This manuscript highlights the achievements of Matthew with significant help by Jib and Yanan and describes our successful characterization of the biosynthesis of malayamycin A, a unique C6-sugar nucleoside antifungal. The study revealed that the biosynthesis proceeds through cryptic phosphorylation analogous to that in nikkomycin and polyoxin. The study also revealed a divergent biosynthesis of high-carbon sugar nucleoside natural products, their evolutional relationships, and the potential for future genome mining discovery. 
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Recent Entries
- Bach received TriCEM fellowship to study the natural evolution of antibiotics
- Hai’s paper on the discovery of radical SAM oxygenase is published in JACS
- Elisha and Rachel presented posters at SURF
- Chitin synthase structure paper was published in Nature Structural & Molecular Biology
- Haoran successfully defended his Ph.D. dissertation
- Our latest manuscript about malayamycin biosynthesis was published in ACS Chemical Biology
- Haoran received 2021-2022 Chancellor’s Award for Research Excellence (CARE)
- Our perspective on MoaA and MoaC is published in ACS Bio Med Chem Au
- Haoran’s paper is highlighted in JACS Spotlight
- Haoran’s paper is published in JACS.
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