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GI Journal Club – June 24th, 2021

Article 1:

Regular use of proton pump inhibitors and risk of type 2 diabetes: results from three prospective cohort studies
Yuan J, et al. Gut 2021;70:1070–1077

DOI: 10.1136/gutjnl-2020-322557
PDF: Yuan et al PPI type 2 DM Gut 2021.full

Summary:

PPI use has been associated with a number of medical conditions, including C diff infection, community-acquired pneumonia, and bone density loss. The authors combined 3 large prospective cohorts (Nurses’ Health Study I and II and Health Professionals Follow up  Study) and found that regular PPI users had a higher risk of incident diabetes (HR 1.24, 95% CI 1.17-1.31), with the risk associated with duration of PPI use. The authors propose that changes in the gut microbiome could be responsible for this effect.

Fellow Presenter: Kara Wegermann
Faculty Preceptor: Rick Wood

 

Article 2:

Tofacitinib for Biologic-Experienced Hospitalized Patients With Acute Severe Ulcerative Colitis: A Retrospective Q1 Case-Control Study
J Clin Invest. 2021;131(3):e143301

DOI: doi.org/10.1016/j.cgh.2021.05.038
PDF: Berinstein et al. Tofacitinib for Severe UC in Hospitalize Biologic-Experienced Pts

Summary:

Tofacitinib, a Janus kinase inhibitor, has proven efficacy in treating ulcerative colitis and may provide additional means for preventing colectomy in patients with acute severe ulcerative colitis. This study is a retrospective case-control study performed to evaluate the efficacy of tofacitinib induction in biologic-experienced patients with acute severe ulcerative colitis and demonstrates that tofacitinib in conjunction with IV steroids may be an effective induction strategy in this patient population.

Fellow Presenter: Talisha Ramchal
Faculty Preceptor: CeCe Zhang

GI Journal Club – January 28th, 2021

Article 1:
HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn’s Disease
Aleksejs Sazonovs,1 Nicholas A. Kennedy,2,3 Loukas Moutsianas,1 Graham A. Heap,2,4 Daniel L. Rice,1 Mark Reppell,4 Claire M. Bewshea,3 Neil Chanchlani,2,3 Gareth J. Walker,2,3 Mandy H. Perry,5 Timothy J. McDonald,5 Charlie W. Lees,6 J. R. Fraser Cummings,7,8 Miles Parkes,9 John C. Mansfield,10 Peter M. Irving,11 Jeffrey C. Barrett,1 Dermot McGovern,12 James R. Goodhand,2,3 Carl A. Anderson,1 Tariq Ahmad,2,3 and PANTS Consortium
Gastroenterology 2020;158:189–1
DOI: https://doi.org/10.1053/j.gastro.2019.09.041
PDF: Sazonovs
Fellow Presenter: Nicole Jawitz
Faculty Preceptor: CeCe Zhang

Article 2:
Outcomes of early endoscopic intervention for pancreatic necrotic collections: a matched case-control study
Nicholas Oblizajek, MD,1 Naoki Takahashi, MD,2 Sevda Agayeva, MD,1 Fateh Bazerbachi, MD,1 Vinay Chandrasekhara, MD,1 Michael Levy, MD,1 Andrew Storm, MD,1 Todd Baron, MD,3 Suresh Chari, MD,1 Ferga C. Gleeson, MB, BCh,1 Randall Pearson, MD,1 Bret T. Petersen, MD,1 Santhi Swaroop Vege, MD,1 Ryan Lennon, MS,4 Mark Topazian, MD,1 Barham K. Abu Dayyeh, MD, MPH1
Gastrointest Endosc 2020;91:1303-9
DOI: https://doi.org/10.1016/j.gie.2020.01.017
PDF: Endoscopic intervention pancreatic fluid collections
Fellow Presenter: Josh Lee
Faculty Preceptor: Rebecca Burbridge

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