Presenter: Jeremy Gillespie
Faculty Discussant: Brian Sullivan
Title: Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death
Authors: M. Bretthauer, M. Løberg, P. Wieszczy, M. Kalager, L. Emilsson, K. Garborg, M. Rupinski, E. Dekker, M. Spaander, M. Bugajski, Ø. Holme, A.G. Zauber, N.D. Pilonis, A. Mroz, E.J. Kuipers, J. Shi, M.A. Hernán, H.-O. Adami, J. Regula, G. Hoff, and M.F. Kaminski, for the NordICC Study Group*
NEJM – October 9, 2022
Summary: Randomized trial involving presumptively healthy men and women 55 to 64 years of age drawn from population registries in Poland, Norway, Sweden, and the Netherlands between 2009 and 2014. The participants were randomly assigned in a 1:2 ratio to either receive an invitation to undergo a single screening colonoscopy (the invited group) or to receive no invitation or screening (the usual-care group). The primary end points were the risks of colorectal cancer and related death, and the secondary end point was death from any cause.
Conclusions: In this randomized trial, the risk of colorectal cancer at 10 years was lower among participants who were invited to undergo screening colonoscopy than among those who were assigned to no screening
Presenter: Josh Lee
Faculty Discussant: David Leiman
Title: Comparative Outcomes of Cap Assisted Endoscopic Resection and Endoscopic Submucosal Dissection in Dysplastic Barrett’s Esophagus
Authors: D. Chamil Codipilly,*,a Lovekirat Dhaliwal,*,a Meher Oberoi,* Parth Gandhi,* Michele L. Johnson,* Ramona M. Lansing,* W. Scott Harmsen,‡ Kenneth K. Wang,* and Prasad G. Iyer*
Clinical Gastroenterology and Hepatology 2022;20:65–73
Summary: We queried a prospectively maintained database of all patients undergoing cEMR and ESD followed by ablation at our institution from January 2006 to March 2020. Our primary outcomes included the rate of complete remission of dysplasia (CRD): absence of dysplasia on surveillance histology, and complete remission of intestinal metaplasia (CRIM): absence of intestinal metaplasia. Our secondary outcome included complication rates.
Conclusions: BE patients with dysplasia or intramucosal adenocarcinoma undergoing ESD reach CRD at higher rates than those treated with cEMR, although CRIM rates at 2 years and complication rates were similar between the 2 groups.
Presenter: Nancy Yang
Faculty Discussant: Matt Kappus
Title: Fecal microbiota transplant improves cognition in hepatic encephalopathy and its effect varies by donor and recipient
Authors: Bloom PP, Donlan J, Soto MT, Daidone M, Hohmann E & Chung RT.
Presenter: Alex Reddy
Faculty Discussant: Amit Patel
Title: Vonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the United States and Europe: Randomized Clinical Trial
Authors: William D. Chey, Francis Mégraud, Loren Laine, Luis J. López, Barbara J. Hunt, Colin W.Howden