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GI Journal Club – April 28th, 2022

Article 1:

Reappraisal of the characteristics, management, and prognosis of intramucosal colorectal cancers and their comparison with T1 carcinomas
Gastrointest Endosc 2021;93:477-85

DOI: https://doi.org/10.1016/j.gie.2020.06.052
PDF: Article

Summary: The recent description of “invasive” forms of intramucosal carcinoma (IMC) has rekindled interest in studying the characteristics, management, and prognosis of IMCs and comparing them with T1 colorectal cancers (CRCs). This population-based study included 282 cases of IMC and 207 cases of T1 CRC diagnosed by colonoscopy after a positive fecal blood test through a screening program..

Presenter: Josh Lee

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Article 2:

Full-Thickness Scar Resection After R1/Rx Excised T1 Colorectal Cancers as an Alternative to Completion Surgery
Am J Gastroenterol 2022;117:647–653

DOI: doi: 10.14309/ajg.0000000000001621
PDF: Article

Summary: Local full-thickness resections of the scar (FTRS) after local excision of a T1 colorectal cancer (CRC) with uncertain resection margins is proposed as an alternative strategy to completion surgery (CS), provided that no local intramural residual cancer (LIRC) is found. However, a comparison on long-term oncological outcome between both strategies is missing. In this study, a large cohort of patients with consecutive T1 CRC between 2000 and 2017 was used. Patients were selected if they underwent a macroscopically complete local excision of a T1 CRC but positive or unassessable (R1/Rx) resection margins at histology and without lymphovascular invasion or poor differentiation. Patients treated with CS or FTRS were compared on the presence of CRC recurrence, a 5-year overall survival, disease-free survival, and metastasis-free survival.

Presenter: Jose Ruiz

GI Journal Club – January 28th, 2021

Article 1:
HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn’s Disease
Aleksejs Sazonovs,1 Nicholas A. Kennedy,2,3 Loukas Moutsianas,1 Graham A. Heap,2,4 Daniel L. Rice,1 Mark Reppell,4 Claire M. Bewshea,3 Neil Chanchlani,2,3 Gareth J. Walker,2,3 Mandy H. Perry,5 Timothy J. McDonald,5 Charlie W. Lees,6 J. R. Fraser Cummings,7,8 Miles Parkes,9 John C. Mansfield,10 Peter M. Irving,11 Jeffrey C. Barrett,1 Dermot McGovern,12 James R. Goodhand,2,3 Carl A. Anderson,1 Tariq Ahmad,2,3 and PANTS Consortium
Gastroenterology 2020;158:189–1
DOI: https://doi.org/10.1053/j.gastro.2019.09.041
PDF: Sazonovs
Fellow Presenter: Nicole Jawitz
Faculty Preceptor: CeCe Zhang

Article 2:
Outcomes of early endoscopic intervention for pancreatic necrotic collections: a matched case-control study
Nicholas Oblizajek, MD,1 Naoki Takahashi, MD,2 Sevda Agayeva, MD,1 Fateh Bazerbachi, MD,1 Vinay Chandrasekhara, MD,1 Michael Levy, MD,1 Andrew Storm, MD,1 Todd Baron, MD,3 Suresh Chari, MD,1 Ferga C. Gleeson, MB, BCh,1 Randall Pearson, MD,1 Bret T. Petersen, MD,1 Santhi Swaroop Vege, MD,1 Ryan Lennon, MS,4 Mark Topazian, MD,1 Barham K. Abu Dayyeh, MD, MPH1
Gastrointest Endosc 2020;91:1303-9
DOI: https://doi.org/10.1016/j.gie.2020.01.017
PDF: Endoscopic intervention pancreatic fluid collections
Fellow Presenter: Josh Lee
Faculty Preceptor: Rebecca Burbridge

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