The Kinesin-14 (formerly C-terminal motor) proteins have in common a C-terminal motor domain, differing from other kinesin proteins. At least four members of the group (DmNcd, ScKAR3, CgCHO2, AtKCBP) have been demonstrated to be minus-end directed motors, in contrast to the plus-end directed motility of other kinesin proteins. The Kinesin-14 family tree was found using the heuristic search method of PAUP v4.0b10 (Swofford, 2002), a maximum parsimony program, and random stepwise addition. The tree is one of two optimal trees that resulted from 600 trees that were built. The bootstrap values adjacent to the nodes are the percentages of 1,810 heuristic bootstrap trials in which the indicated groups were found. The tree contains Kinesin-14 proteins from humans and several model organisms. Kinesin-14 proteins from other organisms are also shown in the table and sequence alignment below.
| Species/protein | Molecular mass (kDa) | Motor polarity & velocity | Subcellular localization | Comments |
|---|---|---|---|---|
| C. elegans KLP17 (W02B12) | 68 | ND | ND | |
| C. elegans KLP16 (C41G7.2) | 64 | ND | ND | |
| C. elegans KLP15 (M01E11.6) | 64 | ND | ND | |
| D. melanogaster Ncd | 78 | Minus, 8-15 µm/min | Spindle/centrosomes | Required for formation of meiotic spindle, mitotic spindle integrity |
| S. cerevisiae Kar3 | 84 | Minus, 1-2 µm/min | Spindle/poles | Required for karyogamy, mutants have mitotic defect, opposes action of Cin8/Kip1 |
| H. sapiens CHO2 | ND | ND | ||
| A. thaliana KatC | 84 | ND | ND | |
| A. thaliana KatB | 82 | ND | ND | |
| A. thaliana C17L7.110 | 88 | |||
| A. thaliana KatA | 89 | ND | ND | |
| A. thaliana F15H18.10 | 131 | |||
| A. thaliana F25P22.28 | 118 | |||
| A. thaliana F24D7.17 | 118 | |||
| A. thaliana K1013.11 | 108 | |||
| A. thaliana T30B22.20 | 108 | ND | ND | |
| A. thaliana T12M4.14 | 114 | |||
| A. thaliana KatD | 110 | ND | ND | |
| A. thaliana T32N15.10 | 86 | ND | ND | |
| A. thaliana F14P13.9 | 100 | |||
| A. thaliana F15F15.20 | 70 | |||
| A. thaliana T5A14.3 | 100 | |||
| A. thaliana T9I22.5 | ||||
| A. thaliana T9N14.6 | 133 | |||
| A. thaliana F15A18.10 | 48 | |||
| C. elegans Klp | 67 | |||
| H. sapiens KIFC3 | 77 | ND | ND | |
| H. sapiens KIFC2 | ||||
| A. thaliana KCBP | 143 | Minus, 8-10 µm/min | ND | Calmodulin binding |
| A. thaliana MNA5.20 | ||||
| A. thaliana F12B17.180 | ||||
| A. nidulans KlpA | 86 | ND | Functions in spindle | Opposes force produced by bimC, complements kar3 mutant |
| C. griseus CHO2 | 69 | Minus, 1-8 µm/min | Spindle/centrosomes | Spindle at mitosis, centrosome in interphase |
| D. rerio ZfKns12 | ND | ND | ||
| L. major L6066 | ND | ND | ND | |
| M. musculus KIFC1 | 66 | ND | ND | |
| M. musculus KIFC2 | 86 | ND | Neurons – cell bodies, dendrites | |
| M. saxatilis FKIF2 | 87 | ND | ND | |
| N. haematococca KRP1 | ND | ND | ||
| N. tabacum KCBP | 144 | ND | ND | |
| S.tuberosum PoKCBP | 143 | ND | ND | Calmodulin binding |
| S. pombe Pkl1 | 96 | ND | ND | |
| S. pombe Klp2 | 93 | ND | ND | |
| S. purpuratus KinC | 181 | ND | ND | Calmodulin binding |
| X. laevis CTK1 | 96 | ND | ND | |
| X. laevis CTK2 | 72 | ND | ND |
1 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390
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CeKLP17 LRGQIRVAIRVRDFERDGSSNFSIISQNEVQLQQTTGQS------------------------NTYSFEHVFFPPTAQSGVFGEIKELIMCALHGKNVCLIAYGPTGSGKTFTMRGE--DSADSEGVIPRAIRFMLEQSKRDLAMIGWNYKFQASFIEVYNEEVYDLLDGKQ-----------------KLEVKINGSKTNVVGLKKIEIGNISDVDVILNLADSQRSVASTASNEHSSRSHAIFQIFVDGQN--ASGEMVQCC-LNLVDLAGSERAKETQ---------ARGKQFTELTNINQSLSTLKKCIRAQMTKM------------SHVPYRDSKLTMVLREYLGAGSSKTMFIAHANPR--DVAETKRTLEFTSEL-RST-NLGKAVV CeKLP17
CeKLP16 LRGQIRVAVRVRPLIKSEVDTSSSAIEYPAVDAIKINEGSK--------------------PGNVVKFENVFTPVFSQKEVFANVEEFIRSSLHGYNVGLIAYGQTGSGKTHTMRGG---NGEEEGIIPRAAAFLFAESKK-LESLGWKFDFSLSFLEVYNNVAYDLLSGRD-----------------VVQLRLNDQTVSMIGLSEHTISNVSDVARLLRVADGGRKTAATKCNGSSSRSHAVYMWKIKAHQ--PSTGISTTCQLKLVDLAGSERAKESG---------VSGDQFKEMTNINQSLSILQMCISQQRSQK------------GHVSYRDSKLTQVLMDCLGRGSSKTMVVVNLNPCNEQATESKRSIEFASKM-RST-HIGSAVQ CeKLP16
CeKLP15 LRGQIRVAVRVRPLIKSEADASSSAIEYPAIDTIRINEGSK--------------------PGIVVKFEKVFTPVFSQKEVFANVEEFIRSSLHGYNVGLIAYGQTGSGKTHTMRGG---NGEEEGIIPRAAAFLFAESRK-LESLGWKFDFSLSFLEVYNNVAYDLLSDRA-----------------VVQLRLNDQTVSMIGLSEHTISNVSDVARLLRVADGGRKTAATKCNESSSRSHAVYMWKITAHQ--PSTGISTSCQLKLVDLAGSERAKESG---------VSGDQFKEMTNINQSLSILQMCISQQRSQK------------GHVSYRDSKLTQVLMDCLGRGNSKTMVVVNLNPCNEQATESKRSIEFASKM-RST-NIGSAVQ CeKLP15
DmNcd LRGNIRVFCRIRPPLESEENRMCCTWTYHDESTVELQSIDA--------------QAKSKMGQQIFSFDQVFHPLSSQSDIFEMVSPLIQSALDGYNICIFAYGQTGSGKTYTMDGV----PESVGVIPRTVDLLFDSIRGY-RNLGWEYEIKATFLEIYNEVLYDLLSNEQ-------------KDMEIRMAKNNKNDIYVSNITEETVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAVTKLELIGRH--AEKQEISVGSINLVDLAGSESPKTS-------------TRMTETKNINRSLSELTNVILALLQKQ------------DHIPYRNSKLTHLLMPS-LGGNSKTLMFINVSPFQDCFQESVKSLRFAASV-NSC-KMTKAKR DmNcd
ScKAR3 LRGNIRVYCRIRPALKNLENSDTSLINVNEFDDNSGVQSME------------VTKIQNTAQVHEFKFDKIFDQQDTNVDVFKEVGQLVQSSLDGYNVCIFAYGQTGSGKTFTMLNP------GDGIIPSTISHIFNWINKL-KTKGWDYKVNCEFIEIYNENIVDLLRSDN-----NNKEDTSIGLKHEIRHDQETKTTTITNVTSCKLESEEMVEIILKKANKLRSTASTASNEHSSRSHSIFIIHLSGSN--AKTGAHSYGTLNLVDLAGSERINVSQ---------VVGDRLRETQNINKSLSCLGDVIHALGQPD---------STKRHIPFRNSKLTYLLQYS-LTGDSKTLMFVNISPSSSHINETLNSLRFASKV-NST-RLVSRK- ScKAR3
HsCHO2 LKGNIRVFCRVRPVLPGEPTPPPGLLLFPSGPGGPSDPPTRLSLSRSDERRGTLSGAPAPPTRHDFSFDRVFPPGSGQDEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPGGDPQLEGLIPRALRHLFSVAQEL-SGQGWTYSFVASYVEIYNETVRDLLATGT--------RKGQGGECEIRRAGPGSEELTVTNARYVPVSCEKEVDALLHLARQNRAVARTAQNERSSRSHSVFQLQISGEH--SSRGLQCGAPLSLVDLAGSERLDPGL-----ALGPGERERLRETQAINSSLSTLGLVIMALSNKE------------SHVPYRNSKLTYLLQNS-LGGSAKMLMFVNISPLEENVSESLNSLRFASKV-NQC-VIGTAQA HsCHO2
AtKATC LKGNIRVFCRVRPLLPGENNGDEGKTISYPTSLEALGRGID---------------LMQNAQKHAFTFDKVFAPTASQEDVFTEISQLVQSALDGYKVCIFAYGQTGSGKTYTMMGRP-GNVEEKGLIPRCLEQIFETRQSL-RSQGWKYELQVSMLEIYNETIRDLLSTNK----EAVRTDSGVSPQKHAIKHDASGNTHVAELTILDVKSSREVSFLLDHAARNRSVGKTQMNEQSSRSHFVFTLRISGVN--ESTEQQVQGVLNLIDLAGSERLSKSG---------STGDRLKETQAINKSLSSLGDVIFALAKKE------------DHVPFRNSKLTYLLQPC-LGGDAKTLMFVNIAPESSSTGESLCSLRFAARV-NAC-EIGTPRR AtKATC
AtKATB LKGNIRVFCRVRPLLSGENSSEEAKTISYPTSLEALGRGID---------------LLQNGQSHCFTFDKVFVPSASQEDVFVEISQLVQSALDGYKVCIFAYGQTGSGKTYTMMGRP-GNPDEKGLIPRCLEQIFQTRQSL-RSQGWKYELQVSMLEIYNETIRDLLSTNK----EAVRADNGVSPQKYAIKHDASGNTHVVELTVVDVRSSKQVSFLLDHAARNRSVGKTAMNEQSSRSHFVFTLKISGFN--ESTEQQVQGVLNLIDLAGSERLSKSG---------STGDRLKETQAINKSLSSLGDVIFALAKKE------------DHVPFRNSKLTYLLQPC-LGGDSKTLMFVNITPEPSSTGESLCSLRFAARV-NAC-EIGTAHR AtKATB
AtKATA LKGNIRVFCRVRPLLPDDGGRHEATVIAYPTSTEAQGRGVD---------------LVQSGNKHPFTFDKVFNHEASQEEVFFEISQLVQSALDGYKVCIFAYGQTGSGKTYTMMGRP-EAPDQKGLIPRSLEQIFQASQSL-GAQGWKYKMQVSMLEIYNETIRDLLSTNRTTSMDLVRADSGTSGKQYTITHDVNGHTHVSDLTIFDVCSVGKISSLLQQAAQSRSVGKTQMNEQSSRSHFVFTMRISGVN--ESTEQQVQGVLNLIDLAGSERLSKSG---------ATGDRLKETQAINKSLSALSDVIFALAKKE------------DHVPFRNSKLTYLLQPC-LGGDSKTLMFVNISPDPTSAGESLCSLRFAARV-NAC-EIGIPRR AtKATA
AtKATD LKGNIRVYCRVRPFLPGQESGGLSAVEDIDEGTITIRVPSK----------------YGKAGQKPFMFNKVFGPSATQEEVFSDMQPLVRSVLDGYNVCIFAYGQTGSGKTFTMTGPKELTEESLGVNYRALADLFLLSNQR--KDTTSYEISVQMLEIYNEQVRDLLAQDG-------------QTKRLEIRNNSHNGINVPEASLVPVSSTDDVIQLMDLGHMNRAVSSTAMNDRSSRSHSCVTVHVQGRD--LTSGSILHGSMHLVDLAGSERVDKSE---------VTGDRLKEAQHINKSLSALGDVISSLSQKT------------SHVPYRNSKLTQLLQDS-LGGSAKTLMFVHISPEPDTLGETISTLKFAERV-GSV-ELGAARV AtKATD
AtT32N15 RIGTIRVYCRVRPFFQEQKDMQSTVDYIGENGNIIINNPFK----------------QEKDARKIFSFNKVFGQTVSQEQIYIDTQPVIRSVLDGFNVCIFAYGQTGSGKTYTMSGPDLMTETTWGVNYRALRDLFQLSNAR--THVVTYEIGVQMIEIYNEQVRDLLVSDV--------------------------------------SNTRDVLDLMRIGQKNRAVGATALNERSSRSHSVLTVHVQGKE--LASGSILRGCLHLVDLAGSERVEKSE---------AVGERLKEAQHINKSLSALGDVIYALAQKS------------SHVPYRNSKLTQVLQDS-LGGQAKTLMFVHINPEVNAVGETISTLKFAQRV-ASI-ELGAARS AtT32N15
CeKLP LNGNIRVFYRIRPQLASETDNQKPVVVIDEMDNGVVHVSNT-----------------TGTRKTSAGADKVIPTDFSQDQIFNEVSPIITSCIDGYNVCIFAYGHTGSGKTYTMDGP----VTMPGINQRAIMQLFETAKER--TGDIKYDIKVAMMEIYNEKIRDLLNTSN---------------TNLAIRQTEEGRSSIPGLEEVSVNSAEEVTETLARGRKNKAVAATEANIESSRSHVIVRVLVSATN--LITKATTVGRLNLVDLAGSERVSQTN---------ATGQLLKEAQAINKSLSELGNVVLALRQNQ------------KHIPFRNCQLTRILEDS-LNGDSKTLVIVHLSPDAKSLNESISSVNFAEKIGQVFTKSGTMKR CeKLP
HsKIFC3 LKGNIRVIARVRPVTKEDGEGPEATNAVTFDADDDSIIHLL-----------------HKGKPVSFELDKVFSPQASQQDVFQEVQALVTSCIDGFNVCIFAYGQTGAGKTYTMEGT----AENPGINQRALQLLFSEVQEK--ASDWEYTITVSAAEIYNEVLRDLLGKEP------------QEKLEIRLCPDGSGQLYVPGLTEFQVQSVDDINKVFEFGHTNRTTEFTNLNEHSSRSHALLIVTVRGVD--CSTGLRTTGKLNLVDLAGSERVGKSG---------AEGSRLREAQHINKSLSALGDVIAALRSRQ------------GHVPFRNSKLTYLLQDS-LSGDSKTLMVVQVSPVEKNTSETLYSLKFAERV-RSV-ELGPGLR HsKIFC3
AtKCBP MKGKIRVYCRIRPLNEKESSEREKQMLTTVDEFTVEHPWKD-------------------DKRKQHIYDRVFDMRASQDDIFEDTKYLVQSAVDGYNVCIFAYGQTGSGKTSTIYGH----ESNPGLTPRATKELFNILKR--DSKRFSFSLKAYMVELYQDTLVDLLLPKS------------ARRLKLEIKKDSTGMVFVENVTTIPISTLEELRMILERGSERRHVSGTNMNEESSRSHLILSVVIESID--LQTQSAARGKLSFVDLAGSERVKKSG---------SAGCQLKEAQSINKSLSALGDVIGALSSGN------------QHIPYRNHKLTMLMSDS-LGGNAKTLMFVNVSPAESNLDETYNSLLYASRV-RTI-VNDPSKH AtKCBP
AnKLPA LKGNIRVFCRVRPTLENEGASDAAQFTYPDEGEDSKEINII-------GPEEKSSFGTVTRKNHNFSFDHVFGPSAQNSDVFDEISQLVQSALDGYNVCIFCYGQTGSGKTHTMSSL-------DGMIPRAVHQIYETATSLEEKGWR-YTMEGNFVEVYNENLNDLLGKAE----------ELDKKKLEIRHDMQRGKTTITDATTVQLESPEMVESLLKRAAANRSVAATKANERSSRSHSIFILKLIGEN--YITGERSEGTLNLVDLAGSERLSHSG---------ATGDRLKETQNINRSLSCLGDVIAALGQGK----------KDGHIPYRNSKLTYLLQFS-LGGNSKTLMFVMVSPLQAHLSETLTSLKFATKV-HNT-HIGTAKK AnKLPA
AtT5A14.3 LKGNIRVFCRVKPLGATEKLRPPVASDTRNVIIKL-----------------------SETKRKTYNFDRVFQPDSSQDDVFLEIEPVIKSVIDGYNACIFAYGQTGTGKTYTMEGL----PNSPGIVPRAIKGLFKQVEES----NHMFTIHFSMLEIYMGNLKDLLLSEA-------TKPISPIPPSLSIHTDPNGEIDIENLVKLKVDDFNEILRLYKVGCRSRATASTNSNSVSSRSHCMIRVSVTSLG--APERRRETNKIWLVDLGGSERVLKTR---------ATGRRFDEGKAINLSLSALGDVINSLQRKN------------SHIPYRNSKLTQVLKDS-LGQDSKTLMLVHISPKEDDLCETICSLNFATRA-KNI-HLGQDES AtT5A14.3
AtT30B22 LKGSIRVYCRVRPFLPGQSSFSSTIGNMEDDTIGINTASRH------------------GKSLKSFTFNKVFGPSATQEEVFSDMQPLIRSVLDGYNVCIFAYGQTGSGKTFTMSGPRDLTEKSQGVNYRALGDLFLLAEQR--KDTFRYDIAVQMIEIYNEQIRNSSQKGL----------------------------SVPDASLVPVSSTFDVIDLMKTGHKNRAVGSTALNDRSSRSHSCLTVHVQGRD--LTSGAVLRGCMHLVDLAGSERVDKSE---------VTGDRLKEAQHINRSLSALGDVIASLAHKN------------PHVPYRNSKLTQLLQDS-LGGQAKTLMFVHISPEADAVGETISTLKFAERV-ATV-ELGAARV AtT30B22
CgCHO2 LKGNIRVFCRVRPVLAGEPTPSPGFLLFPHGPAGPSDPPTRLSLSRSDDRRSTLTRAPAPTTRHDFSFDRVFPPGSKQEEVFEEISMLVQSALDGYPVCIFAYGQTGSGKTFTMEGRPGGDPQLEGLIPRRMRHLFSVAQEM-SGQGWTYSFVASYVEIYNETVRDLLATGT---------RKGQGECEIRRARPGSEELTVTNARYVPVSCEREVEALLHLAHQNRAVARTAQNERSSRSHSVFQLQISGEH--AARGLQCVAPLNLVDLAGSERLDPGL-----TLGPGERDRLRETQSINSSLSTLGLVIMALSNKE------------SHVPYRNSKLTYLLQNS-LGGSAKMLMFVNISPLEENVSESLNSLRFASKV-NQC-VIGTAQA CgCHO2
LmL6066 LKGNIRVYCRVRPMLSNEIKGGYSDVMSYPTQDEVRLIDAS-------------------GRPKLFEFDEVYPPTAPQARVFEDTAPLIDSVVDGFNVCIFAYGQTGSGKTFTMNG----EGENKGINTRALERLFGVIEER--KETEVSTVTVSVLEIYCEQIRDLLATKK-----------EASGLTYEVKQGGPYGTYVTNLKEVPVTSAGDIDGIMATAQTHRSEGMTNMNEHSSRSHMLLYIIVRTTN--KQTNMQGYGKLSLIDLAGSERVDKSG---------AEGQRLKEAVAINKSLSALGDVIAGLAQNS------------KHVPFRNSALTFLLQDS-MAGQAKVLMFVCVSPASYNVSESSSSLLFASRA-RGV-AFGQI LmL6066
MmKIFC1 LKGNIRVFCRVRPVLAGESTPSPGFLVFPPGPAGPSDPPTGLSLSRSDDRRSTLTGAPAPTVRHDFSFDRVFPPGSKQEEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPRGDPQLEGLIPRAMRHLFSVAQEM-SGQGWTYSFVASYVEIYNETVRDLLATGL--------RKGQGGECEIRRASPGSEELTVTNVRYVPVSCEKEVEALLHLAHQNRAVAHTAQNKRSSRSHSVFQLQISGEH--AARGLQCGAPLNLVDLAGSERLDPGL-----HLGPGERDRLRETQAINSSLSTLGLVIMALSNKE------------SHVPYRNRKLTYLLQNS-LGGSAKMLMFVNISPLEENVSESLNSLRFASKV-NQC-VIGTAQA MmKIFC1
MmKIFC2 LKGNIRVLCRLRPAEGQPSSLVSVEPGQGGTITTCY-----------------------RGRQHCFRLDWVFPQDASQEEVFRQLEPAVLSCLQGYSVCIFTYGQTGTGKTYSMEGP----PEDPGIAPRALQLLFREMGTG-----GHHHVTLSMVEIYNEAVRDLLATGP------------PERLVVRQGPAGQGGIQVAGLTHWDVPNLETLHQMLSLGRSNRATAATVMNQHSSRSHALVTLTLRAAS--PPRPQGITGTLHLVDLAGSERVWKAGVASPVQRDPNGARRLREAQAINRSLLALGGVMAALRARR------------PHVPFRDSQLTRLLQPA-LWAGTTAVLLLQISTRAEDLGETICSLKFAERV-GQV-ELGPARR MmKIFC2
MsFKIF2 LKGNIRVFCRVRPVSQEEQDSADARTMLSFDSEDDAVLYLS-----------------NKGKIMTFELDKVFAPQATQEEVFQEVQSLVTSCIDGFNVCIFAYGQTGSGKTYTMEGV----VDDPGINQRALRLLFSEVTEK--APDWDYKITVSMVEIYNETLRNLLGENP------------TDKLDIKMNPDGSGQLYVPGLTEFTVQSPEDINRVFELGHMNRATACTNLNEHSSRSHALLIITVSGTRFNSATGNRTQGKLNLVDLAGSERIAKSG---------AEGSRLREAQCINKSLSALGDVINALRSKH------------SHIPFRNSRLTYLLQDS-LNGDSKTLMMVQVSPLPTNMSESVCSLKFAQRV-RSV-ELSSSSS MsFKIF2
NhKRP1 LKGNIRVMCRVRPPLGDGEGERAQMSFPDDKTSAEIVLAGP---------EEKSSLGNVTRKNYPFEFDRVFIPGTQNHEIFGEISQLVQSALDGYNVCIFCYGQTGSGKTFTMSSA-------DGMIPRATHMIYDTITKL-KEKSWEYTMEGSFVEVYNEELNDLLTPNE-------RSSEGRPKKLEIRHDESRKQTVIMNCKSVRLNSPSSVETMLEEAQNNRSVAATKANERSSRSHSVFILKLVGEN--SATGERCEGTLNLVDLAGSERLKHSQ---------AEGDRMKETQNINKSLSCLGDVIEALGRGS------------GHVPYRNSKLTHLLQYS-LGGNSKTLMFVMVSPLETHLKETLTSLRFATKV-CSV-CFMK--- NhKRP1
NtKCBP MKGKIRVYCRLRPLCEKEIIAKERNVMRSVDEFTIEHIWKD-------------------DKAKQHMYDRVFDGNSTQDDVFEDTKYLVQSAADGYNVCIFAYGQTGSGKTFTIYGA----DSNPGLTPRAISELFRIMKR--DSNKFSFSLKAYMVELYQDTLVDLLLPKN------------AKRLRLDIKKDSKGMVSVENVTVVSISTYEELKTIIQRGSEQRHTTGTLMNEQSSRSHLIVSVIIESTN--LQTQAIARGKLSFVDLAGSERVKKSG---------SAGNQLKEAQSINKSLSALGDVISALSSGN------------QHIPYRNHKLTMLMSDS-LGGNAKTLMFVNISPAESNLDETHNSLTYASRV-RSI-VNDPSKN NtKCBP
PoKCBP MKGKIRVYCRLRPLCEKEIIAKERNAIRSVDEFTVEHLWKD-------------------DKAKQHMYDRVFDGNATQDDVFEDTKYLVQSAVDGYNVCIFAYGQTGSGKTFTIYGA----DSNPGLTPRAMSELFRIMKK--DSNKFSFSLKAYMVELYQDTLVDLLLPKQ------------AKRLKLDIKKDSKGMVSVENVTVVSISTYEELKTIIQRGSEQRHTTGTLMNEQSSRSHLIVSVIIESTN--LQTQAIARGKLSFVDLAGSERVKKSG---------SAGNQLKEAQSINKSLSALGDVISALSSGN------------QHIPYRNHKLTMLMSDS-LGGNAKTLMFVNISPAESNLDETHNSLTYASRV-RSI-VNDPSKN PoKCBP
SpoPKL1 LKGNIRVFCRVRPLLPSEESEYCIADVLQFPDKDALEPQKL----ILKGPNVESSLGHTYDRNYEFSFDRVFAPESDNSTVFEEISQLIQSAIDGYNVSIFAYGQTGSGKTYTMSSQDGMIAMSIKHIFNYLSTLREKGWV--------YKLRGQFLEIYNEAIYDLLNKAE----------MLKNPKHDIHHDEKERRTTVDNVSIIDFNEEDTVYKMLNRAGENRFIAATKANERSSRSHTVFMLYIDGEN--SRTKQICKGTLNLVDLAGSERLSYSQ---------AVGDRLRETQAINKSLSCLGDVIHALGNAS-----NSTTKEKSHIPYRNSKLTYLLKYS-LGKGAKTLMFVNVSPLKSQFMDTLNSLRFATKV-NDT-KVGSIKH SpoPKL1
SpoKLP2 LKGNIRVFCRVRPPLGDGESAQIAFPDQNSEASTIEIVAQA----------PGSSLTGNGIKQYAFNFDRVFSPETTNEDVFNELSQLIQSAMDGYNVCIFAYGQTGSGKTHTMSSN-------TGMIPSSVRMIYNRSTSL-KERGWEYRMEGQFLEIYNETIIDLLASGN--------EEEKGKKKLEIYHDTKAGRTTITNITSEPLDTPEQVTWLLDQASKNRSVAATNANEHSSRSHSVFMLHLNGSN--STTGETCRSTLNLIDLAGSERLSSSQ---------SVGEPFEGTQAINKVVLGDVYMLGGLSCLGDVIHALGSGKEGTYIPYRNSKLTNLLQYS-LGGNSKTLIFVNISPLKQHVPETLCSLRFATKV-NNT-QIGTARK SpoKLP2
SpKinC MKGKIRVYCRARPLSGSEKERGNFSIIKRPDEYTVDITSTR--------------------GQKEFQFDHIFMPENTQAEIFEDTDRLIQSAVDGYNVCIFAYGQTGSGKTFTMIGD--KEQKFPGIAPRAFQKVYELIEEN--KSKFSFRVYTYMLELYNEKLIDLYNKNK------------GEPPKLDIKKDKKGMVYINGSVIQEAGNSKELYGLFEEGSANRHVASTKMNSESSRSHLVIGVIIESTN--LGTGAVVKGKLTLVDLAGSERSAKTG---------ATAEQLKEANSINKSLSALADVISALSSEQ------------SFIPYRNNKLTMLMQDS-LGGNAKTLMFVNISPADYNAEETVISLTYASRV-KLI-TNDASKN SpKinC
XlCTK1 LRGNIRVFARVRPITTEDGVGPGAENIVTFDPDDDGVLYVA-----------------QKGKEMSFELDKIFTPSATQEEVFRDVSPLITSCLDGYSVCILAYGQTGSGKTYSMEGI----PSDPGINQRALRLLLSEVKER--SSSWEHELSVSMVEIYNESLRDLLGSDP------------SNSLEIKILPGSVGELYVPNLTQRQVQSMEDINKILELGHKQRATEHTNLNTHSSRSHALLILTAKGRE--TSTGICSTGKLYLVDLAGSERVSRSG---------AAGERLREAQCINRSLSALGDVISALRSQQ------------GHIPYRNSKLTYLLQEP-LSREGKALLLLQVSPAEKNISESLCSLRFGDRV-RAV-ELGAPSR XlCTK1
XlCTK2 LKGNIRVFCRVRPTLTPERELPAGHISFPSNDGKAIVLSKM--------EESHIGREKKDAVKYDFNFDCVFPPPCSQESVFEEISLLVQSALDGYPVCIFAYGQTGSGKTYTMEGPEDVTDDSMGMIPRAIHQIFSSAEEL-KAKGWQYTFTASFLEIYNETIRDLLINRP----------DKKLEYEIRKVNSANMLLYVTNLRYVKVSCVEEVHELLKIAKANRSVAKTAINDRSSRSHSVFQLKIEGEN--KQRDLKTSSMISLIDLAGSERLDRSL---------STGDRLKETQCINTSLSTLGMVITSLCNKD------------SHIPYRNSKLTYLLQNS-LGGNAKVLMFVNISPLEENFAESLNSLRFASKV-NEC-VIGTARA XlCTK2
ZfKnsl2 LKGNIRVFCRVRPLLTGNQSDILHIQLPPHDNKALTLAKME---------ESHTGRTTDTQKSYNFSFDRVFGPRSSQSEVFEEISLLVQSALDGYNVCCFAYGQTGSGKTFTMEGG--EQEELWGVIPRAVQQIFKSAKAL-SEQGWQYTFTASFVEIYNETLRDLLYKGK-----------PNKRPEHEIRKVSNNEITVTNLTYQKVNNEDEVHNLIMLANQNRSTARTCMNDHSSRSHSVFQLDIEGEN--TARDSKCKSMLCLVDLAGSERVQKSQ---------SQGERFKEMTAINSSLTNLGIVIAALANKD------------SFVPYRNSKLTYLLQNC-LGGNSKTLMFANISPEEESFSESLNSLRFASKV-NDC-VIGTASA ZfKnsl2
If you use diagrams, trees, or sequence alignments from the Kinesin site, we ask that you cite either the home page and authors, or the appropriate source publication in your work.
Copyright 1996-2005. All rights reserved.
Created 16 July 1996 00:00 GMT
Modified 25 October 2005 7:32 GMT
