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Highlights September 8th Week

Former Fellows Reunite at ESC 2019

Peter Quigley, Peter Clemmensen and Magnus Ohman were able to catch up with one another while at the European Society of Cardiology held last weekend in Paris. They all worked together in the late 1980s and worked with Galen Wagner and Richard Stack.

The meeting was highlighted by several important clinical trials and presentations by many of the Duke Heart Faculty.  We will have a full list of presentations and publications forthcoming.  Several advances in Heart Failure, management of diabetes, and patients needing complete revascularization at the time of acute MI were presented.





CSTI Announces TransPop Expansion; MURDOCK Celebrates 10th Anniversary

In conjunction with the 10th anniversary of the first participant enrolled in the landmark MURDOCK Study, the Duke CTSI Translational Population Health Research group has announced plans to double its clinical research space at the North Carolina Research Campus in Kannapolis.

“The MURDOCK Study is our foundational study and has paved the way for TransPop’s growing clinical research presence in Kannapolis,” said L. Kristin Newby, MD, principal investigator for the MURDOCK Study and director for Translational Population Health Research (TransPop). “The value of the MURDOCK Study is its ability to help researchers answer big questions to better understand health and disease. We could not do this work without our dedicated participants.”

One of the largest community-based research studies of its kind, the MURDOCK Study Community Registry and Biorepository has more than 12,500 participants and about 430,000 biological samples. People from 20 zip codes in and around Kannapolis and Cabarrus County joined the study. Participants complete a follow-up form every year, and researchers track changes to their health over time.

The study has more than 50 collaborations, including 150 collaborators across 21 institutions, and 47 peer reviewed publications. More than 100 Duke faculty members have used MURDOCK Study samples and data to explore a broad range of research questions, and two new cohorts launched this year, the MURDOCK Fractures and Falls Study and MURDOCK Kidney Health Study.

“I’m excited about all that has been accomplished over the past decade through the MURDOCK Study, and I’m confident and excited about what the future holds. Our core values in the School of Medicine remind us that we are here to accelerate discovery, advance the care of patients, and to train the next generation of heath care providers,” said Mary E. Klotman, M.D., Dean, Duke University School of Medicine. “I can think of few projects that are a better example than the MURDOCK Study of how we are living out these values in the work we all do at Duke.”

To continue to support a growing network of investigators and their research projects and to better serve participants and study staff, TransPop will double its state-of-the-art clinical office to 10,100 square feet, giving the group much-needed space to onboard new studies based in Kannapolis, Newby said. Construction is expected to take place this fall on the third floor of the North Carolina Research Campus Medical Office Building.

“The planned expansion will create an ideal research environment for our investigators, study participants, and our staff,” Newby said. She noted the TransPop expansion coincides with an ambitious overhaul of downtown Kannapolis and encouraged Duke collaborators to visit.

Duke CTSI is observing the MURDOCK Study 10th anniversary throughout the year. The celebration continues Oct. 12 with the Duke Dash 5K & Healthfest at the North Carolina Research Campus in Kannapolis.

MURDOCK stands for Measurement to Understand the Reclassification of Disease Of Cabarrus and Kannapolis. Duke University School of Medicine received a generous from David H. Murdock through the David H. Murdock Institute for Business and Culture to establish the MURDOCK Study in September 2007. The first participant was enrolled in 2009.

To learn more about collaborating with the MURDOCK Study and Duke CTSI TransPop, go to duketranspop.org.


Project Baseline Update

Svati Shah discusses advancing health science to improve heart attack and stroke prevention in a new Project Baseline Q&A. Shah is Duke’s principal investigator for the Project Baseline Health Study and also partners on the new Project Baseline Heart Biomarker Study. She’s director of the Duke Adult Cardiovascular Genetics Clinic.

The Health Study is the first initiative of Project Baseline, an ambitious effort to develop a well-defined “baseline” of human health, and a rich data platform to help researchers better understand health and disease and the transitions between them. Collaborators include Duke, VerilyStanford Medicine and Google.


Department of Medicine Grand Rounds

Neha Pagidipati, Svati Shah, and Sreekanth Vemulapalli presented at the Friday, Sept. 6 Department of Medicine Grand Rounds.  The grand rounds focused on data science projects that were supported by the Department of Medicine and our Division.  Neha focused on cardiometabolic disease and obesity and Svati and Sreek presented around the imaging relationships between echo and the underlying genetics and myocardial disease.

 Great Job!


Shout Outs to CCU Fellows; Jade Clausen

Jen Rymer sent kudos out the week ending Sept. 1 to CCU fellows Vanessa, Chris and Jeff. She said, “Thanks to the hard work of all the CCU fellows! We appreciated their clear and timely communication and their hard work to transition patients in and out of the Cath lab when the hospital was very busy.” Many thanks to Anna Lisa Crowley for sharing this with us!


Special thanks to Jade Clausen, NP for inpatient cardiology transplant! She went above and beyond for a patient family this week ahead of Hurricane Dorian. Per Adam Devore:  “This week we had a heart transplant patient completing PLEX and ATG for rejection but hoping to get home before the Hurricane Dorian landed. Jade came in early to make sure the patient was discharged before 7 am so that the patient could make it home to his family.” Todd McVeigh, co-team lead for Cardiology APPs, shared with us that Jade came to the hospital well ahead of the start of her shift in order to discharge the patient, putting him and his family at ease.


Great job, Vanessa, Chris, Jeff and Jade!


Commemorative 25th Anniversary Books Available

Own a piece of history! We have a limited number of extra copies of the Duke Heart Center 25th anniversary commemorative photo book available while supplies last. They are located on the 8th floor of the HAFS building and are available on a first come, first served basis at no cost. Please see Renee Story in person this week if you would like a copy.



Upcoming Opportunities/Save the Date:

September 22: Triangle Heart Walk.

Check in starts at 12:30 p.m.; the walk is at 2 p.m. at PNC Arena. Have you registered? Help Duke beat UNC – we need more walkers!

It is not too late to register as a team captain or to join an already formed team (there are several to join as part of Duke Heart as well as all major DUHS entities) – please visit: https://www2.heart.org/site/TR?company_id=209022&fr_id=4327&pg=company

Consider joining our Heart Center team aimed at partnering to advance cardiovascular health through community engagement (PACE). Here is the link (or search for “PACE”): http://www2.heart.org/goto/PACEHeartWalkTeam


Cardiology Grand Rounds

Join us for Cardiology Grand Rounds with Michael Fradley of USF Health. He will present Nuts and Bolts of Cardio-Oncology: From pathophysiology to program development. Monday, Sept. 9, 7:15 a.m., DN, 2001. Breakfast will be available, but please arrive early if you want dibs on your favorites!

Upcoming Grand Rounds:

  • 17: Ron Witteles, of Stanford Medicine. Cardiac Amyloidosis. 7:15 a.m., DN, 2003.


Have news to share?

If you have news to share with the Pulse readership, please contact Tracey Koepke, director of communications for Duke Heart at tracey.koepke@duke.edu. We would love to hear about your latest accomplishments, professional news, cool happenings, and any events or opportunities that may be of interest to our Duke Heart family. Please call with any questions: 919-681-2868. Feedback on Pulse is welcome and encouraged.


Duke Heart in the News:

August 30 — Yaron Barac

Cardiovascular Business

TBI donor hearts found viable for transplant



August 31 — Matthew Roe


Bleeding in ACS Patients on DAPT Should Prompt Cancer Search



August 31 — E. Magnus Ohman

tctMD/the heart beat

Evolocumab in Acute ACS Safely Reduces LDL Cholesterol: EVOPACS



September 1 — Sana Al-Khatib


Take a Vacation, Your Heart Will Thank You



September 2 — Christopher Granger

tctMD/the heart beat

BMI Not the Best Option for Predicting CV Events, Global Analysis Suggests



September 2 — Sana Al-Khatib

Healio/Cardiology Today

Periodic repolarization dynamics may identify ICD candidates



September 3 — Sana Al-Khatib

Medpage Today

ICDs Still Save Lives in HF



September 4 — Christopher Granger and Renato Lopes

Medpage Today

Dual Tx With Edoxaban Noninferior to Standard Triple Tx



September 5 — James Blumenthal (Psychiatry)


Want a Healthy Brain? Stanford Neuroscientists Say Doing This 1 Easy Activity Improves Memory, Boosts Mood, and Prevents Dementia



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