Publications

Quantitative (129)Xe MRI detects early impairment of gas-exchange in a rat model of pulmonary hypertension

Virgincar RS, Nouls JC, Wang Z, Degan S, Qi Y, Xiong X, Rajagopal S, Driehuys B. Quantitative (129)Xe MRI detects early impairment of gas-exchange in a rat model of pulmonary hypertension. Sci Rep. 2020 Apr 30;10(1):7385. doi: 10.1038/s41598-020-64361-1. PubMed PMID: 32355256; PubMed Central PMCID: PMC7193602.

Illuminating Lung Inflammation at the Alveolar Capillary Interface

Mummy D, Driehuys B. Illuminating Lung Inflammation at the Alveolar Capillary Interface. J Magn Reson Imaging. 2020 Jun;51(6):1677-1678. doi: 10.1002/jmri.27086. Epub 2020 Feb 12. PubMed PMID: 32048777; PubMed Central PMCID: PMC7225024.

Generalized Linear Binning to Compare Hyperpolarized (129)Xe Ventilation Maps Derived from 3D Radial Gas Exchange Versus Dedicated Multislice Gradient Echo MRI

He M, Wang Z, Rankine L, Luo S, Nouls J, Virgincar R, Mammarappallil J, Driehuys B. Generalized Linear Binning to Compare Hyperpolarized (129)Xe Ventilation Maps Derived from 3D Radial Gas Exchange Versus Dedicated Multislice Gradient Echo MRI. Acad Radiol. 2019 Nov 27. pii: S1076-6332(19)30530-6. doi: 10.1016/j.acra.2019.10.016. [Epub ahead of print] PubMed PMID: 31786076.

Diverse cardiopulmonary diseases are associated with distinct xenon magnetic resonance imaging signatures

Wang Z, Bier EA, Swaminathan A, Parikh K, Nouls J, He M, Mammarappallil JG, Luo S, Driehuys B, Rajagopal S. Diverse cardiopulmonary diseases are associated with distinct xenon magnetic resonance imaging signatures. Eur Respir J. 2019 Dec 12;54(6). pii: 1900831. doi: 10.1183/13993003.00831-2019. Print 2019 Dec. PubMed PMID: 31619473.

129Xenon Gas Exchange Magnetic Resonance Imaging as a Potential Prognostic Marker for Progression of Idiopathic Pulmonary Fibrosis

Rankine LJ, Wang Z, Wang JM, He M, McAdams HP, Mammarappallil J, Rackley CR, Driehuys B, Tighe RM. 129Xenon Gas Exchange Magnetic Resonance Imaging as a Potential Prognostic Marker for Progression of Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2020 Jan;17(1):121-125. doi: 10.1513/AnnalsATS.201905-413RL. PMID: 31593488; PMCID: PMC6944348.

A thermally polarized 129Xe phantom for quality assurance in multi‐center hyperpolarized gas MRI studies

Bier EA, Nouls JC, Wang Z, He M, Schrank G, Morales-Medina N, Hashoian R, Svetlik H, Mugler JP 3rd, Driehuys B. A thermally polarized 129 Xe phantom for quality assurance in multi-center hyperpolarized gas MRI studies. Magn Reson Med. 2019 Nov;82(5):1961-1968. doi: 10.1002/mrm.27836. Epub 2019 Jun 19. PMID: 31218753; PMCID: PMC6660390.

Applications of 3D printing in small animal magnetic resonance imaging

Nouls JC, Virgincar RS, Culbert AG, Morand N, Bobbert DW, Yoder AD, Schopler RS, Bashir MR, Badea A, Hochgeschwender U, Driehuys B. Applications of 3D printing in small animal magnetic resonance imaging. J Med Imaging (Bellingham). 2019 Apr;6(2):021605. doi: 10.1117/1.JMI.6.2.021605. Epub 2019 May 15. PMID: 31131288; PMCID: PMC6519666.

New Developments in Imaging Idiopathic Pulmonary Fibrosis With Hyperpolarized Xenon Magnetic Resonance Imaging

Mammarappallil JG, Rankine L, Wild JM, Driehuys B. New Developments in Imaging Idiopathic Pulmonary Fibrosis With Hyperpolarized Xenon Magnetic Resonance Imaging. J Thorac Imaging. 2019 Mar;34(2):136-150. doi: 10.1097/RTI.0000000000000392. PMID: 30801449; PMCID: PMC6392051.

Multireader Determination of Clinically Significant Obstruction Using Hyperpolarized 129Xe-Ventilation MRI

Ebner L, Virgincar RS, He M, Choudhury KR, Robertson SH, Christe A, Mileto A, Mammarapallil JG, McAdams HP, Driehuys B, Roos JE. Multireader Determination of Clinically Significant Obstruction Using Hyperpolarized 129Xe-Ventilation MRI. AJR Am J Roentgenol. 2019 Apr;212(4):758-765. doi: 10.2214/AJR.18.20036. Epub 2019 Feb 19. PMID: 30779661; PMCID: PMC7079551.

A protocol for quantifying cardiogenic oscillations in dynamic 129 Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis

Bier EA, Robertson SH, Schrank GM, Rackley C, Mammarappallil JG, Rajagopal S, McAdams HP, Driehuys B. A protocol for quantifying cardiogenic oscillations in dynamic 129 Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis. NMR Biomed. 2019 Jan;32(1):e4029. doi: 10.1002/nbm.4029. Epub 2018 Nov 20. PMID: 30457202; PMCID: PMC6447038.

A Comparison of Two Hyperpolarized 129Xe MRI Ventilation Quantification Pipelines: The Effect of Signal to Noise Ratio

He M, Zha W, Tan F, Rankine L, Fain S, Driehuys B. A Comparison of Two Hyperpolarized 129Xe MRI Ventilation Quantification Pipelines: The Effect of Signal to Noise Ratio. Acad Radiol. 2019 Jul;26(7):949-959. doi: 10.1016/j.acra.2018.08.015. Epub 2018 Sep 27. PMID: 30269957; PMCID: PMC6437021.

A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents

Virgincar RS, Dahlke J, Robertson SH, Morand N, Qi Y, Degan S, Driehuys B, Nouls JC. A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents. J Magn Reson. 2018 Oct;295:63-71. doi: 10.1016/j.jmr.2018.07.017. Epub 2018 Jul 23. PMID: 30125865; PMCID: PMC6719309.

Hyperpolarized 129 Xe gas transfer MRI: the transition from 1.5T to 3T

Wang Z, He M, Bier E, Rankine L, Schrank G, Rajagopal S, Huang YC, Kelsey C, Womack S, Mammarappallil J, Driehuys B. Hyperpolarized 129 Xe gas transfer MRI: the transition from 1.5T to 3T. Magn Reson Med. 2018 Dec;80(6):2374-2383. doi: 10.1002/mrm.27377. Epub 2018 Jul 19. PMID: 30024058; PMCID: PMC6318005.

Correlation of Regional Lung Ventilation and Gas Transfer to Red Blood Cells: Implications for Functional-Avoidance Radiation Therapy Planning

Rankine LJ, Wang Z, Driehuys B, Marks LB, Kelsey CR, Das SK. Correlation of Regional Lung Ventilation and Gas Transfer to Red Blood Cells: Implications for Functional-Avoidance Radiation Therapy Planning. Int J Radiat Oncol Biol Phys. 2018 Aug 1;101(5):1113-1122. doi: 10.1016/j.ijrobp.2018.04.017. Epub 2018 Apr 14. PMID: 29907488; PMCID: PMC6689416.

Functional airway obstruction observed with hyperpolarized 129 Xenon-MRI

Song EJ, Kelsey CR, Driehuys B, Rankine L. Functional airway obstruction observed with hyperpolarized 129 Xenon-MRI. J Med Imaging Radiat Oncol. 2018 Feb;62(1):91-93. doi: 10.1111/1754-9485.12660. Epub 2017 Sep 22. PMID: 28940774; PMCID: PMC5801072.

Uncovering a third dissolved-phase 129 Xe resonance in the human lung: Quantifying spectroscopic features in healthy subjects and patients with idiopathic pulmonary fibrosis

Robertson SH, Virgincar RS, Bier EA, He M, Schrank GM, Smigla RM, Rackley C, McAdams HP, Driehuys B. Uncovering a third dissolved-phase 129 Xe resonance in the human lung: Quantifying spectroscopic features in healthy subjects and patients with idiopathic pulmonary fibrosis. Magn Reson Med. 2017 Oct;78(4):1306-1315. doi: 10.1002/mrm.26533. Epub 2016 Nov 8. PMID: 28940334; PMCID: PMC5422139.

Using hyperpolarized 129Xe MRI to quantify regional gas transfer in idiopathic pulmonary fibrosis

Wang JM, Robertson SH, Wang Z, He M, Virgincar RS, Schrank GM, Smigla RM, O’Riordan TG, Sundy J, Ebner L, Rackley CR, McAdams P, Driehuys B. Using hyperpolarized 129Xe MRI to quantify regional gas transfer in idiopathic pulmonary fibrosis. Thorax. 2018 Jan;73(1):21-28. doi: 10.1136/thoraxjnl-2017-210070. Epub 2017 Aug 31. PMID: 28860333; PMCID: PMC5897768.

Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI

Wang Z, Robertson SH, Wang J, He M, Virgincar RS, Schrank GM, Bier EA, Rajagopal S, Huang YC, O’Riordan TG, Rackley CR, McAdams HP, Driehuys B. Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI. Med Phys. 2017 Jun;44(6):2415-2428. doi: 10.1002/mp.12264. Epub 2017 May 18. PMID: 28382694.

Vagal innervation is required for pulmonary function phenotype in Htr4-/- mice

House JS, Nichols CE, Li H, Brandenberger C, Virgincar RS, DeGraff LM, Driehuys B, Zeldin DC, London SJ. Vagal innervation is required for pulmonary function phenotype in Htr4-/- mice. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1;312(4):L520-L530. doi: 10.1152/ajplung.00495.2016. Epub 2017 Jan 27. PMID: 28130264; PMCID: PMC5407097.

Crossing the Chasm(s): Demonstrating the Clinical Value of Hyperpolarized Gas MRI

Driehuys B. Crossing the Chasm(s): Demonstrating the Clinical Value of Hyperpolarized Gas MRI. Acad Radiol. 2017 Jan;24(1):1-3. doi: 10.1016/j.acra.2016.11.002. Epub 2016 Nov 21. PMID: 27884465; PMCID: PMC6414057.

The role of hyperpolarized 129xenon in MR imaging of pulmonary function

Ebner L, Kammerman J, Driehuys B, Schiebler ML, Cadman RV, Fain SB. The role of hyperpolarized 129xenon in MR imaging of pulmonary function. Eur J Radiol. 2017 Jan;86:343-352. doi: 10.1016/j.ejrad.2016.09.015. Epub 2016 Sep 16. PMID: 27707585; PMCID: PMC5195899.

Hyperpolarized 129Xenon Magnetic Resonance Imaging to Quantify Regional Ventilation Differences in Mild to Moderate Asthma: A Prospective Comparison Between Semiautomated Ventilation Defect Percentage Calculation and Pulmonary Function Tests

Ebner L, He M, Virgincar RS, Heacock T, Kaushik SS, Freemann MS, McAdams HP, Kraft M, Driehuys B. Hyperpolarized 129Xenon Magnetic Resonance Imaging to Quantify Regional Ventilation Differences in Mild to Moderate Asthma: A Prospective Comparison Between Semiautomated Ventilation Defect Percentage Calculation and Pulmonary Function Tests. Invest Radiol. 2017 Feb;52(2):120-127. doi: 10.1097/RLI.0000000000000322. PMID: 27662575; PMCID: PMC5488725.

Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution

He M, Driehuys B, Que LG, Huang YT. Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution. Acad Radiol. 2016 Dec;23(12):1521-1531. doi: 10.1016/j.acra.2016.07.014. Epub 2016 Sep 9. PMID: 27617823; PMCID: PMC5411263.

Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease

Dahhan T, Kaushik SS, He M, Mammarappallil JG, Tapson VF, McAdams HP, Sporn TA, Driehuys B, Rajagopal S. Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease. Pulm Circ. 2016 Mar;6(1):126-31. doi: 10.1086/685110. PMID: 27162620; PMCID: PMC4860552.

Establishing an accurate gas phase reference frequency to quantify 129 Xe chemical shifts in vivo

Virgincar RS, Robertson SH, Nouls J, Degan S, Schrank GM, He M, Driehuys B. Establishing an accurate gas phase reference frequency to quantify 129 Xe chemical shifts in vivo. Magn Reson Med. 2017 Apr;77(4):1438-1445. doi: 10.1002/mrm.26229. Epub 2016 Apr 5. PMID: 27059646; PMCID: PMC5052090.

A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized (3)He MRI

Thomas AC, Potts EN, Chen BT, Slipetz DM, Foster WM, Driehuys B. A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized (3)He MRI. NMR Biomed. 2015 Sep;28(9):1185. doi: 10.1002/nbm.3365. Epub 2015 Jul 15. Erratum for: NMR Biomed. 2009 Jun;22(5):502-15. PMID: 26174861.

Single-breath clinical imaging of hyperpolarized (129)Xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1-point Dixon acquisition

Kaushik SS, Robertson SH, Freeman MS, He M, Kelly KT, Roos JE, Rackley CR, Foster WM, McAdams HP, Driehuys B. Single-breath clinical imaging of hyperpolarized (129)Xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1-point Dixon acquisition. Magn Reson Med. 2016 Apr;75(4):1434-43. doi: 10.1002/mrm.25675. Epub 2015 May 18. PMID: 25980630; PMCID: PMC4651856.

Hyperpolarized Gas MR Imaging: Technique and Applications

Roos JE, McAdams HP, Kaushik SS, Driehuys B. Hyperpolarized Gas MR Imaging: Technique and Applications. Magn Reson Imaging Clin N Am. 2015 May;23(2):217-29. doi: 10.1016/j.mric.2015.01.003. PMID: 25952516; PMCID: PMC4428591.

Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI

He M, Robertson SH, Kaushik SS, Freeman MS, Virgincar RS, Davies J, Stiles J, Foster WM, McAdams HP, Driehuys B. Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI. Magn Reson Imaging. 2015 Sep;33(7):877-85. doi: 10.1016/j.mri.2015.04.005. Epub 2015 Apr 30. PMID: 25936684; PMCID: PMC4466055.