Antimicrobial Resistance and Stewardship – Ruhuna-Duke Centre for Infectious Diseases

Manuscripts

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Colonization with multidrug-resistant Enterobacteriaceae among infants: an observational study in southern Sri Lanka. Meredith HR, Kularatna S, Nagaro K, Nagahawatte A, Bodinayake C, Kurukulasooriya R, Wijesingha N, Harden LB, Piyasiri B, Hammouda A, Wiegmann BM, Nicholson BP, Joyce M, Woods CW, Van Vliet AHM, Thakur S, Tillekeratne LG. 2021. Antimicrobial Resistance & Infection Control, 10(1), pp.1-12.

Barriers to implementing antimicrobial stewardship programs in three low-and middle-income country tertiary care settings: Rolfe R Jr, Kwobah C, Muro F, Ruwanpathirana A, Lyamuya F, Bodinayake C, Nagahawatte A, Piyasiri B, Sheng T, Bollinger J, Zhang C, Ostbye T, Ali S, Drew R, Kussin P, Anderson DJ, Woods CW, Watt MH, Mmbaga BT, Tillekeratne LG. findings from a multi-site qualitative study. Antimicrobial Resistance & Infection Control, 10(1), pp.1-11.2021

Point-prevalence survey of outpatient antibiotic prescription at a tertiary medical center in Sri Lanka: Zhang HL, Bodinayake C, Wijayaratne GB, Jayatissa P, Piyasiri DLB, Kurukulasooriya R, Sheng T, Nagahawatte A, Woods C, Tillekeratne LG. opportunities to improve prescribing practices for respiratory illnesses. BMC Infect Dis. 2021 Jan 21;21(1):97. doi: 10.1186/s12879-021-05804-6. PMID: 33478430; PMCID: PMC7818802.

Methicillin-resistant Staphylococcus aureus: prevalence of and risk factors associated with colonization of patients on admission to the Teaching Hospital, Karapitiya; Kurukulasooriya MRP, Tillekeratne LG, Wijayaratne WMDGB, Bodinayake CK, de Silva AD, Nicholson BP, Ostbye T, Woods CW, Nagahawatte A De S. Journal of the University of Ruhuna, 2018 Sep; 6(2): 70-75

Point-prevalence study of antimicrobial use in public hospitals in southern Sri Lanka; identifies opportunities for improving prescribing practices. Infect Control Hosp Epidemiol. Sheng T, Wijayaratne GB, Dabrera TM, Drew RJ, Nagahawatte A, Bodinayake CK, Kurukulasooriya R, Østbye T, Nagaro KJ, De Silva C, Ranawakaarachchi H, Sudarshana AT, Anderson DJ, Woods CW, Tillekeratne LG. 2019 Feb;40(2):224-227. doi: 10.1017/ice.2018.321. Epub 2018 Dec 7. PMID: 30522538; PMCID: PMC6353688.

Extended-Spectrum ß-Lactamase-Producing Enterobacteriaceae as a Common Cause of Urinary Tract Infections, Sri Lanka. Tillekeratne LG*, Vidanagama D*, Tippalagama R, Lewkebandara R, Joyce M, Nicholson BP, Nagahawatte A, Bodinayake C, De Silva AD, Woods, CW. Infect Chemother. 2016 Sep; 48(3):160-165.

Abstracts, Posters and Oral Presentations

Opportunities for Improving Antimicrobial Stewardship: Findings From a Prospective, Multi-Center Study in Three Low-or Middle-Income Countries Florida J Muro, Furaha S Lyamuya, Charles Kwobah, John Bollinger, Champika K Bodinayake, Ajith Nagahawatte, Bhagya Piyasiri, Ruvini Kurukulasooriya, Shamim Ali, Rose Mallya, Robert Rolfe Jr, Anushka Ruwanpathirana, Tianchen Sheng, Truls Ostbye, Richard Drew, Peter Kussin, Christoper W Woods, Deverick J Anderson, Blandina T Mmbaga, L Gayani Tillekeratne. Public Health,in April 2022

Microbiological and molecular characterization of methicillin-resistant Staphylococcus aureus in clinical cultures collected from two tertiary care hospitals in southern Sri Lanka. MRP Kurukulasooriya, MDGB Wijayaratne, LG Tillekeratne, CK Bodinayake, B Piyasiri, DP Abeywamaarachchi, AD de Silva, BP Nicholson, T Ostbye, CW Woods, ADeS Nagahawatt. 19th Academic Sessions, University of Ruhuna in March 2022.

Prevalence of Staphylococcus aureus and methicillin-resistant S. aureus in humans, animals and livestock products in southern Sri Lanka. MRP Kurukulasooriya, WMDB Wijayaratne, Tillekeratne LG, CK Bodinayake, AD De Silva, BP Nicholson, T Ostbye, CW Woods, ADeS Nagahawatte. Oral presentation at the Faculty of Medicine Sessions, University of Ruhuna, December 2021.

One-Health approach: Colonization prevalence of Staphylococcus aureus and MRSA in farm personnel, livestock and livestock products in southern Sri Lanka. MRP Kurukulasooriya, Tillekeratne LG, WMDGB Wijayaratne, CK Bodinayake, UHBY Dilshan, AD De Silva, BP Nicholson, T Østbye, CW Woods, ADeS Nagahawatte. Oral presentation at the Young Scientists’ Conference on Multidisciplinary Research, YSCMR_October 2021

A One Health approach to describe the prevalence of methicillin-resistant Staphylococcus aureus colonizing livestock farmers, livestock and livestock products in southern Sri Lanka. MRP Kurukulasooriya, Tillekeratne LG, WMDGB Wijayaratne, CK Bodinayake, UHBY Dilshan, AD De Silva, BP Nicholson, T Østbye, CW Woods, ADeS Nagahawatte. Poster presentation at the American Society of Tropical Medicine and Hygiene, November 2021

High prevalence of community-associated methicillin-resistant Staphylococcus aureus in patients infected with Staphylococcus aureus at a tertiary care centre; Kurukulasooriya, M.R.P., Piyasiri, B., Wijayaratne, W.M.D.G.B., Tillekeratne, L.G., Bodinayake, C.K., De Silva, A.D., Nicholson, B.P., Østbye, T., Woods, C.W., Nagahawatte, A.De.S. The Sri Lanka College of Microbiologists-Annual Academic Sessions, Colombo, Sri Lanka (August 2020).

Barriers to implementing antimicrobial stewardship programs in low-or middle-income country settings: findings from a multi-site qualitative study. In Open Forum Infectious Diseases. Rolfe Jr, R.J., Kwobah, C.M., Ruwanpathirana, A.S., Lyamuya, F., Bodinayake, C.K., Nagahawatte, A., Piyasiri, D.L.B., Sheng, T., Bollinger, J.W., Zhang, C. and Drew, R.H., 2020, October. 166. (Vol. 7, No. Suppl 1, p. S91). Oxford University Press.

Methicillin-resistant Staphylococcus aureus: high prevalence of community-associated types in patients hospitalized at a tertiary care hospital in Southern Sri Lanka. Ruvini Kurukulasooriya1, BhagyaPiyasiri2, Weerasinghe M. D. G. B. Wijayaratne1, GayaniTillekeratne3, ChampikaBodinayake1, A Dharshande Silva4, Bradly Nicholson3, TrulsØstbye3, Christopher Woods3, AjithNagahawatte1. American Society of Tropical Medicine and Hygiene, November 2020.

Prevalence and Patterns of Outpatient Antibiotic Prescription at a Public Tertiary Medical Center in Southern Province, Sri Lanka. In Open Forum Infectious Diseases. Zhang, H.L., Wijayaratne, G.B., Jayatissa, P., Piyasiri, B., Sheng, T., Bodinayake, C.K., Nagahawatte, A., Woods, C.W. and Tillekeratne, L.G., 2019, October. 1677. (Vol. 6, No. Supplement_2, pp. S614-S614). US: Oxford University Press.

Community-Associated Methicillin-resistant Staphylococcus aureus (MRSA) is the predominant type of colonizing MRSA among patients admitted to Teaching Hospital, Karapitiya (THK); Kurukulasooriya, M.R.P.1, Wijayaratne, W.M.D.G.B.1, Tillekeratne, L.G.2, Bodinayake, C.K.1, De Silva, A.D.3, Nicholson, B.P.2, Østbye, T.2, Woods, C.W.2, Nagahawatte, A.De.S.1 The Sri Lanka College of Microbiologists-Annual Academic Sessions, Colombo, Sri Lanka (August 2019).

Prevalence and Patterns of Outpatient Antibiotic Prescription at a Public Tertiary Medical Center in Southern Province, Sri Lanka Helen L. Zhang Gaya B. Wijayaratne, Pasangi Jayatissa Bhagya Piyasiri, Tianchen Sheng, Champica K. Bodinayake, Ajith Nagahawatte, Chris W. Woods,L. Gayani Tillekeratne, Open Forum Infectious Diseases, Volume 6, Issue Supplement2, October 2019, Page S614

Molecular epidemiology of colonizing Methicillin-resistant Staphylococcus aureus at Teaching Hospital, Karapitiya; MRP Kurukulasooriya, WMDGB Wijayaratne, LG Tillekeratne, CK Bodinayake, MD Rajapakshe, BGJ Umesha, AD de Silva, BP Nicholson, T Østbye, CW Woods, ADeS Nagahawatte.The 15th Academic Sessions of University of Ruhuna, Matara, Sri Lanka (March 2018).

Methicillin-resistant Staphylococcus aureus: prevalence of and risk factors associated with colonization of patients on admission to the Teaching Hospital, Karapitiya.; Kurukulasooriya MRP, Tillekeratne LG, Wijayaratne WMDGB, Bodinayake CK, de Silva AD, Nicholson BP, Ostbye T, Woods CW, Nagahawatte A De S. Journal of the University of Ruhuna, 2018 Sep; 6(2): 70-75

Prevalence and characterization of the colonizing methicillin-resistant Staphylococcus aureus isolated from the patients admitted to Surgical, Medical and Orthopaedic units of Teaching Hospital, Karapitiya. Kurukulasooriya, M.R.P., Tillekeratne, L.G., Wijayaratne, W.M.D.B., Bodinayake, C.K., Rajapakshe, M.D., Umesha, B.G.J., De Silva, A.D., Nicholson, B.P., Østbye, T., Woods, C.W., Nagahawatte, A.De.S. Poster: 01st National Health Research Symposium, Sri Lanka, December 2017.

High prevalence of suspected nosocomial colonization with methicillin-resistant Staphylococcus aureus at a tertiary care hospital in southern Sri Lanka. Ruvini Kurukulasooriya, L Gayani Tillekeratne, WMD GayaB Wijayaratne, Champica K Bodinayake, Malindu D Rajapakshe, BGJ Umesha, TDR Abewickrama, KV Thamali Anuradha, Aruna Dharshan de Silva, Bradly P Nicholson, Truls Østbye, Christopher W Woods, Ajith Nagahawatte. Poster: 66th American Society of Tropical Medicine and Hygiene, November 2017.

Characterization of Methicillin-resistant Staphylococcus aureus isolated from the patients admitted to Teaching Hospital, Karapitiya. Kurukulasooriya MRP, Tillekeratne LG, Wijayaratne WMDGB, Bodinayake CK, Rajapakshe MD, Umesha BGJ, De Silva AD, Nicholson BP, Østbye T, Woods CW, Nagahawatte ADeS. Oral presentation: 76th Annual Academic Sessions of the Galle Medical Association, 12th October 2017.

Methicillin-resistant Staphylococcus aureus: high prevalence of suspected nosocomial colonization in the surgical and medical wards of Teaching Hospital Karapitiya; Ruvini Kurukulasooriya, WMD Gaya B Wijayaratne, L Gayani Tillekeratne, Champica K Bodinayake, Malindu D Rajapakshe, BGJ Umesha, TDR Abewickrama, KV Thamali Anuradha, Aruna Dharshan de Silva, Bradly P Nicholson, Truls Østbye, Christopher W Woods, Ajith Nagahawatte. Oral presentation: The Sri Lanka College of Microbiologists-Annual Academic Sessions, August 2017.

High prevalence of community-acquired urinary tract infections due to extended-spectrum ß–lactamase- producing Enterobacteriaceae in southern Sri Lanka. Tillekeratne LG, Vidanagama D, Tippalagama R, Lewkebandara R, Joyce M, Nicholson B, Nagahawatte A, Bodinayake C, De Silva D, Woods CW. American Society for Microbiology, May 2015.

High prevalence of community-acquired urinary tract infections due to extended-spectrum ß–lactamase- producing Enterobacteriaceae in southern Sri Lanka. x-2007 and 2012- 2013; Champica K. Bodinayake¹, L. Gayani Tillekeratne², Ajith Nagahawatte³, Vasantha Devasiri⁴, Wasantha Kodikara Arachchi⁵, Truls Ostbye², Christopher W. Woods², Megan E. Reller^9- Ceylon College of Physicians; 47^th Annual Academic session, Colombo, Sri Lanka 8^th October 2014.

Prevalence and Patterns of Outpatient Antibiotic Prescription at a Public Tertiary Medical Center in Southern Province, Sri Lanka; Helen L. Zhang Gaya B. Wijayaratne, Pasangi Jayatissa Bhagya Piyasiri, Tianchen Sheng, Champica K. Bodinayake, Ajith Nagahawatte, Chris W. Woods,L. Gayani Tillekeratne, Open Forum Infectious Diseases, Volume 6, Issue Supplement2, October 2019, Page S614

Skin and Soft-tissue Infections Are a Common Reason for Potentially Inappropriate Antimicrobial Use among Inpatients in Sri Lanka. Sheng, T., Wijayaratne, G.B., Dabrera, T.M., Nagahawatte, A., Bodinayake, C.K., Kurukulasooriya, R., Nagaro, K.J., De Silva, C., Ranawakaarachchi, H., Thusitha Sudarshana, A. and Anderson, D.J., 2019, October. 436. In Open Forum Infectious Diseases (Vol. 6, No. Supplement_2, pp. S216-S217). US: Oxford University Press.

Prevalence and Patterns of Outpatient Antibiotic Prescription at a Public Tertiary Medical Center in Southern Province, Sri Lanka. Zhang, Helen L., Gaya B. Wijayaratne, Pasangi Jayatissa, Bhagya Piyasiri, Tianchen Sheng, Champica K. Bodinayake, Ajith Nagahawatte, Chris W. Woods, and L. Gayani Tillekeratne. “1677. ” In Open Forum Infectious Diseases, vol. 6, no. Supplement_2, pp. S614-S614. US: Oxford University Press, 2019.

First point-prevalence study of inpatient antimicrobial use in five public hospitals in southern Sri Lanka. Sheng T, Wijayaratne G, Dabrera T, Bodinayake CK, Kurukulasooriya R, Nagaro K, Sudarshana AT, Anderson D, Drew R, Ostbye T, Woods CW, Nagahawatte A, Tillekeratne LG. “International conference on Infectious Diseases and Antimicrobial Resistance” organized by Sri Lanka College of Microbiologists Annual Sessions, August 2018

High colonization prevalence in peripartum women and their neonates in southern Sri Lanka. Kurukulasooriya MRP, Meredith HR, Kularatna S, Nagaro K, Nagahawatte A, Bodinayake C, Wijesingha N, Piyasiri B, Hammouda A, Wiegmann B, Nicholson BP, Joyce M, Woods CW, Thakur S, Tillekeratne LG. Multidrug-resistant Enterobacteriaceae: Sri Lanka College of Microbiologists Annual Sessions, August 2018

Antibiotic overuse in Outpatient Department; is it patients’ request or doctors’ misconception; Tillakaratne LG, Maduranga KHS, Ajith Nagahawatte Bodinayake CK – Galle Medical Journal, Vol 21: suppliment1, Oct 2016

A multi-site, prospective study of antimicrobial prescribing practices in three low-or middle-income country hospitals. Rolfe Jr, R.J., Muro, F., Lyamuya, F., Kwobah, C.M., Sheng, T., Piyasiri, D.L.B., Bodinayake, C.K., Nagahawatte, A., Yarrington, M.E., Drew, R.H. and Kussin, P.S., 2020, October. 158. In Open Forum Infectious Diseases (Vol. 7, No. Supplement_1, pp. S88-S89). US: Oxford University Press

Barriers to implementing antimicrobial stewardship programs in low-or middle-income country settings: Rolfe Jr, R.J., Kwobah, C.M., Ruwanpathirana, A.S., Lyamuya, F., Bodinayake, C.K., Nagahawatte, A., Piyasiri, D.L.B., Sheng, T., Bollinger, J.W., Zhang, C. and Drew, R.H., 2020, October. 166. findings from a multi-site qualitative study. In Open Forum Infectious Diseases (Vol. 7, No. Suppl 1, p. S91). Oxford University Press.

Multidrug-resistant Enterobacteriaceae: high colonization prevalence in peripartum women and their neonates in southern Sri Lanka; R. P. Kurukulasooriya, H. R. Meredith, S. Kularatna, A. Nagahawatte, C. C. W. Woods, S. Thakur, L. G. Tillekeratne. Annual Scientific Session of the Sri Lanka Collage of Microbiologists 2018