Duke Viral Vector Core

• Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing.  Mol Ther Methods in Clin Dev (5) 153-164 (advanced online publication); 
  • Link 1:  https://doi.org/10.1016/j.omtm.2017.04.002
  • Link 2: http://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(17)30057-8
  • Authors:  Pavel I Ortinski, Bernadette O’Donovan, Xiaoyu Dong, Boris Kantor

Publications: 2018 (New)

• Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models  JoVE.  Dr. Boris Kantor’s lab collaborated on this project with Dr. Ornit Chiba-Falek lab

  • Link: https://www.jove.com/video/59241/lentiviral-vector-platform-for-efficient-delivery-epigenome-editing

• Downregulation of SNCA  expression by targeted editing of DNA- methylation: A potential strategy for precision therapy in PD. Molecular Therapy. Dr. Boris Kantor’s lab collaborated on this project with Dr. Ornit Chiba-Falek lab  
  •   Also, see the related articles in the media:
    • https://parkinsonsnewstoday.com/2018/09/17/gene-editing-to-alter-alpha-synuclein-production-could-become-parkinsons-therapy-study-suggests/
    • https://www.pdlink.org/gene-editing-to-fine-tune-alpha-synuclein-production-could-become-parkinsons-therapy-strategy-study-suggests/
    • https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(18)30422-2