|Lou DeFrate, Sc.D.
Vice Chair of Biomechanics, Movement, and Imaging Research
Professor in the Department of Orthopaedic Surgery
Professor in the Department of Mechanical Engineering & Material Science
Professor in the Department of Biomedical Engineering
Director, Michael W. Krzyzewski Human Performance Laboratory (K-Lab)
|Patrick Bradley, B.S.
Patrick is a Ph.D. candidate in mechanical engineering and materials science. His research interests include gait biomechanics, knee joint mechanics during dynamic loading, and the development of osteoarthritis post traumatic injury.
|Amber Collins, Ph.D.
Amber is a Senior Research Associate currently using various imaging modalities (MRI-DESS and T1rho) to specifically quantify cartilage strain and glycosaminoglycan content in those post ACL injury and in those with a high BMI as a means of better understanding the role of injury and obesity in cartilage degradation. Additionally, Amber hopes to investigate gait biomechanics as a way of bridging the gap between activities of daily living to in vivo biomechanical and biochemical properties of cartilage.
|James Coppock, M.S.
James is a Ph.D. candidate in biomedical engineering. He is currently investigating risk factors associated with the development of low back pain by examining the mechanical and biochemical responses of the intervertebral discs to acute exercise interventions.
|Stephanie Danyluk, M.S.
Stephanie is a Clinical Research Coordinator for the DeFrate Lab. Her role in the lab is mostly regulatory, as she manages all clinical studies involving patients. She makes sure that each study is conducted efficiently, safely, and within the guidelines of ICH’s “good clinical practice.” Within her role, she deals directly with research participants, investigators, and the Institutional Review Board.
|Zoë Englander, Ph.D.
Zoë is a Medical Instructor in the Department of Orthopaedic Surgery specializing in the use of medical imaging techniques to study in vivo biomechanics. Currently she is working on developing a system for using high speed biplanar x-ray images in conjunction with 3D models of the knee joint, created using MR images, to study knee joint kinematics and cartilage deformation during dynamic activity.
|Jacqueline Foody, B.S.
Jacqueline is a Ph.D. student in biomedical engineering studying knee biomechanics, in particular the mechanisms associated with ACL injuries. She is currently investigating the dynamic and morphological factors that may be associated with increased risk for non-contact ACL rupture.
|Lauren Heckelman, Ph.D.
Lauren is currently investigating the how running influences our hip and knee joints. She is also working to streamline the lab’s data analysis protocol for clinical application. Her interests include MR imaging, image processing, sport-related cartilage biomechanics, and engineering education.
|Sophia Kim-Wang, Ph.D.
Sophia is an M.D.-Ph.D. candidate in biomedical engineering studying the biologic and biomechanical changes causing osteoarthritis after meniscus injuries. She also has interests in ACL injury mechanisms and non-invasive diagnostic markers that can detect earlier stages of osteoarthritis.
|Avery Kratzer, B.S.
Avery is a Ph.D. student in biomedical engineering. Her interests are in lower-limb biomechanics, especially in the context of musculoskeletal disorders.
|Xingqi Su, B.S.
Su is a master’s student in biomedical engineering. Her research interests include post-traumatic osteoarthritis and biomechanics of the knee, hip, and spine.
|Karl Thomas, B.A.
Karl Thomas is a Research Technician II investigating biochemical changes that result from ACL and meniscus injuries, as well as the impact of weight loss on cartilage strain and osteoarthritis development.
|Jack Twomey-Kozak, B.S.
Jack is a medical student working on a clinical trial seeking to evaluate recombinant parathyroid hormone (PTH) as a chondro-regenerative therapy for human knee osteoarthritis (OA). Jack is performing the image processing and cartilage strain analyses to investigate how drug-modulation of the PTH signaling pathway affects the biomechanical properties and composition of osteoarthritic knee cartilage. He is interested in integrating the disciplines of cell/molecular biology and biomedical engineering to devise solutions for sports-related orthopaedic injuries and post-traumatic osteoarthritis.
|Nicole Zimmer, B.S.
Nicole is a Ph.D. student in biomedical engineering investigating biomechanical and biochemical biomarkers of low back pain. Her other research interests include sex differences in lumbar spine biomechanics and low back pain.