Quantitative Imaging and Analysis Lab

Group Photo

Posted on March 21, 2023 by Cristian Badea

QIAL members and the Bass Connections team, March 2023

Artist and T-shirts Designer: Nariman (Ali) Mahzarnia

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Animal Models and Their Role in Imaging-Assisted Co-Clinical Trials

Posted on March 16, 2023 by Cristian Badea

This overview paper describes the ten co-clinical trials of investigators from eleven institutions who are supported by the CIRP initiative and are members of the Animal Models and Co-clinical Trials (AMCT) Working Group.

Examples of MRI and micro-CT images in the p53/MCA model and the schematics of the preclinical arm of the clinical trial organized at Duke.

Peehl, D.M.; Badea, C.T.; Chenevert, T.L.; Daldrup-Link, H.E.; Ding, L.; Dobrolecki, L.E.; Houghton, A.M.; Kinahan, P.E.; Kurhanewicz, J.; Lewis, M.T.; Li, S.; Luker, G.D.; Ma, C.X.; Manning, H.C.; Mowery, Y.M.; O’Dwyer, P.J.; Pautler, R.G.; Rosen, M.A.; Roudi, R.; Ross, B.D.; Shoghi, K.I.; Sriram, R.; Talpaz, M.; Wahl, R.L.; Zhou, R. Animal Models and Their Role in Imaging-Assisted Co-Clinical Trials. Tomography 2023, 9, 657-680. https://doi.org/10.3390/tomography9020053

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Identifying vulnerable brain networks associated with Alzheimer’s disease risk

Posted on November 9, 2022 by Cristian Badea

Ali Mahzarnia, Jacques A Stout, Robert J Anderson, Hae Sol Moon, Zay Yar Han, Kate Beck, Jeffrey N Browndyke, David B Dunson, Kim G Johnson, Richard J O’Brien, Alexandra Badea, Identifying vulnerable brain networks associated with Alzheimer’s disease risk, Cerebral Cortex, 2022;, bhac419, https://doi.org/10.1093/cercor/bhac419

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QIAL papers @ CT Meeting 2022

Posted on October 19, 2022 by Cristian Badea

1. C. Badea, D. Clark, A. Alphin, J. C. Ramirez-Giraldo, P. Bhandari, Y. Mowery, K. Ghaghada. Co-clinical photon counting CT research for multi-contrast imaging. Proceedings Volume 12304, 7th International Conference on Image Formation in X-Ray Computed Tomography; 123040G (2022) https://doi.org/10.1117/12.2646399

2. Darin P. Clark, Alex J. Allphin, Yvonne M. Mowery, Cristian T. Badea. Photon-counting x-ray CT perfusion imaging in animal models of cancer . Proceedings Volume 7th International Conference on Image Formation in X-Ray Computed Tomography, 123041B (2022) https://doi.org/10.1117/12.2646403

3. Rohan Nadkarni, Alex Allphin, Darin Clark, Cristian Badea. Material decomposition from photon-counting CT using a convolutional neural network and energy-integrating CT training labels. Proceedings Volume 12304, 7th International Conference on Image Formation in X-Ray Computed Tomography; 123041K (2022)) https://doi.org/10.1117/12.2646405

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Preclinical implementation of a clinical trial

Posted on October 3, 2022 by Cristian Badea

This study aimed to investigate whether adding neoadjuvant radiotherapy (RT), anti-programmed cell death protein-1 (PD-1) antibody (anti-PD-1), or RT + anti-PD-1 to surgical resection improves disease-free survival for mice with soft tissue sarcomas (STS). The paper has been included in the highlights.

https://doi.org/10.1158/1535-7163.MCT-21-0991

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Deep learning based material decomposition for photon counting CT

Posted on July 18, 2022 by Cristian Badea

R Nadkarni, A Allphin, DP Clark, CT Badea. Material decomposition from photon-counting CT using a convolutional neural network and energy-integrating CT training labels. Physics in Medicine & Biology, Volume 67, Number 15 . https://doi.org/10.1088/1361-6560/ac7d34