The incidence of fungal infection has been increasing in the past decade, but our current treatment option is limited due to the toxic side effects of the existing molecules and increasing drug resistance. Inhibitors of fungal cell wall biosynthesis have been found in Nature, and exhibit highly potent and selective antifungal activities. While some of these antifungal molecules have been successfully used in clinics, many others have not been clinically exploited. We are studying those molecules with the long-term goal of providing the novel and clinically useful antifungal agents.
- Matthew and Jib’s work is published online in Nature Chemical Biology
- Our Comprehensive Natural Products reviews are published online
- Haoran and Edward’s work on MoaA is published online in JACS
- Abhi successfully defended his PhD dissertation
- Dr. Ogasawara visited Duke to give a seminar
- Abhi and Anna’s paper on glucan synthase was published in Biochemistry.
- Hai and Matthew won poster award!
- Abhi won a poster prize in the 2019 Enzymes Coenzymes and Pathway GRC
- Hai’s paper on mitomycin biosynthesis was published
- Ken was selected as the 2019 ACS Pfizer Award in Enzyme Chemistry