Welcome to Qianben Wang’s laboratory. Our laboratory is located in the School of Medicine at Duke University, and is part of Duke Pathology, Duke Cancer Institute, and National Cancer Institute (NCI) funded San Antonio-Duke University Research Center for Cancer Systems Biology (SA-Duke RCCSB).
The Wang laboratory is primarily interested in understanding the epigenetic mechanisms driving progression of hormone-dependent cancers. We focus on studying how these cancers are dependent upon transcription factor-centered, multi-layer transcription regulatory networks composed of transcription factors (e.g. nuclear hormone receptors, FoxA1, and HoxB13), transcription coactivators (e.g. Mediator and histone acetyltransferases), and epigenetic regulators (e.g. histone modifications, chromatin looping and nucleosome positioning).