Publications

Check out our papers below!

2024

Dai J, SoRelle ED, Heckenberg E, Song L, Cable JM, Crawford GE, Luftig MA. Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus. mBio. 2024 Jan 16;15(1):e0244423. doi: 10.1128/mbio.02444-23. Epub 2023 Dec 7. PMID: 38059622; PMCID: PMC10790771. [Article]

2023

Willard KA, Barry AP, Oduor CI, Ong’echa JM, Bailey JA, Moormann AM, Luftig MA. Viral and host factors drive a type 1 Epstein-Barr virus spontaneous lytic phenotype. mBio. 2023 Nov 16;14(6):e0220423. doi: 10.1128/mbio.02204-23. PMID: 37971257; PMCID: PMC10746244. [Article]
Leonard RA, Rao VN, Bartlett A, Froggatt HM, Luftig MA, Heaton BE, Heaton NS (2023) A low-background, fluorescent assay to evaluate inhibitors of diverse viral proteases. J Virol. 2023 Aug 14:e0059723. doi: 10.1128/jvi.00597-23. [Article]
SoRelle ED, Reinoso-Vizcaino NM, Dai J, Barry AP, Chan C, Luftig MA (2023) Epstein-Barr virus evades restrictive host chromatin closure by subverting B cell activation and germinal center regulatory loci. Cell Rep. 2023 Aug 9;42(8):112958. doi: 10.1016/j.celrep.2023.112958. [Article]
Stanland LJ, Ang HX, Hoj JP, Chu Y, Tan P, Wood KC, Luftig MA (2023) CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer. Mol Cancer Res. 2023 Jul 26:MCR-23-0034. doi: 10.1158/1541-7786.MCR-23-0034. [Article]
Roche KL, Remiszewski S, Todd MJ, Kulp JL 3rd, Tang L, Welsh AV, Barry AP, De C, Reiley WW, Wahl A, Garcia JV, Luftig MA, Shenk T, Tonra JR, Murphy EA, Chiang LW (2023) An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity. J Clin Invest. 2023 Jun 15;133(12):e158978. doi: 10.1172/JCI158978. [Article]
Zaffiri L, Messinger JE, Bush EJ, Staats JS, Patel P, Palmer SM, Weinhold KJ, Snyder LD, Luftig MA (2023) Evaluation of host cellular responses to Epstein-Barr virus (EBV) in adult lung transplant patients with EBV-associated diseases. J Med Virol. 2023 Apr;95(4):e28724. [Article]
Saikumar Lakshmi P, Oduor CI, Forconi CS, M’Bana V, Bly C, Gerstein RM, Otieno JA, Ong’echa JM, Münz C, Luftig MA, Brehm MA, Bailey JA, Moormann AM (2023) Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies. Life Sci Alliance. 2023 Mar 6;6(5):e202101355. doi: 10.26508/lsa.202101355. [Article]

2022

SoRelle ED, Dai J, Reinoso-Vizcaino NM, Barry AP, Chan C, Luftig MA (2022) Time-resolved transcriptomes reveal diverse B cell fate trajectories in the early response to Epstein-Barr virus infection. Cell Rep. 2022 Aug 30;40(9):111286. [Article]
SoRelle ED, Reinoso-Vizcaino NM, Horn GQ and Luftig MA (2022) Epstein-Barr virus perpetuates B cell
germinal center dynamics and generation of autoimmune-associated phenotypes in vitro. Front. Immunol. 13:1001145. doi: 10.3389/fimmu.2022.1001145 [Article]

2021

SoRelle ED, Dai J, Bonglack EN, Heckenberg E, Zhou JY, Giamberardino SN, Bailey JA, Gregory SG, Chan C, Luftig MA (2021) Single-cell characterization of transcriptomic heterogeneity in lymphoblastoid cell lines. eLife Jan 27;10: e62586. [Article]
Bonglack EN, Messinger JE, Cable JM, Parnell KM, Ch’ng J, Christofk HR, Luftig MA (2021) Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas. Proc Natl Acad Sci U S A 118: e2022495118 doi 10.1073/pnas.2022495118. [Article]
Zaffiri, L., Frankel, C., Bush, E.J., Neely, M.L., Pavlisko, E.N., Mokrova, I.L., Luftig, M.A., and Palmer, S.M. (2021). Evidence of Epstein-Barr virus heterogeneous gene expression in adult lung transplant recipients with posttransplant lymphoproliferative disorder. J Med Virol 93, 5040-5047. [Article]
Yellen BB, Zawistowski JS, Czech EA, Sanford CI, SoRelle ED, Luftig MA, Forbes ZG, Wood KC, Hammerbacher J (2021) Massively parallel quantification of phenotypic heterogeneity in single cell drug responses. Science Advances. 7(38):eabf9840. [Article]
Padmanabhan N, Kyon HK, Boot A, Lim K, Srivastava S, Chen S, Wu Z, Lee HO, Mukundan VT, Chan C, Chan YK, Xuewen O, Pitt JJ, Isa ZFA, Xing M, Lee MH, Tan ALK, Ting SHW, Luftig MA, Kappei D, Kruger WD, Bian J, Ho YS, Teh M, Rozen SG, Tan P (2021) Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation. Genome Biol 22: 167. [Article]
Klionsky DJ,… Luftig MA, …, Brand-Saberi B, Dong XC, Kenchappa CS, Li Z, Lin Y, Oshima S, Rong Y, Sluimer JC, Stallings CL, Tong CK (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy 17: 1-382. [Article]
Dai J, Heckenberg E, Song L, Crawford GE, Luftig MA (2021) Epstein-Barr virus promotes survival through germinal center light zone chromatin architecture. bioRxiv. [Article]
SoRelle ED, White S, Yellen BB, Wood KC, Luftig MA, Chan C (2021) Comparing instance segmentation methods for analyzing clonal growth of single cells in microfluidic chips. bioRxiv. [Article]

2020

Kaymaz Y, Oduor CI, Aydemir O, Luftig MA, Otieno JA, Ong’echa JM, Bailey JA, Moormann AM (2020) Epstein-Barr Virus Genomes Reveal Population Structure and Type 1 Association with Endemic Burkitt Lymphoma. J Virol Aug 17;94(17):e02007-19. [Article]
Stanland LJ, Luftig MA (2020) The Role of EBV-Induced Hypermethylation in Gastric Cancer Tumorigenesis. Viruses 12(11):1222. [Article]

2019

Stanland LJ and Luftig MA (2019) Molecular features and translational outlook for Epstein-Barr virus-associated gastric cancer. Future Virology 13 (11): 803–18. [Article]
Messinger, JE, Dai J, Stanland LJ, Price AM, Luftig MA (2019) Identification of Host Biomarkers of EBV Latency IIb and Latency III. mBio 10:e01006-19. [Article]
Purdy JG, Luftig MA (2019) Reprogramming of cellular metabolic pathways by human oncogenic viruses. Curr Opin Virol. Dec;39:60-69. [Article]
Panea RI, Love CL, Shingleton JR, Reddy A, Bailey JA, Moormann AM, Otieno JA, Ong’echa JM, Oduor CI, Schroeder KMS, Masalu N, Chao NJ, Agajanian M, Major MB, Fedoriw Y, Richards KL, Rymkiewicz G, Miles RR, Alobeid B, Bhagat G, Flowers CR, Ondrejka SL, Hsi ED, Choi WWL, Au-Yeung RKH, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig MA, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus BC, Seshadri V, Kim SY, Gascoyne RD, Levy S, Mukhopadyay M, Dunson DB, Dave SS (2019) The whole-genome landscape of Burkitt lymphoma subtypes. Blood. Nov 7;134(19):1598-1607. doi: 10.1182/blood.2019001880. [Article]

2018

Hafez AY and Luftig MA (2018) DNA Tumour Viruses and the Host DNA damage response. DNA Tumour Viruses: Virology, Pathogenesis, and Vaccines. Ed. Sally Roberts. Caister Academic Press Jun pas 215-230. doi: 10.21775/9781910190791.11. [Article]
Dai J and Luftig MA (2018) Intracellular BH3 profiling reveals shifts in antiapoptotic dependency in human B cell maturation and mitogen-stimulated proliferation. J Immunol Mar 1;200(5):1727-1736. doi: 10.4049/jimmunol.1701473. [Article]
Price AM*, Messinger JE*, Luftig MA (2018) c-Myc represses transcription of Epstein-Barr virus latent membrane protein 1 early after primary B cell infection. J Virol Jan 2;92(2):e01178-17. doi: 10.1128/JVI.01178-17. (* authors contributed equally to this article) [Article]

2017

Hafez AY and Luftig MA (2017) Characterization of the EBV-induced persistent DNA damage response. Viruses MDPI Dec 1;9(12):366. doi: 10.3390/v9120366. [Abstract] [Article]
Grossman L, Chang C, Dai J, Nikitin PA, Jima DD, Dave SS, Luftig MA (2017) Epstein-Barr virus induces adhesion receptor CD226 (DNAM-1) expression during primary B-cell transformation of lymphoblastoid cell lines. mSphere Nov 29;2(6):e00305-17. doi: 10.1128/mSphere.00305-17. [Article]
Poling BC, Price AM, Luftig MA, Cullen BR (2017) The Epstein-Barr virus miR-BHRF1 microRNAs regulate viral gene expression in cis. Virology Oct 20;512:113-123. doi: 10.1016/j.virol.2017.09.015. [Article]
Hafez AY, Messinger JE, Fenyofalvi G, McFadden K, Shepard CN, Lenzi GM, Kim B, Luftig MA (2017) Limited nucleotide pools restrict Epstein-Barr virus-mediated B-cell immortalization. Oncogenesis Jun 12;6(6):e349. doi: 10.1038/oncsis.2017.46. [Article]
Price AM, Dai J, Bazot Q, Patel L, Nikitin PA, Djavadian R, Winter PS, Salinas CA, Barry AP, Wood KC, Johannsen EC, Letai A, Allday MJ, Luftig MA (2017) Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection. Elife e22509. doi: 10.7554/eLife.22509. [Article]
Stanfield BA, Luftig MA (2017) Recent advances in understanding Epstein-Barr virus. F1000Res 2017 Mar 29;6:386. doi: 10.12688/f1000research.10591.1. [Article]

2016

McFadden K, Hafez AY, Kishton R, Messinger JE, Nikitin PA, Rathmell JC, Luftig MA (2016) Metabolic stress is a barrier to Epstein-Barr virus mediated B-cell immortalization. Proc Natl Acad Sci U S A 113:E782-90. [Article]

2015

Price AM, Luftig, MA (2015) To Be or Not IIb: A Multi-Step Process for Epstein-Barr Virus Latency Establishment and Consequences for B Cell Tumorigenesis. PLoS Pathog 11: e1004656.PLoS Pathog. 2015 Mar 19;11(3):e1004656. doi: 10.1371/journal.ppat.1004656. [Article]

2014

Luftig, M.A. (2014). “Viruses and the DNA Damage Response: Activation and Antagonism.” Annual Review of Virology, Vol. 1:605 -625 (Volume publication date November 2014). [Abstract] [Article] [PDF]
Nikitin, P.A., Price, A.M., McFadden, K., Yan, C.M., Luftig M.A. (2014). “Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest.” PLoS One. (2014). 9(1):e87299. [Article]
Price, A.M., Luftig, M.A. (2014). “Dynamic Epstein-Barr virus gene expression on the path to B-cell transformation.” Adv Virus Res. 88:279-313. [Abstract] [Article]

2013

Olive, V., Sabio, E., Bennett, M.J., De Jong, C.S., Biton, A., McGann, J.C., Greaney, S.K., Sodir, N.M., Zhou, A.Y., Balakrishnan, A., Foth, M., Luftig, M.A., Goga, A., Speed, T.P., Xuan, Z., Evan, G.I., Wan, Y., Minella, A.C., He, L. (2013). “A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.” Elife. Oct 15;2:e00822. [Abstract] [Article]
Homa, N.J., Salinas, R., Forte, E., Robinson, T.J., Garcia-Blanco, M.A., Luftig, M.A. (2013). “Epstein-Barr virus induces global changes in cellular mRNA isoform usage important for the maintenance of latency.” J Virol. 2013 Sep 11. [Abstract] [Article]
McFadden, K., Luftig, M.A. “Interplay between DNA tumor viruses and the host DNA damage response.” (2013). Curr Top Microbiol Immunol. 371:229-57. Review. [Abstract] [Article]

2012

Price, A.M., J.P. Tourigny, E. Forte, R. E. Salinas, S.S. Dave, Luftig, M.A. (2012). “Analysis of EBV-Regulated Host Gene Expression Changes through Primary B-Cell Outgrowth Reveals Delayed Kinetics of LMP1-Mediated NFΚB Activation.” J Virol. 86(20):11096-106. [Abstract] [Article]
Robinson, T.J., E. Forte, R.E. Salinas, S. Puri, M. Marengo, M.A. Garcia-Blanco, Luftig, M.A. (2012). “SplicerEX: A tool for the automated detection and classification of mRNA changes from conventional and splice-sensitive microarray expression data.” RNA. 18(8):1435-45. [Abstract] [Article]
Nikitin, P.A., Luftig, M.A. (2012). “The DNA damage response in viral-induced cellular transformation. Br J Cancer. 106:429-435. [Article]
Skalsky, R.L., Corcoran, D.L., Gottwein, E., Frank, C.L., Kang, D., Hafner, M., Nusbaum, J.D., Feederle, R., Delecluse, H.J., Luftig, M.A., Tuschl, T., Ohler, U., Cullen, B.R. (2012). “The viral and cellular microRNA targetome in lymphoblastoid cell lines.” PLoS Pathog. 8: e1002484. [Article]
Forte, E., Salinas, R., Chang, C., Zhou, T., Linnstaedt, S.D., Gottwein, E., Jacobs, C., Jima, D., Li, Q.J., Dave, S.S., Luftig. M.A. (2012). The Epstein-Barr virus induced tumor suppressor miR-34a is growth promoting in EBV-infected B cells. J Virol. 86, 6889-6898. [Article]

2010

Nikitin, P.A., Yan, C.M., Forte, E., Bocedi, A., Tourigny, J.P., Hu, K., Guo, J., Tainter, D., Rusyn, E. and Luftig, M.A. (2010). “An ATM/Chk2-mediated DNA damage responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells.” Cell Host Microbe. Dec 16;8(6):510-22. [Article]
Linnstaedt, S.D., E. Gottwein, R.L. Skalsky, Luftig, M.A., and Cullen, B.R. (2010). “Virally induced cellular miR-155 plays a key role in B-cell immortalization by EBV.” J Virol. Nov;84(22):11670-11678. [Epub 2010 Sept 15]. [Article]

2009

Forte, E. and Luftig, M.A. (2009). “MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B cell growth transformation and infected cell survival.” J Virol.(2009). 83:2491-2499. [Epub 2009 Jan 14]. [Article]

These and additional Luftig Lab publications are available here.