Xenon MRI Service Center

Optimized quantitative mapping of cardiopulmonary oscillations using hyperpolarized ¹²⁹ Xe gas exchange MRI: Digital phantoms and clinical evaluation in CTEPH

Lu J, Alenezi F, Bier E, Leewiwatwong S, Mummy D, Kabir S, Rajagopal S, Robertson S, Niedbalski PJ, Driehuys B. Optimized quantitative mapping of cardiopulmonary oscillations using hyperpolarized ¹²⁹ Xe gas exchange MRI: Digital phantoms and clinical evaluation in CTEPH. Magn Reson Med. 2024 Apr;91(4):1541-1555. doi: 10.1002/mrm.29965. Epub 2023 Dec 12. PMID: 38084439; PMCID: PMC10872359.

Quantifying Regional Radiation-Induced Lung Injury in Patients Using Hyperpolarized ¹²⁹Xe Gas Exchange Magnetic Resonance Imaging

Rankine LJ, Lu J, Wang Z, Kelsey CR, Marks LB, Das SK, Driehuys B. Quantifying Regional Radiation-Induced Lung Injury in Patients Using Hyperpolarized ¹²⁹Xe Gas Exchange Magnetic Resonance Imaging. Int J Radiat Oncol Biol Phys. 2024 Mar 5:S0360-3016(24)00359-6. doi: 10.1016/j.ijrobp.2024.02.049. Epub ahead of print. PMID: 38452858.

Cluster Analysis to Identify Long COVID Phenotypes Using ¹²⁹Xe Magnetic Resonance Imaging: A Multi-centre Evaluation

Eddy RL, Mummy D, Zhang S, Dai H, Bechtel A, Schmidt A, Frizzell B, Gerayeli FV, Leipsic JA, Leung JM, Driehuys B, Que LG, Castro M, Sin DD, Niedbalski PJ. Cluster Analysis to Identify Long COVID Phenotypes Using ¹²⁹Xe Magnetic Resonance Imaging: A Multi-centre Evaluation. Eur Respir J. 2024 Feb 8;63(3):2302301. doi: 10.1183/13993003.02301-2023. Epub ahead of print. PMID: 38331459; PMCID: PMC10973687.

Combining neural networks and image synthesis to enable automatic thoracic cavity segmentation of hyperpolarized ¹²⁹Xe MRI without proton scans

Leewiwatwong S, Lu J, Dummer I, Yarnall K, Mummy D, Wang Z, Driehuys B. Combining neural networks and image synthesis to enable automatic thoracic cavity segmentation of hyperpolarized ¹²⁹Xe MRI without proton scans. Magn Reson Imaging. 2023 Nov;103:145-155. doi: 10.1016/j.mri.2023.07.001. Epub 2023 Jul 4. PMID: 37406744; PMCID: PMC10528669.

Establishing a hemoglobin adjustment for ¹²⁹ Xe gas exchange MRI and MRS

Bechtel A, Lu J, Mummy D, Bier E, Leewiwatwong S, Mugler J 3rd, Kabir S, Church A, Driehuys B. Establishing a hemoglobin adjustment for ¹²⁹ Xe gas exchange MRI and MRS. Magn Reson Med. 2023 Oct;90(4):1555-1568. doi: 10.1002/mrm.29712. Epub 2023 May 29. PMID: 37246900; PMCID: PMC10524939.

Erratum: Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report

Erratum: Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report. Ann Am Thorac Soc. 2023 Apr;20(4):620. doi: 10.1513/AnnalsATS.v20Erratum4. Erratum for: Ann Am Thorac Soc. 2023 Feb;20(2):161-195. PMID: 37000149; PMCID: PMC10112404.

Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report

Hsia CCW, Bates JHT, Driehuys B, Fain SB, Goldin JG, Hoffman EA, Hogg JC, Levin DL, Lynch DA, Ochs M, Parraga G, Prisk GK, Smith BM, Tawhai M, Vidal Melo MF, Woods JC, Hopkins SR. Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report. Ann Am Thorac Soc. 2023 Feb;20(2):161-195. doi: 10.1513/AnnalsATS.202211-915ST. Erratum in: Ann Am Thorac Soc. 2023 Apr;20(4):620. PMID: 36723475; PMCID: PMC9989862.

Comparison of hyperpolarized ³He-MRI, CT based parametric response mapping, and mucus scores in asthmatics

Carey KJ, Hotvedt P, Mummy DG, Lee KE, Denlinger LC, Schiebler ML, Sorkness RL, Jarjour NN, Hatt CR, Galban CJ, Fain SB. Comparison of hyperpolarized ³He-MRI, CT based parametric response mapping, and mucus scores in asthmatics. Front Physiol. 2023 Aug 1;14:1178339. doi: 10.3389/fphys.2023.1178339. PMID: 37593238; PMCID: PMC10431597.

View-sharing for 4D magnetic resonance imaging with randomized projection-encoding enables improvements of respiratory motion imaging for treatment planning in abdominothoracic radiotherapy

Subashi E, Feng L, Liu Y, Robertson S, Segars P, Driehuys B, Kelsey CR, Yin FF, Otazo R, Cai J. View-sharing for 4D magnetic resonance imaging with randomized projection-encoding enables improvements of respiratory motion imaging for treatment planning in abdominothoracic radiotherapy. Phys Imaging Radiat Oncol. 2023 Jan 2;25:100409. doi: 10.1016/j.phro.2022.12.006. PMID: 36655213; PMCID: PMC9841273.

Monitoring and Management of Respiratory Function in Pompe Disease: Current Perspectives

El Haddad L, Khan M, Soufny R, Mummy D, Driehuys B, Mansour W, Kishnani PS, ElMallah MK. Monitoring and Management of Respiratory Function in Pompe Disease: Current Perspectives. Ther Clin Risk Manag. 2023 Sep 1;19:713-729. doi: 10.2147/TCRM.S362871. PMID: 37680303; PMCID: PMC10480292.

Persistent ¹²⁹Xe MRI Pulmonary and CT Vascular Abnormalities in Symptomatic Individuals with Post-acute COVID-19 Syndrome

Matheson AM, McIntosh MJ, Kooner HK, Lee J, Desaigoudar V, Bier E, Driehuys B, Svenningsen S, Santyr GE, Kirby M, Albert MS, Shepelytskyi Y, Grynko V, Ouriadov A, Abdelrazek M, Dhaliwal I, Nicholson JM, Parraga G. Persistent ¹²⁹Xe MRI Pulmonary and CT Vascular Abnormalities in Symptomatic Individuals with Post-acute COVID-19 Syndrome. Radiology. 2022 Nov;305(2):466-476. doi: 10.1148/radiol.220492. Epub 2022 Jun 28. PMID: 35762891; PMCID: PMC9272782.

MR Imaging for the Evaluation of Diffuse Lung Disease: Where Are We?

O’Sullivan-Murphy B, Driehuys B, Mammarappallil J. MR Imaging for the Evaluation of Diffuse Lung Disease: Where Are We? Radiol Clin North Am. 2022 Nov;60(6):1021-1032. doi: 10.1016/j.rcl.2022.06.007. Epub 2022 Sep 16. PMID: 36202473.

Pediatric ¹²⁹ Xe Gas-Transfer MRI-Feasibility and Applicability

Willmering MM, Walkup LL, Niedbalski PJ, Wang H, Wang Z, Hysinger EB, Myers KC, Towe CT, Driehuys B, Cleveland ZI, Woods JC. Pediatric ¹²⁹ Xe Gas-Transfer MRI-Feasibility and Applicability. J Magn Reson Imaging. 2022 Oct;56(4):1207-1219. doi: 10.1002/jmri.28136. Epub 2022 Mar 4. PMID: 35244302; PMCID: PMC9519191.

Bias field correction in hyperpolarized ¹²⁹ Xe ventilation MRI using templates derived by RF-depolarization mapping

Lu J, Wang Z, Bier E, Leewiwatwong S, Mummy D, Driehuys B. Bias field correction in hyperpolarized ¹²⁹ Xe ventilation MRI using templates derived by RF-depolarization mapping. Magn Reson Med. 2022 May 4. doi: 10.1002/mrm.29254. Epub ahead of print. PMID: 35506520.

Mucus Plugs in Asthma at CT Associated with Regional Ventilation Defects at ³He MRI

Mummy DG, Dunican EM, Carey KJ, Evans MD, Elicker BM, Newell JD Jr, Gierada DS, Nagle SK, Schiebler ML, Sorkness RL, Jarjour NN, Denlinger LC, Fahy JV, Fain SB. Mucus Plugs in Asthma at CT Associated with Regional Ventilation Defects at ³He MRI. Radiology. 2022 Apr;303(1):184-190. doi: 10.1148/radiol.2021204616. Epub 2021 Dec 21. PMID: 34931858; PMCID: PMC8962781.

Utilizing flip angle/TR equivalence to reduce breath hold duration in hyperpolarized ¹²⁹ Xe 1-point Dixon gas exchange imaging

Niedbalski PJ, Lu J, Hall CS, Castro M, Mugler JP 3rd, Shim YM, Driehuys B. Utilizing flip angle/TR equivalence to reduce breath hold duration in hyperpolarized ¹²⁹ Xe 1-point Dixon gas exchange imaging. Magn Reson Med. 2022 Mar;87(3):1490-1499. doi: 10.1002/mrm.29040. Epub 2021 Oct 13. PMID: 34644815; PMCID: PMC8776583.

Pulmonary functional MRI: Detecting the structure-function pathologies that drive asthma symptoms and quality of life

Kooner HK, McIntosh MJ, Desaigoudar V, Rayment JH, Eddy RL, Driehuys B, Parraga G. Pulmonary functional MRI: Detecting the structure-function pathologies that drive asthma symptoms and quality of life. Respirology. 2022 Feb;27(2):114-133. doi: 10.1111/resp.14197. Epub 2022 Jan 10. PMID: 35008127; PMCID: PMC10025897.

Noninvasive diagnosis of pulmonary hypertension with hyperpolarised ¹²⁹Xe magnetic resonance imaging and spectroscopy

Hyperpolarized 129 Xe MRI and Spectroscopy of Gas-Exchange Abnormalities in Nonspecific Interstitial Pneumonia

Mummy DG, Bier EA, Wang Z, Korzekwinski J, Morrison L, Barkauskas C, McAdams HP, Tighe RM, Driehuys B, Mammarappallil JG. Hyperpolarized 129Xe MRI and Spectroscopy of Gas-Exchange Abnormalities in Nonspecific Interstitial Pneumonia. Radiology. 2021 Oct;301(1):211-220. doi: 10.1148/radiol.2021204149. Epub 2021 Jul 27. PMID: 34313473; PMCID: PMC8487218.

Regional Gas Exchange Measured by ¹²⁹ Xe Magnetic Resonance Imaging Before and After Combination Bronchodilators Treatment in Chronic Obstructive Pulmonary Disease

Mummy DG, Coleman EM, Wang Z, Bier EA, Lu J, Driehuys B, Huang YC. Regional Gas Exchange Measured by ¹²⁹ Xe Magnetic Resonance Imaging Before and After Combination Bronchodilators Treatment in Chronic Obstructive Pulmonary Disease. J Magn Reson Imaging. 2021 Sep;54(3):964-974. doi: 10.1002/jmri.27662. Epub 2021 May 7. PMID: 33960534; PMCID: PMC8363573.

Hyperpolarized 129 Xe Magnetic Resonance Imaging for Functional Avoidance Treatment Planning in Thoracic Radiation Therapy: A Comparison of Ventilation- and Gas Exchange-Guided Treatment Plans

Rankine LJ, Wang Z, Kelsey CR, Bier E, Driehuys B, Marks LB, Das SK. Hyperpolarized 129Xe Magnetic Resonance Imaging for Functional Avoidance Treatment Planning in Thoracic Radiation Therapy: A Comparison of Ventilation- and Gas Exchange-Guided Treatment Plans. Int J Radiat Oncol Biol Phys. 2021 Jul 13:S0360-3016(21)00871-3. doi: 10.1016/j.ijrobp.2021.07.002. Epub ahead of print. PMID: 34265395.

Using hyperpolarized 129 Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity

Wang Z, Rankine L, Bier EA, Mummy D, Lu J, Church A, Tighe RM, Swaminathan A, Huang YT, Que LG, Mammarappallil JG, Rajagopal S, Driehuys B. Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity. J Appl Physiol (1985). 2021 May 1;130(5):1398-1409. doi: 10.1152/japplphysiol.00702.2020. Epub 2021 Mar 18. PMID: 33734831; PMCID: PMC8354826.

Ventilation defects on hyperpolarized helium-3 MRI in asthma are predictive of 2-year exacerbation frequency

Mummy DG, Carey KJ, Evans MD, Denlinger LC, Schiebler ML, Sorkness RL, Jarjour NN, Fain SB. Ventilation defects on hyperpolarized helium-3 MRI in asthma are predictive of 2-year exacerbation frequency. J Allergy Clin Immunol. 2020 Oct;146(4):831-839.e6. doi: 10.1016/j.jaci.2020.02.029. Epub 2020 Mar 13. PMID: 32173351; PMCID: PMC7487001.

Transverse relaxation rates of pulmonary dissolved-phase Hyperpolarized ¹²⁹ Xe as a biomarker of lung injury in idiopathic pulmonary fibrosis

Kammerman J, Hahn AD, Cadman RV, Malkus A, Mummy D, Fain SB. Transverse relaxation rates of pulmonary dissolved-phase Hyperpolarized ¹²⁹ Xe as a biomarker of lung injury in idiopathic pulmonary fibrosis. Magn Reson Med. 2020 Oct;84(4):1857-1867. doi: 10.1002/mrm.28246. Epub 2020 Mar 11. PMID: 32162357; PMCID: PMC7329592.

Quantitative (129)Xe MRI detects early impairment of gas-exchange in a rat model of pulmonary hypertension

Virgincar RS, Nouls JC, Wang Z, Degan S, Qi Y, Xiong X, Rajagopal S, Driehuys B. Quantitative (129)Xe MRI detects early impairment of gas-exchange in a rat model of pulmonary hypertension. Sci Rep. 2020 Apr 30;10(1):7385. doi: 10.1038/s41598-020-64361-1. PubMed PMID: 32355256; PubMed Central PMCID: PMC7193602.

Illuminating Lung Inflammation at the Alveolar Capillary Interface

Mummy D, Driehuys B. Illuminating Lung Inflammation at the Alveolar Capillary Interface. J Magn Reson Imaging. 2020 Jun;51(6):1677-1678. doi: 10.1002/jmri.27086. Epub 2020 Feb 12. PubMed PMID: 32048777; PubMed Central PMCID: PMC7225024.

Generalized Linear Binning to Compare Hyperpolarized (129)Xe Ventilation Maps Derived from 3D Radial Gas Exchange Versus Dedicated Multislice Gradient Echo MRI

He M, Wang Z, Rankine L, Luo S, Nouls J, Virgincar R, Mammarappallil J, Driehuys B. Generalized Linear Binning to Compare Hyperpolarized (129)Xe Ventilation Maps Derived from 3D Radial Gas Exchange Versus Dedicated Multislice Gradient Echo MRI. Acad Radiol. 2019 Nov 27. pii: S1076-6332(19)30530-6. doi: 10.1016/j.acra.2019.10.016. [Epub ahead of print] PubMed PMID: 31786076.

Diverse cardiopulmonary diseases are associated with distinct xenon magnetic resonance imaging signatures

Wang Z, Bier EA, Swaminathan A, Parikh K, Nouls J, He M, Mammarappallil JG, Luo S, Driehuys B, Rajagopal S. Diverse cardiopulmonary diseases are associated with distinct xenon magnetic resonance imaging signatures. Eur Respir J. 2019 Dec 12;54(6). pii: 1900831. doi: 10.1183/13993003.00831-2019. Print 2019 Dec. PubMed PMID: 31619473.

¹²⁹Xenon Gas Exchange Magnetic Resonance Imaging as a Potential Prognostic Marker for Progression of Idiopathic Pulmonary Fibrosis

Rankine LJ, Wang Z, Wang JM, He M, McAdams HP, Mammarappallil J, Rackley CR, Driehuys B, Tighe RM. ¹²⁹Xenon Gas Exchange Magnetic Resonance Imaging as a Potential Prognostic Marker for Progression of Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2020 Jan;17(1):121-125. doi: 10.1513/AnnalsATS.201905-413RL. PMID: 31593488; PMCID: PMC6944348.

A thermally polarized ¹²⁹Xe phantom for quality assurance in multi‐center hyperpolarized gas MRI studies

Bier EA, Nouls JC, Wang Z, He M, Schrank G, Morales-Medina N, Hashoian R, Svetlik H, Mugler JP 3rd, Driehuys B. A thermally polarized ¹²⁹ Xe phantom for quality assurance in multi-center hyperpolarized gas MRI studies. Magn Reson Med. 2019 Nov;82(5):1961-1968. doi: 10.1002/mrm.27836. Epub 2019 Jun 19. PMID: 31218753; PMCID: PMC6660390.

Applications of 3D printing in small animal magnetic resonance imaging

Nouls JC, Virgincar RS, Culbert AG, Morand N, Bobbert DW, Yoder AD, Schopler RS, Bashir MR, Badea A, Hochgeschwender U, Driehuys B. Applications of 3D printing in small animal magnetic resonance imaging. J Med Imaging (Bellingham). 2019 Apr;6(2):021605. doi: 10.1117/1.JMI.6.2.021605. Epub 2019 May 15. PMID: 31131288; PMCID: PMC6519666.

New Developments in Imaging Idiopathic Pulmonary Fibrosis With Hyperpolarized Xenon Magnetic Resonance Imaging

Mammarappallil JG, Rankine L, Wild JM, Driehuys B. New Developments in Imaging Idiopathic Pulmonary Fibrosis With Hyperpolarized Xenon Magnetic Resonance Imaging. J Thorac Imaging. 2019 Mar;34(2):136-150. doi: 10.1097/RTI.0000000000000392. PMID: 30801449; PMCID: PMC6392051.

Multireader Determination of Clinically Significant Obstruction Using Hyperpolarized ¹²⁹Xe-Ventilation MRI

Ebner L, Virgincar RS, He M, Choudhury KR, Robertson SH, Christe A, Mileto A, Mammarapallil JG, McAdams HP, Driehuys B, Roos JE. Multireader Determination of Clinically Significant Obstruction Using Hyperpolarized ¹²⁹Xe-Ventilation MRI. AJR Am J Roentgenol. 2019 Apr;212(4):758-765. doi: 10.2214/AJR.18.20036. Epub 2019 Feb 19. PMID: 30779661; PMCID: PMC7079551.

A protocol for quantifying cardiogenic oscillations in dynamic ¹²⁹ Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis

Bier EA, Robertson SH, Schrank GM, Rackley C, Mammarappallil JG, Rajagopal S, McAdams HP, Driehuys B. A protocol for quantifying cardiogenic oscillations in dynamic ¹²⁹ Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis. NMR Biomed. 2019 Jan;32(1):e4029. doi: 10.1002/nbm.4029. Epub 2018 Nov 20. PMID: 30457202; PMCID: PMC6447038.

A Comparison of Two Hyperpolarized ¹²⁹Xe MRI Ventilation Quantification Pipelines: The Effect of Signal to Noise Ratio

He M, Zha W, Tan F, Rankine L, Fain S, Driehuys B. A Comparison of Two Hyperpolarized ¹²⁹Xe MRI Ventilation Quantification Pipelines: The Effect of Signal to Noise Ratio. Acad Radiol. 2019 Jul;26(7):949-959. doi: 10.1016/j.acra.2018.08.015. Epub 2018 Sep 27. PMID: 30269957; PMCID: PMC6437021.

A portable ventilator with integrated physiologic monitoring for hyperpolarized ¹²⁹Xe MRI in rodents

Virgincar RS, Dahlke J, Robertson SH, Morand N, Qi Y, Degan S, Driehuys B, Nouls JC. A portable ventilator with integrated physiologic monitoring for hyperpolarized ¹²⁹Xe MRI in rodents. J Magn Reson. 2018 Oct;295:63-71. doi: 10.1016/j.jmr.2018.07.017. Epub 2018 Jul 23. PMID: 30125865; PMCID: PMC6719309.

Hyperpolarized ¹²⁹ Xe gas transfer MRI: the transition from 1.5T to 3T

Correlation of Regional Lung Ventilation and Gas Transfer to Red Blood Cells: Implications for Functional-Avoidance Radiation Therapy Planning

Functional airway obstruction observed with hyperpolarized ¹²⁹ Xenon-MRI

Uncovering a third dissolved-phase ¹²⁹ Xe resonance in the human lung: Quantifying spectroscopic features in healthy subjects and patients with idiopathic pulmonary fibrosis

Using hyperpolarized ¹²⁹Xe MRI to quantify regional gas transfer in idiopathic pulmonary fibrosis

Quantitative analysis of hyperpolarized ¹²⁹ Xe gas transfer MRI

Vagal innervation is required for pulmonary function phenotype in Htr4-/- mice

Crossing the Chasm(s): Demonstrating the Clinical Value of Hyperpolarized Gas MRI

The role of hyperpolarized ¹²⁹xenon in MR imaging of pulmonary function

Hyperpolarized 129Xenon Magnetic Resonance Imaging to Quantify Regional Ventilation Differences in Mild to Moderate Asthma: A Prospective Comparison Between Semiautomated Ventilation Defect Percentage Calculation and Pulmonary Function Tests

Using Hyperpolarized ¹²⁹Xe MRI to Quantify the Pulmonary Ventilation Distribution

Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease

Establishing an accurate gas phase reference frequency to quantify ¹²⁹ Xe chemical shifts in vivo

A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized (3)He MRI

Single-breath clinical imaging of hyperpolarized (129)Xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1-point Dixon acquisition

Hyperpolarized Gas MR Imaging: Technique and Applications

Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI