Exercise Protects the Aging Heart in High-Fat Diet APOE Mice

Using photon-counting CT and deep learning, we show that voluntary exercise significantly mitigates high-fat diet–induced cardiac dysfunction in adult APOE-targeted mice, with the strongest benefits observed in APOE4 and humanized innate immune (HN) backgrounds.

Exercise mitigates high-fat diet–induced cardiac dysfunction via APOE genotype- and immune-dependent mechanisms: a photon-counting CT study in adult mice. Nadkarni R., Allphin A. J., Clark D. P., Qi Y., Han Z. Y., Ghaghada K. B., Badea A., Badea C. T. PLOS ONE, 2025. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0339293