Article 1:
Gastrointestinal Infection and Risk of Microscopic Colitis: A Nationwide Case-Control Study in Sweden
Gastro Volume 160, Issue 5, April 2021, Pages 1599-1607.e5
DOI: https://doi.org/10.1053/j.gastro.2021.01.004
PDF: GI Infection and Risk of MC
Summary: Gastrointestinal infections have been linked to changes in the composition and function of gut microbiome and development of inflammatory bowel diseases. We therefore sought to examine in this case-control study the relationship between gastroenteritis and risk of microscopic colitis (MC).
Fellow Presenter: Mike Noujaim
Faculty Preceptor: Dan Wild
Article 2:
Chemical pancreatectomy treats chronic pancreatitis while preserving endocrine function in preclinical models
J Clin Invest. 2021;131(3):e143301
DOI: https://www.jci.org/articles/view/143301
PDF: https://duke.box.com/s/1s6utpjabxse8gtplo881yxy68zkulnq
Summary: Here we present a paradigm-shifting nonsurgical “chemical pancreatectomy” as a potential therapy for chronic pancreatitis. Remarkably, in mice and NHPs, this procedure led to near-total ablation of the exocrine pancreas, but with complete preservation of the endocrine cells, and relieved chronic pancreatitis-associated pain. Since pancreatic diabetes in both chronic pancreatitis and CF is thought to be due to an “innocent bystander” injury to islets from the inflammation, nonsurgical removal of the inflamed exocrine pancreas should theoretically protect the islets indefinitely and possibly ameliorate existing diabetes.
Accompanying Editorial by Dr. Liddle
DOI: 10.1172/JCI146210
Fellow Presenter: Jose Ruiz
Faculty Preceptor: Rodger Liddle
