Journal Articles

Campbell, J. X.; Schulte, N. B.; Lai, B.; Harris, H. H.; Franz, K. J., Histatin-5 interacts with cellular copper to promote antifungal activity against Candida albicans. Metallomics 2023, 15(12), mfad070.

Robison, A. T. R.; Sturrock, G. R.; Zaengle-Barone, J. M.; Wiebelhaus, N.; Dharani, A.; Williams, I. G.; Fitzgerald, M. C.; Franz, K. J., Analysis of copper-induced protein precipitation across the E. coli proteome. Metallomics 2023, 15(1), mfac098.

Reznik, N.; Gallo, A. D.; Rush, K. W.; Javitt, G.; Fridmann-Sirkis, Y.; Ilani, T.; Nairner, N. A.; Fishilevich, S.; Gokhman, D.; Chacón, K. N.; Franz, K. J.; Fass, D., Intestinal mucin is a chaperone of multivalent copper. Cell 2022.

Campbell, J. X.; Gao, S.; Anand, K. S.; Franz, K. J., Zinc Binding Inhibits Cellular Uptake and Antifungal Activity of Histatin-5 in Candida albicans. ACS Infect. Dis. 2022, 8(9), 1920-1934.

Salcedo-Sora, J. E.; Robison, A. T. R.; Zaengle-Barone, J.; Franz, K. J.; Kell, D. B., Membrane Transporters Involved in the Antimicrobial Activities of Pyrithione in Escherichia coli. Molecules, 2021, 26(19), 5826.

Hunsaker, E. W.; Yu, C. H.; Franz, K. J., Copper Availability Influences the Transcriptomic Response of Candida albicans to Fluconazole StressG3 202111 (4).

Razgoniaev, A. O.; Glasstetter, L. M.; Kouznetsova, T. B.; Hall, K. C.; Horst, M.; Craig, S. L.; Franz, K.J., Single-Molecule Activation and Quantification of Mechanically Triggered Palladium-Carbene Bond DissociationJ. Am. Chem. Soc. 2021, 143 (4), 1784-1789.

Wiebelhaus, N.; Zaengle-Barone, J. M.; Hwang, K. K.; Franz, K. J.; Fitzgerald, M. C., Protein Folding Stability Changes Across the Proteome Reveal Targets of Cu Toxicity in E. coliACS Chem. Bio. 202016 (1), 214-224.

Jackson, A. C.; Pinter, T. B. J.; Talley, D. C.; Baker-Agha, A.; Patel, D.; Smith, P. J.; Franz, K. J., Benzimidazole and Benzoxazole Zinc Chelators as Inhibitors of Metallo-β-Lactamase NDM-1ChemMedChem 2020

Hunsaker, E. W.; McAuliffe, K. J.; Franz, K. J., Fluconazole analogues with metal-binding motifs impact metal-dependent processes and demonstrate antifungal activity in Candida albicans. JBIC Journal of Biological Inorganic Chemistry 202025 (5), 729-745.

Jackson, A. C.; Zaengle-Barone, J. M.; Puccio, E. A.; Franz, K. J., A Cephalosporin Prochelator Inhibits New Delhi Metallo-β-Lactamase 1 without Removing Zinc. ACS Infectious Diseases 2020, 6 (5), 1264-1272.

Bakthavatsalam, S.; Wiangnak, P.; George, D. J.; Zhang, T.; Franz, K. J., Dithiocarbamate prodrugs activated by prostate specific antigen to target prostate cancer. Bioorg. Med. Chem. Lett. 2020, 127148.

Gallo, A. D.; Franz, K. J., Grab ‘n Go: Siderophore-Binding Proteins Provide Pathogens a Quick Fix to Satisfy Their Hunger for Iron. ACS Central Science 2020.

Garcia-Santamarina, S.; Probst, C.; Festa, R. A.; Ding, C.; Smith, A. D.; Conklin, S. E.; Brander, S.; Kinch, L. N.; Grishin, N. V.; Franz, K. J.; Riggs-Gelasco, P.; Lo Leggio, L.; Johansen, K. S.; Thiele, D. J., A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis. Nat. Chem. Biol. 202016 (3), 337-344.

Hunsaker, E. W.; Franz, K. J., Candida albicans Reprioritizes Metal Handling During Fluconazole Stress.Metallomics 2019,11 (12), 2020-2032.

Hunsaker, E. W., and Franz, K. J. Emerging Opportunities To Manipulate Metal Trafficking for Therapeutic Benefit.Inorg. Chem. 2019, 58 (20), 13528-13545.

Hunsaker, E. W.; Franz, K. J., Copper Potentiates Azole Antifungal Activity in a Way that Does Not Involve Complex Formation. Dalton Trans. 201948, 9654-9662.








Franz, K. J.; Metzler-Nolte, N., Introduction: Metals in Medicine. Chem. Rev. 2019,119 (2), 727-729. (part of thematic issue on Metals in Medicine co-edited by K. J. Franz)











Franz, K. J., Metallomics: Emerging Investigators 2019. Metallomics 2019,11 (1), 9-14. (part of Emerging Investigators 2019 issue edited by K. J. Franz)

Wang, Q.; Franz, K. J., Modifying aroylhydrazone prochelators for hydrolytic stability and improved cytoprotection against oxidative stress. Biorg. Med. Chem. 2018,26 (22), 5962-5972.

Bakthavatsalam, S.; Sleeper, M. L.; Dharani, A.; George, D. J.; Zhang, T.; Franz, K. J., Leveraging gamma-glutamyl transferase to direct cytotoxicity of copper dithiocarbamates against prostate cancer cells.Angewandte Chemie International Edition2018,57 (39), 12780-12784.

Zaengle-Barone, J. M.; Jackson, A. C.; Besse, D. M.; Becken, B.; Arshad, M.; Seed, P. C.; Franz, K. J., Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria.ACS Infectious Diseases 2018, 4 (6), 1019-1029.

Hall, K. C.; Franks, A. T.; McAtee, R. C.; Wang, M. S.; Lu, V. I.; Franz, K. J., Metal-binding hydrazone photoswitches for visible light reactivity and variable relaxation kinetics. Photochem Photobiol Sci 2017,16 (11), 1604-1612.

Conklin, S. E.; Bridgman, E. C.; Su, Q.; Riggs-Gelasco, P.; Haas, K. L.; Franz, K. J., Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans.Biochemistry 2017,56 (32), 4244-4255.

Wang, Q.; Franz, K. J., The hydrolytic susceptibility of prochelator BSIH in aqueous solutions. Bioorg. Med. Chem. Lett. 2017, 27 (17), 4165-4170.

Helsel, M. E.; White, E. J.; Razvi, S. Z.; Alies, B.; Franz, K. J., Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans. Metallomics 2017, 9 (1), 69-81.

Wang, Q.; Franz, K. J., Stimulus-Responsive Prochelators for Manipulating Cellular Metals. Acc. Chem. Res. 2016, 49 (11), 2468-2477.

Sansee, A, Meksawangwong, S, Chainok, K, Franz, KJ, Gál, M, Pålsson, L-O, Puniyan, W, Traiphol, R, Pal, R, and Kielar, F. “Novel aminoalkyl tris-cyclometalated iridium complexes as cellular stains.” Dalton transactions (Cambridge, England : 2003) 45.43 (November 2016): 17420-17430. Full Text

Hašková, P, Jansová, H, Bureš, J, Macháček, M, Jirkovská, A, Franz, KJ, Kovaříková, P, and Šimůnek, T. “Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury.” Toxicology 371 (September 2016): 17-28. Full Text

Jansová, H, Bureš, J, Macháček, M, Hašková, P, Jirkovská, A, Roh, J, Wang, Q, Franz, KJ, Kovaříková, P, and Šimůnek, T. “Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products.” Toxicology 350-352 (March 2016): 15-24. Full Text

Franks, AT, Wang, Q, and Franz, KJ. “A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress.” Bioorganic & medicinal chemistry letters 25.21 (November 2015): 4843-4847. Full Text

Pushie, MJ, Shaw, K, Franz, KJ, Shearer, J, and Haas, KL. “Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1.” Inorganic chemistry 54.17 (September 2015): 8544-8551. Full Text


Crumbliss, AL, Franz, KJ, and Thiele, DJ. “Preface. Biometals 2014–Proceedings of the 9th International Symposium Biometals 2014 at Duke University, Durham, NC, USA.” Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 28.3 (June 2015): 431-. Full Text

Helsel, ME, and Franz, KJ. “Pharmacological activity of metal binding agents that alter copper bioavailability.” Dalton transactions (Cambridge, England : 2003)44.19 (May 2015): 8760-8770. Full Text

Bureš, J, Jansová, H, Stariat, J, Filipský, T, Mladěnka, P, Šimůnek, T, Kučera, R, Klimeš, J, Wang, Q, Franz, KJ, and Kovaříková, P. “LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH).” Journal of pharmaceutical and biomedical analysis 105 (February 2015): 55-63. Full Text

Safi, R, Nelson, ER, Chitneni, SK, Franz, KJ, George, DJ, Zalutsky, MR, and McDonnell, DP. “Copper signaling axis as a target for prostate cancer therapeutics.” Cancer research 74.20 (October 2014): 5819-5831. Full TextOpen Access Copy

Franks, AT, and Franz, KJ. “A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting.”Chemical communications (Cambridge, England) 50.77 (October 2014): 11317-11320. Full Text

Jansová, H, Macháček, M, Wang, Q, Hašková, P, Jirkovská, A, Potůčková, E, Kielar, F, Franz, KJ, and Simůnek, T. “Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury.” Free radical biology & medicine 74 (September 2014): 210-221. Full Text

Festa, RA, Helsel, ME, Franz, KJ, and Thiele, DJ. “Exploiting innate immune cell activation of a copper-dependent antimicrobial agent during infection.”Chemistry & biology 21.8 (August 2014): 977-987. Full Text

Festa, RA, Helsel, ME, Franz, KJ, and Thiele, DJ. “Innate immune cell activation of a copper-dependent anti-cryptococcal agent.” MYCOSES 57 (May 2014): 56-57.

Franks, AT, Peng, D, Yang, W, and Franz, KJ. “Characterization of a photoswitching chelator with light-modulated geometric, electronic, and metal-binding properties.” Inorganic chemistry 53.3 (February 2014): 1397-1405.Full Text

Folk, DS, Kielar, F, and Franz, KJ. “Bioinorganic Neurochemistry.” 3 (August 1, 2013): 207-240. (Chapter) Full Text

Franz, KJ. “Clawing back: broadening the notion of metal chelators in medicine.”Curr Opin Chem Biol 17.2 (April 2013): 143-149. (Review) Full Text

Kumbhar, AA, Franks, AT, Butcher, RJ, and Franz, KJ. “Light uncages a copper complex to induce nonapoptotic cell death.” Chem Commun (Camb) 49.24 (March 25, 2013): 2460-2462. Full Text


Kielar, F, Wang, Q, Boyle, PD, and Franz, KJ. “A boronate prochelator built on a triazole framework for peroxide-triggered tridentate metal binding.” Inorganica Chim Acta 393 (December 1, 2012): 294-303. Full Text

Folk, DS, Torosian, JC, Hwang, S, McCafferty, DG, and Franz, KJ. “Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe.” Angew Chem Int Ed Engl 51.43 (October 22, 2012): 10795-10799. Full Text

Kielar, F, Helsel, ME, Wang, Q, and Franz, KJ. “Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation.” Metallomics4.9 (August 2012): 899-909. Full Text

Rubino, JT, and Franz, KJ. “Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function.” J Inorg Biochem 107.1 (February 2012): 129-143. (Review) Full Text

Hyman, LM, and Franz, KJ. “A Cell-Permeable Fluorescent Prochelator Responds to Hydrogen Peroxide and Metal Ions by Decreasing Fluorescence.” Inorganica Chim Acta 380 (January 15, 2012): 125-134. Full Text

Franz, KJ. “Application of inorganic chemistry for non-cancer therapeutics.”Dalton Transactions 41.21 (2012): 6333-6334. Full Text

Leed, MGD, Wolkow, N, Pham, DM, Daniel, CL, Dunaief, JL, and Franz, KJ. “Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress.” J Inorg Biochem 105.9 (September 2011): 1161-1172. Full Text

Haas, KL, Putterman, AB, White, DR, Thiele, DJ, and Franz, KJ. “Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1.” J Am Chem Soc 133.12 (March 30, 2011): 4427-4437. Full Text

Ciesienski, KL, and Franz, KJ. “Keys for unlocking photolabile metal-containing cages.” Angew Chem Int Ed Engl 50.4 (January 24, 2011): 814-824. (Review)Full Text

Ciesienski, KL, Haas, KL, and Franz, KJ. “Development of next-generation photolabile copper cages with improved copper binding properties.” Dalton Trans39.40 (October 28, 2010): 9538-9546. Full Text Open Access Copy

Rubino, JT, Riggs-Gelasco, P, and Franz, KJ. “Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I).” J Biol Inorg Chem 15.7 (September 2010): 1033-1049.Full Text

Ciesienski, KL, Hyman, LM, Derisavifard, S, and Franz, KJ. “Toward the detection of cellular copper(II) by a light-activated fluorescence increase.” Inorg Chem49.15 (August 2, 2010): 6808-6810. Full Text Open Access Copy

Folk, DS, and Franz, KJ. “A prochelator activated by beta-secretase inhibits Abeta aggregation and suppresses copper-induced reactive oxygen species formation.” J Am Chem Soc 132.14 (April 14, 2010): 4994-4995. Full TextOpen Access Copy

Hyman, LM, Stephenson, CJ, Dickens, MG, Shimizu, KD, and Franz, KJ. “Toward the development of prochelators as fluorescent probes of copper-mediated oxidative stress.” Dalton Trans 2 (January 14, 2010): 568-576. Full Text

Dickens, MG, and Franz, KJ. “A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation.” Chembiochem 11.1 (January 4, 2010): 59-62. Full Text

Franz, KJ, and He, C. “The highways and byways of bioinorganic chemistry.”Current Opinion in Chemical Biology 14.2 (2010): 208-210. Full Text

Ciesienski, KL, Hyman, LM, Yang, DT, Haas, KL, Dickens, MG, Holbrook, RJ, and Franz, KJ. “A photo-caged platinum(II) complex that increases cytotoxicity upon light activation.” European Journal of Inorganic Chemistry 15 (2010): 2224-2228. Full Text

Tangen, E, Conradie, J, Franz, K, Friedle, S, Telser, J, Lippard, SJ, and Ghosh, A. “Electronic structure of a paramagnetic {MNO}6 complex: MnNO 5,5-tropocoronand.” Inorganic Chemistry 49.6 (2010): 2701-2705. Full Text

Haas, KL, and Franz, KJ. “Application of metal coordination chemistry to explore and manipulate cell biology.” Chem Rev 109.10 (October 2009): 4921-4960. (Review) Full Text

Palmer, AE, and Franz, KJ. “Introduction to cellular metal homeostasis and trafficking.” Chemical Reviews 109.10 (2009): 4533-4535. Full Text

Charkoudian, LK, Dentchev, T, Lukinova, N, Wolkow, N, Dunaief, JL, and Franz, KJ. “Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide.” J Inorg Biochem 102.12 (December 2008): 2130-2135. Full Text

Ciesienski, KL, Haas, KL, Dickens, MG, Tesema, YT, and Franz, KJ. “A photolabile ligand for light-activated release of caged copper.” J Am Chem Soc 130.37 (September 17, 2008): 12246-12247. Full Text

Tesema, YT, Pham, DM, and Franz, KJ. “Counterions influence reactivity of metal ions with cysteinyldopa model compounds.” Inorg Chem 47.3 (February 4, 2008): 1087-1095. Full Text

Franz, KJ. “Copper shares a piece of the π.” Nature Chemical Biology 4.2 (2008): 85-86. Full Text

Charkoudian, LK, Pham, DM, Kwon, AM, Vangeloff, AD, and Franz, KJ. “Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress.” Dalton Trans 43 (November 21, 2007): 5031-5042. Full Text

Liu, LL, and Franz, KJ. “Phosphorylation-dependent metal binding by alpha-synuclein peptide fragments.” J Biol Inorg Chem 12.2 (February 2007): 234-247.Full Text

Charkoudian, LK, Pham, DM, and Franz, KJ. “A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation.” J Am Chem Soc 128.38 (September 27, 2006): 12424-12425. Full Text

Jiang, J, Nadas, IA, Kim, MA, and Franz, KJ. “A Mets motif peptide found in copper transport proteins selectively binds Cu(I) with methionine-only coordination.” Inorg Chem 44.26 (December 26, 2005): 9787-9794. Full Text

Liu, LL, and Franz, KJ. “Phosphorylation of an alpha-synuclein peptide fragment enhances metal binding.” J Am Chem Soc 127.27 (July 13, 2005): 9662-9663.Full Text

Nitz, M, Sherawat, M, Franz, KJ, Peisach, E, Allen, KN, and Imperiali, B. “Structural origin of the high affinity of a chemically evolved lanthanide-binding peptide.” Angewandte Chemie – International Edition 43.28 (2004): 3682-3685.Full Text

Franz, KJ, Nitz, M, and Imperiali, B. “Lanthanide-binding tags as versatile protein coexpression probes.” ChemBioChem 4.4 (2003): 265-271. Full Text

Nitz, M, Franz, KJ, Maglathlin, RL, and Imperiali, B. “A powerful combinatorial screen to identify high-affinity terbium(III)-binding peptides.” ChemBioChem 4.4 (2003): 272-276. Full Text

Wöhnert, J, Franz, KJ, Nitz, M, Imperiali, B, and Schwalbe, H. “Protein Alignment by a Coexpressed Lanthanide-Binding Tag for the Measurement of Residual Dipolar Couplings.” Journal of the American Chemical Society 125.44 (2003): 13338-13339. Full Text

Franz, KJ, Doerrer, LH, Spingler, B, and Lippard, SJ. “Pentacoordinate cobalt(III) thiolate and nitrosyl tropocoronand compounds.” Inorganic Chemistry 40.15 (2001): 3774-3780. Full Text

Franz, KJ, Singh, N, and Lippard, SJ. “Metal-based NO sensing by selective ligand dissociation.” Angewandte Chemie – International Edition 39.12 (June 16, 2000): 2120-2122. Full Text


Franz, KJ, Singh, N, Spingler, B, and Lippard, SJ. “Aminotroponiminates as ligands for potential metal-based nitric oxide sensors.” Inorganic Chemistry39.18 (2000): 4081-4092. Full Text

Franz, KJ, and Lippard, SJ. “Nitrosyl transfer from manganese to iron in tropocoronand complexes.” Inorganic Chemistry 39.16 (2000): 3722-3723.Full Text

Franz, KJ, and Lippard, SJ. “NO disproportionation reactivity of Fe tropocoronand complexes.” Journal of the American Chemical Society 121.45 (1999): 10504-10512. Full Text


Franz, KJ, and Lippard, SJ. “Disproportionation of nitric oxide promoted by a Mn tropocoronand.” Journal of the American Chemical Society 120.35 (1998): 9034-9040. Full Text

Loehlin, JH, Franz, KJ, Gist, L, and Moore, RH. “Supramolecular Alcohol-Amine Crystals and Their Hydrogen-Bond Patterns.” Acta Crystallographica Section B: Structural Science 54.5 (1998): 695-704.