Research
The overarching goals of the Luftig Lab research program are to understand the molecular mechanisms that enable Epstein-Barr virus to establish latency, switch to the lytic cycle, and promote disease. We use cutting-edge, cross-disciplinary and highly collaborative approaches to characterize the temporal dynamics and single cell heterogeneity of EBV infection. With these strategies, we aim to discover fundamental molecular circuits underlying transcriptional control, viral manipulation of host signaling pathways, and metabolic regulation that collectively influence infected cell fate decisions. By understanding the nature of viral control of infected host cells, we are also well positioned to discover vulnerabilities in EBV-associated diseases and characterize new therapeutic interventions in cell-based and pre-clinical animal models.
Go to Interplay Between EBV and Pf malaria in eBL Pathogenesis
Interplay Between EBV and Pf malaria in eBL Pathogenesis
Go to spontaneous productive infection from B-cell latency with new ebv strains
spontaneous productive infection from B-cell latency with new ebv strains
Go to Therapeutic advances for ebv-associated diseases
Therapeutic advances for ebv-associated diseases
Go to Cellular factors regulating ebv infection in epithelial cells
Cellular factors regulating ebv infection in epithelial cells
Our Lab Philosophy
Lab Info
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