News

September 2021

Kexin Li from Peking Union Medical College  joined the lab as a postdoctoral fellow. Welcome, Kexin!

June 2021

Our PDE5i research was selected by Department of Defense (DoD) Prostate Cancer Research Program as a 2021 Research Highlight.

May 2021

Qianben was invited to serve on the School of Medicine Clinical Sciences Appointment, Promotion, and Tenure Committee at Duke University.

April 2021

Qianben was invited to deliver lectures (virtual) at Louisiana State University and UNC Chapel Hill. The title of his talk was “Epigenetic regulation in hormone-dependent cancers”.

March 2021

Qianben organized the 2021 NCI virtual visit to San Antonio-Duke University Research Center for Cancer Systems Biology on March 31, 2021. Center PIs presented project progress at the virtual meeting. Agenda for 2021 NCI Virtual Visit to SA-Duke U54 Center.

December 2020

Bill’s paper entitled “Prostate cancer cell phenotypes remain stable following PDE5 inhibition in the clinically relevant range” was the most downloaded Translational Oncology  article in 2020.

September 2020

Furong’s paper entitled “The oncogenomic function of androgen receptor in esophageal squamous cell carcinoma is directed by GATA3” was accepted by Cell Research.

August 2020

Zhong was awarded a five-year NCI R50 grant entitled “Systems analysis of the prostate cancer epigenome”.  Reported by Duke Pathology News: “Chen Receives National Cancer Institute R50 Research Specialist Award.”

July 2020

Furong successfully defended his dissertation and obtained his PhD degree in June. He joined the lab as a fresh postdoctoral fellow. Welcome, Furong!

June 2020

Qianben was awarded a pilot grant from Duke Cancer Institute.

May 2020

Bill’s paper entitled “Prostate cancer cell phenotypes remain stable following PDE5 inhibition in the clinically relevant range” was accepted by Translational Oncology.

February 2020

Our invited review article entitled “Shaping chromatin states in prostate cancer by pioneer transcription factors” was accepted by Cancer Research.

February 2020

Qianben obtained a DOD Prostate Cancer Program Idea Development Award entitled “Targeting neuroendocrine prostate cancer by engineering 3′ untranslated regions”.

November 2019

Qianben was invited to speak at the 2019 Society for Basic Urological Research (SBUR) annual meeting in New Orleans, LA. The title of his talk was “Epigenomic approaches to discover transcriptional vulnerabilities of prostate cancer”.

Fuwen presented a poster at the meeting entitled “Molecular determinants for enzalutamide-induced oncogenic transcription in prostate cancer”.

Bill presented a poster at the meeting entitled “Prostate cancer cell phenotypes are stable following PDE5 inhibition in the clinical range but antagonized by supraphysiological concentrations.”

Reported by Duke Pathology News: “Duke Well Represented at SBUR Meeting“.

October 2019

Fuwen’s DoD Early Investigator Research Award application was funded. Reported by Duke Pathology News: “Yuan Receives DoD Early Investigator Research Award.”

Zhifen’s DoD Early Investigator Research Award application was recommended as alternate.

October 2019

Fuwen’s review article entitled “Alternative polyadenylation of mRNA and its role in cancer” was accepted by Genes & Diseases.

September 2019

Fuwen’s paper entitled “Molecular determinants for enzalutamide- induced transcription in prostate cancer” was accepted by Nucleic Acids Research.

Jinjin Wu from Department of Pathology started rotation in our lab. Welcome, Jinjin!

August 2019

Haiyan He from Penn State University  joined the lab as a postdoctoral fellow. Welcome, Haiyan!

May 2019

Qianben was invited to deliver a lecture at the Vancouver Prostate Cancer Centre in Canada. The title of his talk was “Epigenomic approaches to discover transcriptional vulnerabilities of prostate cancer”.

April 2019

In conjunction with the NCI visit to the San Antonio-Duke University Research Center for Cancer Systems Biology on April 19th, 2019, Drs. Qianben Wang, Victor Jin and Nameer Kirma co-organized a one-day San Antonio-Duke Cancer Systems Biology Symposium, “Modeling and Interrogation of Hormone-Independent Cancer Progression” at the University of Texas Health San Antonio campus.  Our center PIs and postdocs including Drs. Qianben Wang and Fuwen Yuan presented project progress at the symposium.  https://pathology.duke.edu/news/wang-co-organizes-san-antonio-duke-cancer-systems-biology-symposium

News on U54 website: http://molecularmedicine.uthscsa.edu/CSBC_U54.aspx

April 2019

Our San Antonio-Duke University Research Center for Cancer Systems Biology proposed session “Systems Epigenetics in Hormone-Driven Cancers” was selected by the 2019 AACR Program Committee as a Major Symposium. Center PIs Drs. Tim Huang and Qianben Wang as well as Dr. Myles Brown from Harvard presented at this Major Symposium during the 2019 AACR Annual Meeting (Atlanta, GA)

Reported by Duke Pathology News: “Duke Pathology Featured at AACR Meeting in Atalanta.”

March 2019

Lu Tang  joined the lab as a visiting scholar. Welcome, Lu!

October 2018

We moved to a new lab space at Room 1014, GSRB1!!

September 2018

Zhifen Cui from Shanghai Institute of Applied Physics, Chinese Academy of Sciences joined the lab as a postdoctoral fellow. Welcome, Zhifen!

September 2018

Qianben was invited to present on The 12th National Symposium on Prostate Cancer and Dr. Sidney A. McNairy Jr. Student Symposium in Atlanta, GA.

September 2018

Qianben was invited to present on 2018 Duke Basic Science Day: “Genomic Determinants for Andorgen Receptor-V7 Oncogenic Function in Castration-Resistant Prostate Cancer.”

September 2018

Furong Huang from Peking Union Medical College joined the lab as a visiting scholar. Welcome, Furong!

August 2018

Kathryn Ware joined the lab as a senior research associate.  She is  co-supervised by Drs. Qianben Wang and Andrew Armstrong. Welcome, Kathryn!

June 2018

William (Bill) Hankey has been selected as one of the only two trainees in NIH T32 Post-Doctoral Program in Genomic Medicine at The Duke Center for Applied Genomics and Precision Medicine. Congratulations, Bill !!

Reported by Duke Center for Applied Genomics & Precision Medicine: ” New Postdoc fellows ready to dive into genomic research“.

Reported by Duke Pathology News: “Hankey Selected NIH T32 Post-Doc Training Program“.

June 2018

Qianben was awarded a pilot grant from Duke Cancer Institute.

May 2018

Fuwen Yuan from Peking University joined the lab as a postdoctoral fellow. Welcome, Fuwen!

May 2018

Zhong’s paper entitled “Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13” was accepted by PNAS.

Commentary by Héctor I. Navarro and Andrew S. Goldstein on PNAS:  “HoxB13 mediates AR-V7 activity in prostate cancer“.

Reported by Duke University School of Medicine News and Communications and Reprinted on Duke Pathology News: “Researchers Identify Promising New Drug Target for Lethal Prostate Cancer“.

Reported by DukeMed Alumni News, Fall 2018 (Page 7): “Research Points to Promising New Target in Prostate Cancer“.

April 2018

Qianben was invited to present on 2018 Duke Department of Pathology Retreat: ““Diverse AR-V7 cistromes in castration-resistant prostate cancer are govern by HoxB13”.

December 2017

Qianben Wang’s lab moved from The Ohio State University to Duke University Department of Pathology and Duke Cancer Institute.

Hongyan Wang joined the lab as a senior research scientist/lab manager. Welcome, Hongyan!

William Hankey joined the lab as a postdoctoral fellow. Welcome, Bill!

November 2017

David Frankhouser (co-supervised by Drs. Lisa Yee and Qianben Wang) earned his PhD upon successful defense of his thesis entitled “Methylome analysis: From computation workflow development to implementation in a breast cancer prevention trial”.

October 2017

Qianben was invited to speak at the NCI Cancer Systems Biology Consortium Annual Meeting (Boston, Massachusetts).

August 2017

Qianben served as a co-chair of the “Nuclear Receptor Function and Co-factors” session of the Gordon Research Conference on Hormone-Dependent Cancers (Newry, Maine).

July 2017

Drs. Qianben Wang, Jiaoti Huang, and Steven Clinton were awarded a Multi-PI NCI R01 grant entitled “Role of oncogenic phosphorylated MED1 in aggressive prostate cancer”.

June 2017

Qianben obtained a NIGMS R01 grant entitled “Novel genomic mechanism for ligand-dependent transcription by androgen receptor”.

May 2017

Drs. Tim Huang, Victor Jin and Qianben Wang were awarded a five-year Multi-PI NCI U54 center grant totaling $9.12 million entitled “Systems Analysis of Epigenomic Architecture in Cancer Progression”.  Our center is one of only nine NCI funded Cancer Systems Biology Centers in the country (https://www.cancer.gov/about-nci/organization/dcb/research-programs/csbc/announcement; https://csbconsortium.org/?page_id=476).

Qianben serves as a PI to provide oversight for Project 2 tasks and outreach and administrative activities. Qianben is also Experimental Leader of Project 2.

August 2016

Drs. Qianben Wang, Jiaoti Huang, and Steven Clinton have been awarded a Multi-PI Synergistic Idea Award by the Department of Defense Prostate Cancer Research Program. The project is entitled “Novel Tumor Suppressive Role of Phosphodiesterases in Prostate Cancer”.

March 2016
Ben earned his PhD in Biochemistry upon successful defense of his dissertation entitled “Looking beyond the androgen receptor for transcriptional drivers of prostate cancer.”

January 2016
Ben and Dayong’s paper entitled “Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence” was accepted by Nucleic Acids Research.

August 2015
Zhong’s paper entitled “Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer” was accepted by Nature Communications.

August 2015

Kaifu and Zhong’s paper entitled “Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes.” was accepted by Nature Genetics.

June 2015
Qianben received an OSU Pelotonia Idea Grant with our Co-PI, Dr. Steven Clinton.

December 2014
Zhong’s paper entitled “Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer” was accepted by EMBO J.

July 2014
Qianben received an OSU Pelotonia Idea Grant with our Co-PI, Dr. Steven Clinton.

July 2014
Ben was awarded a Ruth L. Kirschstein National Research Service Award (NRSA, F31) from the NIH/NCI.

May 2014
Ben received an award for “Outstanding Poster Presentation” at the annual Life Sciences Interdisciplinary Graduate Programs (IGP) Symposium.

May 2014
Ben was selected for the 2014 cohort of the Pelotonia Graduate Student Fellowship program.

December 2013
Dayong and Ben’s paper entitled “Three-tiered role of the pioneer factor GATA2 in promoting androgen-dependent gene expression in prostate cancer” was accepted by Nucleic Acids Research. The article has been selected by the editors of Nucleic Acids Research as a Breakthrough Article.

December 2013
Zhenqing and Zhong’s paper entitled “Computational analysis reveals a correlation of exon-skipping events with splicing, transcription and epigenetic factors” was accepted by Nucleic Acids Research.

September 2013
Qianben was promoted to an Associate Professor with Tenure.

July 2013
Qianben was invited to serve on the Editorial Board of Molecular Cancer Research (AACR journal).

September 2012
Xiangtao Liu from Yale University joined the Wang lab as a postdoctoral fellow. He is co-mentored by Dr. Shili Lin at the Department of Statistics. Welcome, Xiangtao!

July 2012
Cassandra has been awarded a NIH T32 Oncology Training Grant. Congratulations, Cassandra!

July 2012
Cassandra Grenade joined the Wang lab as a postdoctoral fellow. Welcome, Cassandra!

June 2012
Qianben received a 2012 Endocrine Society Early Investigators Award.

June 2012
Ben Sunkel was accepted into the Howard Hughes Medical Institute (HHMI) MED into GRAD Scholars Program at The Ohio State University. Congratulations, Ben!

June 2012
Ben Sunkel from the Ohio State Biochemistry Graduate Program (OSBP) joined the Wang lab as a graduate student. Welcome!

December 2011
Qianben’s proposal was recommended for funding by Department of Defense Prostate Cancer Research Program (Idea Development Award – Established Investigators).

November 2011
Chunpeng published an article entitled “Definition of a FoxA1 Cistrome That Is Crucial for G1 to S-Phase Cell-Cycle Transit in Castration-Resistant Prostate Cancer” in Cancer Research.

October 2011
Qianben was awarded the 2011 V Scholar grant
Qianben obtained his OSU pelotonia idea grant

September 2011
Ying Ying Lee from Chinese University of Hong Kong joined us as a Visiting Scholar. Welcome!

August 2011
Our invited review article entitled “Androgen receptor-driven chromatin looping in prostate cancer” was published in Trends Endocrinol Metab.
Qianben obtained a NCI R01 grant.

July 2011
Hongyan published an article entitled “CCI-779 Inhibits Cell-Cycle G2/M Progression and Invasion of Castration-Resistant Prostate Cancer via Attenuation of UBE2C Transcription and mRNA Stability” in Cancer Research.

June 2011
Zhong published an article entitled “Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth” in EMBO J.

November 2010
Qianben received a “2010 Young Investigator Award” from Society for Basic Urologic Research

August 2010
Zhong published a review article entitled “Histone modifications and chromatin organization in prostate cancer” in Epigenomics.

February 2010
The Ohio State-Indiana University Center for Cancer Systems Biology, lead by Dr. Tim Huang, was funded by the National Cancer Institute. Dr. Wang becomes the prostate cancer project leader.

July 2009

Our paper entitled “Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer” was published by Cell as the Featured Article.