Representative Publications

2019


Stanland LJ and Luftig MA (2019) Molecular features and translational outlook for Epstein-Barr virus-associated gastric cancer. Future Virology 13 (11): 803–18.

Messinger, JE, Dai J, Stanland LJ, Price AM, Luftig MA (2019) Identification of Host Biomarkers of EBV Latency IIb and Latency III. mBio 10:e01006-19.

Purdy JG, Luftig MA (2019) Reprogramming of cellular metabolic pathways by human oncogenic viruses.  Curr Opin Virol. Dec;39:60-69.

Panea RI, Love CL, Shingleton JR, Reddy A, Bailey JA, Moormann AM, Otieno JA, Ong’echa JM, Oduor CI, Schroeder KMS, Masalu N, Chao NJ, Agajanian M, Major MB, Fedoriw Y, Richards KL, Rymkiewicz G, Miles RR, Alobeid B, Bhagat G, Flowers CR, Ondrejka SL, Hsi ED, Choi WWL, Au-Yeung RKH, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig MA, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus BC, Seshadri V, Kim SY, Gascoyne RD, Levy S, Mukhopadyay M, Dunson DB, Dave SS (2019) The whole-genome landscape of Burkitt lymphoma subtypes. Blood. Nov 7;134(19):1598-1607. doi: 10.1182/blood.2019001880.

2018


Hafez AY and Luftig MA (2018) DNA Tumour Viruses and the Host DNA damage response. DNA Tumour Viruses: Virology, Pathogenesis, and Vaccines. Ed. Sally Roberts. Caister Academic Press Jun pas 215-230. doi: 10.21775/9781910190791.11. [Article]

Dai J and Luftig MA (2018) Intracellular BH3 profiling reveals shifts in antiapoptotic dependency in human B cell maturation and mitogen-stimulated proliferation. J Immunol Mar 1;200(5):1727-1736. doi: 10.4049/jimmunol.1701473.  [Article]

Price AM*, Messinger JE*, Luftig MA (2018) c-Myc represses transcription of Epstein-Barr virus latent membrane protein 1 early after primary B cell infection. J Virol Jan 2;92(2):e01178-17. doi: 10.1128/JVI.01178-17. (* authors contributed equally to this article) [Article]

 

2017


Hafez AY and Luftig MA (2017) Characterization of the EBV-induced persistent DNA damage response. Viruses MDPI Dec 1;9(12):366. doi: 10.3390/v9120366. [Article]

Grossman L, Chang C, Dai J, Nikitin PA, Jima DD, Dave SS, Luftig MA (2017) Epstein-Barr virus induces adhesion receptor CD226 (DNAM-1) expression during primary B-cell transformation of lymphoblastoid cell lines. mSphere Nov 29;2(6):e00305-17. doi: 10.1128/mSphere.00305-17.  [Article]

Poling BC, Price AM, Luftig MA, Cullen BR (2017) The Epstein-Barr virus miR-BHRF1 microRNAs regulate viral gene expression in cisVirology Oct 20;512:113-123. doi: 10.1016/j.virol.2017.09.015. [Article]

Hafez AY, Messinger JE, Fenyofalvi G, McFadden K, Shepard CN, Lenzi GM, Kim B, Luftig MA (2017) Limited nucleotide pools restrict Epstein-Barr virus-mediated B-cell immortalization. Oncogenesis Jun 12;6(6):e349. doi: 10.1038/oncsis.2017.46. [Article]

Price AM, Dai J, Bazot Q, Patel L, Nikitin PA, Djavadian R, Winter PS, Salinas CA, Barry AP, Wood KC, Johannsen EC, Letai A, Allday MJ, Luftig MA (2017) Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection. Elife e22509. doi: 10.7554/eLife.22509. [Article]

Stanfield BA, Luftig MA (2017) Recent advances in understanding Epstein-Barr virus.  F1000Res 2017 Mar 29;6:386. doi: 10.12688/f1000research.10591.1. [Article]

 

2016


McFadden K, Hafez AY, Kishton R, Messinger JE, Nikitin PA, Rathmell JC, Luftig MA (2016) Metabolic stress is a barrier to Epstein-Barr virus mediated B-cell immortalization. Proc Natl Acad Sci U S A 113:E782-90. [Article]

 

2015


Price AM, Luftig, MA (2015) To Be or Not IIb: A Multi-Step Process for Epstein-Barr Virus Latency Establishment and Consequences for B Cell Tumorigenesis. PLoS Pathog 11: e1004656.PLoS Pathog. 2015 Mar 19;11(3):e1004656. doi: 10.1371/journal.ppat.1004656. [Article]

 

2014


Luftig, M.A. (2014). “Viruses and the DNA Damage Response: Activation and Antagonism.” Annual Review of Virology, Vol. 1:605 -625 (Volume publication date November 2014). [Abstract] [Article] [PDF]

Nikitin, P.A., Price, A.M., McFadden, K., Yan, C.M., Luftig M.A. (2014). “Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest.” PLoS One. (2014). 9(1):e87299. [Abstract] [Article]

Price, A.M., Luftig, M.A. (2014). “Dynamic Epstein-Barr virus gene expression on the path to B-cell transformation.” Adv Virus Res. 88:279-313. [Abstract]

 

2013


Olive, V., Sabio, E., Bennett, M.J., De Jong, C.S., Biton, A., McGann, J.C., Greaney, S.K., Sodir, N.M., Zhou, A.Y., Balakrishnan, A., Foth, M., Luftig, M.A., Goga, A., Speed, T.P., Xuan, Z., Evan, G.I., Wan, Y., Minella, A.C., He, L. (2013). “A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.” Elife. Oct 15;2:e00822. [Abstract]

Homa, N.J., Salinas, R., Forte, E., Robinson, T.J., Garcia-Blanco, M.A., Luftig, M.A. (2013). “Epstein-Barr virus induces global changes in cellular mRNA isoform usage important for the maintenance of latency.” J Virol. 2013 Sep 11. [Epub ahead of print] [Abstract]

McFadden, K., Luftig, M.A. “Interplay between DNA tumor viruses and the host DNA damage response.” (2013). Curr Top Microbiol Immunol. 371:229-57. Review.[Abstract]

 

2012


Price, A.M., J.P. Tourigny, E. Forte, R. E. Salinas, S.S. Dave, Luftig, M.A. (2012). “Analysis of EBV-Regulated Host Gene Expression Changes through Primary B-Cell Outgrowth Reveals Delayed Kinetics of LMP1-Mediated NFΚB Activation.” J Virol. 86(20):11096-106.[Abstract] [Article]

Robinson, T.J., E. Forte, R.E. Salinas, S. Puri, M. Marengo, M.A. Garcia-Blanco, Luftig, M.A. (2012). “SplicerEX: A tool for the automated detection and classification of mRNA changes from conventional and splice-sensitive microarray expression data.” RNA. 18(8):1435-45.[Abstract] [Article]

Nikitin, P.A., Luftig, M.A. (2012). “The DNA damage response in viral-induced cellular transformation. Br J Cancer. 106:429-435. [Abstract] [Article]

Skalsky, R.L., Corcoran, D.L., Gottwein, E., Frank, C.L., Kang, D., Hafner, M., Nusbaum, J.D., Feederle, R., Delecluse, H.J., Luftig, M.A., Tuschl, T., Ohler, U., Cullen, B.R. (2012). “The viral and cellular microRNA targetome in lymphoblastoid cell lines.” PLoS Pathog. 8: e1002484. [Abstract] [Article]

Forte, E., Salinas, R., Chang, C., Zhou, T., Linnstaedt, S.D.,  Gottwein, E., Jacobs, C., Jima, D., Li, Q.J., Dave, S.S., Luftig. M.A. (2012). The Epstein-Barr virus induced tumor suppressor miR-34a is growth promoting in EBV-infected B cells. J Virol. 86, 6889-6898. [Abstract] [Article]

 

2011


Forte, E., Luftig, M.A. (2011). “The role of microRNAs in Epstein-Barr virus latency and lytic reactivation.” Microbes Infect. 13:1156-1167. [Abstract] [Article]

Nikitin, P.A, Luftig, M.A. (2011). “At a crossroads: Human DNA tumor viruses and the host DNA damage response.”  Future Virol. 6: 813-830. [Abstract] [Article]

 

2010


Nikitin, P.A., Yan, C.M., Forte, E., Bocedi, A.,  Tourigny, J.P., Hu, K.,  Guo, J., Tainter, D., Rusyn, E. and Luftig, M.A. (2010). “An ATM/Chk2-mediated DNA damage responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells.” Cell Host Microbe. Dec 16;8(6):510-22. [Abstract] [Article]

Linnstaedt, S.D., E. Gottwein, R.L. Skalsky, Luftig, M.A., and Cullen, B.R. (2010). “Virally induced cellular miR-155 plays a key role in B-cell immortalization by EBV.” J Virol. Nov;84(22):11670-11678. [Epub 2010 Sept 15].[Abstract] [Article]

 

2009


Forte, E. and Luftig, M.A. (2009). “MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B cell growth transformation and infected cell survival.” J Virol.(2009). 83:2491-2499. [Epub 2009 Jan 14]. [Abstract] [Article]

 

These and additional Luftig Lab publications are available here.