Author Archives: Cristian Badea

A Calibrated Digital Twin for Preclinical PCCT

Posted on June 8, 2026 by Cristian Badea

This work presents a calibrated virtual photon-counting micro-CT platform combining realistic mouse vasculature, AI-generated tumors, and calibrated iodine/barium imaging. Nadkarni R, Clark DP, Allphin AJ, Qi Y, Mowery Y, Segars PW, Badea CT. Virtual photon-counting micro-CT platform for simulation of … Continue reading →

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QIAL @ SPIE 2026: Photon-Counting CT and AI

Posted on May 15, 2026 by Cristian Badea

QIAL’s strong SPIE Medical Imaging 2026 contributions: virtual photon-counting micro-CT, self-supervised DL denoising, brain–heart imaging in APOE mice, and high-resolution 5D cardiac PCCT. Nadkarni, R., D. P. Clark, A. J. Allphin, Y. Qi, Y. M. Mowery, W. P. Segars, et … Continue reading →

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QIAL Perspective

Posted on April 14, 2026 by Cristian Badea

239 steps up Duke Chapel with the QIAL team! Worth it for the view, the reset, and the reminder to step back and see the bigger picture.

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QIAL Celebrates a PhD Milestone

Posted on March 26, 2026 by Cristian Badea

Congratulations to Dr. Rohan Nadkarni on successfully defending his PhD today. We are proud of all his hard work and contributions in the QIAL lab, and we wish him the very best ahead.

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Predictive Alzheimer’s Risk

Posted on December 19, 2025 by Cristian Badea

Congratulations to QIAL’s Dr. Alexandra Badea and Dr. Trong-Kha Truong on receiving the 2025 Medical Physics Fall Seed Grant Award for their project, “Predictive Modeling of Alzheimer’s Disease Risk Using Explainable AI and High-Resolution MRI.”

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Exercise Protects the Aging Heart in High-Fat Diet APOE Mice

Posted on December 16, 2025 by Cristian Badea

Using photon-counting CT and deep learning, we show that voluntary exercise significantly mitigates high-fat diet–induced cardiac dysfunction in adult APOE-targeted mice, with the strongest benefits observed in APOE4 and humanized innate immune (HN) backgrounds. Exercise mitigates high-fat diet–induced cardiac dysfunction … Continue reading →

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Imaging Bone Aging with Photon-Counting CT

Posted on November 13, 2025 by Cristian Badea

How do genetics, sex, and immune signaling shape bone health as mice age?Our study shows that photon-counting CT  in APOE mouse models reveals strong sex- and immune-dependent bone loss, with female HN mice showing the most pronounced decline. Nadkarni, R.; … Continue reading →

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Visiting Fulbright Scholar: Dr Kristina Bliznakova

Posted on October 6, 2025 by Cristian Badea

Delighted to host Dr. Kristina Bliznakova, Fulbright Scholar, at Duke’s Quantitative Imaging & Analysis Lab. Looking forward to teaming up on photon-counting CT and virtual  imaging.

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Identifying Alzheimer’s network biomarkers

Posted on August 15, 2025 by Cristian Badea

New article and three institutions collaborating! We identify network biomarkers of Alzheimer’s risk by combining high-res MRI with multifactorial analysis in ApoE mouse models. Joint volume + texture patterns reveal how genotype, sex, diet, & immunity interact to shape brain … Continue reading →

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Virtual Wistar Rats Enable Realistic PCCT Simulations

Posted on August 14, 2025 by Cristian Badea

Our team developed anatomically variable digital Wistar rat phantoms for realistic preclinical imaging simulations, enabling PCCT studies & reducing animal use. Segars, H. E., Nadkarni, R., Badea, C. T., Badea, A., Chin, B., Johnson, G. A., Payne, J., Samei, E., … Continue reading →

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