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Author Archives: Cristian Badea
Alzheimer’s Risk in Brain Networks
Our study links APOE gene, age, sex, and diet to brain network changes in Alzheimer’s disease. Winter, S., Mahzarnia, A., Anderson, R. J., Han, Z. Y., Tremblay, J., Stout, J. A., Moon, H. S., Marcellino, D., Dunson, D. B., & … Continue reading
Fast Denoising of 5D Cardiac Photon-Counting CT
Using deep learning denoising we achieve a 32x speedup over iterative methods for 5D cardiac PCCT in the mouse! Rohan Nadkarni, Darin P. Clark, Alex Allphin, and Cristian T. Badea. Investigating Deep Learning Strategies for Fast Denoising of 5D Cardiac … Continue reading
Posted in spectral CT
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New Turn-Table Micro-CT Scanner for Perfusion Imaging
Our new turn-table micro-CT scanner offers high-resolution, low-dose dynamic perfusion imaging in mice. Allphin AJ, Nadkarni R, Clark DP, Gil CJ, Tomov M, Serpooshan V, Badea CT. Turn-table micro-CT scanner for dynamic perfusion imaging in mice: design, implementation, and evaluation. … Continue reading
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AI-Driven Brain Age Estimation in Alzheimer’s Mouse Models
Our study on Alzheimer’s disease risk uses advanced AI models to estimate brain age in APOE/hNOS2 mouse models: Hae Sol Moon, Ali Mahzarnia, Jacques Stout, Robert J Anderson, Zay Yar Han, Jessica T Tremblay, Cristian T. Badea, Alexandra Badea; Feature attention graph neural network for estimating brain … Continue reading
Tagged Brain
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High-Resolution Photon Counting CT for Brain Imaging in APOE Mouse Models
Our team developed a high-res photon counting CT pipeline for mouse brain imaging. Faster than MRI, it reveals key differences in brain regions across APOE genotypes. Nadkarni R, Han ZY, Anderson RJ, Allphin AJ, Clark DP, Badea A, et al. … Continue reading
Posted in spectral CT
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QIAL@ SPIE Medical Imaging 2024
QIAL Contributions at SPIE Medical Imaging, San Diego, 2024 Predicting brain age and associated structural networks in mouse models with humanized APOE alleles using integrative and interpretable graph neural networks HS Moon, A Mahzarnia, J Stout, RJ Anderson, ZY Han, … Continue reading
Posted in spectral CT
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Congratulations to Hae Sol Moon!
Congratulations to runner-up Hae Sol Moon of the Robert F. Wagner All-Conference Best Student Paper Award, sponsored by SPIE and the Medical Imaging Perception Society!
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Gene Set Analysis Links Vascular Endothelial Growth Factor to Alzheimer’s via ITGA5
Our new study delves into Alzheimer’s disease, revealing molecular pathways tied to hallmark biomarkers & cognitive decline. Pathway analysis identified VEGF-RB as a common link, offering insights into disease mechanisms & potential treatment avenues. Mahzarnia, Ali, Lutz, Michael W., and … Continue reading
Impact of Age Related Macular Degeneration through Advanced Imaging
Exciting research on Age-related Macular Degeneration (AMD) and its impact on the brain! Using diffusion MRI, we observed significant brain changes in AMD patients, including reduced volume in key cognitive areas and altered brain connections. Stout, J.A.; Mahzarnia, A.; Dai, … Continue reading
Understanding Alzheimer’s, brain aging, & the role of APOE2 allele
In our study, we adopted an integrative approach that combined behavioral assessments, brain imaging, and blood transcriptomics to focus on the transition from middle to old age in APOE2 mice, leading to the identification of critical brain sub-networks and regions … Continue reading
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