The motor domain sequence alignment shown below was based on the multiple alignment program, Tulla v 2.1 (Subbiah and Harrison, 1989). Tulla-optimized alignments are intended to be those that most closely reflect the 3-dimensional structural alignment of the proteins. The final alignment was adjusted and optimized manually, and the final protein sequences were added by hand, aided by the Wisconsin GCG Program, Bestfit. The alignment begins with DmKHC sequence AEDSIKV and ends with KNVVCVN, corresponding to amino acids 9-340. A sequence alignment like the one below was used to build the tree shown on the Kinesin Tree page. The proteins are grouped by subfamily in the following order: Kinesin-14 (formerly C-terminal Motor), Kinesin-6 (formerly MKLP1), Kinesin-8 (formerly Kip3), Kinesin-1 (formerly KHC), Kinesin-2 (formerly KRP85/95 or kinesin-II), Kinesin-5 (formerly BimC), Kinesin-3 (formerly Unc104/KIF1), Kinesin-4 (formerly Chromokinesin/KIF4) and Kinesin-13 (formerly MCAK/KIF2), followed by the Orphan or ungrouped kinesin proteins. The positions of structural elements from crystal structures of HsKHC and DmNcd are indicated.
View conserved motifs in the kinesin motor domains.
1 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660
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|beta1| | alpha1 | |beta3|| L4 || a2|| L5 || alpha2 || L6 || beta4 || L7||b5| L8 ||b5| | alpha3 || L9 ||a3a| | beta6 || L10 || beta7 || L11 || alpha4 || L12 || alpha5 | | beta8| | alpha6 |
LmL6066 LKGNIRVYCRVRPMLSNEIKGGYSDVMSYPTQDEVRLIDAS---------------------GRPKLFEFDEVYPPTA----------PQARVFEDTA-PLIDSVVDGFNVCIFAYGQTGSGKTFTMNGT--------------EGENKGINTRALERLFGVIEERKETEV---------------------------------------------------------------------------------------------------STVTVSVLEIYCEQIRDLLATKK-------------------------------------------------------------------------------------------------------EASGLTYEVKQGGPYGTYVTNLKEVPVTSAGDIDGIMATAQTHRSEGMTNMNEHSSRSHMLLYIIVRTTN----------------KQTNMQGYGKLSLIDLAGSERVDKSG--------------------------AEGQRLKEAVAINKSLSALGDVIAGLAQNS--------------------------------------KHVPFRNSALTFLLQDS-MAGQAKVLMFVCVSPASYNVSESSSSLLFASRA-RGV-AFGQI-- LmL6066
AtKATD LKGNIRVYCRVRPFLPGQESGGLSAVEDIDEGTITIRVPSK------------------YGKAGQKPFMFNKVFGPSA----------TQEEVFSDMQ-PLVRSVLDGYNVCIFAYGQTGSGKTFTMTGP-----------KELTEESLGVNYRALADLFLLSNQRKDTTS---------------------------------------------------------------------------------------------------YEISVQMLEIYNEQVRDLLAQDG---------------------------------------------------------------------------------------------------------QTKRLEIRNNSHNGINVPEASLVPVSSTDDVIQLMDLGHMNRAVSSTAMNDRSSRSHSCVTVHVQGRD----------------LTSGSILHGSMHLVDLAGSERVDKSE--------------------------VTGDRLKEAQHINKSLSALGDVISSLSQKT--------------------------------------SHVPYRNSKLTQLLQDS-LGGSAKTLMFVHISPEPDTLGETISTLKFAERV-GSV-ELGAARV AtKATD
AtT30B22 LKGSIRVYCRVRPFLPGQSSFSSTIGNMEDDTIGINTASRH--------------------GKSLKSFTFNKVFGPSA----------TQEEVFSDMQ-PLIRSVLDGYNVCIFAYGQTGSGKTFTMSGP-----------RDLTEKSQGVNYRALGDLFLLAEQRKDTFR---------------------------------------------------------------------------------------------------YDIAVQMIEIYNEQIRNSSQKGL------------------------------------------------------------------------------------------------------------------------SVPDASLVPVSSTFDVIDLMKTGHKNRAVGSTALNDRSSRSHSCLTVHVQGRD----------------LTSGAVLRGCMHLVDLAGSERVDKSE--------------------------VTGDRLKEAQHINRSLSALGDVIASLAHKN--------------------------------------PHVPYRNSKLTQLLQDS-LGGQAKTLMFVHISPEADAVGETISTLKFAERV-ATV-ELGAARV AtT30B22
AtT32N15 RIGTIRVYCRVRPFFQEQKDMQSTVDYIGENGNIIINNPFK------------------QEKDARKIFSFNKVFGQTV----------SQEQIYIDTQ-PVIRSVLDGFNVCIFAYGQTGSGKTYTMSGP-----------DLMTETTWGVNYRALRDLFQLSNARTHVVT---------------------------------------------------------------------------------------------------YEIGVQMIEIYNEQVRDLLVSDV----------------------------------------------------------------------------------------------------------------------------------SNTRDVLDLMRIGQKNRAVGATALNERSSRSHSVLTVHVQGKE----------------LASGSILRGCLHLVDLAGSERVEKSE--------------------------AVGERLKEAQHINKSLSALGDVIYALAQKS--------------------------------------SHVPYRNSKLTQVLQDS-LGGQAKTLMFVHINPEVNAVGETISTLKFAQRV-ASI-ELGAARS AtT32N15
XlCTK1 LRGNIRVFARVRPITTEDGVGPGAENIVTFDPDDDGVLYVA-------------------QKGKEMSFELDKIFTPSA----------TQEEVFRDVS-PLITSCLDGYSVCILAYGQTGSGKTYSMEGI---------------PSDPGINQRALRLLLSEVKERSSSWE---------------------------------------------------------------------------------------------------HELSVSMVEIYNESLRDLLGSDP--------------------------------------------------------------------------------------------------------SNSLEIKILPGSVGELYVPNLTQRQVQSMEDINKILELGHKQRATEHTNLNTHSSRSHALLILTAKGRE----------------TSTGICSTGKLYLVDLAGSERVSRSG--------------------------AAGERLREAQCINRSLSALGDVISALRSQQ--------------------------------------GHIPYRNSKLTYLLQEP-LSREGKALLLLQVSPAEKNISESLCSLRFGDRV-RAV-ELGAPSR XlCTK1
HsKIFC3 LKGNIRVIARVRPVTKEDGEGPEATNAVTFDADDDSIIHLL-------------------HKGKPVSFELDKVFSPQA----------SQQDVFQEVQ-ALVTSCIDGFNVCIFAYGQTGAGKTYTMEGT---------------AENPGINQRALQLLFSEVQEKASDWE---------------------------------------------------------------------------------------------------YTITVSAAEIYNEVLRDLLGKEP--------------------------------------------------------------------------------------------------------QEKLEIRLCPDGSGQLYVPGLTEFQVQSVDDINKVFEFGHTNRTTEFTNLNEHSSRSHALLIVTVRGVD----------------CSTGLRTTGKLNLVDLAGSERVGKSG--------------------------AEGSRLREAQHINKSLSALGDVIAALRSRQ--------------------------------------GHVPFRNSKLTYLLQDS-LSGDSKTLMVVQVSPVEKNTSETLYSLKFAERV-RSV-ELGPGLR HsKIFC3
MsFKIF2 LKGNIRVFCRVRPVSQEEQDSADARTMLSFDSEDDAVLYLS-------------------NKGKIMTFELDKVFAPQA----------TQEEVFQEVQ-SLVTSCIDGFNVCIFAYGQTGSGKTYTMEGV---------------VDDPGINQRALRLLFSEVTEKAPDWD---------------------------------------------------------------------------------------------------YKITVSMVEIYNETLRNLLGENP--------------------------------------------------------------------------------------------------------TDKLDIKMNPDGSGQLYVPGLTEFTVQSPEDINRVFELGHMNRATACTNLNEHSSRSHALLIITVSGTR--------------FNSATGNRTQGKLNLVDLAGSERIAKSG--------------------------AEGSRLREAQCINKSLSALGDVINALRSKH--------------------------------------SHIPFRNSRLTYLLQDS-LNGDSKTLMMVQVSPLPTNMSESVCSLKFAQRV-RSV-ELSSSSS MsFKIF2
MmKIFC2 LKGNIRVLCRLRPAEGQPSSLVSVEPGQGGTITTCY-------------------------RGRQHCFRLDWVFPQDA----------SQEEVFRQLE-PAVLSCLQGYSVCIFTYGQTGTGKTYSMEGP---------------PEDPGIAPRALQLLFREMGTGGH------------------------------------------------------------------------------------------------------HHVTLSMVEIYNEAVRDLLATGP--------------------------------------------------------------------------------------------------------PERLVVRQGPAGQGGIQVAGLTHWDVPNLETLHQMLSLGRSNRATAATVMNQHSSRSHALVTLTLRAAS----------------PPRPQGITGTLHLVDLAGSERVWKAG-----------------VASPVQRDPNGARRLREAQAINRSLLALGGVMAALRARR--------------------------------------PHVPFRDSQLTRLLQPA-LWAGTTAVLLLQISTRAEDLGETICSLKFAERV-GQV-ELGPARR MmKIFC2
CeKLP3 LNGNIRVFYRIRPQLASETDNQKPVVVIDEMDNGVVHVSNT-------------------TGTRKTSAGADKVIPTDF----------SQDQIFNEVS-PIITSCIDGYNVCIFAYGHTGSGKTYTMDGP---------------VTMPGINQRAIMQLFETAKERTGDIK---------------------------------------------------------------------------------------------------YDIKVAMMEIYNEKIRDLLNTSN-----------------------------------------------------------------------------------------------------------TNLAIRQTEEGRSSIPGLEEVSVNSAEEVTETLARGRKNKAVAATEANIESSRSHVIVRVLVSATN----------------LITKATTVGRLNLVDLAGSERVSQTN--------------------------ATGQLLKEAQAINKSLSELGNVVLALRQNQ--------------------------------------KHIPFRNCQLTRILEDS-LNGDSKTLVIVHLSPDAKSLNESISSVNFAEKIGQVFTKSGTMKR CeKLP3
AtT5A14.3 LKGNIRVFCRVKPLGATEKLRPPVASDTRNVIIKL-------------------------SETKRKTYNFDRVFQPDS----------SQDDVFLEIE-PVIKSVIDGYNACIFAYGQTGTGKTYTMEGL---------------PNSPGIVPRAIKGLFKQVEESNHMFTI-----------------------------------------------------------------------------------------------------HFSMLEIYMGNLKDLLLSEA---------------------------------------------------------------------------------------------------TKPISPIPPSLSIHTDPNGEIDIENLVKLKVDDFNEILRLYKVGCRSRATASTNSNSVSSRSHCMIRVSVTSLG----------------APERRRETNKIWLVDLGGSERVLKTR--------------------------ATGRRFDEGKAINLSLSALGDVINSLQRKN--------------------------------------SHIPYRNSKLTQVLKDS-LGQDSKTLMLVHISPKEDDLCETICSLNFATRA-KNI-HLGQDES AtT5A14.3
DmNcd LRGNIRVFCRIRPPLESEENRMCCTWTYHDESTVELQSIDA----------------QAKSKMGQQIFSFDQVFHPLS----------SQSDIFEMVS-PLIQSALDGYNICIFAYGQTGSGKTYTMDGV---------------PESVGVIPRTVDLLFDSIRGYRNLGWE--------------------------------------------------------------------------------------------------YEIKATFLEIYNEVLYDLLSNEQ---------------------------------------------------------------------------------------------------------KDMEIRMAKNNKNDIYVSNITEETVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAVTKLELIGRH----------------AEKQEISVGSINLVDLAGSESPKTS------------------------------TRMTETKNINRSLSELTNVILALLQKQ--------------------------------------DHIPYRNSKLTHLLMPS-LGGNSKTLMFINVSPFQDCFQESVKSLRFAASV-NSC-KMTKAKR DmNcd
XlCTK2 LKGNIRVFCRVRPTLTPERELPAGHISFPSNDGKAIVLSKM----------EESHIGREKKDAVKYDFNFDCVFPPPC----------SQESVFEEIS-LLVQSALDGYPVCIFAYGQTGSGKTYTMEGP-----------EDVTDDSMGMIPRAIHQIFSSAEELKAKGWQ--------------------------------------------------------------------------------------------------YTFTASFLEIYNETIRDLLINRP------------------------------------------------------------------------------------------------------DKKLEYEIRKVNSANMLLYVTNLRYVKVSCVEEVHELLKIAKANRSVAKTAINDRSSRSHSVFQLKIEGEN----------------KQRDLKTSSMISLIDLAGSERLDRSL--------------------------STGDRLKETQCINTSLSTLGMVITSLCNKD--------------------------------------SHIPYRNSKLTYLLQNS-LGGNAKVLMFVNISPLEENFAESLNSLRFASKV-NEC-VIGTARA XlCTK2
ZfKnsl2 LKGNIRVFCRVRPLLTGNQSDILHIQLPPHDNKALTLAKME-----------ESHTGRTTDTQKSYNFSFDRVFGPRS----------SQSEVFEEIS-LLVQSALDGYNVCCFAYGQTGSGKTFTMEGG-------------EQEELWGVIPRAVQQIFKSAKALSEQGWQ--------------------------------------------------------------------------------------------------YTFTASFVEIYNETLRDLLYKGK-------------------------------------------------------------------------------------------------------PNKRPEHEIRKVSNNEITVTNLTYQKVNNEDEVHNLIMLANQNRSTARTCMNDHSSRSHSVFQLDIEGEN----------------TARDSKCKSMLCLVDLAGSERVQKSQ--------------------------SQGERFKEMTAINSSLTNLGIVIAALANKD--------------------------------------SFVPYRNSKLTYLLQNC-LGGNSKTLMFANISPEEESFSESLNSLRFASKV-NDC-VIGTASA ZfKnsl2
CgCHO2 LKGNIRVFCRVRPVLAGEPTPSPGFLLFPHGPAGPSDPPTR--LSLSRSDDRRSTLTRAPAPTTRHDFSFDRVFPPGS----------KQEEVFEEIS-MLVQSALDGYPVCIFAYGQTGSGKTFTMEGR-----------PGGDPQLEGLIPRRMRHLFSVAQEMSGQGWT--------------------------------------------------------------------------------------------------YSFVASYVEIYNETVRDLLATGT-----------------------------------------------------------------------------------------------------RKGQGECEIRRARPGSEELTVTNARYVPVSCEREVEALLHLAHQNRAVARTAQNERSSRSHSVFQLQISGEH----------------AARGLQCVAPLNLVDLAGSERLDPGL----------------------TLGPGERDRLRETQSINSSLSTLGLVIMALSNKE--------------------------------------SHVPYRNSKLTYLLQNS-LGGSAKMLMFVNISPLEENVSESLNSLRFASKV-NQC-VIGTAQA CgCHO2
MmKIFC1 LKGNIRVFCRVRPVLAGESTPSPGFLVFPPGPAGPSDPPTG--LSLSRSDDRRSTLTGAPAPTVRHDFSFDRVFPPGS----------KQEEVFEEIA-MLVQSALDGYPVCIFAYGQTGSGKTFTMEGG-----------PRGDPQLEGLIPRAMRHLFSVAQEMSGQGWT--------------------------------------------------------------------------------------------------YSFVASYVEIYNETVRDLLATGL----------------------------------------------------------------------------------------------------RKGQGGECEIRRASPGSEELTVTNVRYVPVSCEKEVEALLHLAHQNRAVAHTAQNKRSSRSHSVFQLQISGEH----------------AARGLQCGAPLNLVDLAGSERLDPGL----------------------HLGPGERDRLRETQAINSSLSTLGLVIMALSNKE--------------------------------------SHVPYRNRKLTYLLQNS-LGGSAKMLMFVNISPLEENVSESLNSLRFASKV-NQC-VIGTAQA MmKIFC1
HsCHO2 LKGNIRVFCRVRPVLPGEPTPPPGLLLFPSGPGGPSDPPTR--LSLSRSDERRGTLSGAPAPPTRHDFSFDRVFPPGS----------GQDEVFEEIA-MLVQSALDGYPVCIFAYGQTGSGKTFTMEGG-----------PGGDPQLEGLIPRALRHLFSVAQELSGQGWT--------------------------------------------------------------------------------------------------YSFVASYVEIYNETVRDLLATGT----------------------------------------------------------------------------------------------------RKGQGGECEIRRAGPGSEELTVTNARYVPVSCEKEVDALLHLARQNRAVARTAQNERSSRSHSVFQLQISGEH----------------SSRGLQCGAPLSLVDLAGSERLDPGL----------------------ALGPGERERLRETQAINSSLSTLGLVIMALSNKE--------------------------------------SHVPYRNSKLTYLLQNS-LGGSAKMLMFVNISPLEENVSESLNSLRFASKV-NQC-VIGTAQA HsCHO2
ScKAR3 LRGNIRVYCRIRPALKNLENSDTSLINVNEFDDNSGVQSME--------------VTKIQNTAQVHEFKFDKIFDQQD----------TNVDVFKEVG-QLVQSSLDGYNVCIFAYGQTGSGKTFTMLNP-----------------GDGIIPSTISHIFNWINKLKTKGWD--------------------------------------------------------------------------------------------------YKVNCEFIEIYNENIVDLLRSDN-------------------------------------------------------------------------------------------------NNKEDTSIGLKHEIRHDQETKTTTITNVTSCKLESEEMVEIILKKANKLRSTASTASNEHSSRSHSIFIIHLSGSN----------------AKTGAHSYGTLNLVDLAGSERINVSQ--------------------------VVGDRLRETQNINKSLSCLGDVIHALGQPD-----------------------------------STKRHIPFRNSKLTYLLQYS-LTGDSKTLMFVNISPSSSHINETLNSLRFASKV-NST-RLVSRK- ScKAR3
SpoPKL1 LKGNIRVFCRVRPLLPSEESEYCIADVLQFPDKDALEPQKL------ILKGPNVESSLGHTYDRNYEFSFDRVFAPES----------DNSTVFEEIS-QLIQSAIDGYNVSIFAYGQTGSGKTYTMSSQ------------------DGMIAMSIKHIFNYLSTLREKGWV--------------------------------------------------------------------------------------------------YKLRGQFLEIYNEAIYDLLNKAE------------------------------------------------------------------------------------------------------MLKNPKHDIHHDEKERRTTVDNVSIIDFNEEDTVYKMLNRAGENRFIAATKANERSSRSHTVFMLYIDGEN----------------SRTKQICKGTLNLVDLAGSERLSYSQ--------------------------AVGDRLRETQAINKSLSCLGDVIHALGNAS-------------------------------NSTTKEKSHIPYRNSKLTYLLKYS-LGKGAKTLMFVNVSPLKSQFMDTLNSLRFATKV-NDT-KVGSIKH SpoPKL1
SpoKLP2 LKGNIRVFCRVRPPLGDGESAQIAFPDQNSEASTIEIVAQA------------PGSSLTGNGIKQYAFNFDRVFSPET----------TNEDVFNELS-QLIQSAMDGYNVCIFAYGQTGSGKTHTMSSN------------------TGMIPSSVRMIYNRSTSLKERGWE--------------------------------------------------------------------------------------------------YRMEGQFLEIYNETIIDLLASGN----------------------------------------------------------------------------------------------------EEEKGKKKLEIYHDTKAGRTTITNITSEPLDTPEQVTWLLDQASKNRSVAATNANEHSSRSHSVFMLHLNGSN----------------STTGETCRSTLNLIDLAGSERLSSSQ--------------------------SVGEPFEGTQAINKVVLGDVYMLGGLSCLG--------------------------DVIHALGSGKEGTYIPYRNSKLTNLLQYS-LGGNSKTLIFVNISPLKQHVPETLCSLRFATKV-NNT-QIGTARK SpoKLP2
AnKLPA LKGNIRVFCRVRPTLENEGASDAAQFTYPDEGEDSKEINII---------GPEEKSSFGTVTRKNHNFSFDHVFGPSA----------QNSDVFDEIS-QLVQSALDGYNVCIFCYGQTGSGKTHTMSSL------------------DGMIPRAVHQIYETATSLEEKGWR--------------------------------------------------------------------------------------------------YTMEGNFVEVYNENLNDLLGKAE------------------------------------------------------------------------------------------------------ELDKKKLEIRHDMQRGKTTITDATTVQLESPEMVESLLKRAAANRSVAATKANERSSRSHSIFILKLIGEN----------------YITGERSEGTLNLVDLAGSERLSHSG--------------------------ATGDRLKETQNINRSLSCLGDVIAALGQGK------------------------------------KDGHIPYRNSKLTYLLQFS-LGGNSKTLMFVMVSPLQAHLSETLTSLKFATKV-HNT-HIGTAKK AnKLPA
NhKRP1 LKGNIRVMCRVRPPLGDGEGERAQMSFPDDKTSAEIVLAGP-----------EEKSSLGNVTRKNYPFEFDRVFIPGT----------QNHEIFGEIS-QLVQSALDGYNVCIFCYGQTGSGKTFTMSSA------------------DGMIPRATHMIYDTITKLKEKSWE--------------------------------------------------------------------------------------------------YTMEGSFVEVYNEELNDLLTPNE---------------------------------------------------------------------------------------------------RSSEGRPKKLEIRHDESRKQTVIMNCKSVRLNSPSSVETMLEEAQNNRSVAATKANERSSRSHSVFILKLVGEN----------------SATGERCEGTLNLVDLAGSERLKHSQ--------------------------AEGDRMKETQNINKSLSCLGDVIEALGRGS--------------------------------------GHVPYRNSKLTHLLQYS-LGGNSKTLMFVMVSPLETHLKETLTSLRFATKV-CSV-CFMK--- NhKRP1
AtKATA LKGNIRVFCRVRPLLPDDGGRHEATVIAYPTSTEAQGRGVD-----------------LVQSGNKHPFTFDKVFNHEA----------SQEEVFFEIS-QLVQSALDGYKVCIFAYGQTGSGKTYTMMGR------------PEAPDQKGLIPRSLEQIFQASQSLGAQGWK--------------------------------------------------------------------------------------------------YKMQVSMLEIYNETIRDLLSTNR--------------------------------------------------------------------------------------------TTSMDLVRADSGTSGKQYTITHDVNGHTHVSDLTIFDVCSVGKISSLLQQAAQSRSVGKTQMNEQSSRSHFVFTMRISGVN----------------ESTEQQVQGVLNLIDLAGSERLSKSG--------------------------ATGDRLKETQAINKSLSALSDVIFALAKKE--------------------------------------DHVPFRNSKLTYLLQPC-LGGDSKTLMFVNISPDPTSAGESLCSLRFAARV-NAC-EIGIPRR AtKATA
AtKATB LKGNIRVFCRVRPLLSGENSSEEAKTISYPTSLEALGRGID-----------------LLQNGQSHCFTFDKVFVPSA----------SQEDVFVEIS-QLVQSALDGYKVCIFAYGQTGSGKTYTMMGR------------PGNPDEKGLIPRCLEQIFQTRQSLRSQGWK--------------------------------------------------------------------------------------------------YELQVSMLEIYNETIRDLLSTNK------------------------------------------------------------------------------------------------EAVRADNGVSPQKYAIKHDASGNTHVVELTVVDVRSSKQVSFLLDHAARNRSVGKTAMNEQSSRSHFVFTLKISGFN----------------ESTEQQVQGVLNLIDLAGSERLSKSG--------------------------STGDRLKETQAINKSLSSLGDVIFALAKKE--------------------------------------DHVPFRNSKLTYLLQPC-LGGDSKTLMFVNITPEPSSTGESLCSLRFAARV-NAC-EIGTAHR AtKATB
AtKATC LKGNIRVFCRVRPLLPGENNGDEGKTISYPTSLEALGRGID-----------------LMQNAQKHAFTFDKVFAPTA----------SQEDVFTEIS-QLVQSALDGYKVCIFAYGQTGSGKTYTMMGR------------PGNVEEKGLIPRCLEQIFETRQSLRSQGWK--------------------------------------------------------------------------------------------------YELQVSMLEIYNETIRDLLSTNK------------------------------------------------------------------------------------------------EAVRTDSGVSPQKHAIKHDASGNTHVAELTILDVKSSREVSFLLDHAARNRSVGKTQMNEQSSRSHFVFTLRISGVN----------------ESTEQQVQGVLNLIDLAGSERLSKSG--------------------------STGDRLKETQAINKSLSSLGDVIFALAKKE--------------------------------------DHVPFRNSKLTYLLQPC-LGGDAKTLMFVNIAPESSSTGESLCSLRFAARV-NAC-EIGTPRR AtKATC
AtKCBP MKGKIRVYCRIRPLNEKESSEREKQMLTTVDEFTVEHPWKD---------------------DKRKQHIYDRVFDMRA----------SQDDIFEDTK-YLVQSAVDGYNVCIFAYGQTGSGKTSTIYGH---------------ESNPGLTPRATKELFNILKR-DSKRFS--------------------------------------------------------------------------------------------------FSLKAYMVELYQDTLVDLLLPKS--------------------------------------------------------------------------------------------------------ARRLKLEIKKDSTGMVFVENVTTIPISTLEELRMILERGSERRHVSGTNMNEESSRSHLILSVVIESID----------------LQTQSAARGKLSFVDLAGSERVKKSG--------------------------SAGCQLKEAQSINKSLSALGDVIGALSSGN--------------------------------------QHIPYRNHKLTMLMSDS-LGGNAKTLMFVNVSPAESNLDETYNSLLYASRV-RTI-VNDPSKH AtKCBP
PoKCBP MKGKIRVYCRLRPLCEKEIIAKERNAIRSVDEFTVEHLWKD---------------------DKAKQHMYDRVFDGNA----------TQDDVFEDTK-YLVQSAVDGYNVCIFAYGQTGSGKTFTIYGA---------------DSNPGLTPRAMSELFRIMKK-DSNKFS--------------------------------------------------------------------------------------------------FSLKAYMVELYQDTLVDLLLPKQ--------------------------------------------------------------------------------------------------------AKRLKLDIKKDSKGMVSVENVTVVSISTYEELKTIIQRGSEQRHTTGTLMNEQSSRSHLIVSVIIESTN----------------LQTQAIARGKLSFVDLAGSERVKKSG--------------------------SAGNQLKEAQSINKSLSALGDVISALSSGN--------------------------------------QHIPYRNHKLTMLMSDS-LGGNAKTLMFVNISPAESNLDETHNSLTYASRV-RSI-VNDPSKN PoKCBP
NtKCBP MKGKIRVYCRLRPLCEKEIIAKERNVMRSVDEFTIEHIWKD---------------------DKAKQHMYDRVFDGNS----------TQDDVFEDTK-YLVQSAADGYNVCIFAYGQTGSGKTFTIYGA---------------DSNPGLTPRAISELFRIMKRDSNKFS---------------------------------------------------------------------------------------------------FSLKAYMVELYQDTLVDLLLPKN--------------------------------------------------------------------------------------------------------AKRLRLDIKKDSKGMVSVENVTVVSISTYEELKTIIQRGSEQRHTTGTLMNEQSSRSHLIVSVIIESTN----------------LQTQAIARGKLSFVDLAGSERVKKSG--------------------------SAGNQLKEAQSINKSLSALGDVISALSSGN--------------------------------------QHIPYRNHKLTMLMSDS-LGGNAKTLMFVNISPAESNLDETHNSLTYASRV-RSI-VNDPSKN NtKCBP
SpKinC MKGKIRVYCRARPLSGSEKERGNFSIIKRPDEYTVDITSTR----------------------GQKEFQFDHIFMPEN----------TQAEIFEDTD-RLIQSAVDGYNVCIFAYGQTGSGKTFTMIGD-------------KEQKFPGIAPRAFQKVYELIEENKSKFS---------------------------------------------------------------------------------------------------FRVYTYMLELYNEKLIDLYNKNK--------------------------------------------------------------------------------------------------------GEPPKLDIKKDKKGMVYINGSVIQEAGNSKELYGLFEEGSANRHVASTKMNSESSRSHLVIGVIIESTN----------------LGTGAVVKGKLTLVDLAGSERSAKTG--------------------------ATAEQLKEANSINKSLSALADVISALSSEQ--------------------------------------SFIPYRNNKLTMLMQDS-LGGNAKTLMFVNISPADYNAEETVISLTYASRV-KLI-TNDASKN SpKinC
CeKLP17 LRGQIRVAIRVRDFERDGSSNFSIISQNEVQLQQTTGQS--------------------------NTYSFEHVFFPPT----------AQSGVFGEIK-ELIMCALHGKNVCLIAYGPTGSGKTFTMRGE-------------DSADSEGVIPRAIRFMLEQSKRDLAMIGWN-------------------------------------------------------------------------------------------------YKFQASFIEVYNEEVYDLLDGKQ-------------------------------------------------------------------------------------------------------------KLEVKINGSKTNVVGLKKIEIGNISDVDVILNLADSQRSVASTASNEHSSRSHAIFQIFVDGQN----------------ASGEMVQCC-LNLVDLAGSERAKETQ--------------------------ARGKQFTELTNINQSLSTLKKCIRAQMTKM--------------------------------------SHVPYRDSKLTMVLREYLGAGSSKTMFIAHANPR--DVAETKRTLEFTSEL-RST-NLGKAVV CeKLP17
CeKLP16 LRGQIRVAVRVRPLIKSEVDTSSSAIEYPAVDAIKINEGSK----------------------PGNVVKFENVFTPVF----------SQKEVFANVE-EFIRSSLHGYNVGLIAYGQTGSGKTHTMRGG--------------NGEEEGIIPRAAAFLFAESKKLESLGWK--------------------------------------------------------------------------------------------------FDFSLSFLEVYNNVAYDLLSGRD-------------------------------------------------------------------------------------------------------------VVQLRLNDQTVSMIGLSEHTISNVSDVARLLRVADGGRKTAATKCNGSSSRSHAVYMWKIKAHQ----------------PSTGISTTCQLKLVDLAGSERAKESG--------------------------VSGDQFKEMTNINQSLSILQMCISQQRSQK--------------------------------------GHVSYRDSKLTQVLMDCLGRGSSKTMVVVNLNPCNEQATESKRSIEFASKM-RST-HIGSAVQ CeKLP16
CeKLP15 LRGQIRVAVRVRPLIKSEADASSSAIEYPAIDTIRINEGSK----------------------PGIVVKFEKVFTPVF----------SQKEVFANVE-EFIRSSLHGYNVGLIAYGQTGSGKTHTMRGG--------------NGEEEGIIPRAAAFLFAESRKLESLGWK--------------------------------------------------------------------------------------------------FDFSLSFLEVYNNVAYDLLSDRA-------------------------------------------------------------------------------------------------------------VVQLRLNDQTVSMIGLSEHTISNVSDVARLLRVADGGRKTAATKCNESSSRSHAVYMWKITAHQ----------------PSTGISTSCQLKLVDLAGSERAKESG--------------------------VSGDQFKEMTNINQSLSILQMCISQQRSQK--------------------------------------GHVSYRDSKLTQVLMDCLGRGNSKTMVVVNLNPCNEQATESKRSIEFASKM-RST-NIGSAVQ CeKLP15
HsMKLP1 LKTQLG-YCRVR-LGFPDQECCIEVINNTTVQLHTPEGYRL----------------NRNGDYKETQYSFKQVFGTHT----------TQKELFDVVANPLVNDLIHGKNGLLFTYGVTGSGKTHTMTGS---------------PGEGGLLPRCLDMIFNSIGSFQAKRYVFKSNDRNSMDIQCEVDALLERQKREAM-----------------------------------PNPKTSSSKRQVDPEFADMITVQEFCKAEEVDEDSVYGVFVSYIEIYNNYIYDLLEEVPFDPI--------------------------------------------------------------------------------------------------NPNLHNLNCFVKIKNHNMYVAGCTEVEVKSTEEAFEVFWRGQKKRRIANTHLNRESSRSHSVFNIKLVQAPLD-------ADGDNVLQEKEQITISQLSLVDLAGSERTNRTR--------------------------AEGNRLREAGNINQSLMTLRTCMDVLRENQ---------------------------------MYGTNKMVPYRDSKLTHLFKNYFDGEG-KVRMIVCVNPKAEDYEENLQVMRFAEVT-QEV-EVARPVD HsMKLP1 CgCHO1 LKDPVGVYCRVRPLSCPDQECCVEVVSNTTVQLHTPEGYRL----------------NRNGDYKETQYSFKQVFGTHT----------TQKELFEVVASPLVDDLIHGKNGLLFTYGVTGSGKTHTMTGS---------------PGSGGLLPRCLNMIFNSIGSFQAKRYVFKSNDRNSMEIQCEVDALLERQKREAV-----------------------------------SIPKTPSSKRQADPEFSDMINVQEFCKAEEVDEDSVYGVFVSYIEIYNNYIYDLLEEVQFDPI--------------------------------------------------------------------------------------------------KPKLPQSKILREDKNHNMYVAGCTEVEVKSTEEAFEVFWRGQKKRRIANTHLNRESSRSHSVFSIKLVQAPLD-------ADGDNVLQEKEQITISQLSLVDLAGSERTNRTK--------------------------AEGNRLREAGNINQSLMTLRTCMEVLRENQ---------------------------------TYGTNKMVPYRDSKLTHLFKNYFDGEG-KVRMIVCVNPKAEDYEESLQVMRFAEVT-QEV-EVARPVD CgCHO1 ZfMKLP1 QKDPVGVYCRVRPLGAEDEECCIEVISNTTIQLHAPDGLKA----------------NRNGEFKETQYSFKKVFGIKT----------TQRELFEDVAKPLAQDLIHGKNGLLFTYGVTGSGKTHTMTGS---------------PGQGGLLPRSLDMIFNSIGPYQAKRYVFKPDDKNGMEVQNQVDALLDRQKRDSQ-----------------------------------TSVPKTPNTRRVDPEFADMISPEEACKAEGVDEDSSYSVFVSYIEIYNNYIYDLLEETPFDPI--------------------------------------------------------------------------------------------------KPKPPQSKILREDQNHNMYVAGCTEVEVKSTEEAFEVFWRGQKKRRIANTQLNRESSRSHSVFIVKLAQAPLD-------ADGDNVLQDKNQVNVSQLCLVDLAGSERTSRTR--------------------------AEGNRLREAGNINQSLMTLRTCIEVLRENQ---------------------------------MCGTNKMVPYRDSKVTHLFKNYFDGEG-KVRMVVCVNPKADDYEETLLVMRFAEMT-QEV-EVARPVD ZfMKLP1 DmPAV ARDPVNVFCRVRPLQSDADLTSLRVKNSTTIALNPQDQLLQ-------------HHKPHNGAQREVQYIFKHVFQPDA----------TQQDVYAAVAQPLVENLLKGRNSLLFTYGVTGSGKTYTMTGN---------------LRHRGIMPRCLDVLFRTISDYQAKKFVFKPDKLNGFEILSEEDALLERQHEMNQ---------------------------------RFAGSGRFAFRHKDSDPEIASQASVEPIPLLGLDEDNMYSVFVTYIEIYNNSVYDLLEDSGIQ------------------------------------------------------------------------------------------------------KTLQSKIIREDANRHMFVHGVTEVEVKTVEDALEVFQMGQKRKRMGHTVLNAESSRSHSVFNIRLVQAPTD-------SQGENVVQDRQNITVSQLSLVDLAGSERSSRTK--------------------------NTGVRLREAGNINNSLMTLRTCLEYLRENQ-----------------------------LAASNGLAPKKVPYRDSKITHMFKNYFDGEG-QVSMIVCINPRIEDYDENMQVMKFAEMT-QEV-QIARATP DmPAV CeZen4 EETDSIEVVCRLCPYTGSTPSLIAIDEGSIQTVLPPAQFRR-----------------ENAPQVEKVFRFGRVFSEND----------GQATVFERTSVDLILNLLKGQNSLLFTYGVTGSGKTYTMTGK--------------PTETGTGLLPRTLDVIFNSINNRVEKCIFYPSALNTFEIRATLDAHLKRHQMAAD---------------------------------------------RLSTSREITDRYCEAIKLSGYNDDMVCSVFVTYVEIYNNYCYDLLEDAR-------------------------------------------------------------------------------------------------------NGVLTKREIRHDRQQQMYVDGAKDVEVSSSEEALEVFCLGEERRRVSSTLLNKDSSRSHSVFTIKLVMAPRA-----YETKSVYPTMDSSQIIVSQLCLVDLAGSERAKRTQ--------------------------NVGERLAEANSINQSLMTLRQCIEVLRRNQ-------------------------------KSSSQNLEQVPYRQSKLTHLFKNYLEGNG-KIRMVICVNPKPDDYDENMSALAFAEES-QTI-EVKKQVE CeZen4
ScKIP3 RNPLNKVSDQVLNSMRARATKATASSINNSNATNKFSSQRR-------------------RHGGEIKFVFDKLFDETS----------SQARVYKETTSPLLDSVLDGFNSTVFAYGATGCGKTYTVSGT---------------PSQPGIIFLAMEELFNKITDLKDEKD---------------------------------------------------------------------------------------------------FEISLSYLEIYNERIRDLLKPET---------------------------------------------------------------------------------------------------------PSKRLVIREDTQNHIKVANLSYHHPNTVEDVMDLVVQGNINRTTSPTEANEVSSRSHAVLQIHIMQTN-------------KLVDLTSQHTFATLSIIDLAGSERAAATR--------------------------NRGIRLHEGANINRSLLALGNCINALCLNDGSRS----------------------------------CHIPYRDSKLTRLLKFS-LGGNCKTVMIVCISPSSSHYDETLNTLKYANRA-KEI-KT-KIIR ScKIP3 SpoBC2f12 VLVFDPPDETTATLSATNRRLSTSQQSLARLSRKSNNSAGF---------------------GRDLRYAFDRVFDETA----------TQQQVYERTARPLLDNILDGFNATIFAYGATGCGKTHTISGT---------------MQDPGLIYLTLKELFERMDHLRDEKI---------------------------------------------------------------------------------------------------FDLRLSYLEIYNETIRDLLVSPT-------------------------------------------------------------------------------------------------------PNQAKPLNLREDADRRITVPGLTSLSPESLEEIIDIIMKGNANRTMSPTEANAASSRSHAVLQVTLIQKP-------------RTAGINEDHTLATLSIIDLAGSERATATK--------------------------LRGSRLFEGANINKSLLALGNCINALCDPHRR------------------------------------AHVPYRDSKLTRLLKFS-LGGNCRTVMIVCVSPSSVHYEETHNTLKYANRA-KNI-KTEVLRN SpoBC2f12 SpoBC649 IRKIVRVLDDNVLIFDPPEENPLAKVQKSLLPAGKRF--------------------------RDVRYAFDRLFGEEA----------SQEDVYKGTTEPLLDSVLQGYNATVFAYGATGCGKTHTISGR---------------PDDPGIIFLTMRALLDRVEGLKRTMN---------------------------------------------------------------------------------------------------VDISVSYLEIYNEKIRDLLVQDP-----------------------------------------------------------------------------------------------------LSMEKPKSLNICEDAEQNVSVPGLSYFTPTNLEEVMEIIIRGNSNRTMSPTEANAVSSRSHAVLQIYITQTP------KSGEKQEESESQNSHKVRSVFSFIDLAGSERASATK--------------------------NRGKRLVEGANINRSLLALGNCINSLCEPRRR------------------------------------QHVPYRDSKLTRLLKFS-LGGNCRTCMIVCISPSSEHYDETHNTLKYGNRA-KNI-KTKVSRN SpoBC649 PfMAL3P7 AYSNVKVAVRIKPIGESEENIVSIFNKNYVLIEKENEKEC----------------YLLSQKKKQSTYVFDSVFDVNA----------TQEEVFFQTAKPLIPHVFKGINCTVFAYGATGSGKTYTMLDD---------------KNQNGIVQLSLLELFTIINEKKCRN----------------------------------------------------------------------------------------------------IKVLMSFLEVYNETIRDLLGKEK-----------------------------------------------------------------------------------------------------------NKTLEVQEDVAEVKVSNLCEIEVNNYEQAMLLINEGVKNRKMSPTRANKVSSRSHAILQIYVYNE-------------ILDDNMNTISYKAKLCFVDLAGSERASATS--------------------------NKGERFKEGSYINQSLLALANCINSLASNR----------------------------------NISKVRVKYRDSKLTHLLKNS-LEGNCLVVMIANINPSRTSFQESNNTLKYAFRA-RNIKLCATVQT PfMAL3P7 DmKlp67A QHTNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKKLTMEFDRVFDIDN----------SNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGS---------------EAHPGLTYLTMQDLFDKIQAQSDVRK---------------------------------------------------------------------------------------------------FDVGVSYLEVYNEHVMNLLTKSG------------------------------------------------------------------------------------------------------------PLKLREDNNGVV-VSGLCLTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITE----------------RKTDTKRTVKLSMIDLAGSERAASTK--------------------------GIGVRFKEGASINKSLLALGNCINKLADGL--------------------------------------KHIPYRDSNLTRILKDS-LGGNCRTLMVANVSMSSLTYEDTYNTLKYASRA-KKI-RTTLKQN DmKlp67A
DmKHC AEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIA-----------------------GKVYLFDKVFKPNA----------SQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGV------------IGDSVKQGIIPRIVNDIFNHIYAMEVNLE---------------------------------------------------------------------------------------------------FHIKVSYYEIYMDKIRDLLDVSK-----------------------------------------------------------------------------------------------------------VNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQEN----------------LENQKKLSGKLYLVDLAGSEKVSKTG--------------------------AEGTVLDEAKNINKSLSALGNVISALADGN-------------------------------------KTHIPYRDSKLTRILQES-LGGNARTTIVICCSPASFNESETKSTLDFGRRA-KTV-KNVVCVN DmKHC LpKHC SECNIKVICRVRPLNEAEERAGSKFILKFP---TDDSISIA-----------------------GKVFVFDKVLKPNV----------SQEYVYNVGAKPIVADVLSGCNGTIFAYGQTSSGKTHTMEGV------------LDKPSMHGIIPRIVQDIFNYIYGMDENLE---------------------------------------------------------------------------------------------------FHIKISYYEIYLDKIRDLLDVTK-----------------------------------------------------------------------------------------------------------TNLAVHEDKNRVPFVKGATERFVSSPEEVMEVIDEGKNNRHVAVTNMNEHSSRSHSVFLINVKQEN----------------VETQKKLSGKLYLVDLAGSEKVSKTG--------------------------AEGAVLDEAKNINKSLSALGNVISALADGN-------------------------------------KSHVPYRDSKLTRILQES-LGGNARTTMVICCSPASYNESETKSTLLFGQRA-KTI-KNVVSVN LpKHC HsKHC AECNIKVMCRFRPLNESEVNRGDKYIAKFQ---GEDTVVIA-----------------------SKPYAFDRVFQSST----------SQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGK------------LHDPEGMGIIPRIVQDIFNYIYSMDENLE---------------------------------------------------------------------------------------------------FHIKVSYFEIYLDKIRDLLDVSK-----------------------------------------------------------------------------------------------------------TNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQEN----------------TQTEQKLSGKLYLVDLAGSEKVSKTG--------------------------AEGAVLDEAKNINKSLSALGNVISALAEGS--------------------------------------TYVPYRDSKMTRILQDS-LGGNCRTTIVICCSPSSYNESETKSTLLFGQRA-KTI-KNTVCVN HsKHC MmKIF5B AECNIKVMCRFRPLNESEVNRGDKYVAKFQ---GEDTVVIA-----------------------SKPYAFDRVFQSST----------SQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGK------------LHDPEGMGIIPRIVQDIFNYIYSMDENLE---------------------------------------------------------------------------------------------------FHIKVSYFEIYLDKIRDLLDVSK-----------------------------------------------------------------------------------------------------------TNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQEN----------------TQTEQKLSGKLYLVDLAGSEKVSKTG--------------------------AEGAVLDEAKNINKSLSALGNVISALAEGS--------------------------------------TYVPYRDSKMTRILQDS-LGGNCRTTIVICCSPSSYNESETKSTLLFGQRA-KTI-KNTVCVN MmKIF5B HsnKHC NECSIKVLCRFRPLNQAEILRGDKFIPIFQ---GDDSVVIG-----------------------GKPYVFDRVFPPNT----------TQEQVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGK------------LHDPQLMGIIPRIARDIFNHIYSMDENLE---------------------------------------------------------------------------------------------------FHIKVSYFEIYLDKIRDLLDVTK-----------------------------------------------------------------------------------------------------------TNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQEN----------------METEQKLSGKLYLVDLAGSEKVSKTG--------------------------AEGAVLDEAKNINKSLSALGNVISALAEGT-------------------------------------KSYVPYRDSKMTRILQDS-LGGNCRTTMFICCSPSSYNDAETKSTLMFGQRA-KTI-KNTASVN HsnKHC MmKIF5A NECSIKVLCRFRPLNQAEILRGDKFIPIFQ---GDDSVIIG-----------------------GKPYVFDRVFPPNT----------TQEQVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGK------------LHDPQLMGIIPRIARDIFNHIYSMDENLE---------------------------------------------------------------------------------------------------FHIKVSYFEIYLDKIRDLLDVTK-----------------------------------------------------------------------------------------------------------TNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQEN----------------VETEQKLSGKLYLVDLAGSEKVSKTG--------------------------AEGAVLDEAKNINKSLSALGNVISALAEGT-------------------------------------KSYVPYRDTKMTRILQDS-LGGNCRTTMFICCSPSSYNDAETKSTLMFGQRA-KTI-KNTASVN MmKIF5A MmKIF5C AECSIKVMCRFRPLNEAEILRGDKFIPKFK---GEETVVIG----------------------QGKPYVFDRVLPPNT----------TQEQVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGK------------LHDPQLMGIIPRIAHDIFDHIYSMDENLE---------------------------------------------------------------------------------------------------FHIKVSYFEIYLDKIRDLLDVSK-----------------------------------------------------------------------------------------------------------TNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQEN----------------VETEKKLSGKLYLVDLAGSEKVSKTG--------------------------AEGAVLDEAKNINKSLSALGNVISALAEGT-------------------------------------KTHVPYRDSKMTRILQDS-LGGNCRTTIVICCSPSVFNEAETKSTLMFGQRA-KTI-KNTVSVN MmKIF5C HsxKHC AECSIKVMCRFRPLNEAEILRGDKFIPKFK---GDETVVIG----------------------QGKPYVFDRVLPPNT----------TQEQVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGK------------LHDPQLMGIIPRIAHDIFDHIYSMDENLE---------------------------------------------------------------------------------------------------FHIKVSYFEIYLDKIRDLLDVSK-----------------------------------------------------------------------------------------------------------TNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQEN----------------VETEKKLSGKLYLVDLAGSEKVSKTG--------------------------AEGAVLDEAKNINKSLSALGNVISALAEGT-------------------------------------KTHVPYRDSKMTRILQDS-LGGNCRTTIVICCSPSVFNEAETKSTLMFGQRA-KTI-KNTVSVN HsxKHC SpKHC AECNIKVVCRVRPMNATEQNTSHICTKFI----SEEQVQIG-----------------------GKLNMFDRIFKPNT----------TQEEVYNKAARQIVKDVLDGYNGTIFAYGQTSSGKTFTMEGV------------MGNPQYMGIIPRIVQDIFNHIYQMDESLE---------------------------------------------------------------------------------------------------FHIKVSYFEIYMDRIRDLLDVSK-----------------------------------------------------------------------------------------------------------TNLSVHEDKNRVPFVKGATERFASSPEEVMDVIEEGKSNRHIAVTNMNEHSSRSHSIFLIQVKQEN----------------METKKKLSGKLYLVDLAGSEKVSKTG--------------------------AEGTVLDEAKNINKSLSALGNVISALADGK-------------------------------------KSHIPYRDSKMTRILQES-LGGNARTTIVICCSPSSFNESESKSTLMFGQRA-KTI-KNTVTVN SpKHC CeKHC AECGVQVFCRIRPLNKTEEKNADRFLPKFP---SEDSISLG-----------------------GKVYVFDKVFKPNT----------TQEQVYKGAAYHIVQDVLSGYNGTVFAYGQTSSGKTHTMEGV------------IGDNGLSGIIPRIVADIFNHIYSMDENLQ---------------------------------------------------------------------------------------------------FHIKVSYYEIYNEKIRDLLDPEK-----------------------------------------------------------------------------------------------------------VNLSIHEDKNRVPYVKGATERFVGGPDEVLQAIEDGKSNRMVAVTNMNEHSSRSHSVFLITVKQEH----------------QTTKKQLTGKLYLVDLAGSEKVSKTG--------------------------AQGTVLEEAKNINKSLTALGIVISALAEGT-------------------------------------KSHVPYRDSKLTRILQES-LGGNSRTTVIICASPSHFNEAETKSTLLFGARA-KTI-KNVVQIN CeKHC NcKHC SANSIKVVARFRPQNRVEIESGGQPIVTFQ---GPDTCTVD-------------------SKEAQGSFTFDRVFDMSC----------KQSDIFDFSIKPTVDDILNGYNGTVFAYGQTGAGKSYTMMGT-----------SIDDPDGRGVIPRIVEQIFTSILSSAANIE---------------------------------------------------------------------------------------------------YTVRVSYMEIYMERIRDLLAPQN-----------------------------------------------------------------------------------------------------------DNLPVHEEKNRGVYVKGLLEIYVSSVQEVYEVMRRGGNARAVAATNMNQESSRSHSIFVITITQKN----------------VETGSAKSGQLFLVDLAGSEKVGKTG--------------------------ASGQTLEEAKKINKSLSALGMVINALTDGK-------------------------------------SSHVPYRDSKLTRILQES-LGGNSRTTLIINCSPSSYNDAETLSTLRFGMRA-KSI-KNKAKVN NcKHC NhKin1 SANSIKVVARFRPQNKVELASGGMPIVSFD---GEDTCSLD-------------------SKEAQGSFTFDRVFDMAC----------KQQDIFDFSIRSTVDDILNGYNGTVFAYGQTGAGKSYTMMGT-----------NIDDDDGRGVIPRIVEQIFASIMSSPGTIE---------------------------------------------------------------------------------------------------YTVRVSYMEIYMERIRDLLAPQN-----------------------------------------------------------------------------------------------------------DNLPVHEEKNRGVYVKGLLEIYVSSVQEVYEVMRRGGNARAVAATNMNQESSRSHSIFVITITQKN----------------VETGSAKSGQLFLVDLAGSEKVGKTG--------------------------ASGQTLEEAKKINKSLSALGMVINALTDGK-------------------------------------SSHIPYRDSKLTRILQES-LGGNSRTTLIINCSPSSYNDAETLSTLRFGLRA-KSI-KNKAKVN NhKin1 SpoKlp3 -MTSIKVVCRIRPTNQLEQDLGGNNVIYPLNDSTVHIET----------------------SDYSGNFVFDRVFHPSS----------TLNDIFSYSIESTVDDLFLGYNGTVLAYGQTGSGKTYTMMGI------------ENNFEKEGMTPRMLRRIFDKIRDSPSTTE---------------------------------------------------------------------------------------------------YEVKVSYMEIYMEKIHDLLSEKN-----------------------------------------------------------------------------------------------------------DRLTVHEDKLQGVYVQGLKTIYVSSETEALDILNKGMGSRAVASTSMNAQSSRSHSIFVLEVVQTD----------------TESGETRRGRLFLVDLAGSESVGKSG--------------------------AVGQTLEEAKKINRSLSTLGMVINSLTDSK-------------------------------------LSHVPYRDSKLTRILKES-LGGNSRTTLIINCSPDSYNATETLSTLRFGHRA-KSI-KNKAVVN SpoKlp3 UmKin2 MSNNIKVVCRFRPPNAIEQREGSDIVVDFSDDGSLVKLTRG----------------VSTSGPEAGGFVFDKVFPMNT----------MQRDVFEFGIKETVEDVLNGYNGTIFAYGQTGSGKTFTMMGS-----------DIDNDNLKGIIPRITEQIFENIMASPPHLE---------------------------------------------------------------------------------------------------YLVKVSYMEIYMEKIRDLLAPQN-----------------------------------------------------------------------------------------------------------DNLQVHEEKNRGVYVKGLSDFYVGGQADVYEIMRQGGLARAVSSTNMNAESSRSHSIFLITIQQRN----------------TETGSAKTGNLYLVDLAGSEKVGKTG--------------------------ASGQTLEEAKKINKSLSALGMVINALTDGK-------------------------------------SSHIPYRDSKLTRILQES-LGGNSRTTLIVNASPCVYNADETLSTLRFGVRA-KSI-KNKARVN UmKin2 SyKin1 SGNNIKVVCRFRPQNSLEIREGGTPIIDID-PEGTQLELKG--------------------KEFKGNFNFDKVFGMNT----------AQKDVFDYSIKTIVDDVTAGYNGTVFAYGQTGSGKTFTMMGA-----------DIDDEKTKGIIPRIVEQIFDSIMASPSNLE---------------------------------------------------------------------------------------------------FTVKVSYMEIYMEKVRDLLNPSS-----------------------------------------------------------------------------------------------------------ENLPIHEDKTKGVYVKGLLEVYVGSTDEVYEVMRRGSNNRVVAYTNMNAESSRSHSIVMFTITQKN----------------VDTGAAKSGKLYLVDLAGSEKVGKTG--------------------------ASGQTLEEAKKINKSLTALGMVINALTDGK-------------------------------------SSHVPYRDSKLTRILQES-LGGNSRTTLIINCSPSSYNEAETLSTLRFGARA-KSI-KNKAKVN SyKin1 DdK7 VSSNIRVVCRVRPLTELEKGRNEHSIVHFF---DSKSISIR---------------------ANGPQFTFDRIFGYQE----------TQSQIFEDVAEPIVNDFLDGYHGTIIAYGQTASGKTFTMVGD---------------PDSHGIIPRVIESIFVGISKMREKDTSLSLA----------------------------------------------------------------------------------------------FCLKISALELYNEKLYDLYIASK-----------------------------------------------------------------------------------------------------------SNLNIREHKQNGIYVEGISEIVITSIEEAYNFLNISNNNRAIASTKMSAASSRSHSVLMIELSQQN----------------LSMESSKISKLFLVDLAGSDISHKTG--------------------------AEGDRMQEAKNINLSLSALGKVINALTCGV--------------------------------------NYVPYRDSKLTRVLQDS-LGGNSKTSLIINCSPSNNNEHETITTLQFGTRA-KTI-KNQPKIN DdK7
CrFLA10 GSESVKVVVRCRPLNGKEKADGRSRIVDMDVDAGQVKVRNPK----------------ADASEPPKAFTFDQVYDWNC----------QQRDVFDITARPLIDSCIEGYNGTIFAYGQTGTGKSHTMEG------------KDEPPELRGLIPNTFRYVFEIIARDSGTKE---------------------------------------------------------------------------------------------------FLVRSSYLEIYNEEVRDLLGKDH----------------------------------------------------------------------------------------------------------SKKMELKESPDRGVYVKDLSQFVCKNYEEMNKVLLAGKDNRQVGATLMNQDSSRSHSIFTITIECIEKLESAAAQK--PGAKKDDSNHVRVGKLNLVDLAGSERQDKTG--------------------------ATGDRLKEGIKINLSLTALGNVISALVDGK-------------------------------------SGHIPYRDSKLTRLLQDS-LGGNTKTVMVANIGPADWNYDETMSTLRYANRA-KNI-QNKPKIN CrFLA10 TtKin1 NDECVKVVVRCRPLNSKEKEDGRTQVVFVNQSRGEISVTNPK----------------GDSAEAPKVFTFDSTFEPEV----------EQETVYKNTAYPIVESVLEGYNGTIFAYGQTGTGKTHTMEG------------KDEPKHLRGIIPRTFDHIFRSIKGTPNVQ----------------------------------------------------------------------------------------------------FLVRVSFLELYNEEIRDLLQKNI-----------------------------------------------------------------------------------------------------------KKLELREKPGSGVYVKDLSTFMIQDQEELREKLLHGRENRAVGATQMNQDSSRSHSIFGITIERCD--------------IVNGESHIRVGKLNLVDLAGSERQSKTQ--------------------------ATGSRLKEAININQSLTTLGNVISSLIDPK-------------------------------------ATHVPYRDSKLTRLLQDS-LGGNTKTVMVANVGPADFT-MMNYSTLRYAHRA-KSI-QNHAKIN TtKin1 TtKin2 NSECFKVAVRCRPLNNDEIQNERSSVVSVNPQRGEIQIKQKH-----------------DQAEQHRIFAFDQVFEPDI----------QQEVVYKCIAYPIVESVLEGYNGTIFAYGQTGTGKTHTIQG------------RNEPINERGIIPRAFEHIFHSIKGSPNTQ----------------------------------------------------------------------------------------------------FLVHVSFLELYNEEIQDLLSTKN-----------------------------------------------------------------------------------------------------------KKLELREKAETGVFVKDLTSFLVQNEQELNDKFQQGILNRKVGQTKMSSCSSRSHSILSVTIERCD--------------VVNGENHIKVGKLNLVDLAGSERQSKTQ--------------------------ATGSRFKEGVYINLSLTTLGNVISSLIDPK-------------------------------------ASHIPYRDSKLTRILQDS-LGGNTKTVMIANIGPADYNQDETISTLRYAHRA-KSI-QNHAQIN TtKin2 MmKIF3B SSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPK----------------GTSHEMPKTFTFDAVYDWNA----------KQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEG------------VRGDPEKRGVIPNSFDHIFTHISRSQNQQ----------------------------------------------------------------------------------------------------YLVRASYLEIYQEEIRDLLSKDQ----------------------------------------------------------------------------------------------------------TKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSE-------------VGLDGENHIRVGKLNLVDLAGSERQAKTG--------------------------AQGERLKEATKINLSLSALGNVISALVDGK-------------------------------------STHIPYRDSKLTRLLQDS-LGGNAKTVMVANVGPASYNVEETLTTLRYANRA-KNI-KNKPRVN MmKIF3B HsKIF3B SSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPK----------------GTAHEMPKTFTFDAVYDWNA----------KQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEG------------IRGDPEKRGVIPNSFDHIFTHISRSQNQQ----------------------------------------------------------------------------------------------------YLVRASYLEIYQEEIRDLLSKDQ----------------------------------------------------------------------------------------------------------TKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSE-------------VGLDGENHIRVGKLNLVDLAGSERQAKTG--------------------------AQGERLKEATKINLSLSALGNVISALVDGK-------------------------------------STHIPYRDSKLTRLLQDS-LGGNAKTVMVANVGPASYNVEETLTTLRYANRA-KNI-KNKPRVN HsKIF3B XlKlp3 SSESVRVVVRCRPMNSKELAAGYERVVDVDVKLGQVSVKVHK----------------GATNELSKTFTFVATYDSNS----------NEVELYVETFRPLVDSVLLGLNGTIFATGQTGTGKTYTMEG------------VRGDPEKRGVIPNSFEHIFTHISRSQNQQ----------------------------------------------------------------------------------------------------YLVRASYLEIYQEEIRDLLSKDQ----------------------------------------------------------------------------------------------------------SKRLELKERPDIGVYVKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFMITIECSQ-------------IGLDGENHIRVGKLNLVDLAGSERQTKTG--------------------------AQGERLKEATKINLSLSALGNVISALVDGR-------------------------------------STHIPYRDSKLTRLLQDS-LGGNAKTVMVANIGPASYNVEETLTTLRYSNRA-KNI-KNKPRVN XlKlp3 HsKIF3C ASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPR----------------AAPGELPKTFTFDAVYDASS----------KQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQG------------TWVEPELRGVIPNAFEHIFTHISRSQNQQ----------------------------------------------------------------------------------------------------YLVRASYLEIYQEEIRDLLSKEP----------------------------------------------------------------------------------------------------------GKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQTRAVGSTHMNEVSSRSHAIFIITVECSE-------------RGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTAGGAATP--SSGGGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNR-------------------------------------STHIPYRDSKLTRLLQDS-LGGNAKTIMVATLGPASHSYDESLSTLRFANRA-KNI-KNKPRVN HsKIF3C MmKIF3C ASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPR----------------AAPGELPKTFTFDAVYDASS----------KQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQG------------TWVEPELRGVIPNAFEHIFTHISRSQNQQ----------------------------------------------------------------------------------------------------YLVRASYLEIYQEEIRDLLSKEP----------------------------------------------------------------------------------------------------------GKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQARAVGSTHMNEVSSRSHAIFVITVECSE-------------RGSDGQDHIRVGKLNLVDLAGSERQNKAGPNAAGGPATQPTAGGGSGSGSASGSASSGERPKEASKINLSLSALGNVIAALAGNR-------------------------------------STHIPYRDSKLTRLLQDS-LGGNAKTIMVATLGPASHSYDESLSTLRFANRA-KNI-KNKPRVN MmKIF3C RnKIF3C ASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPR----------------AAPGELPKTFTFDAVYDASS----------KQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQG------------TWVEPELRGVIPNAFEHIFTHISRSQNQQ----------------------------------------------------------------------------------------------------YLVRASYLEIYQEEIRDLLSKEP----------------------------------------------------------------------------------------------------------GKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQARAVGSTHMNEVSSRSHAIFVITVECSE-------------RGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTPGGPATQSTAGGGGGGGGTSGSGSSGERPKEASKINLSLSALGNVIAALAGNR-------------------------------------STHIPYRDSKLTRLLQDS-LGGNAKTIMVATLGPASHSYDESLSTLRFANRA-KNI-KNKPRVN RnKIF3C SpKRP95 SAETVKVVVRCRPMNSKEISQGHKRIVEMDNKRGLVEVTNPK----------------GPPGEPNKSFTFDTVYDWNS----------KQIDLYDETFRSLVESVLQGFNGTIFAYGQTGTGKTFTMEG------------VRSNPELRGVIPNSFEHIFTHIARTQNQQ----------------------------------------------------------------------------------------------------FLVRASYLEIYQEEIRDLLAKDK-----------------------------------------------------------------------------------------------------------KRLDLKERPDTGVYVKDLSSFVTKSVKEIEHVMTVGNNNRSVGSTNMNEHSSRSHAIFIITIECSE-------------LGVDGENHIRVGKLNLVDLAGSERQAKTG--------------------------ATGDRLKEATKINLSLSALGNVISALVDGK-------------------------------------SSHIPYRDSKLTRLLQDS-LGGNAKTVMVANMGPASYNFDETITTLRYANRA-KNI-KNKPKIN SpKRP95 CeKLP11 KQETVKVIVRCRPLSSQEIANNYSKIVHMRPQRGQIELKNPK-----------------EQDEPSKDFTFDAIYDENS----------TQSDLYEETFRDLVDSVLNGYNATIFAYGQTGTGKTHTMEG------------KSSDPEQRGVIYKCIDHIFEHMAASHNQE----------------------------------------------------------------------------------------------------YLVRASYLEIYQEELRDLLEAES----------------------------------------------------------------------------------------------------------NKKLEIKERPDGGVYVKDLTSKLTRTVGEIHEVMIRGNGHRSVGRTNMNEHSSRSHAIFIITVECSR-------------IGEDGESHITVGRLNLVDLAGSERQSKTG--------------------------ATGERFKEATKINLSLSALGNVISALVDAK-------------------------------------SAHIPYRDSKLTRLLQDS-LGGNSKT--------------ETLGTLRYANRA-KNI-KNQPKIN CeKLP11 MmKIF3A SCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTD-----------------SSNEPPKTFTFDTVFGPES----------KQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEG------------VRAVPGLRGVIPNSFAHIFGHIAKAEGDTR---------------------------------------------------------------------------------------------------FLVRVSYLEIYNEEVRDLLGKDQ----------------------------------------------------------------------------------------------------------TQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSE-------------KGVDGNMHVRMGKLHLVDLAGSERQAKTG--------------------------ATGQRLKEATKINLSLSTLGNVISALVDGK-------------------------------------STHVPYRNSKLTRLLQDS-LGGNSKTMMCANIGPADYNYDETISTLRYANRA-KNI-KNKARIN MmKIF3A HsKIF3 SCDNVKVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHKTD-----------------SSNEPPKTFTFDTVFGPES----------KQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEG------------VRAIPELRGIIPNSFAHIFGHIAKAEGDTR---------------------------------------------------------------------------------------------------FLVRVSYLEIYNEEVRDLLGKDQ----------------------------------------------------------------------------------------------------------TQRLAVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSE-------------KGIDGNMHVRMGKLHLVDLAGSERQAKTG--------------------------ATGQRLKEATKINLSLSTLGNVISALVDGK-------------------------------------STHVPYRNSKLTRLLQDS-LGGNSKTMMCANIGPADYNYDETISTLRYANRA-KNI-KNKARIN HsKIF3 SpKRP85 GNDNVRVVVRCRPLNSKETGQGFKSVVKMDEMRGTVQVTNPN----------------APSGEPPKSFTFDTVFAPGA----------KQTDVYNQTARPIVDAIIEGYNGTIFAYGQTGTGKTFTMEG------------VRSQPELRGIIPNSFAHIFGHIAKEQENVR---------------------------------------------------------------------------------------------------FLVRVSYLEIYNEEVKDLLGKDQ----------------------------------------------------------------------------------------------------------QHRLEVKERPDVGVYVKDLSAFVVNNADDMDRIMTLGNKNRSVGATNMNESSSRSHAIFTITLERSD-------------MGLDKEQHVRVGKLHMVDLAGSERQTKTG--------------------------ATGQRLKEATKINLSLSTLGNVISSLVDGK-------------------------------------STHIPYRNSKLTRLLQDS-LGGNAKTVMCANIGPAEYNYDETISTLRYANRA-KNI-KNKAKIN SpKRP85 DmKlp64D EIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPN----------------ATANEPPKTYYFDNVFDGGS----------NQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSG------------NPDSPQTKGIIPNAFAHIFGHIAKAKENQK---------------------------------------------------------------------------------------------------FLVRVSYMEIYNEEVRDLLGKDV----------------------------------------------------------------------------------------------------------GKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSE-------------LGEGDVQHVRMGKLQLVDLAGSERQSKTQ--------------------------ASGQRLKEATKINLSLSVLGNVISALVDGK-------------------------------------STHIPYRNSKLTRLLQDS-LGGNSKTVMCATISPADSNYMETISTLRYASRA-KNI-QNRMHIN DmKlp64D CeY50D7 GAEKVKVVVRCRPISTTEKLQGHKIAVTCNDEEKAVNIKSLS------------------QEDPPRTFYFDAVFSPNT----------DQMTVYNVAARPIVENVLKGYNGTIFAYGQTGTGKTFTMAGD------------LEPVEMRGIIPNSFAHIFDHIAKCQHDTT---------------------------------------------------------------------------------------------------FLVRVSYLEIYNEEIRDLLSKDH----------------------------------------------------------------------------------------------------------NGNLEIKERPDVGVYVRNLSNPTVENASKMQALMEFGSKNRKVGATAMNLESSRSHAMFTVTIESCR------------------NGLVTQGKLQLVDLAGSERQSKTG--------------------------AQGERLKEAAKINLSLSTLGNVISSLVDGK-------------------------------------STHIPYRNSKLTRLLQDS-LGGNSKTVMIANVGPATYNYDETLSTLRYANRA-KNI-QNVAKIN CeY50D7 Dmklp68D PNECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQN----------------VVDGNKEQRKVFTYDAAYDASA----------TQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEG------------VRGNDELMGIIPRTFEQIWLHINRTENFQ----------------------------------------------------------------------------------------------------FLVDVSYLEIYMEELRDLLKPNS------------------------------------------------------------------------------------------------------------KHLEVRERGSGVYVPNLHAINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCD----------------TETNTIKVGKLNLIDLAGSERQSKTG--------------------------ASAERLKEASKINLALSSLGNVISALAESS--------------------------------------PHVPYRDSKLTRLLQDS-LGGNSKTIMIANIGPSNYNYNETLTTLRYGSRA-KSI-QNQPIKN Dmklp68D CeOsm3 LELWVRNRGNCRKLYKVFWGTRGLLLGTRDGKALEIDEFLL-GTRENVSKFPAIVGMTPNVGQVNLNAPDGAAKDFTF--DGAYFMIRPGEQIYNDIVFPLVENVIEGYNGTVFAYGQTGSGKTFSMQG------------IETIPAQRGVIPRAFDHIFTATATTENVK----------------------------------------------------------------------------------------------------FLVHCSYLEIYNEEVRDLLGADN----------------------------------------------------------------------------------------------------------KQKLEIKEQPDRGVYVAGLSMHVCHDVPACKELMTRGFNNRHVGATLMNKDSSRSHSIFTVYVEGIT-----------------ETGSIRMGKLNLVDLAGSERQSKTG--------------------------ATGDRLKEATKINLSLSALGNVISALVDGK-------------------------------------SKHIPYRDSKLTRLLQDS-LGGNTKTIMIACVSPSSDNYDETLSTLRYANRA-KNI-KNKPTIN CeOsm3
SpoCut7 NETNINVVVRVRGRTDQEVRDNSSLAVSTSGAMGAELAIQS----------------DPSSMLVTKTYAFDKVFGPEA----------DQLMLFENSVAPMLEQVLNGYNCTIFAYGQTGTGKTYTMSGD-------LSDSDGILSEGAGLIPRALYQLFSSLDNSNQE-----------------------------------------------------------------------------------------------------YAVKCSYYELYNEEIRDLLVSEE-------------------------------------------------------------------------------------------------------LRKPARVFEDTSRRGNVVITGIEESYIKNAGDGLRLLREGSHRRQVAATKCNDLSSRSHSIFTITLHRKVSSGMTDETNS-LTINNNSDDLLRASKLHMVDLAGSENIGRSG--------------------------AENKRARETGMINQSLLTLGRVINALVEKA--------------------------------------HHIPYRESKLTRLLQDS-LGGKTKTSMIVTVSSTNTNLEETISTLEYAARA-KSI-RNKPQNN SpoCut7 AnBimC EDTSIHVVVRCRGRNEREVKENSGVVLQTEGVKGKTVELSM-----------------GPNAVSNKTYTFDKVFSAAA----------DQITVYEDVVLPIVTEMLAGYNCTIFAYGQTGTGKTYTMSGD-------MTDTLGILSDNAGIIPRVLYSLFAKLADTEST-------------------------------------------------------------------------------------------------------VKCSFIELYNEELRDLLSAEE------------------------------------------------------------------------------------------------------NPKLKIYDNEQKKGHMSTLVQGMEETYIDSATAGIKLLQQGSHKRQVAATKCNDLSSRSHTVFTITVNIKR-------------TTESGEEYVCPGKLNLVDLAGSENIGRSG--------------------------AENKRATEAGLINKSLLTLGRVINALVDKS--------------------------------------QHIPYRESKLTRLLQDS-LGGRTKTCIIATMSPARSNLEETISTLDYAFRA-KNI-RNKPQIN AnBimC ScKip1 SDSNIHVYVRCRSRNKREIEEKSSVVISTLGPQGKEIILSN--------------GSHQSYSSSKKTYQFDQVFGAES----------DQETVFNATAKNYIKEMLHGYNCTIFAYGQTGTGKTYTMSGDINILGDVQSTDNLLLGEHAGIIPRVLVDLFKELSSLNKE-----------------------------------------------------------------------------------------------------YSVKISFLELYNENLKDLLSDSE-----------------------------------------------------------------------------------------------DDDPAVNDPKRQIRIFDNNNNNSSIMVKGMQEIFINSAHEGLNLLMQGSLKRKVAATKCNDLSSRSHTVFTITTNIVE---------QDSKDHGQNKNFVKIGKLNLVDLAGSENINRSG--------------------------AENKRAQEAGLINKSLLTLGRVINALVDHS--------------------------------------NHIPYRESKLTRLLQDS-LGGMTKTCIIATISPAKISMEETASTLEYATRA-KSI-KNTPQVN ScKip1 ScCin8 EELNITVAVRCRGRNEREISMKSSVVVNVPDITGSKEISIN-----------TTGDTGITAQMNAKRYTVDKVFGPGA----------SQDLIFDEVAGPLFQDFIKGYNCTVLVYGMTSTGKTYTMTGD-------EKLYNGELSDAAGIIPRVLLKLFDTLELQQND-----------------------------------------------------------------------------------------------------YVVKCSFIELYNEELKDLLDSNSNGSSNTGFDGQFMKKLRIFASSTANNTTSNSASSSRSNSRNSSPRSLNDLTPKAALLRKRLRTKSLPNTIKQQYQQQQAVNSRNNSSSNSGSTTNNASSNTNTNNGQRSSMAPNDQTNGIYIQNLQEFHITNAMEGLNLLQKGLKHRQVASTKMNDFSSRSHTIFTITLYKKH-----------------QDELFRISKMNLVDLAGSENINRSG--------------------------ALNQRAKEAGSINQSLLTLGRVINALVDKS--------------------------------------GHIPFRESKLTRLLQDS-LGGNTKTALIATISPAKVTSEETCSTLEYASKA-KNI-KNKPQLG ScCin8 NtKRP125 KGVNVQVLLRCRPFSNDELRNNAPQVVTCNDYQREVAVSQN-----------------IAGKHIDRIFTFDKVFGPSA----------QQRDLYDQAIVPIVNEVLEGFNCTIFAYGQTGTGKTYTMEGE-------CKRSKSGPNGELPQEAGVIPRAVKQVFDTLES-------------------------------------------------------------------------------------------------QNAEYSVKVTFLELYNEEITDLLAPED-------------------------------------------------------------------------------------------------LKVALEDRQKKQLPLMEDGKGGVLVRGLEEEIVTSANEIFTLLERGSAKRRTAETLLNKQSSRSHSLFSITIHIKE-------------ATPEGEELIKCGKLNLVDLAGSENISRSG--------------------------AREGRAREAGEINKSLLTLGRVINALVEHL--------------------------------------GHIPYRDSKLTRLLRDS-LGGRTKTCIIATVSPAVHCLEETLSTLDYAHRA-KNI-KNKPEVN NtKRP125 XlEg5 KGKNIQVVVRCRPFNQLERKASSHSVLECDSQRKEVYVRTG----------------EVNDKLGKKTYTFDMVFGPAA----------KQIEVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGE----RSSDEEFTWEQDPLAGIIPRTLHQIFEKLSENGTE-----------------------------------------------------------------------------------------------------FSVKVSLLEIYNEELFDLLSPSP------------------------------------------------------------------------------------------------------DVGERLQMFDDPRNKRGVIIKGLEEISVHNKDEVYHILERGAAKRKTASTLMNAYSSRSHSVFSVTIHMKE-------------TTVDGEELVKIGKLNLVDLAGSENIGRSG--------------------------AVDKRAREAGNINQSLLTLGRVITALVERA--------------------------------------PHIPYRESKLTRILQDS-LGGRTKTSIIATVSPASINLEETVSTLDYASRA-KSI-MNKPEVN XlEg5 XlEg52 KGKNIQVVVRCRPFNQLERKASSHSVLECESQRKEVCVRTG----------------EVNDKLGKKTYTFDMVFGPAA----------KQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGE----RSSDEEFTWEQDPLAGIIPRTLHQIFEKLSEIGTE-----------------------------------------------------------------------------------------------------FSVKVSLLEIYNEELFDLLSPSP------------------------------------------------------------------------------------------------------DVGERLQMFDDPRNKRGVIIKGLEEISVHNKDEVYQILERGAAKRKTASTLMNAYSSRSHSVFSVTIHMKE-------------TTIDGEELVKIGKLNLVDLAGSENIGRSG--------------------------AVDKRAREAGNINQSLLTLGRVITALVERA--------------------------------------PHIPYRESKLTRILQDS-LGGRTKTSIIATVSPASINLEETMSTLDYASRA-KNI-MNKPEVN XlEg52 HsKSP KGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTG----------------GLADKSSRKTYTFDMVFGAST----------KQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGE----RSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTE-----------------------------------------------------------------------------------------------------FSVKVSLLEIYNEELFDLLNPSS------------------------------------------------------------------------------------------------------DVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKE-------------TTIDGEELVKIGKLNLVDLAGSENIGRSG--------------------------AVDKRAREAGNINQSLLTLGRVITALVERT--------------------------------------PHVPYRESKLTRILQDS-LGGRTRTSIIATISPASLNLEETLSTLEYAHRA-KNI-LNKPEVN HsKSP CeF23B12 PTSNLRVAVRIRPMNGTERSEKCTNVVKVDKGK------------------------QAIELKGKSFGPFFRTYDPDT----------TQEEIYSDLVSSQIKKVIAGFNCTVFAYGQTGTGKTFTMEGG------RTDAKSSTDDPTTGIIPRAVEDIFEQLERCGCE----------------------------------------------------------------------------------------------------EYSLRVSYIELYNEELFDLLASTD------------------------------------------------------------------------------------------------------NEDRERLRIFDDPNKKGVIVSGVEEVPVRNRSDVFKLLQLGAEKRRTAATLMNMHSSRSHSLFMVNVVIRE-------------NTTTGEELVKQGKLNLVDLAGSENIGRSG--------------------------AQGNRAKEAGSINQSLLTLGRVIRLLTTNG--------------------------------------QHIPYRESKLTRLLQDS-LGGSTITSLIATLSPSSSNFEESQSTLEYAMRA-ANI-KNKPVCN CeF23B12 DmKlp61F SNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTL-------------------DSKLTKKFTFDRSFGPES----------KQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGN----ETAELKSSWEDDSDIGIIPRALSHLFDELRMMEVE-----------------------------------------------------------------------------------------------------YTMRISYLELYNEELCDLLSTDD--------------------------------------------------------------------------------------------------------TTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRE-------------NGIEGEDMLKIGKLNLVDLAGSENVSKAG-------------------------NEKGIRVRETVNINQSLLTLGRVITALVDRA--------------------------------------PHVPYRESKLTRLLQES-LGGRTKTSIIATISPGHKDIEETLSTLEYAHRA-KNI-QNKPEVN DmKlp61F BmKRP KNQNIQVFVRLRPLNQRERDLKSLGVVEVHNNKEVVVRISQ-------------------QNSITKKFTFDRAFAPYA----------NQVEVYQEVVSPLIEEVLAGYNCTVFAYGQTGTGKTHTMVGE-----NTGDETTWQKDPLAGIIPRALSQLFDELRISNTE-----------------------------------------------------------------------------------------------------YTVRVSYLELYNEELFDLLATSE-------------------------------------------------------------------------------------------------------DNSKLRIYEDVTRKGSNIVNGLEEITVYNKKEVFRIMAQGQERKKVASTLMNAQSSRSHTVFTIVVHMKE------------NSLPEGEELVKIGKLNLVDLAGSENISKAG----------------------SDNPAKRERARECVNINQSLLTLGRVITALVERH--------------------------------------PHVPYRESKLTRILQES-LGGRTKTSIIATISPGHKDLEETMSTLEYLTEQ-RTF-RTSLRST BmKRP
DmKlp98A MDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYS--------------------------YWSFDAEDPHFA----------TQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGT---------------PNNPGLIPRICEELFARMRVGQESGTG--------------------------------------------------------------------------------------------------YRTHASYLEIYNERVKDLLAAQS---------------------------------------------------------------------------------------------------------TGHGLRVREHRSLGPYVENLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAV--------------FMNDMPSETVSKIHLVDLAGSERANATG--------------------------ATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHN------------------------------SSSSYIPYRDSILTWLLKDS-LGGNSKTIMIAALSPADCNYSETLSTLRYANRA-KNI-INKPTVN DmKlp98A CeKLP6 MPDEETTVIRDPKTNDEKRFTYDHSYWSHDGFS-----------------------------EKKNGYLEPTDPHYA----------DQRRVFEDLGRGVLANAWAGYNCSLFAYGQTGSGKSYSIVGF---------------KNNKGIVPIVCEELFKQIADNKKKNMQ--------------------------------------------------------------------------------------------------FEVFVSMMEIYCEKVRDLLSSTP--------------------------------------------------------------------------------------------------------PPKGGLKVREHPKNGFYVENLTTVPVNSFKEIEAKIEEGTKSRTIAATQMNATSSRAHTIVKITFNQKS-------------SKQAGGTSMKKSEINLVDLAGSERQSAAG--------------------------TEGDRLKEGIVINQSLTTLGRVIKALHDSQ-------------------------------KAKSGKKTQIPYRDSVLTCLLKNA-LGGNSKTIMIAAISPADINFEETLSTLRFADRA-KSI-KTNAVVN CeKLP6 HsCMKRP ENSQVTVAVRVRPFTKREKIEKASQVVFMSGKEITVEHPD--------------TKQVYNFIYDVSFWSFDECHPHYA----------SQTTVYEKLAAPLLERAFEGFNTCLFAYGQTGSGKSYTMMGF---------------SEEPGIIPRFCEDLFSQVARKQTQEVS--------------------------------------------------------------------------------------------------YHIEMSFFEVYNEKIHDLLVCKD-----------------------------------------------------------------------------------------------------ENGQRKQPLRVREHPVYGPYVEALSMNIVSSYADIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTK----------TEFVEGEEHDHRITSRINLIDLAGSERCSTAH--------------------------TNGDRLKEGVSINKSLLTLGKVISALSEQA----------------------------------NQRSVFIPYRESVLTWLLKES-LGGNSKTAMIATISPAASNIEETLSTLRYANQA-RLI-VNIAKVN HsCMKRP DmKlp38B EESNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQ----------------AGSSADASAGVTHFFSYDQVYYSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGI--EALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQ-------------------------------------------------------------------------------------------------VEVEVSYFEIYNEKIHDLLSVQH----------------------------------------------------------------------------------------AAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSG--------------------------SNGERIREGVSINKSLLTLGKVIAALADSRKASANGPLGSGTP------------------------STFVPYRESVLTWLLREN-LGGNSKTVMLATISPASIHADETLATLRYACKA-RSI-VNRVKVN DmKlp38B CeUnc104 MSSVKVAVRVRPFNQREISNTSKCVLQVNGNTTTINGHS--------------------INKENFSFNFDHSYWSFA--SRNDPHFITQKQVYEELGVEMLEHAFEGYNVCIFAYGQTGSGKSYTMMGK------------ANDPDEMGIIPRLCNDLFARIDNNNDKDVQ--------------------------------------------------------------------------------------------------YSVEVSYMEIYCERVKDLLNPNS----------------------------------------------------------------------------------------------------------GGNLRVREHPLLGPYVDDLTKMAVCSYHDICNLMDEGNKARTVAATNMNSTSSRSHAVFTIVLTQKR------------HCADSNLDTEKHSKISLVDLAGSERANSTG--------------------------AEGQRLKEGANINKSLTTLGLVISKLAEEST------------------------------KKKKSNKGVIPYRDSVLTWLLREN-LGGNSKTAMLAALSPADINFDETLSTLRYADRA-KQI-VCQAVVN CeUnc104 MmKIF1A AGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPK-------------------QPKETPKSFSFDYSYWSHT--SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGK-------------QEKDQQGIIPQLCEDLFSRINDTTNDNMS--------------------------------------------------------------------------------------------------YSVEVSYMEIYCERVRDLLNPKN----------------------------------------------------------------------------------------------------------KGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKPRTVAATNMNETSSRSHAVFNIIFTQKR------------HDAETNITTEKVSKISLVDLAGSERADSTG--------------------------AKGTRLKEGANINKSLTTLGKVISALAEMDSGPN--------------------------KNKKKKKTDFIPYRDSVLTWLLREN-LGGNSRTAMVAALSPADINYDETLSTLRYADRA-KQI-RCNAIIN MmKIF1A HsATSV AGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPK-------------------QPKETPKSFSFDYSYWSHT--SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGK-------------QEKDQQGIIPQLCEDLFSRINDTTNDNMS--------------------------------------------------------------------------------------------------YSVEVSYMEIYCERVRDLLNPKN----------------------------------------------------------------------------------------------------------KGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKR------------HDAETNITTEKVSKISLVDLAGSERADSTG--------------------------AKGTRLKEGANINKSLTTLGKVISALAEMDSGPN--------------------------KNKKKKKTDFIPYRDSVLTWLLREN-LGGNSRTAMVAALSPADINYDETLSTLRYADRA-KQI-RCNAVIN HsATSV MmKIF1B SGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPK-------------------NPKEAPKSFSFDYSYWSHT--SPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGK-------------QEESQAVIIPQLCEELFEKINDNCNEEMS--------------------------------------------------------------------------------------------------YSVEVSYMEIYCERVRDLLNPKN----------------------------------------------------------------------------------------------------------KGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKK------------QDPETNLSTEKVSKISLVDLAGSERADSTG--------------------------AKGTRLKEGANINKSLTTLGKVISALAEVS--------------------------------KKKKKTDFIPYRDSVLTWLLREN-LGGNSRTAMVAALSPADINYDETLSTLRYADRA-KQI-KCNAVIN MmKIF1B RnKIF1B SGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPK--------------------NPKEAPKSFSFDYSYWSH--SPEDPCFASQSRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGK-------------QEESQAGIIPTCCEELFEKINDNCNEDMS--------------------------------------------------------------------------------------------------YSV-SSYMEIYCERVRDLLNPKN----------------------------------------------------------------------------------------------------------KGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKK------------QDPETNLSTEKVTKISLVDLAGSERADSTG--------------------------AKGTRLKEGRNINKSLTTLGKVISALAEVS--------------------------------KKKKKTDFIPYRDSVLTWLLREN-LGGNSRTAMVAALSPADINYDETLSTLRYADRA-KQI-KCNAVIN RnKIF1B RnKIF1D AGASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPK---------------------QSRMFLKASFDYSYWSH-TSVEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGR-------------QEPGQQGIVPQLCEDLFSRVNVNQSAQLS--------------------------------------------------------------------------------------------------YSVEVSYMEIYCERVRDLLNPKS----------------------------------------------------------------------------------------------------------RGSLRVREHPILGPYVQDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRS------------HDQLTGLDSEKVSKISLVNLAGSERADSSG--------------------------ARGMRLKEGANINKSLTTLGKVISALADLQS--------------------------------KKRKSDFIPYRDSVLTWLLKEN-LGGNSRTAMIAALSPADINYEETLSTLRYADRT-KQI-RCNAVIN RnKIF1D HsKIF1C AGASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPK-------------------QSKDAPKSFTFDYSYWSHT--STEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGR-------------QEPGQQGIVPQLCEDLFSRVSENQSAQLS--------------------------------------------------------------------------------------------------YSVEVSYMEIYCERVRDLLNPKS----------------------------------------------------------------------------------------------------------RGSLRVREHPILGPYVQDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRC------------HDQLTGLDSEKVSKISLVDLAGSERADSSG--------------------------ARGMRLKEGANINKSLTTLGKVISALADMQS--------------------------------KKRKSDFIPYRDSVLTWLLKEN-LGGNSRTAMIAALSPADINYEETLSTLRYADRT-KQI-RCNAIIN HsKIF1C DmKlp53D KMSSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPK----------------VPPNTSDSVKRFNFDYSYWSHD---HHDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGR-------------QEEQQEGIIPMICKDLFTRIQDTETDDLK--------------------------------------------------------------------------------------------------YSVEVSYMEIYCERVRDLLNPKN----------------------------------------------------------------------------------------------------------KGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRR------------HDLMTNLTTEKVSKISLVDLAGSERADSTG--------------------------AKGTRLKEGANINKSLTTLGKVISALAEVAS-----------------------------KKKNTKKADFIPYRDSALTWLLREN-LGGNSKTAMIAAISPADINYDETLSTLRYADRA-KQI-VCKAVVN DmKlp53D CeF56E3 EESAVKVAIRVRPFNKRELDLKTKSVVRIQKEQCVLHHPI--------------------EEKNSKTFTFDHSFCSTD---PHSYDFASQETVSYHLGSGVVENAFSGYNACIFAYGQTGSGKSYTMMGT---------------PDQPGIIPRVCNDIFTRIQETSNSSLS--------------------------------------------------------------------------------------------------FKVEVSYMEIYNERVRDLLDPKK---------------------------------------------------------------------------------------------------------SSKALKVREHKILGPMVDGLSILAVNSFEQISNLLEEGNKSRTVAATNMNAESSRSHAVFSLIVTQTL------------HDLENGFSGEKVAKISLVDLAGSERAGKTG--------------------------AVGKRLEEGGNINKNLVSIFLRNDLEKKIDFKFSADVYVFINQKLDFRSLTTLGMVISALAERNSKKDKFIPYRDSVLTWLLKDS-LGGNSRTVMIATLSPAADNYEETLSTLRYADRA-KKI-VNHAIIN CeF56E3 DmKlp73 ASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPP---------------PLEKIERKQPKTFAFDHCFYSLN---PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGT---------------QESKGIIPRLCDQLFSAIANKSTPELM--------------------------------------------------------------------------------------------------YKVEVSYMEIYNEKVHDLLDPKP---------------------------------------------------------------------------------------------------------NKQSLKVREHNVMGPYVDGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQIL------------TDQATGVSGEKVSRMSLVDLAGSERAVKTG--------------------------AVGDRLKEGSNINKSLTTLGLVISKLADQSNG------------------------------KKSGNDKFVPYRDSVLTWLLKDN-LGGNSRTVMVATISPSADNYEETLSTLRYADRA-KRI-VNHAVVN DmKlp73
DmKlp31D KDSSVRVAVRIRPQNSRELIDMCRICTTVTLGEPQIFLGS------------------------DKAFTFDYVFDTNS----------NQCDIYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTG------FDHESESSDSVQLGIIPRAVRHIFSGIEQLEGSS----------------------------------------------------------------------------------------TSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFN---------------------------------------------------------------------------------------------------------KNSNFKIHEDASGQITISGASIKPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQR-------LLTPSDNVPDNDLETLTSKFHFVDLAGSERLKRTQ--------------------------ATGERAREGISINCGLLALGNCISALGDKS-----------------------------------KRALHVPYRDSKLTRLLQDS-LGGNSQTLMIACVSPSDRDFMETLNTLKYANRA-RNI-KNKVKIN DmKlp31D DmKlp31E KDSSVRVAVRIRPQNSRELIDMCRICTTVTLGEPQIFLGS------------------------DKAFTFDYVFDTNS----------NQCDIYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTG------FDHESESSDSVQLGIIPRAVRHIFSGIEQLEGSS----------------------------------------------------------------------------------------TSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFN---------------------------------------------------------------------------------------------------------KNSNFKIHEDASGQITISGASIKPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQR-------LLTPSDNVPDNDLETLTSKFHFVDLAGSERLKRTQ--------------------------ATGERAREGISINCGLLALGNCISALGDKS-----------------------------------KRALHVPYRDSKLTRLLQDS-LGGNSQTLMIACVSPSDRDFMETLNTLKYANRA-RNI-KNKVKIN DmKlp31E CeT01G1 NDRDLISVKSIRPQGNREKLEGSRVCTSVLPNDPQVTIGG------------------------DRSFTYDHVFDMPT----------LQYVVYESCVEKLVDGLFDGYNATVLAYGQTGSGKTHTMGTA-------FDAAVTQKEEDLGVIPRAIQHTFRKIAECKAQA-------------------------------------------------------------------------------------------IEQGLLEPAFEVSVQFVELYNDDVLDLLSDDR--------------------------------------------------------------------------------------------------------SMSSSIRIHEDSRGEIVLHGVEQRSVFDMHGTMDILKNGALNRTVAATNMNEQSSRSHAIFTLHLKQQR--VAAPLDESGEQKTGELEMEMLCAKFHFVDLAGSERMKRTG--------------------------ATGDRAKEGISINVGLLALGNVIAALGGAN-----------------------------------GKVSHVPYRDSKLTRLLQDS-LGGNSRTLMIACCSPMDSDFVETLNTMKYANRA-KEI-KNKVVAN CeT01G1 CeY43F4B SDASLRVVVRARPMNGRETKEGASRCVQFYENTKQIVINE------------------------SATFTFDAVFADTS----------DQESVYETTALPLLDRIFAGFNATVLAYGQTGSGKTYTMGTE---------DNVGTDEMRRGIIPRLVSALFQRIMNTEAPE---------------------------------------------------------------------------------------------------SFAVTVSMFEVYGDNVYDLLRPDK------------------------------------------------------------------------------------------------------------VKLNVHGDEKNCTVVNLTAVPVIDLKGALKQLAVGCHYRTKAETAMNAMSSRSHAVFTVFVEKTA---------------TAECDSAFSAKLQLVDLAGSERLKKTE--------------------------AEGNRMKEGININGGLLILSQVIAALAT--------------------------------------KQKHIPYRNSVITRVLQDS-LGGNSFTVFLACISPADSNSQETLNTLRYADRA-KQI-KNKPIVN CeY43F4B GgChrkin EKGIPVRVVRCRPLVPKETSEGCQMCLSFVPGEPQVIVGS------------------------DKAFTYDYVFDPSV----------EQEEVFNTAVAPLIRGIFKGYNATVLAYGQTGSGKTYSMGGT--------YTASQEHDPSMGVIPRVIKLLFKEKEQRQDWE----------------------------------------------------------------------------------------------------FVLKVSYLEIYNEDILDLLCSSR--------------------------------------------------------------------------------------------------------ERSSQISIREDPKEGIKIVGLTERNVASARDTVSCLEQGNNCRTVASTAMNSQSSRSHAIFTICIDQKK---------------KNDKNSSFHSKLHLVDLAGSERQKKTK--------------------------AEGDRLKEGININRGLLCLGNVISALGEEN-----------------------------------KKGGFVPYRDSKLTRLLQDS-LGGNSHTLMIACVSPADSNLEETLNTLRYADRA-RKI-KNKPIVN GgChrkin MmKIF4 KGIPVRVALRCRPLVSKEIKEGCQTCLSFVPGEPQVVVGN------------------------DKSFTYDFVFDPST----------EQEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGA--------YTAEQEHDSAIGVIPRVIQLLFKEINKKSDFE----------------------------------------------------------------------------------------------------FTLKVSYLEIYNEEILDLLCSSR--------------------------------------------------------------------------------------------------------EKATQINIREDPKEGIKIVGLTEKTVLVASDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRK---------------KNDKNSSFRSKLHLVDLAGSERQKKTK--------------------------AEGDRLREGININRGLLCLGNVISALGDD------------------------------------KKGNFVPYRDSKLTRLLQDS-LGGNSHTLMIACVSPADSNLEETLNTLRYADRA-RKI-KNKPIIN MmKIF4 HsKIF4 KGIPVRVALRCRPLVPKEISEGCQMCLSFVPGEPQVVVGT------------------------DKSFTYDFVFDPST----------EQEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGA--------YTAEQENEPTVGVIPRVIQLLFKEIDKKSDFE----------------------------------------------------------------------------------------------------FTLKVSYLEIYNEEILDLLCPSR---------------------------------------------------------------------------------------------------------EKAQINIREDPKEGIKIVGLTEKTVLVALDTVSCLEQGNNSRTVASTAMNSQSSRSHAILTISLEQGK---------------KSDKNSSFRSKLHLVDLAGSERQKKTK--------------------------AEGDRLKEGININRGLLCLGNVISALGDD------------------------------------KKGGFAPYRDSKLTRLLQDS-LGGNSHTLMIACVSPADSNLEETLNTLRYADRA-RKI-KNKPIVN HsKIF4 Xlklp1 EGIPVRVALRCRPLVPKENNEGCKMCLTFVPGEQQVIVGT------------------------EKSFTYDYVFDPSA----------EQEEVYNSAVAPLIKGLFKGYNATVLAYGQTGSGKTYSMGGA--------YTHNQENEPTVGVIPRTVIALFREIHQRPEWE----------------------------------------------------------------------------------------------------FNLKVSYLEIYNEEILDLLYAAR--------------------------------------------------------------------------------------------------------DKTNTISIREDPKEGIKICGLTERDVKTALDTLSCLEQGNSSRTVASTAMNSQSSRSHAIFTISIEQRK---------------EGDKNNSFRSKLHLVDLAGSERQKKTK--------------------------AEGDRLKEGISINRGLLCLGNVISALGDES-----------------------------------KKGGFVPYRDSKLTRLLQDS-LGGNSHTLMIACVSPADSNMEETLNTLRYADRA-RKI-KNKPIVN Xlklp1 DmKlp3A DPSCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVN-----------------------RNESYTYNYVFDIDD----------SQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTA----------FNGVLDDHVGVIPRAVHDIFTAIAEMQSEF---------------------------------------------------------------------------------------------------RFAVTCSFVELYQEQFYDLFSSKT---------------------------------------------------------------------------------------------------------RDKATVDIREVKNRIIMPGLTELVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATK---------------LDGKQSVTTSRFNLVDLAGSERCSKTL--------------------------ASGDRFKEGVNINKGLLALGNVINALGSGQ------------------------------------AAGYIPYRQSKLTRLLQDS-LGGNSITLMIACVSPADYNVAETLSTLRYADRA-LQI-KNKPVVN DmKlp3A
XlKCM1 EEHRICVCVRKRPLNKQELSKKEIDIISVPSKNIVLVHEP------------KLKVD-LTKYLENQAFRFDFSFDETA----------TNEVVYRFTARPLVQSIFEGGKATCFAYGQTGSGKTHTMGGDFSGKSQ---------NVSKGVYAFASRDVFLLLDQPRYKHLD--------------------------------------------------------------------------------------------------LDVFVTFFEIYNGKVFDLLNKKT------------------------------------------------------------------------------------------------------------KLRVLEDAKQEVQVVGLLEKQVISADDVFKMIEIGSACRTSGQTFANTSSSRSHACLQIILRRG---------------------SKLHGKFSLVDLAGNERGVDTA-------------------------SADRITRMKGAEINRSLLALKECIRALGQNK--------------------------------------SHTPFRESKLTQILRDSFIGENSRTCMIAMLSPGFNSCEYTLNTLRYADRV-KEL-SPQNAET XlKCM1 CgMCAK EEHRICVCVRKRPLNKQELAKKEIDVISVPSKCLLFVHEP------------KLKVD-LTKYLENQAFCFDFAFDETA----------SNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKSQ---------NTSKGIYAMASRDVFLLKSQPRYRNLN--------------------------------------------------------------------------------------------------LEVYVTFFEIYNGKVFDLLNKKA------------------------------------------------------------------------------------------------------------KLRVLEDSKQQVQVVGLQEYLVNCADDVIKMLNMGSACRTSGQTFANSNSSRSHACFQILLRAK---------------------GRLHGKFSLVDLAGNERGADTS-------------------------SADRQTRMEGAEINKSLLALKECIRALGQNK--------------------------------------AHTPFRESKLTQVLRDSFIGENSRTCMIAMISPGISSCEYTLNTLRYADRV-KEL-SPHSGLS CgMCAK RnKRP2 EEHRICVCVRKRPLNKQELAKKEIDVISVPSKCLLLVHEP------------KLKVD-LTKYLENQAFCFDFAFDETA----------SNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKSQ---------NASKGIYAMASRDVFLLKNQPRYRSLN--------------------------------------------------------------------------------------------------LEVYVTFFEIYNGKVFELLNKKA------------------------------------------------------------------------------------------------------------KLRVLEDSKQQVQVVGLQEYLVTCADDVIKMINMGSACRTSGQTFANSNSSRSHACFQILLRAK---------------------GRLHGKFSLVDLAGNERGADTS-------------------------SADRQTRMEGAEINKSLLALKESIRALGQNK--------------------------------------AHTPFRESKLTQVLRDSFIGENSRTCMIAMISPGISSCEYTLNTLRYADRV-KEL-SPHSGPS RnKRP2 HsMCAK EEHRICVCVRKRPLNKQELAKKEIDVISIPSKCLLLVHEP------------KLKVD-LTKYLENQAFCFDFAFDETA----------SNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKAQ---------NASKGIYAMASRDVFLLKNQPCYRKLG--------------------------------------------------------------------------------------------------LEVYVTFFEIYNGKLFDLLNKKA------------------------------------------------------------------------------------------------------------KLRVLEDGKQQVQVVGLQEHLVNSADDVIKMLDMGSACRTSGQTFANSNSSRSHACFQIILRAK---------------------GRMHGKFSLVDLAGNERGADTS-------------------------SADRQTRMEGAEINKSLLALKECIRALGQNK--------------------------------------AHTPFRESKLTQVLRDSFIGENSRTCMIATISPGISSCEYTLNTLRYADRV-KEL-SPHSGPS HsMCAK DmKlp10A DDHQITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEP------------RSKVD-LTKFLENHKFRFDYAFNDTC----------DNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGE---------FNGKVQDCKNGIYAMAAKDVFVTLNMPRYRAMN--------------------------------------------------------------------------------------------------LVVSASFFEIYSGKVFDLLSDKQ------------------------------------------------------------------------------------------------------------KLRVLEDGKQQVQVVGLTEKVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQ-------------------GSTKIHGKFSFIDLAGNERGVDTS-------------------------SADRQTRMEGAEINKSLLALKECIRALGKQS--------------------------------------AHLPFRVSKLTQVLRDSFIGEKSKTCMIAMISPGLSSCEHTLNTLRYADRV-KEL-VVKDIVE DmKlp10A DmKlp59C NCHQIMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEP------------RKHVN-LVKFLENHSFRFDYVFDEEC----------SNATVYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGGQ---------FPGRHQSSMDGIYAMAAKDVFSTLKTVPYNKLN--------------------------------------------------------------------------------------------------LKVYCSFFEIYGTRVFDLLMPGK-----------------------------------------------------------------------------------------------------------PQLRVLEDRNQQVQVVGLTQNPVQNTAEVLDLLELGNSVRTSGHTSANSKSSRSHAVFQIVLRSA-------------------AGEKLHGKFSLIDLAGNERGADNS-------------------------SADRQTRLEGSEINKSLLVLKECIRALGRQS--------------------------------------SHLPFRGSKLTQVLRDSFIGKKVKTCMIAMISPCLHSVEHTLNTLRYADRV-KEL-SVESIPS DmKlp59C MmKIF2 DEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEP------------KQKVD-LTRYLENQTFRFDYAFDDSA----------PNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQ---------DCSKGIYALAARDVFLMLKKPNYKKLE--------------------------------------------------------------------------------------------------LQVYATFFEIYSGKVFDLLNRKT------------------------------------------------------------------------------------------------------------KLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRK---------------------GKLHGKFSLIDLAGNERGADTS-------------------------SADRQTRLEGAEINKSLLRLKECIRALGRNK--------------------------------------PHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRV-KEF-GISPSDI MmKIF2 HsKin2 DEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEP------------KQKVD-LTRYLENQTFRFDYAFDDSA----------PNEMVYRFTAKPLVETIFERGMATCFAYGQTGSGKTHTMGGD---------FSGKNQDCSKGIYALAARDVFLMLKKPNYKKLE--------------------------------------------------------------------------------------------------LQVYATFFEIYSGKVFDLLNRKT------------------------------------------------------------------------------------------------------------KLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRK---------------------GKLHGKFSLIDLAGNERGADTS-------------------------SADRQTRLEGAEINKSLLALKECIRALGRNK--------------------------------------PHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRV-KEL-TVDPTAA HsKin2 MmKIF2C DEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEP------------KQKVD-LTRYLENQTFRFDYAFDDSA----------PNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQ---------DCSKGIYALAARDVFLMLKKPNYKKLE--------------------------------------------------------------------------------------------------LQVYATFFEIYSGKVFDLLNRKT------------------------------------------------------------------------------------------------------------KLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRK---------------------GKLHGKFSLIDLAGNERGADTS-------------------------SADRQTRLEGAEINKSLLALKECIRALGRNK--------------------------------------PHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRV-KEL-TVNPAAA MmKIF2C XlKCM2 DEHRICVCVRKRPLNKKETTIKDLDVITIPIKDVVMVHEP------------KQKVD-LTRFLENQTFRFDYAFDETA----------PNETVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQ---------DCSKGIYALAARDVFQMLKKPNYKKLE--------------------------------------------------------------------------------------------------LQVYATFFEIYSGKVFDLLNRKT------------------------------------------------------------------------------------------------------------KLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIEIGNSCRTSGQTSANAHSSRSHAVFQIILRKK---------------------GKMHGKFSLIDLAGNERGADTS-------------------------SADRQTRLEGAEINKSLLALKECIRALGRNK--------------------------------------PHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRV-KEL-DPSRCRR XlKCM2 CeK11D9.c NENRISVCVRKRPLNKKELTKAEVDVITIPSRDITILHQP------------QTRVD-LTKYLDNQKFRFDYSFDEYA----------NNELVYRFTAAPLVKTVFDNGTATCFAYGQTGSGKTHTMGGDFSGKKQ---------NASMGIYALTARDVFRMLEQPQYRRKD--------------------------------------------------------------------------------------------------LSVHCAFFEIYGTKTYDLLNDKA------------------------------------------------------------------------------------------------------------ELRVLEDKMQKVQVVGLKEEQAHNEQDVLELINKGTLVRTAGTTSANANSSRSHAIFQIILRQG---------------------KKVWGKFSLIDLAGNERGQDTR-------------------------ECDRDTRKEGANINTSLLALKECIRGMARNS--------------------------------------SHVPFRQSKLTMVLRDSFIGEKSRTVMISMISPGISSSDHTLNTLRYADRV-KEM-GTDGSGE CeK11D9.c LmKin RKSRILVAIRKRPLSAGEQTNGFTDIMDADNSGEIVLKEP------------KVKVD-LRKYTHVHRFFFDEVFDEAC----------DNVDVYNRAARALIDTVFDGGCATCFAYGQTGSGKTHTMLGKGPEP---------------GLYALAAKDMFDRLTSD--------------------------------------------------------------------------------------------------------TRIVVSFYEIYSGKLFDLLNGRR------------------------------------------------------------------------------------------------------------PLRALEDDKGRVNIRGLTEHCSTSVEDLMTIIDQGSGVRSCGSTGANDTSSRSHAILEIKLKAK-------------------RTSKQSGKFTFIDLAGSERGADTV-------------------------DCARQTRLEGAEINKSLLALKECIRFLDQNR--------------------------------------KHVPFRGSKLTEVLRDSFIG-NCRTVMIGAVSPSNNNAEHTLNTLRYADRV-KEL-KRNATER LmKin CfDSK1 TNSNICIAVRKRPISDKERQKLDHDSVSCFQNKVWIHSA-------------KLKVDGITKYLTHNSFQLDHTFGEDS---------TTEQIYLATTLPLVDHVVSTQGRATVFCYGQTGSGKTYTMNG------------------IQQILAYDLYGQ-LAEHTDD-------------------------------------------------------------------------------------------------------LEITVAFFELYSGNVLDLLHGCQ------------------------------------------------------------------------------------------------------------RCKLLEDGNGEVNITGLREVPAPTPEAFLQVIEEGHSLRTTQKTEANDASSRSHAICQVFLRDY--------------------GGNLRGKLGLVDLAGSERGSDTK-------------------------QHNSQRRTESADINTSLLALKECIRALGQKS--------------------------------------AHVPYRGSKLTLILKDCF-SPDSKTTMVATVSPGASAADHSLNTLRYADRI-KEQ-RVSSNGQ CfDSK1
DmKlp54D PEDNINVVVRVRPLNDKEKRDRHGSTLQFPGNGQVILEGNDV----------GQKRSHNRDSVRVFTYNVVFEPGATQ-----------EDILDYSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTGP----PDLFVGKPNPKDPRHGLIFRSFLYLFQLIKNRKDVN----------------------------------------------------------------------------------------------------YVLKASFMEIYNERVIDLLNPGS--------------------------------------------------------------------------------------------------------ARKPLAVRWSKKSGGFFVENLFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHILSDQ-------------QTDGGVFLSKHGKINFVDLAGSELTKKTM--------------------------SEGKTLEEANNINKSLMVLGYCISSLSDSK-----------------------------------KRTGHIPYRDSQLTKLLADS-LAGNGVTLMIACVSPAHYNHAETLNTLRYASRA-KRI-RTKPVIK DmKlp54D CeC06G3.2 MSQYIKCYGRVRPSARLGAPSESLFVGGRVVTIETDNGSK--------------------------RYELHHIFDSSS----------SQEDVFGTVAKKIVEDCVEGYNGTVFAYGQTGSGKTHTMLGP---------CDSWTDQELMGLIPRSVEHVFQHLDTKAKECQKLT------------------------------------------------------------------------------------------------FSVSVEFVELYNEVIYDLLNAKN-------------------------------------------------------------------------------------------------------------KVQLRDSGKDIQLVGALSKNVDNPLDLMHLVQKGWQERSTGSTAMNAESSRSHALLIIRIKTQ--------------ERTGELVKERSSILNLVDLAGSERQTHTK--------------------------SSGDRLKEATNINSSLTVLGRCIRLLADPS-----------------------------------KAKGHVPYRDSHLTHILKNS-LGGNSKTAVIVNMHPDRDFAQESNSTLMFAQSC-TMI-MNIATRN CeC06G3.2 CrKlp1 VKQAVKVFVRTRPTATSGSGLKLGPDGQSVSVNVPKDLSA----------------GPVNNQQEQFSFKFD-GVLENV----------SQEAAYTTLAHEVVDSLMAGYHGTIFAYGQTGAGKTFTMSGG------------GTAYAHRGLIPRAIHHVFREVDMRADKM----------------------------------------------------------------------------------------------------YRVHVSYLEIYNEQLYDLLGDTP--------------------------------------------------------------------------------------------------------GTSDALAVLEDSNSNTYVRGLTLVPVRSEEEALAQFFLGEQGRTTAGHVLNAESSRSHTVFTIHVEMR--------------TSDAASERAVLSKLNLVDLAGSERTKKTG--------------------------VTGQTLKEAQFINRSLSFLEQTVNALSRKD--------------------------------------TYVPFRQTKLTAVLRDA-LGGNCKTVMVANIWAEPSHNEETLSTLRFASRV-RTL-TTDLALN CrKlp1 MmKlp174 TSEKVKVYLRIRPFLTSELDRQEDQGCVCIENTETLVLQA-------PKDSFALKSNERGVGQATHKFTFSQIFGPEV----------GQVAFFNLTMKEMVKDVLKGQNWLIYTYGVTNSGKTYTIQGT---------------SKDAGILPQSLALIFNSLQGQLHPTPDLKPLLSNEVIWLDSKQIRQEEMKKLSLLIGGLQEEELSTSVKKRVHTESRIGASNSFDSGVAGLSSTSQFTSSSQLDETSQLWAQPDTVPVSVPADIRFSVWISFFEIYNELLYDLLEPPS------------------------------------------------------------------------------------------------------HQHKRQTLRLCEDQNGNPYVKDLNWIHVRDVEEAWKLLKVGRKNQSFASTHMNQQSSRSHSIFSIRILHL---------------QGEGDIVPKISELSLCDLAGSERCKHQ---------------------------KSGERLKEAGNINTSLHTLGRCIAALRQNQ--------------------------------QNRSKQNLIPFRDSKLTRVFQGF-FTGRGRSCMIVNVNPCASTYDETLHAAKFSALA-SQL-VHAPPVH MmKlp174 DmKlp54E VETGPQVFLRLRPVKDASKAYIVSEEANVLITSCKVDSTS------------------NNVNRMEKHFGFTSIFDSTV-------------GQRDIYDTCVGPKIMEEECVTIMTYGTSGSGKTYTLLGD---------------DVRAGIIPRALENIFTIYQDTVFRSP---------------------------------------KLKLINGSIVFLQDDASLKELQIRKKLLDLCPDISAHHQRLKQVIDGDHMFETKASTDVSVLVWVSFVEIYNELVYDLLAIPP--------------------------------------------------------------------------------------------------KQDKLGEVPRKNLKIVGNKGHVFIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTVDILKYN-----------------RSGITTQSSYKFCDLAGSERVNNTG--------------------------TSGLRLKEAKNINTSLMVLGRCLDAASTVQ---------------------------------KKKNADIIPYRDSKLTMLLQAA-LLGKEKLAMIVTVTPLDKYYEENLNVLNFASIA-KNI-IFKEPVI DmKlp54E HsKid PPARVRVAVRLRPFVDGTAGASDPPCVRGMDSCSLEIANW-------------------RNHQETLKYQFDAFYGERS----------TQQDIYAGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGS---------------PEQPGVIPRALMDLLQLTREEGAEGRPWA------------------------------------------------------------------------------------------------LSVTMSYLEIYQEKVLDLLDPAS-----------------------------------------------------------------------------------------------------------GDLVIREDCRGNILIPGLSQKPISSFADFERHFLPASRNRTVGATRLNQRSSRSHAVLLVKVDQR---------------ERLAPFRQREGKLYLIDLAGSEDNRRTG--------------------------NKGLRLKESGAINTSLFVLGKVVDALNQGL--------------------------------------PRVPYRDSKLTRLLQDS-LGGSAHSILIANIAPERRFYLDTVSALNFAARS-KEV-INRPFTN HsKid ScKip2 DTYTGSITVTIRPKPRSVGTSRDHVGLKSPRYSQPRSNSHH-GSNTFVRDPWFITNDKTIVHEEIGEFKFDHVFASHC----------TNLEVYERTSKPMIDKLLMGFNATIFAYGMTGSGKTFTMSGN---------------EQELGLIPLSVSYLFTNIMEQSMNGDKK-------------------------------------------------------------------------------------------------FDVIISYLEIYNERIYDLLESGLEESGSRISTPSRLYMSKS-----------------------------------------------------------------------------------NSNGLGVELKIRDDSQYGVKVIGLTERRCESSEELLRWIAVGDKSRKIGETDYNARSSRSHAIVLIRLTSTN----------------VKNGTSRSSTLSLCDLAGSERATGQE------------------------------RRKEGSFINKSLLALGTVISKLSADK------QMNSVGSNIPSPSASGSSSSSGNATNNGTSPSNHIPYRDSKLTRLLQPA-LSGDSIVTTICTVDTRNDAAAETMNTLRFASRA-KNV-ALHVSKK ScKip2 CaKRP RSRPSSAMSISRPSTPSMKSQEPYTGAITVSIRPNPNTIDN-KNWSIDEFDNSIINTTDGTRFVFDNVFPMDRQLSNI------------QVYNKSCYNVVNKFLEEGYNGTIFAYGMTGSGKTFSMKGC---------------ENDPGFVELAINDIFQKINDNTTTKKYK---------------------------------------------------------------------------------------------------MDISYLEIYNEKIIDLLSGSPSSQTTSQSNQDLKIRDDV--------------------------------------------------------------------------------------------------DFGTKVVGLTSANISSKPQLLQLIKYGDTNRKTSATDFNARSSRSHSILQIRLQVID----------------LLTETELKSTLSLCDLAGSERAATSL-----------------------------ERRKEGSFINKSLLALSNVINKLSSSA-------------------------------------LEHIPYRDSKLTRLLQPA-LSGSSLVSILCTIHMGGNQQNSQQCVAETYKTLRFAARAKDIVIN CaKRP SpoBC1604 VGSGIITSIRIRPIGKNQGVWSHGKLSNDPYGREYIRQQT-----------------STSSSTIQQEYLFNNVFGMES----------KNYDIYKRSVKSVVRNVFSGYNGIVFAYGMTGTGKTYSMQGT---------------ENEPGIIPLAMNDLFEMVENNSDDDT---------------------------------------------------------------------------------------------------FQIRISYLEIYNERIRDLIGNSD-----------------------------------------------------------------------------------------------------------EEPRIRENASGEVNVTPLTRVLVTSPEEVSQVIEQCNAIRKTAATDFNTYSSRSHAILQVFLIRNN----------------PTAHTSQISSLSLVDLAGSERASAHH-----------------------------ERRKEGAFINKSLLTLGTVISRLSAAA------------------------------NPSLTSNSGHIPYRESKLTRLLQQS-LSGQSQISLLATISIESNHTMETTNTLKFASRA-QNL-PQDIRQA SpoBC1604 AtFCA0.24 PPRKLRSAKENAPPLDRNTSTPDHRSMRMKNPLPPRPPPS-----------------NPLKRKLSAETATESGFSDSG----------VKEQMFQLVGAPLVENCLSGFNSSVFAYGQTGSGKTYTMWGP-----ANGLLEEHLCGDQRGLTPRVFERLFARIKEVMPGFVQFVVLTLNKSSMLKGNSITNVGAHYSRFSDWLHYISLDDLQRANNRPTGPKPEKPDGKHGVHRFSLMCHQIREDVKS----------------------GVYVENLTEEYVKNLTDVSQLLI---------------------------------------------------------------------------------------------------------------------------------------------KGLGNRRTGATSVNTESSRSHCVFTCVVESR------------CKNVADGLSSFKTSRINLVDLAGSERQKSTG--------------------------AAGERLKEAGNINRSLSQLGNLINILAEIS---------------------------------QTGKPRHIPYRDSRLTFLLQES-LGGNAKLAMVCAVSPSQR--SETFSTLRFAQRA-KAI-QNKAVVN AtFCA0.24 Xlklp2 EEDAIKVFVRIRPPVEGTLTGVDGEQGLCLTALSSTTIRL-------------------HSKPEPKMFTFDHVANVDT----------NQESVFSSVAKNIVESCMNGYNGTIFAYGQTGSGKTFTMLGP--------SESDNFTHNLRGVIPRSFEYLFFLINREKEKAGEGKS-----------------------------------------------------------------------------------------------FLCKCSFIEIYNEQIFDLLDSAS-----------------------------------------------------------------------------------------------------------AGLFLREHIKKGVFVVGAVEQVVTSAAEAYQVLSMGWRNRRVASTSMNRESSRSHAVFTVTIESM--------------EKTNDLVNIRSSQLNLVDLAGSERQKDTQ--------------------------TEGVRLKEAGSINRSLSCLGQVITALVDVA----------------------------------NGRQRHICYRDSKLTFLLRDS-LGGNAKTFYIANVHPGSKCFGETLSTLQFAQRA-KLI-KNKAVVN Xlklp2 HsCENP-E EEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVD-----------------------GSKSFNFDRVFHGNE----------TTKNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGS---------------EDHLGVIPRAIHDIFQKIKKFPDRE----------------------------------------------------------------------------------------------------FLLRVSYMEIYNETITDLLCGTQ---------------------------------------------------------------------------------------------------------KMKPLIIREDVNRNVYVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESR-----------EKGEPSNCEGSVKVSHLNLVDLAGSERAAQTG--------------------------AAGVRLKEGCNINRSLFILGQVIKKLSDGQ------------------------------------VGGFINYRDSKLTRILQNS-LGGNPKTRIICTITPVSF--DETLTALQFASTA-KYM-KNTPYVN HsCENP-E UmKin1 PTEHHPAIAKRTTSSERAGAGASIAAAPSSHDLDHEDPTS-----------------------STYHFQFDKLITGAQ----------TTDDMYHSHIAPVVRAAVEGYNGTVFAYGQTGSGKTHTMSGS---------------DAEPGVIPRAVEQIFQMIKDEPDRE----------------------------------------------------------------------------------------------------FLLRVSYLEIYNETLKDLLAPLP-------------------------------------------------------------------------PLTGSTGSSLQTTDRPASPIKGGSSHAAGQSQSCTLRIIEDQKSSRVIITGLREEIVTDANTVLCLIQRGQDERHVGATDWNERSSRSHCVFQLTIESR-------------SPAPSASKEVRISQLNLIDLAGSERAA-----------------------------SQAERRKEGAFINKSLLTLGTVIGKLTEPV----------------------------------ENGDAHIPYRDSKLTRILQTS-LSGNARIAVICTLSPDTEHANETLSTLKFGKRC-KLV-VTTAKKG UmKin1 AtT19F6 GEEKILVSVRVRPLNEKEKTRNDRCDWECINDTTIICKFH--------------------NLPDKSSYTFDKVFGFEC----------PTKQVYDDGAKEVALCVLSGINSSIFAYGQTSSGKTYTMSGI---------------------TEFAMDDIFAYIDKHKQERK---------------------------------------------------------------------------------------------------FTLKFSAMEIYNEAVRDLLCEDS----------------------------------------------------------------------------------------------------------STPLRLLDDPERGTVVEKLREETLRDRSHLEELLSICETQRKIGETSLNEISSRSHQILRLTIESS------------SQQFSPESSATLAASVCFVDLAGSERASQTL--------------------------SAGSRLKEGCHINRSLLTLGTVIRKLSKGK-------------------------------------NGHIPYRDSKLTRILQNS-LGGNARTAIICTMSPARSHLEQSRNTLLFATCA-KEV-TTNAQVN AtT19F6 DmCmeta NASSIQVCIKVRPCEPGLTSLWQVKEGRSIHLADSHAEPY------------------------VFDYVFDEGASNQE--------------VFDRMARHIVHACMQGFNGTIFAYGQTSSGKTYTMMGD---------------EQNPGVMVLAAKEIFQQISSETERD----------------------------------------------------------------------------------------------------FLLRVGYIEIYNEKIYDLLNKKN------------------------------------------------------------------------------------------------------------QDLKIHESGNGIVNVNCEECIITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESR-------------KSDHSDDDAVIQSVLNLVDLAGSERADQTG--------------------------ARGARLKEGGHINKSLLFLSNVIKSLSENA------------------------------------DNRFTNYRDSKLTRILQAS-LGGNAFTSIICTIKPSIM--EESQSTLSFATRA-KKI-RIKPQVN DmCmeta DmCana NASSIQVCIKVRPCEPGLTSLWQVKEGRSIQLADSHAEPY------------------------VFDYVFDEGASNQE--------------VFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGD---------------EQNPGVMVLAAKEIFQQISSETERD----------------------------------------------------------------------------------------------------FLLRVGYIEIYNEKIYDLLNKKN------------------------------------------------------------------------------------------------------------QDLKIHESGNGIVNVNCKESIVTSEDDLLRQLYMGNKERVVGETNMNERSSRSHAIFRIIIESR-------------KSDHSDNDTVKQSVLSLVDLAGSEQVDPAD---------------------------HASSLMIFRNLVKSLSESV----------------------------------------------DSKPNSFRDSKLPRIMLPS-LGGNVLTSIICTITPSFV--EESSSTISFGTCA-KKI-RCKPQVC DmCana LmL6586 MEGQERRSVVEMTNTKTILLDPKDGWAPKAQFDFDASLW-----------------SIPPTHRIVHTFQ-DTKHKTYA----------TQKDVYNLIAKDLVPHVFNGFNSCILTYGQTGSGKTYTMMGL------YDPNASCGGDGEEGIIPRVSNDIFIILKERMEEEAK-----------------------------------------------------------------------------------------TRPPRDRTKFRVEVSFVEIYMERVRDLLDPAL--------------------------------------------------------------------------------------------------RHTRSNEHLQDARIRQDPYSGPFVEGVTKYEVENWTQCCTLLERGSQHRTTCATAVHNQSSRSHAIFQLTVVQE-------QVVPGNNKYALPAFKTQAGRINLVDLAGSERGGFQD------------------------------YVKESAAINTSLLALRRVIDNLTERQ-----------------NMLMEMAEAEITGKHYQERPLPQVPFRDSVLTWLLSDS-IGGNARTTMVATLSPLVKNYADTLATLQWSSRA-RNL-VTLVKMN LmL6586 LcKIN EAERVKVSVRVRPLNERENNAPEGTKVTVAAKQAAAVVTV---KVLGGSNNSGAAESMGTARRVAQDFQFDHVFWSVETPDACGATPATQADVFRTIGYPLVQHAFDGFNSCLFAYGQTGSGKTYTMMGA---------DVSALSGEGNGVTPRICLEIFARKASVEAQGHSR-------------------------------------------------------------------------------------------------WIVELGYVEVYNERVSDLLGKRK--------------------------------------------------------------------------------------------------KGVKGGGEEVYVDVREHPSRGVFLEGQRLVEVGSLDDVVRLIEIGNGVRHTASTKMNDRSSRSHAIIMLLLREE--------RTMTTKSGETIRTAGKSSRMNLVDLAGSERVAQSQ--------------------------VEGQQFKEATHINLSLTTLGRVIDVLADMA------------------------------TKGAKAQYSVAPFRDSKLTFILKDS-LGGNSKTFMIATVSPSALNYEETLSTLRYASRA-RDI-VNVAQVN LcKIN DmNod GAKLSAVRIAVREAPYRQFLGRREPSVVQFPPWSDGKSLI----------------------VDQNEFHFDHAFPATI----------SQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMT---------PPGEILPEHLGILPRALGDIFERVTARQENNKDA-------------------------------------------------------------------------------------------------IQVYASFIEIYNEKPFDLLGST-----------------------------------------------------------------------------------------------------------------PHMPMVAARCQRCTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHVKSK----------------------THHSRMNIVDLAGSEGVRRTG--------------------------HEGVARQEGVNINLGLLSINKVVMSMAAGH--------------------------------------TVIPYRDSVLTTVLQAS-LTAQSYLTFLACISPHQCDLSETLSTLRFGTSA-KKL-RLNPMQV DmNod AtFCA1.2 KTPNPDGSKDPSPPEHPVEVIGRIRDYPDRKEKSPSILQV---------NTDNQTVRVRADVGYRDFTLDGVSFSEQE----------GLEEFYKKFIEERIKGVKVGNKCTIMMYGPTGAGKSHTMFGC---------------GKEPGIVYRSLRDILGDSDQDGV------------------------------------------------------------------------------------------------------TFVQVTVLEVYNEEIYDLLSTNS-------------------------------------------------------------------------------------------------SNNLGIGWPKGASTKVRLEVMGKKAKNASFISGTEAGKISKEIVKVEKRRIVKSTLCNERSSRSHCIIILDVPTV------------------------GGRLMLVDMAGSENIDQAG-------------------------QTGFEAKMQTAKINQGNIALKRVVESIANGD--------------------------------------SHVPFRDSKLTMLLQDSFEDDKSKILMILCASPDPKEMHKTLCTLEYGAKA-KCIVRGSHTPN AtFCA1.2 ScSmy1 EPCHIEVILRAIPEKGLQNNESTFKIDPYENTVLFRTNNP----------------LHETTKETHSTFQFDKVFDANA----------TQEDVQKFLVHPIINDVLNGYNGTVITYGPSFSGKSYSLIGS---------------KESEGILPNICKTLFDTLEKNEETKGDS-------------------------------------------------------------------------------------------------FSVSVLAFEIYMEKTYDLLVPLP--------------------------------------------------------------------------------------------------------ERKPLKLHRSSSKMDLEIKDICPAHVGSYEDLRSYIQAVQNVGNRMACGDKTERSRSHLVFQLHVEQR----------------NRKDDILKNSSLYLVDLHGAEKFDKRT--------------------------ESTLSQDALKKLNQSIEALKNTVRSLSMKE----------------------------RDSAYSAKGSHSSAYRESQLTEVLKDS-LGGNRKTKVILTCFLS--NVPTTLSTLEFGDSI-RQI-NNKVTDN ScSmy1
Go to the table of Kinesin Proteins listed by organism.
Go to the phylogenetic tree derived from kinesin motor domain sequences.
Return to the Kinesin Home Page.
If you use diagrams, trees, or sequence alignments from the Kinesin site, we ask that you cite either the home page and authors, or the appropriate source publication in your work.
Copyright 1996-2005. All rights reserved.
Created 7 July 1996 20:00 GMT
Modified 25 January 2005 8:32 GMT
