This paper characterizes the amide ligases in peptidyl nucleoside antifungal biosynthesis and demonstrates that the cryptic phosphorylation retains until the last step of these pathways. Cryptic phosphorylation is a mechanism recently identified in these pathways and emerging in other nucleoside and aminoglycoside pathways. The results provide further insights into the crytpic phosphorylation in natural product biosynthesis in general.
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- Bach received TriCEM fellowship to study the natural evolution of antibiotics
- Hai’s paper on the discovery of radical SAM oxygenase is published in JACS
- Elisha and Rachel presented posters at SURF
- Chitin synthase structure paper was published in Nature Structural & Molecular Biology
- Haoran successfully defended his Ph.D. dissertation
- Our latest manuscript about malayamycin biosynthesis was published in ACS Chemical Biology
- Haoran received 2021-2022 Chancellor’s Award for Research Excellence (CARE)
- Our perspective on MoaA and MoaC is published in ACS Bio Med Chem Au
- Haoran’s paper is highlighted in JACS Spotlight
- Haoran’s paper is published in JACS.
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