Publications

Frankhouser DE , Steck S , Sovic MG , Belury MA , Wang Q , Clinton SK ,  Bundschuh R , Yan PS , Yee LD. Dietary omega-3 fatty acid intake impacts peripheral blood DNA methylation-anti inflammatory effects and individual variability in a pilot study. J Nutr Biochem 2021; Aug 16;108839. doi: 10.1016/j.jnutbio.2021.108839. Online ahead of print.

Xu L, Yin Y, Li Y, Chen X, Chang Y, Zhang H, Liu J, Beasley J, McCaw P, Zhang H, Young S, Groth J, Wang Q, Locasale JW, Gao X, Tang DG, Dong X, He Y, George D, Hu H, Huang J.  A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer. Porc Natl Acad Sci 2021; 118(13): e2012748118.

Huang F, Chen H, Zhu X, Gong T, Li X, Hankey W, Wang H, Chen Z*, Wang Q* and Liu Z*. The oncogenomic function of androgen receptor in esophageal squamous cell carcinoma is directed by GATA3. Cell Res 2021; 31(3):362-5. (*Corresponding authors).

Hankey W, Sunkel B, Yuan F, He H, Thomas-Ahner JM, Chen Z, Clinton SK, Huang J and Wang QProstate Cancer Cell Phenotypes Remain Stable Following PDE5 Inhibition in the Clinically Relevant Range. Transl Oncol 2020;  13(9): 100797.

Hankey W, Chen Z and Wang Q. Shaping chromatin states in prostate cancer by pioneer transcription factors. Cancer Res 2020; 80(12): 2427-36.

Li Y, He Y, Butler W, Xu L, Chang Y, Lei K, Zhang H, Zhou Y, Gao AC, Zhang Q, Taylor DG, Cheng D, Farber-Katz S, Karam R, Landrith T, Li B, Wu S, Hsuan V, Yang Q, Hu H, Chen X, Flowers M, McCall SJ, Lee JK, Smith BA, Park JW, Goldstein AS, Witte ON, Wang Q, Rettig MB, Armstrong AJ, Cheng Q, Huang J. Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer. Sci Transl Med 2019; 11(521): 1-11.

Yuan F, Hankey W, Wagner EJ, Li W, Wang QAlternative polyadenylation of mRNA and its role in cancer.  Genes & Diseases 2019; 8:61-72.

Yuan F, Hankey W, Wu D, Wang H, Somarelli J, Armstrong A, Huang J, Chen Z, Wang Q. Molecular determinants for enzalutamide-induced transcription in prostate cancer. Nucleic Acids Res 2019; 47(19):10104-14.

Hankey W, Chen Z, Bergman MJ, Fernandez MO, Hancioglu B, Lan X, Jegga AG, Zhang J, Jin VX, Aronow BJ, Wang Q, Gorden J.   Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1.  Oncotarget 2018; 9(58): 31214-30.

Lee YY, Mok MT, Kang W, Yang W, Tang W, Wu F, Xu L, Yan M, Yu Z, Lee SD, Tong JHM, Cheung YS, Lai PBS, Yu DY, Wang Q, Wong GLH, Chan AM, Yip KY, To KF, Cheng ASL. Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.  Nucleic Acids Res  2018; 46(17): 8832-47.

Chen Z, Wu D, Thomas-Ahner JM, Lu C, Zhao P, Zhang Q, Geraghty C, Yan PS, Hankey W, Sunkel B, Cheng X, Antonarakis ES, Wang QE, Liu Z, Huang TH, Jin VX, Clinton SK, Luo J, Huang J, Wang Q. Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13.  Proc Natl Acad Sci U S A  2018; 115(26):6810-15.                                                                                                                       See commentary article: Navarro HI and Goldstein AS. HoxB13 mediates AR-V7 activity in prostate cancer.  Proc Natl Acad Sci U S A. 2018; 115(26): 6528-9.

Horning AM, Wang Y, Lin CK, Louie AD, Jadhav RR, Hung CN, Wang CM, Lin CL, Kirma  NB, Liss MA, Kumar AP, Sun L, Liu Z, Chao WT,  Wang Q, Jin VX, Chen CL, Huang TH. Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle-Related Transcription and Attenuated Androgen Response.  Cancer Res 2018; 78(4):853-64.

McNair C, Urbanucci A, Comstock CE, Augello MA, Goodwin JF, Launchbury R, Zhao SG, Schiewer MJ, Ertel A, Karnes J, Davicioni E, Wang L, Wang Q, Mills IG, Feng FY, Li W, Carroll JS, Knudsen KE.  Cell cycle-coupled expansion of AR activity promotes cancer progression.  Oncogene 2017; 36(12):1655-68.

Ye Z^, Chen Z^Sunkel B, Frietze S, Huang TH, Wang Q*, Jin VX*.  Genome-wide analysis reveals positional-nucleosome-oriented binding pattern of pioneer factor FOXA1.  Nucleic Acids Res 2016; 44(16):7540-54( ^ first authors, *Corresponding authors).

Tang X, Liu H, Srivastava A, Pecot T, Chen Z, Wang Q, Huang K, Saenz-Robles MT, Cantalupo P, Pipas J, and Leone G.  Transcriptome regulation and chromatin occupancy by E2F3 and MYC in mice.  Sci Data 2016; 3:160008.

Sunkel B^Wu D^, Chen Z, Wang CM, X Liu, Ye Z, Horning AM, Liu J, Mahalingam D, Lopez-Nicora H, Lin CL, Goodfellow PJ, Clinton SK, Jin VX, Chen CL, Huang TH, and  Wang Q.  Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence.  Nucleic Acids Res  2016; 44(9):4105-22 (^ first authors).

Chen Z*, Lan X, Wu D, Sunkel B, Ye Z, Huang J, Liu Z, Clinton SK, Jin VX and Wang Q*Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer. Nat Commun 2015; 6:8323 (*Corresponding authors).

Chen K^, Chen Z^, Wu D, Zhang L, Lin X, Su J, Rodriguez B, Xi Y, Xia Z, Chen X, Shi X, Wang Q* and Li W*. Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes.  Nat Genet 2015; 47(10):1149-57 (^first authors, *Corresponding authors).

Liu H, Tang X, Srivastava A, Pécot T, Daniel P, Hemmelgarn B, Reyes S, Fackler N, Bajwa A, Kladney R, Koivisto C, Chen Z, Wang Q, Huang K, Machiraju R, Sáenz-Robles MT, Cantalupo P, Pipas JM, Leone G.  Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.   Nat Cell Biol  2015;17(8):1036-48.

He H, Li W, Liyanarachchi S, Srinivas M, Wang Y, Akagi K, Wang Y, Wu D, Wang Q, Jin V, Symer DE, Shen R, Phay J, Nagy R, de la Chapelle A. Multiple functional variants in long-range enhancer elements contribute to the risk of SNP rs965513 in thyroid cancer.   Proc Natl Acad Sci U S A 2015; 112(19): 6128-33.

Chen Z^, Lan X^, Thomas-Ahner, JM, Wu D, Liu X,Ye Z, Wang L, Sunkel B, Grenade C, Chen J, Zynger DL, Yan PS, Huang J, Nephew KP, Huang THM, Lin S, Clinton SK, Li W, Jin VX,  Wang Q.   Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer.  EMBO J 2015; 34(4):502-16 (^ first author).

Wu D^, Sunkel B^, Chen Z, Liu X, Ye Z, Li Q, Grenade C, Ke J, Chen H, Nephew KP, Huang THM, Liu Z, Jin VX, Wang QThree-tiered role of the pioneer factor GATA2 in promoting androgen-dependent gene expression in prostate cancer.  Nucleic Acids Res 2014; 42(6):3607-22 (^ first author) (Breakthrough Article).

Ye Z^, Chen Z^, Lan X, Hara S, Sunkel B, Huang THM, Elnitski L, Wang Q*, Jin VX*.  Computational analysis reveals a correlation of exon-skipping events with splicing, transcription and epigenetic factors.   Nucleic Acids Res 2014; 42(5):2856-69 (^ first author, * corresponding authors).

Chen H, Ma J, Sunkel B, Luo A, Ding F, Li Y, He H, Zhang S, Xu C, Jin Q, Wang Q, Liu Z. S100A14: novel modulator of terminal differentiation in esophageal cancer.   Mol Cancer Res 2013; 11(12): 1542-53.

He H, Li W, Wu D, Nagy R, Liyanarachchi S, Akagi K, Jendrzejewski J, Jiao H, Hoag K, Wen B, Srinivas M, Waidyaratne G, Wang R, Wojcicka A, Lattimer IR, Stachlewska E, Czetwertynska M, Dlugosinska J, Gierlikowski W, Ploski R, Krawczyk M, Jazdzewski K, Kere J, Symer DE, Jin V, Wang Q, de la Chapelle A. Ultra-rare mutation in long-range enhancer predisposes to thyroid carcinoma with high penetrance.  PLoS One  2013; 8(5):e61920.

Cai C, Wang H, He HH, Chen S, He L, Ma F, Mucci L, Wang Q, Fiore C, Sowalsky AG, Loda M, Liu XS, Brown M, Balk SP, Yuan X.  ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer.  J Clin Invest 2013; 123(3): 1109-22.

Sunkel B, Wang Q. “Chromatin Looping and Long Distance Regulation by Androgen Receptor” Androgen-Responsive Genes in Prostate Cancer Wang, Z., Ed. Springer: New York, 2013.

Cui J, Germer K, Wu T, Wang J, Luo J, Wang SC, Wang Q, Zhang X. Cross-talk between HER2 and MED1 regulates tamoxifen resistance of human breast cancer cells.ross-talk between HER2 and MED1 regulates tamoxifen resistance of human breast cancer cells.   Cancer Res 2012; 72(21): 5625-34.

Sunkel B, Wang Q.  Mapping mutations in prostate cancer exomes.   Asian J Androl  2012; 14(6):801-2.

Lan X, Witt H, Katsumura K, Ye Z, Wang Q, Bresnick EH, Farnham PJ, Jin VX. Integration of Hi-C and ChIP-seq data reveals distinct types of chromatin linkages.   Nucleic Acids Res 2012; 40(16):7690-704.

Taslim C, Chen Z,  Huang K, Huang TH, Wang Q*, Lin S*. Integrated analysis identifies a class of androgen-responsive genes regulated by short combinatorial long-range mechanism facilitated by CTCF.  Nucleic Acids Res 2012; 40(11): 4754-64 (*corresponding author).

Zhao JC, Yu J, Runkle C, Wu L, Hu M, Wu D, Liu JS, Wang Q, Qin ZS, Yu J. Cooperation between Polycomb and androgen receptor during oncogenic transformation.  Genome Res 2012; 22(2): 322-31.

Wu D, Zhang CShen Y, Nephew KP, Wang Q. Androgen receptor-driven chromatin looping in prostate cancer.  Trends Endocrinol Metab  2011; 22(12):474-80.

Zhang C^, Wang L^, Wu D^, Chen H, Chen Z, Thomas-Ahner JM, Zynger DL, Eeckhoute J, Yu J, Luo J, Brown M, Clinton SK, Nephew KP, Huang TH, Li W*, Wang Q*.  Definition of a FoxA1 Cistrome that is crucial for G1 to S-phase cell-cycle transit in castration-resistant prostate cancer.  Cancer Res 2011; 71(21):6738-48. (^ first author, * corresponding author).

Wang H, Zhang C, Rorick A, Wu D, Chiu M, Thomas-Ahner J, Chen Z, Chen H, Clinton SK, Chan KK, Wang Q.  CCI-779 inhibits cell-cycle G2-M progression and invasion of castration-resistant prostate cancer via attenuation of UBE2C transcription and mRNA stability.   Cancer Res 2011; 71(14):4866-76.

Chen Z, Zhang C, Wu D, Chen H, Rorick A, Zhang X, Wang Q. Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth.  EMBO J 2011; 30(12): 2405-19.

Chen CH, Huang PH, Chiu PC, Chen MC, Chou CC, Wang D, Kulp SK, Teng CM, Wang Q and Chen CS.  Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression.  J Biol Chem 2011; 286(12):9968-76.

Frigo DE, Howe MK, Wittmann BM, Brunner AM, Cushman I, Wang Q, Brown M, Means AR and McDonnell DP.  CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells.  Cancer Res 2011; 71(2):528-37.

Chen Z^, Wang L^, Wang Q*, Li W*. Histone modifications and chromatin organization in prostate cancer.   Epigenomics 2010; 2(4): 551-60 (^ first author, * corresponding author).

Hsu PY, Hsu HK, Singer GA, Yan PS, Rodriguez BA, Liu JC, Weng YI, Deatherage DE, Chen Z, Pereira JS, Lopez R, Russo J, Wang Q, Lamartiniere CA, Nephew KP and Huang TH.  Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping.  Genome Res 2010; 20(6):733-44.

He HH, Meyer CA, Shin H, Bailey ST, Wei G, Wang Q, Zhang Y, Xu K, Ni M, Lupien M, Mieczkowski P, Lieb JD, Zhao K, Brown M and Liu XS.  Nucleosome dynamics define transcriptional enhancers. Nat Genet 2010; 42(4):343-7.

Wang Q*^, Li W^, Zhang Y, Yuan X, Xu K, Yu J, Chen Z, Beroukhim R, Wang H, Lupien M, Wu T, Regan MM, Meyer CA, Carroll JS, Manrai AK, Ja¨ nne OA, Balk SP, Mehra R, Han B, Chinnaiyan AM, Rubin MA, True L, Fiorentino M, Fiore C, Loda M, Kantoff PW, Liu XS,* Brown M*. Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.   Cell  2009;138:245-56 (^ first author, * corresponding author)(Featured Article).
Highlighted by: Faculty of 1000 and Nature Reviews Cancer

Frigo DE, Sherk AB, Wittmann BM, Norris JD, Wang Q, Joseph JD, Toner AP, Brown M, McDonnell DP.  Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro.  Mol Endocrinol 2009; 23(9):1385-96.

Sun T, Wang Q, Balk SP, Brown M, Lee GS and Kantoff PW. The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines. Cancer Res 2009; 69:3356-63.

Wang Q and Brown M (2009) “Mapping the androgen receptor cistrome” In Tindall DJ and Mohler JL, eds. Androgen Action in Prostate Cancer, New York, NY: Springer Science and Business Media, pp.663-80.

Nwachukwu JC, Mita P, Ruoff R, Ha S, Wang Q, Huang SJ, Taneja SS, Brown M, Gerald WL, Garabedian MJ and Logan SK.  Genome-wide impact of androgen receptor trapped clone-27 loss on androgen-regulated transcription in prostate cancer cells. Cancer Res 2009; 69(7): 3140-7.

Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Carroll JS, Liu XS, and Brown M. FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell  2008; 132:958-70.

Bao BY, Chuang BF, Wang Q, Kantoff PW, Brown M, Sartor O, and Lee GS Androgen receptor mediates the expression of UDP-glucuronosyltransferase 2 B15 and B17 genes.  Prostate 2008; 68:839-48.

Agoulnik IU, Bingman WE 3rd, Nakka M, Li W, Wang Q, Liu XS, Brown M, Weigel NL..Target gene-specific regulation of androgen receptor activity by p42/p44 mitogen-activated protein kinase.  Mol Endocrinol 2008; 22: 2420-32.

Wang Q, Li W, Liu XS, Carroll JS, Jänne OA, Keeton EK, Chinnaiyan AM, Pienta KJ and Brown M. A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth.  Mol Cell  2007; 27: 380-92 (Featured Article).

Wang QF, Prabhakar S, Wang Q,  Moses AM, Chanan S, Brown M, Eisen MB, Cheng JF, Rubin EM, and Boffelli D. Primate-specific evolution of an LDLR enhancer.  Genome Biol  2006; 7: R68.

Carroll JS, Meyer CA, Song J, Li W, Brodsky AS, Geistlinger TR, Eeckhoute J, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS and Brown M. Genome-wide analysis of estrogen receptor binding sites.  Nat Genet 2006; 38: 1289-97.

Wang Q, Carroll JS and Brown M. Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking.  Mol Cell 2005; 19: 631-42.

Wang Q, Udayakumar TS, Vasaitis TS, Brodie AH and Fondell JD.  Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells.  J Biol Chem  2004; 279:17319-28.

Wang H, Wang Q, Srivastava RK, Gong SS, Lao L, Fondell JD, Wang JB.  Effects of total glycosides from Baishouwu on human breast and prostate cancer cell proliferation.  Altern Ther Health Med  2003; 9(5):62-6.

Wang Q,  Dipali S, Ren Y and Fondell JD.  A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression.  J Biol Chem  2002; 277:42852-8.

Zhang Y, Fondell JD, Wang Q, Xia X, Cheng A, Lu M, Hamburger AW. Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1.  Oncogene 2002; 21(36): 5609-18.

Wang Q, Fondell JD. Generation of a mammalian cell line stably expressing a tetracycline-regulated epitope-tagged human androgen receptor: implications for steroid hormone receptor research.  Anal Biochem 2001; 289(2): 217-30.

Ren Y, Behre E, Ren Z, Zhang J, Wang Q, Fondell JD.  Specific structural motifs determine TRAP220 interactions with nuclear hormone receptors.  Mol Cell Biol 2000; 20(15): 5433-46.