Haoran’s paper about the catalytic function of the auxiliary cluster of MoaA is now published online on JACS. In this work we determined the reduction potentials of the two 4Fe-4S clusters in MoaA and compared them with theoretical reduction potentials of the putative aminyl radical intermediate. The results suggested PCET mechanism for the aminyl radical reduction. Furthermore, the EPR characterization of the C4′ radical revealed an electronic coupling between GTP and the auxiliary cluster, suggesting a potentially missing mechanism of catalysis.
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- Bach received TriCEM fellowship to study the natural evolution of antibiotics
- Hai’s paper on the discovery of radical SAM oxygenase is published in JACS
- Elisha and Rachel presented posters at SURF
- Chitin synthase structure paper was published in Nature Structural & Molecular Biology
- Haoran successfully defended his Ph.D. dissertation
- Our latest manuscript about malayamycin biosynthesis was published in ACS Chemical Biology
- Haoran received 2021-2022 Chancellor’s Award for Research Excellence (CARE)
- Our perspective on MoaA and MoaC is published in ACS Bio Med Chem Au
- Haoran’s paper is highlighted in JACS Spotlight
- Haoran’s paper is published in JACS.
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