Learning Objectives

After participating in this module, students should understand the following:

  1. The properties of a compound that make it oxidizable
  2. How oxygen participates in an oxidative reaction
  3. How a compound becomes reduced
  4. Why neurons with oxidizable neurotransmitters are most susceptible to damage
  5. How an oxygen radical is formed
  6. How oxygen radicals oxidize substrates such as proteins, lipids and DNA
  7. The role of enzymes in oxidative reactions
  8. How oxidation of cellular components produces toxicity

This module integrates information from the following areas: chemistry, neurobiology, cell biology, biochemistry