New paper: Rossie Clark-Cotton and Samuel Chen, together with four high school interns, published a paper in Molecular BIology of the Cell

Masayuki Onishi

Clark-Cotton, M. R., Chen, S. A., Gomez, A., Mulabagal, A. J., Perry, A., Malhotra, V., & Onishi, M. (2025).
Imaging-based screen identifies novel natural compounds that perturb cell and chloroplast division in Chlamydomonas reinhardtii. Molecular Biology of the Cell, 36(4), br14.
https://doi.org/10.1091/mbc.E24-09-0425

New paper by Samed Delic: The evolutionary origins and ancestral features of septins. in Frontiers in Cell Dev Biol

Masayuki Onishi

https://pubmed.ncbi.nlm.nih.gov/38994454/

Graduate Student Samed Delic published his paper on a pan-eukaryote search for septins and their ancestral features. This is a collaboration paper with co-first author Brent Shuman in Michelle Momany’s lab at UGA, as well as with Shoken Lee and Shirin Bahmayer at Yale.

Building upon this paper, Samed is now studying the role of septin proteins in Chlamydomonas and other photosynthetic organisms. Stay tuned!

New collaboration paper (Yaning Yuan): Alternative proteoforms and proteoform-dependent assemblies in humans and plants. in Mol Syst Biol

Masayuki Onishi

https://pubmed.ncbi.nlm.nih.gov/38918600/

See also: https://www.oeaw.ac.at/gmi/news-events/news-press/tracing-the-origin-of-truncated-protein-variants

Graduate Student Yaning Yuan took part in a collaboration with Claire McWhite (Princeton) and Silvia Ramundo (GMI Vienna) in the study that identified a large number of proteins showing alternative proteoforms. One of such proteins, fibrocystin/PKHD1 shows the same pattern of cleavage-dependent processing as in humans. Yaning is now studying the potential role of PKHD1 in cell division in both Chlamydomonas and humans. Stay tuned!