. Correction: Cardiovascular Risk Factors and Clinical Outcomes among Patients Hospitalized with COVID-19: Findings from the World Heart Federation COVID-19 Study. Glob Heart 2022 Oct 31;17(1):79. PM: 36382154.

Rao VN, Mentz RJ, Coniglio AC, Kelsey MD, Fudim M, Fonarow GC, Matsouaka RA, DeVore AD, Caughey MC. Neighborhood Socioeconomic Disadvantage and Hospitalized Heart Failure Outcomes in the American Heart Association Get With The Guidelines-Heart Failure Registry. Circ Heart Fail 2022 Nov;15(11):e009353. PM: 36378758.

Regan JA, Truby LK, Tahir UA, Katz DH, Nguyen M, Kwee LC, Deng S, Wilson JG, Mentz RJ, Kraus WE, Hernandez AF, Gerszten RE, Peterson ED, Holman RR, Shah SH. Protein biomarkers of cardiac remodeling and inflammation associated with HFpEF and incident events. Sci Rep 2022 Nov 22;12(1):20072. PM: 36418363.

Reid HW, Parente V, Gupta MD, Hantzmon S, Olsen MK, Yang H, Jackson LR, Johnson KS, Pollak KI. Examining the relationship between clinician communication and patient participatory behaviors in cardiology encounters. Patient Educ Couns 2022 Dec;105(12):3473- 3478. PM: 36137906.

Scherba JC, Karra R, Turek JW, Bursac N. Toward improved understanding of cardiac development and congenital heart disease: The advent of cardiac organoids. J Thorac Cardiovasc Surg 2022 Dec;164(6):2013-2018. PM: 35307217.

Sedrakyan A, Marinac-Dabic D, Campbell B, Aryal S, Baird CE, Goodney P, Cronenwett JL, Beck AW, Paxton EW, Hu J, Brindis R, Baskin K, Cowley T, Levy J, Liebeskind DS, Poulose BK, Rardin CR, Resnic FS, Tcheng J, Fisher B, Viviano C, Devlin V, Sheldon M, Eldrup-Jorgensen J, et al. Advancing the Real-World Evidence for Medical Devices through Coordinated Registry Networks. BMJ Surg Interv Health Technol 2022 Nov 11;4(Suppl 1):e000123. PM: 36393894.

Selvaraj S, Seidelmann SB, Soni M, Bhattaru A, Margulies KB, Shah SH, Dugyala S, Qian C, Pryma DA, Arany Z, Kelly DP, Chirinos JA, Bravo PE. Comprehensive nutrient consumption estimation and metabolic profiling during ketogenic diet and relationship with myocardial glucose uptake on FDG-PET. Eur Heart J Cardiovasc Imaging 2022 Nov17;23(12):1690-1697. PM: 35366303.

Simard T, Vemulapalli S, Jung RG, Vekstein A, Stebbins A, Holmes DR, Czarnecki A, Hibbert B, Alkhouli M. Transcatheter Edge-to-Edge Mitral Valve Repair in Patients With Severe Mitral Regurgitation and Cardiogenic Shock. J Am Coll Cardiol 2022 Nov 29;80(22):2072- 2084. PM: 36126766.

Toro C, Ohnuma T, Komisarow J, Vavilala MS, Laskowitz DT, James ML, Mathew JP, Hernandez AF, Goldstein BA, Sampson JH, Krishnamoorthy V. Early Vasopressor Utilization Strategies and Outcomes in Critically Ill Patients With Severe Traumatic Brain Injury. Anesth Analg 2022 Dec 1;135(6):1245-1252. PM: 35203085.

Winther S, Schmidt SE, Foldyna B, Mayrhofer T, Rasmussen LD, Dahl JN, Hoffmann U, Douglas PS, Knuuti J, Bøttcher M. Coronary Calcium Scoring Improves Risk Prediction in Patients With Suspected Obstructive Coronary Artery Disease. J Am Coll Cardiol 2022 Nov 22;80(21):1965- 1977. PM: 36396197.

Yamada Y, Zhang X, Henderson MET, Sagayama H, Pontzer H, Watanabe D, Yoshida T, Kimura M, Ainslie PN, Andersen LF, Anderson LJ, Arab L, Baddou I, Bedu-Addo K, Blaak EE, Blanc S, Bonomi AG, Bouten CVC, Bovet P, Buchowski MS, Butte NF, Camps SG, Close GL, Cooper JA, Cooper R, Das S. Variation in human water turnover associated with environmental and lifestyle factors. Science 2022 Nov 25;378(6622):909-915. PM: 36423296.