Duke Viral Vector Core aims to offer the latest generations of optogenetics vectors for efficient expression in neurons. Specifically, we recently optimized most of the DREADDs constructs, to address the packaging limit of the AAV vectors (4.7kb). These vectors now available with the replacement of bGH Poly (A) to SV40 Poly (A) signals; IRES to p2A and EF1-apha to EF1-core promoters. All modified vectors were compared with the older versions (see in AAV collection) and verified for high-level of packaging/expression capabilities. For more info regarding the novel tools, please contact Boris.Kantor@duke.edu
