Optimizing Diffusion Imaging Protocols for Structural Connectomics in Mouse Models of Neurological Conditions

Network approaches provide sensitive biomarkers for neurological conditions, such as Alzheimer’s disease (AD). Mouse models can help advance our understanding of underlying pathologies, by dissecting vulnerable circuits. In this work, we have examined the balance between spatial and angular resolutions and inferred suggestions for recommended future protocols. In particular, we examined a set of nodes/brain regions that are relevant for neurodegenerative conditions such as AD.