Extending semiautomatic ventilation defect analysis for hyperpolarized (129)Xe ventilation MRI
He M, Kaushik SS, Robertson SH, Freeman MS, Virgincar RS, McAdams HP, Driehuys B. Extending semiautomatic ventilation defect analysis for hyperpolarized (129)Xe ventilation MRI. Acad Radiol. 2014 Dec;21(12):1530-41. doi: 10.1016/j.acra.2014.07.017. Epub 2014 Sep 26. PMID: 25262951; PMCID: PMC4254215.
Measuring diffusion limitation with a perfusion-limited gas–hyperpolarized 129Xe gas-transfer spectroscopy in patients with idiopathic pulmonary fibrosis
Kaushik SS, Freeman MS, Yoon SW, Liljeroth MG, Stiles JV, Roos JE, Foster W, Rackley CR, McAdams HP, Driehuys B. Measuring diffusion limitation with a perfusion-limited gas–hyperpolarized 129Xe gas-transfer spectroscopy in patients with idiopathic pulmonary fibrosis. J Appl Physiol (1985). 2014 Sep 15;117(6):577-85. doi: 10.1152/japplphysiol.00326.2014. Epub 2014 Jul 18. PMID: 25038105; PMCID: PMC4157168.
3D MRI of impaired hyperpolarized 129Xe uptake in a rat model of pulmonary fibrosis
Cleveland ZI, Virgincar RS, Qi Y, Robertson SH, Degan S, Driehuys B. 3D MRI of impaired hyperpolarized 129Xe uptake in a rat model of pulmonary fibrosis. NMR Biomed. 2014 Dec;27(12):1502-14. doi: 10.1002/nbm.3127. Epub 2014 May 12. PMID: 24816478; PMCID: PMC4229493. (Abstract)
Enabling hyperpolarized (129) Xe MR spectroscopy and imaging of pulmonary gas transfer to the red blood cells in transgenic mice expressing human hemoglobin
Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging
Kaushik SS, Freeman MS, Cleveland ZI, Davies J, Stiles J, Virgincar RS, Robertson SH, He M, Kelly KT, Foster WM, McAdams HP, Driehuys B. Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging. J Appl Physiol (1985). 2013 Sep;115(6):850-60. doi: 10.1152/japplphysiol.00092.2013. Epub 2013 Jul 11. PMID: 23845983; PMCID: PMC3764620.
Quantitative analysis of hyperpolarized 129Xe ventilation imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease
Virgincar RS, Cleveland ZI, Kaushik SS, Freeman MS, Nouls J, Cofer GP, Martinez-Jimenez S, He M, Kraft M, Wolber J, McAdams HP, Driehuys B. Quantitative analysis of hyperpolarized 129Xe ventilation imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease. NMR Biomed. 2013 Apr;26(4):424-35. doi: 10.1002/nbm.2880. Epub 2012 Oct 13. PMID: 23065808; PMCID: PMC3624045. (Abstract)
Effects of corticosteroid treatment on airway inflammation, mechanics, and hyperpolarized ³He magnetic resonance imaging in an allergic mouse model
Thomas AC, Kaushik SS, Nouls J, Potts EN, Slipetz DM, Foster WM, Driehuys B. Effects of corticosteroid treatment on airway inflammation, mechanics, and hyperpolarized ³He magnetic resonance imaging in an allergic mouse model. J Appl Physiol (1985). 2012 May;112(9):1437-44. doi: 10.1152/japplphysiol.01293.2011. Epub 2012 Jan 12. Retraction in: J Appl Physiol (1985). 2015 Jun 15;118(12):1561. PMID: 22241062; PMCID: PMC3362235.
Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients
Driehuys B, Martinez-Jimenez S, Cleveland ZI, Metz GM, Beaver DM, Nouls JC, Kaushik SS, Firszt R, Willis C, Kelly KT, Wolber J, Kraft M, McAdams HP. Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients. Radiology. 2012 Jan;262(1):279-89. doi: 10.1148/radiol.11102172. Epub 2011 Nov 4. PMID: 22056683; PMCID: PMC3244666.
In vivo MR imaging of pulmonary perfusion and gas exchange in rats via continuous extracorporeal infusion of hyperpolarized 129Xe
Cleveland ZI, Möller HE, Hedlund LW, Nouls JC, Freeman MS, Qi Y, Driehuys B. In vivo MR imaging of pulmonary perfusion and gas exchange in rats via continuous extracorporeal infusion of hyperpolarized 129Xe. PLoS One. 2012;7(2):e31306. doi: 10.1371/journal.pone.0031306. Epub 2012 Feb 21. PMID: 22363613; PMCID: PMC3283644.
Relaxation of hyperpolarized 129Xe in a deflating polymer bag
Möller HE, Cleveland ZI, Driehuys B. Relaxation of hyperpolarized 129Xe in a deflating polymer bag. J Magn Reson. 2011 Sep;212(1):109-15. doi: 10.1016/j.jmr.2011.06.017. Epub 2011 Jun 25. PMID: 21752680; PMCID: PMC3163736. (Abstract)
A Constant-Volume Ventilator and Gas Recapture System for Hyperpolarized Gas MRI of Mouse and Rat Lungs
Nouls J, Fanarjian M, Hedlund L, Driehuys B. A Constant-Volume Ventilator and Gas Recapture System for Hyperpolarized Gas MRI of Mouse and Rat Lungs. Concepts Magn Reson Part B Magn Reson Eng. 2011 Apr;39B(2):78-88. doi: 10.1002/cmr.b.20192. PMID: 21625347; PMCID: PMC3103138.
Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease
Kaushik SS, Cleveland ZI, Cofer GP, Metz G, Beaver D, Nouls J, Kraft M, Auffermann W, Wolber J, McAdams HP, Driehuys B. Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease. Magn Reson Med. 2011 Apr;65(4):1154-65. doi: 10.1002/mrm.22697. Epub 2010 Dec 16. PMID: 21413080; PMCID: PMC3351270.
Gradient-induced longitudinal relaxation of hyperpolarized noble gases in the fringe fields of superconducting magnets used for magnetic resonance
Zheng W, Cleveland ZI, Möller HE, Driehuys B. Gradient-induced longitudinal relaxation of hyperpolarized noble gases in the fringe fields of superconducting magnets used for magnetic resonance. J Magn Reson. 2011 Feb;208(2):284-90. doi: 10.1016/j.jmr.2010.11.006. Epub 2010 Dec 4. PMID: 21134771; PMCID: PMC3026078. (Abstract)
Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury
Thomas AC, Nouls JC, Driehuys B, Voltz JW, Fubara B, Foley J, Bradbury JA, Zeldin DC. Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury. Am J Respir Cell Mol Biol. 2011 May;44(5):648-54. doi: 10.1165/rcmb.2009-0287OC. Epub 2010 Jul 1. PMID: 20595465; PMCID: PMC3095984.
Molecular MRI for sensitive and specific detection of lung metastases
Branca RT, Cleveland ZI, Fubara B, Kumar CS, Maronpot RR, Leuschner C, Warren WS, Driehuys B. Molecular MRI for sensitive and specific detection of lung metastases. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3693-7. doi: 10.1073/pnas.1000386107. Epub 2010 Feb 8. PMID: 20142483; PMCID: PMC2840507.
Hyperpolarized Xe MR imaging of alveolar gas uptake in humans
Quantitative analysis of hyperpolarized 3He ventilation changes in mice challenged with methacholine
Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe
Driehuys B, Möller HE, Cleveland ZI, Pollaro J, Hedlund LW. Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe. Radiology. 2009 Aug;252(2):386-93. doi: 10.1148/radiol.2522081550. PMID: 19703880; PMCID: PMC2753782.
Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes
Cleveland ZI, Möller HE, Hedlund LW, Driehuys B. Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes. J Phys Chem B. 2009 Sep 17;113(37):12489-99. doi: 10.1021/jp9049582. PMID: 19702286; PMCID: PMC2747043. (Abstract)
A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI
Thomas AC, Potts EN, Chen BT, Slipetz DM, Foster WM, Driehuys B. A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI. NMR Biomed. 2009 Jun;22(5):502-15. doi: 10.1002/nbm.1362. Erratum in: NMR Biomed. 2015 Sep;28(9):1185. PMID: 19204996; PMCID: PMC2714734. (Abstract)
An official ATS conference proceedings: advances in small-animal imaging application to lung pathophysiology
Brown RH, Irvin CG, Allen GB 3rd, Shapiro SD, Martin WJ, Kolb MR, Hyde DM, Nieman GF, Cody DD, Ishii M, Kadlecek SJ, Driehuys B, Rizi RR, Wu AM, Weber WA, Stout DB; ATS Small Animal Imaging Subcommittee. An official ATS conference proceedings: advances in small-animal imaging application to lung pathophysiology. Proc Am Thorac Soc. 2008 Jul 15;5(5):591-600. doi: 10.1513/pats.200708-116ST. PMID: 18625751.
In vivo MRI using real-time production of hyperpolarized 129Xe
Driehuys B, Pollaro J, Cofer GP. In vivo MRI using real-time production of hyperpolarized 129Xe. Magn Reson Med. 2008 Jul;60(1):14-20. doi: 10.1002/mrm.21651. PMID: 18581406; PMCID: PMC2548276.
Small animal imaging with magnetic resonance microscopy
Driehuys B, Nouls J, Badea A, Bucholz E, Ghaghada K, Petiet A, Hedlund LW. Small animal imaging with magnetic resonance microscopy. ILAR J. 2008;49(1):35-53. doi: 10.1093/ilar.49.1.35. PMID: 18172332; PMCID: PMC2770253.
3He MRI in mouse models of asthma
Driehuys B, Walker J, Pollaro J, Cofer GP, Mistry N, Schwartz D, Johnson GA. 3He MRI in mouse models of asthma. Magn Reson Med. 2007 Nov;58(5):893-900. doi: 10.1002/mrm.21306. PMID: 17969115; PMCID: PMC2746053.
Imaging techniques for small animal models of pulmonary disease: MR microscopy
Driehuys B, Hedlund LW. Imaging techniques for small animal models of pulmonary disease: MR microscopy. Toxicol Pathol. 2007 Jan;35(1):49-58. doi: 10.1080/01926230601132048. PMID: 17325972; PMCID: PMC2747380.
Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI
Driehuys B, Cofer GP, Pollaro J, Mackel JB, Hedlund LW, Johnson GA. Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18278-83. doi: 10.1073/pnas.0608458103. Epub 2006 Nov 13. PMID: 17101964; PMCID: PMC1838742.
Toward molecular imaging with xenon MRI
Driehuys B. Chemistry. Toward molecular imaging with xenon MRI. Science. 2006 Oct 20;314(5798):432-3. doi: 10.1126/science.1134532. PMID: 17053138.
Hybrid spin-exchange optical pumping of 3He
Babcock E, Nelson I, Kadlecek S, Driehuys B, Anderson LW, Hersman FW, Walker TG. Hybrid spin-exchange optical pumping of 3He. Phys Rev Lett. 2003 Sep 19;91(12):123003. doi: 10.1103/PhysRevLett.91.123003. Epub 2003 Sep 16. PMID: 14525358. (Abstract)
Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe
Månsson S, Wolber J, Driehuys B, Wollmer P, Golman K. Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe. Magn Reson Med. 2003 Dec;50(6):1170-9. doi: 10.1002/mrm.10649. PMID: 14648564.
NMR of hyperpolarized (129)Xe in the canine chest: spectral dynamics during a breath-hold
Ruppert K, Brookeman JR, Hagspiel KD, Driehuys B, Mugler JP 3rd. NMR of hyperpolarized (129)Xe in the canine chest: spectral dynamics during a breath-hold. NMR Biomed. 2000 Jun;13(4):220-8. doi: 10.1002/1099-1492(200006)13:4<220::aid-nbm638>3.0.co;2-f. PMID: 10867700. (Abstract)
Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient
Chen XJ, Möller HE, Chawla MS, Cofer GP, Driehuys B, Hedlund LW, Johnson GA. Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient. Magn Reson Med. 1999 Oct;42(4):721-8. doi: 10.1002/(sici)1522-2594(199910)42:4<721::aid-mrm14>3.0.co;2-d. PMID: 10502761. (Abstract)
Sensitivity and resolution in 3D NMR microscopy of the lung with hyperpolarized noble gases
Möller HE, Chen XJ, Chawla MS, Cofer GP, Driehuys B, Hedlund LW, Suddarth SA, Johnson GA. Sensitivity and resolution in 3D NMR microscopy of the lung with hyperpolarized noble gases. Magn Reson Med. 1999 Apr;41(4):800-8. doi: 10.1002/(sici)1522-2594(199904)41:4<800::aid-mrm20>3.0.co;2-k. PMID: 10332857. (Abstract)
Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T *(2)
Chen XJ, Möller HE, Chawla MS, Cofer GP, Driehuys B, Hedlund LW, MacFall JR, Johnson GA. Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T *(2). Magn Reson Med. 1999 Oct;42(4):729-37. doi: 10.1002/(sici)1522-2594(199910)42:4<729::aid-mrm15>3.0.co;2-2. PMID: 10502762. (Abstract)
Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases
Möller HE, Chen XJ, Chawla MS, Driehuys B, Hedlund LW, Johnson GA. Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases. J Magn Reson. 1998 Nov;135(1):133-43. doi: 10.1006/jmre.1998.1563. PMID: 9799687. (Abstract)
Dynamics of magnetization in hyperpolarized gas MRI of the lung
Johnson GA, Cates G, Chen XJ, Cofer GP, Driehuys B, Happer W, Hedlund LW, Saam B, Shattuck MD, Swartz J. Dynamics of magnetization in hyperpolarized gas MRI of the lung. Magn Reson Med. 1997 Jul;38(1):66-71. doi: 10.1002/mrm.1910380111. PMID: 9211381. (Abstract)
MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results
Mugler JP 3rd, Driehuys B, Brookeman JR, Cates GD, Berr SS, Bryant RG, Daniel TM, de Lange EE, Downs JH 3rd, Erickson CJ, Happer W, Hinton DP, Kassel NF, Maier T, Phillips CD, Saam BT, Sauer KL, Wagshul ME. MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results. Magn Reson Med. 1997 Jun;37(6):809-15. doi: 10.1002/mrm.1910370602. PMID: 9178229. (Abstract)
Human lung air spaces: potential for MR imaging with hyperpolarized He-3
MacFall JR, Charles HC, Black RD, Middleton H, Swartz JC, Saam B, Driehuys B, Erickson C, Happer W, Cates GD, Johnson GA, Ravin CE. Human lung air spaces: potential for MR imaging with hyperpolarized He-3. Radiology. 1996 Aug;200(2):553-8. doi: 10.1148/radiology.200.2.8685356. PMID: 8685356. (Abstract)
High-volume production of laser-polarized 129Xe
Driehuys B, Cates GD, Miron E, Sauer K, Walter DK, Happer W. High-volume production of laser-polarized 129Xe. 1996;69:1668-1670. doi.org/10.1063/1.117022. (Abstract)
In vivo He-3 MR images of guinea pig lungs
Black RD, Middleton HL, Cates GD, Cofer GP, Driehuys B, Happer W, Hedlund LW, Johnson GA, Shattuck MD, Swartz JC. In vivo He-3 MR images of guinea pig lungs. Radiology. 1996 Jun;199(3):867-70. doi: 10.1148/radiology.199.3.8638019. PMID: 8638019. (Abstract)
Surface relaxation mechanisms of laser-polarized 129Xe
Driehuys B, Cates GD, Happer W. Surface relaxation mechanisms of laser-polarized 129Xe. Phys Rev Lett. 1995 Jun 12;74(24):4943-4946. doi: 10.1103/PhysRevLett.74.4943. PMID: 10058638. (Abstract)
Biological magnetic resonance imaging using laser-polarized 129Xe
Albert MS, Cates GD, Driehuys B, Happer W, Saam B, Springer CS Jr, Wishnia A. Biological magnetic resonance imaging using laser-polarized 129Xe. Nature. 1994 Jul 21;370(6486):199-201. doi: 10.1038/370199a0. PMID: 8028666. (Abstract)
Extraordinarily slow nuclear spin relaxation in frozen laser-polarized 129Xe
Gatzke M, Cates GD, Driehuys B, Fox D, Happer W, Saam B. Extraordinarily slow nuclear spin relaxation in frozen laser-polarized 129Xe. Phys Rev Lett. 1993 Feb 1;70(5):690-693. doi: 10.1103/PhysRevLett.70.690. PMID: 10054178. (Abstract)
