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GI Journal Club – June 24th, 2021

Article 1:

Regular use of proton pump inhibitors and risk of type 2 diabetes: results from three prospective cohort studies
Yuan J, et al. Gut 2021;70:1070–1077

DOI: 10.1136/gutjnl-2020-322557
PDF: Yuan et al PPI type 2 DM Gut 2021.full


PPI use has been associated with a number of medical conditions, including C diff infection, community-acquired pneumonia, and bone density loss. The authors combined 3 large prospective cohorts (Nurses’ Health Study I and II and Health Professionals Follow up  Study) and found that regular PPI users had a higher risk of incident diabetes (HR 1.24, 95% CI 1.17-1.31), with the risk associated with duration of PPI use. The authors propose that changes in the gut microbiome could be responsible for this effect.

Fellow Presenter: Kara Wegermann
Faculty Preceptor: Rick Wood


Article 2:

Tofacitinib for Biologic-Experienced Hospitalized Patients With Acute Severe Ulcerative Colitis: A Retrospective Q1 Case-Control Study
J Clin Invest. 2021;131(3):e143301

DOI: doi.org/10.1016/j.cgh.2021.05.038
PDF: Berinstein et al. Tofacitinib for Severe UC in Hospitalize Biologic-Experienced Pts


Tofacitinib, a Janus kinase inhibitor, has proven efficacy in treating ulcerative colitis and may provide additional means for preventing colectomy in patients with acute severe ulcerative colitis. This study is a retrospective case-control study performed to evaluate the efficacy of tofacitinib induction in biologic-experienced patients with acute severe ulcerative colitis and demonstrates that tofacitinib in conjunction with IV steroids may be an effective induction strategy in this patient population.

Fellow Presenter: Talisha Ramchal
Faculty Preceptor: CeCe Zhang

GI Journal Club – June 25th, 2020

Please join us on June 25th, 2020 at 5 pm for the next installment of the Virtual GI Journal Club.

Nicole Jawitz will present the following article:
Increased Risk Of High-Grade Dysplasia And Colorectal Cancer In Inflammatory Bowel Disease Patients With Recurrent Low-Grade Dysplasia
Gastrointest Endosc 2020;91:1334-42
Faculty Discussant: Jane Onken
DOI: doi.org/10.1016/j.gie.2019.12.041
PDF: Article

Talisha Ramchal will present the following article:
Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study
Gut 2020;69:859–867
Faculty Discussant: Amy Barto
DOI: doi.org/10.1136/gutjnl-2019-319630
PDF: Article

April Wall will present the following article:
Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation
JAMA. 2020;323(7):616-626
Faculty Discussant: Rick Wood
DOI: doi.org/10.1001/jama.2019.22190
PDF: Article

Prior JC Conferences


June 2024