May 2024

Dr. Park’s post defense celebration

April 2024

Welcome Mason! 

Mason Schmidt -Graduate Student

April 2024

Dr. Anil Kumar Ganga joins the lab as a research scientist!

Anil Kumar Ganga – Research Scientist

April 2024

Dave, Will and Sandy at the Basement Membrane workshop in Manchester, England


May 2024

Welcome Jake Leyhr, our new postdoc!

Jake Leyhr – Postdoctoral Fellow

March 2024

Congratulations Dr. Kenny-Ganzert!!

March 2024

Dave at the Alport Syndrome workshop in Nicosia, Cyprus

November 2023

Postdoc Lena Basta joins the lab, Welcome Lena!

Lena Basta – Postdoctoral Fellow


August 2023

Welcome, Litong and Lian!! 

Litong Yang – Graduate Student

Lian Wang -Graduate Student


July 2022

Lab party celebrating Dr. Payne and Dr. Garde! 


July 2022

Aastha Garde’s defends her thesis on localized glucose transport and specialized lipid biogenesis driving cell invasion through basement membranes! Congratulations Dr. Garde!
Aastha starts her postdoc in the Jonikas Lab at Princeton next month! 

May 2022

Siddharthan, a student from Biology, joins the lab! Welcome Sid!!



May 2022

Ranjay Jayadev’s paper on defining the network of basement membrane proteins is published in Science Advances! Sid has his second cover selected!

May 2022

Sara Payne starts her new job at BioAgilytix. Congratulations Sara!

March 2022

Aastha Garde’s paper on how localized glucose import powers cell invasion through the basement membrane comes out in Developmental Cell! Our talented rotation student – Siddharthan’s cover gets selected!

March 2022

Sara Payne defends her thesis on her germline stem cell niche and B-Link projects! Amazing work Dr. Payne!


October 2021

Dave’s review on how basement membrane remodeling guides cell migration and morphogenesis is published in Current Opinion in Cell Biology!

February 2021

Aastha Garde’s review on how cells fuel invasion through extracellular matrix is published in Trends in Cell Biology!  

September 2020

Kacy Gordon’s paper on how stem cells leave the germ stem cell niche comes out in eLife with a digest article highlighting the work!
Dave attends the British Society of Matrix Biology Virtual Meeting and gives a talk on how basement membranes are linked together.  A talented artist, Alex Cagan, made beautiful visual abstracts for all of the talks as they were being presented 

July 2020

William Ramos-Lewis who received his Ph.D working on Drosophila basement membrane repair in Andrea Page-McCaw’s lab at Vanderbilt joins the lab as a new post-doctoral scholar.  Welcome Will!
Eric Hastie accepts an Assistant Teaching Professor Position at the University of North Carolina Chapel Hill.   Well done!  UNC has recruited an amazing teacher and researcher.

May 2020


Sandy Srinivasan, a UPGG student joins the lab!  Welcome Sandy

April of 2020

Two exciting papers from the lab are accepted:
Keeley, D.P., Hastie, E., Jayadev R., Kelley, L.C., Chi, Q., Payne, S.G., Jeger, J.L., Hoffman, B.D., Sherwood, D.R. (2020). Comprehensive endogenous tagging of basement membrane components reveals dynamic movement within the matrix scaffolding. Dev Cell. In Press.
Gordon, K.L., Zussman, J.W., Li, X., Miller, C., Sherwood, D.R. (2020). Stem cell niche exit in C. elegans via orientation and segregation of daughter cells by a cryptic cell outside the niche.  eLife. In press.

January of 2020

David Sherwood gave a talk at Texas A&M Institute of Biosciences and Technology in Houston and had a wonderful visit seeing many friends–especially host David Reiner

December of 2019

Nice article on Eric Hastie’s work with undergraduate education:
Eric Hastie published two papers with three undergraduates in the lab!   One with Ryan Sellers and Bruno Valen on a scalable CRISPR based CURE with undergraduates in the J Microbiol Biol Educ. ( and one with David Chen on the locailzation of the C. elegans Septin in Micropublication biology (
Dave Sherwood gave at talk at the Department of Biochemistry at University of Washington Seattle (amazing faculty and students), and at the 2019 ASCB Meeting, The Cellular and Molecular Basis of Invasive Metastatic Cancer, “Fueling Cell Invasion through Basement Membranes”

November 2019

Dave Sherwood attends the 9th EMT international Association Meeting in Kumamoto City Japan and discusses how cell invasion adapts to the absence of MMPs.
Dave also gives a talk at the Duke CMB symposium: Cells in Action, Duke University, Cell and Molecular Biology Student Organized, Plenary Talk on Nov 21st, 2019.
Dan Keeley starts a new terrific position at UNC in the Neuroscience Microscopy Core as a Research Associate.  UNC is so fortunate to have recruited Dan–the best of the best in microscopy and helping others.

October 2019

Dan Keeley successfully defends his thesis on the basement membrane toolkit and B-LINK projects!

August 2019

Ranjay’s paper revealing how distinct basement membranes are built by factors that promote tissue-specific activation of distinct integrins is published in the Journal of Cell Biology:
Lab party at Sandra’s Farm (Elodie Farms, to celebrate Ranjay’s Ph.D. and Kacy’s new job

July 2019

Kacy Gordon starts her new lab at UNC down the road.  Well done Kacy!
Another inspiring summer at the MBL in Woods Hole-such generous and intelligent students, course assistants and faculty.
Embryology softball champs three years in a row!

May 2019

Ranjay Jayadev goes through graduation-newly minted  Ph.D.   His mom attends coming all the way from Singapore.  Spectacular student & research.  Well done!

April 2019

Rui heads back to China after a wonderful 8 month visit, leaving us all with amazing drawings of ourselves.


March 2019

Dave is plenary speaker at 2019 International C. elegans Conference
2019 International C. elegans conference

January of 2019

Lara Linden, Sara Payne, and Kacy Gordon’s paper on how ectopic germ cells induce niche like enwrapment from body wall muscle comes out in Current Biology. “Ectopic Germ Cells Can Induce Niche-like Enwrapment by Neighboring Body Wall Muscle”  http://
Laura Kelley’s amazing study on how invasive cells adapt and still invade through basement membrane in the absence of MMPs is published in Developmental Cell and is selected for the cover!. “Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs.”   Dev Cell  2019 Jan 23. pii: S1534-5807(18)31086-4. 

December 2018

Lab Christmas Party
A terrific collaborative paper with Julie Plastino’s group from the Institut Curie in Paris is published in PNAS-go with the force!   “Forces drive basement membrane invasion in Caenorhabditis elegans.”  Proc Natl Acad Sci U S A.  Nov 6;115(45):11537-11542.

August 2018

Two fabulous students join the lab:   Isabel Kenny from the UPGG program and Claire Gianakas from the Pharmacology Training Program.

July 2018

MBL Woods Hole Embryology…Amazing Year.
The class of 2018! So talented and curious….such a special time.
Nothing is better than the people and discussions at the MBL–Bob Goldstein, an amazing scientist, mentor, and friend
Beatson Meeting in Glasgow Scotland–“Talk to the Niche”
Three of my favorite scientists-Alissa Weaver, Danijela Vignjevic & Val Weaver

June 2018

European C. elegans meeting in Barcelona (with Paul Sternberg!)

May 2018

Dan Keeley’s elegant review paper, the first every on basement membrane-basement membrane adhesion is out. “Tissue linkage through adjoining basement membranes: The long and the short term of it.” Matrix Biol. May 24.

January 2018

Julie Pastino and my comprehensive review on cell migration in C. elegans comes out!  Invading, Leading and Navigating Cell in Caenorhabditis elegans:  Insights into Cell Movement In Vivo. Genetics  Jan;208(1):53-78. 

November 2017

Kaleb’s paper “Cell invasion in vivo via rapid exocytosis of a transient lysosome-derived membrane domain” is the featured article in Development Cell.

September 2017

Ranjay’s Dispatch comes out in Current Biology. Morphogenesis: Shaping tissues through extracellular force gradients.  Curr Biol. 2017 Sep 11;27(17):R850-R852. doi: 10.1016/j.cub.2017.07.040.

August 2017

Kaleb Naegeli begins new exciting post-doc at the UNC Catalyst for Rare Diseases–a research group at the Eshelman School of Pharmacy dedicated to understanding the basic biology of rare genetic conditions that interfaces with patient organizations to develop novel therapies for woefully understudied diseases.

July 2017

Dave spends June and July Co-directing the MBL Embryology Course with Rich Schneider and then attending Basement membrane workshop & Collagen Gordon Research Conference.  Love these amazing students

Lara Linden successfully defends her Ph.D.!  Spectacular student and work.

June 2017

Lara Linden’s paper (with Kacy Gordon and Qiuyi Chi), “Identification of regulators of germ stem cell enwrapment by its niche in C. elegans” is accepted by Developmental Biology-a groundbreaking paper starting a new field looking at stem cell enwrapment in C. elegans. 

May 2017

Laura Kelley, Zheng Wang and Elliot Hagedorn paper, “Live-cell confocal microscopy and quantitative 4D image analysis of anchor cell invasion through the basement membrane in C. elegans” is accepted by Nat. Protocols.  The culmination of many long hours spent in the dark microscope room.  Well done!

April 2017

Dave is promoted to Full Professor of Biology.  Many thanks to the current members and alumni of the Sherwood group.  It has been a wonderful journey with many more adventures to come.

March 2017

A hearty congratulations to Kaleb Naegeli for an amazing Ph.D. defense.  Spectacular work and amazing seminar–the committee was blown away.  Very proud of this young lad.
Congratulations to Dan Costa, Aastha Garde, and Sara Payne for passing their preliminary exams!  What a productive and spectacular month.  Well done!
Ranjay’s Primer “Basement Membranes” is Published in Current Biology.  A beautiful summary of basement membranes.

January 2017

Undergraduate Youlie Li joins the lab.  Working with Aastha and forming the dream team. 

October 2016

Dan Keeley is awarded a prestigious fellowship to develop an internship program in the state of North Carolina pairing recent Ph.D.’s with state legislators!

Two Duke PhD Students Win Grant to Study Science & Technology Policy Fellowship Feasibility in NC

October 2016

Dave is appointed one of the new co-directors of the Embryology Course at the MBL in Woods Hole. MA: Duke Today, Regeneration Next Announcement.
Duke undergraduate Jay Zussman joins the lab for independent research.

September 2016

Shelly and Zheng’s paper “Boundary cells restrict dystroglycan trafficking to control basement membrane sliding during tissue remodeling” is published in eLife.
Recent star Duke graduate Jonathan Jeger joins the lab at a technician to work on genome editing of genes encoding basement membrane proteins.
Duke undergraduates Thomas Wang and Tanner Johnson join the lab for independent research.
Dave Returns home from summer sabbatical.

May 2016

Aastha Garde, Dan Costa and Sara Payne join the group from the CMB program as graduate students.  Very excited about what these three will discover.

April 2016

Dave starts his sabbatical in Paris, France at the Institute Curie Institute as Mayent- Rothschild Fellow, see:  Institut Curie

February 2016

Meghan, Ranjay and Qiuyi’s paper “SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane” is published in PLoS Genetics.
Grace Lim receives an honorable mention at the 2016 Student Poster Competition at the AAAS Annual Meeting in Washington, DC, February 13-14  AAAS Student Meeting Winners

December 2015

The multi-talented Eric Hastie joins the lab as a post-doctoral scholar!
Lauren and Matt’s paper is accepted at PLOS Genetics!
Dave S receives the Mayent-Rothschild-Institut Curie Award to visit the Curie institute this coming summer.

November 2015

Matt starts his new position at CELLSCRIPT in Madison, WI.

August 2015

Lauren successfully defends her thesis!
Kaleb is awarded a Fellowship from the Biology Department!
Lauren starts her new position as a Clinical Pharmacology Associate/Project Manager at Nuventra in Research Triangle Park, NC
Meghan starts her post-doc at UCSF in Ron Vale’s lab.
Wei’s paper, “Rab-10-dependent transport is required for dendrite arborization” is accepted at PLOS Genetics.
Dave’s commentary, “A Developmental Biologist Outside-the-Cell Thinking” is published at the Journal of Cell Biology

July 2015

Dave speaks at the MMP Gordon Research Conference in Sunday River, Maine.

June 2015

Dave presents at “Imaging the Cell Meeting” in Bordeaux, France

May 2015

Meghan successfully defends her thesis!

February 2015

Meghan’s review article, “An active role for basement membrane modification and assembly in tissue sculpting” is published in the Journal of Cell Science.  pubmed

January 2015

Kacy Gordon, a new post-doctoral fellow joins the lab.  Kacy was a graduate student at the University of Chicago in Professor Ilya Ruvinsky’s lab, where she studied the evolution of transcriptional regulation.
Grace Lim, Troy Huffman-Devey and Catherine Blebea were all award URS independent study grants for their work in the lab 

November 2014

Matt Clay was awarded a Damon Runyon postdoctoral fellowship for his project entitled, “Understanding how extrinsic signals direct a Rho GTPase switch to control cell invasion in vivo”.
Grace Lim was awarded a George Barthalmus Undergraduate Research Award.
Meghan and Dan’s (with Shelly and Elliott and Qiuyi) paper “B-LINK: A Hemicentin, Plakin, and Integrin-Dependent Adhesion System that Links Tissues by Connecting Adjacent Basement Membranes” is published in Developmental Cell.

October 2014

Lauren’s collaborative work with the Nance lab on a new targeted protein degradation system that can remove tagged proteins rapidly within individual cells is accepted in Development.  “Repurposing an endogenous degradation system for rapid and targeted depletion of C. elegans proteins” Armenti, S.T., Lohmer, L.L, Sherwood, D.R., and Nance, J”  pubmed
The Sherwood lab has been certified as a Gold Level Green Lab (  Thank you Qiuyi for making this possible.

September 2014

Zheng’s paper, “UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity” is published in the Journal of Cell Biology and is featured on the cover. pubmed


August 2014

Dave plays for the Duke faculty team against the senior undergraduates (coached by Grant Hill).

July 2014

A lab gathering/reunion at the SDB meeting in Seattle
Lauren Lilley is a best poster finalist at SDB meeting.
Adam Schindler is awarded a talk in the Hilde Mangold Postdoctoral Symposium at the SDB meeting.

June 2014

Matt Clay was awarded a Duke Cancer Biology Training Grant Postdoctoral Fellowship.
David Matus’ paper,  “Cell division and targeted cell cycle arrest opens and stabilizes basement membrane gaps.” is published in Nature Communicationspubmed
Adam Schindler’s paper “Identification of late larval stage developmental checkpoints in Caenorhabditis elegans regulated by Insulin/IGF and steroid hormone signaling pathways.” is published in PLoS Genetics.  pubmed

April 2014

Benjamin Lacroix from Amy Maddox’s lab publishes an in vivo imaging story of tubulin with help from Shinji in our group in Developmental Cell.  “In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics.”  pubmed

March 2014

Zheng’s paper, ” MIG-10 (lamellipodin) has netrin-independent functions and is a FOS-1A transcriptional target during anchor cell invasion in C. elegans” is published in Development.  pubmed
Laura and Elliott’s paper, “ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo” is published in the Journal of Cell Biologypubmed
Lauren’s paper, “Invadopodia and basement membrane invasion in vivo” is published in Cell Adhesion and Cell Migrationpubmed

February 2014

Laura Kelley’s review, “Traversing the basement membrane in vivo: a diversity of strategies” is published in the Journal of Cell Biologypubmed
Matt Clay, a new post-doctoral fellow, joins the lab.  Matt was a graduate student at the University of Wisconsin in Madison studying neural crest cell migration in zebrafish in Professor Mary Halloran’s laboratory.
Wei Zou begins new position as a post-doctoral fellow in Professor Kang Shen’s lab at Stanford University.

January 2014

David Matus begins new position as an Assistant Professor in the Biochemistry and Cell Biology Department at Stony Brook University.       Dave’s website

Zheng Wang begins new position as a Clinician and Researcher at Wuhan Union Hospital, China.