Co-Clinical Imaging Resource Program (CIRP): Bridging the Translational Divide to Advance Precision Medicine. Shoghi KI, Badea CT, Blocker SJ, Chenevert TL, Laforest R, Lewis MT, Luker GD, Manning HC, Marcus DS, Mowery YM, Pickup S, Richmond A, Ross BD, Vilgelm AE, Yankeelov TE, Zhou R. Tomography. 2020 Sep;6(3):273-287. doi: 10.18383/j.tom.2020.00023.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442091/

We have created an image processing pipeline for high-throughput, reduced-bias segmentation of multiparametric tumor MRI data and radiomics analysis, to better our understanding of preclinical imaging and the insights it provides when studying new cancer therapies.

Link to our new paper

As part of our co-clinical trial studying immunotherapy and radiotherapy in sarcomas, we are using micro-CT of the lungs to detect and measure metastases as a metric of disease progression. In this study, we have addressed the impact of respiratory gating during micro-CT acquisition on improving lung tumor detection and volume quantitation.

S. J. Blocker,M. D. Holbrook,Y. M. Mowery,D. C. Sullivan,C. T. Badea, The impact of respiratory gating on improving volume measurement of murine lung tumors in micro-CT imaging, https://doi.org/10.1371/journal.pone.0225019