2023
MAR
Our lab’s first research paper spreaheaded by Mu-En was accepted by the Journal of Clinical Investigation. In this study, we uncover an RB/E2F/ACSL4 molecular axis that governs ferroptosis and highlight the therapeutic potential of ferroptosis induction in the treatment of RB1 loss-driven prostate tumor growth and metastasis, and perhaps other RB1-deficient malignancies.
2022
NOV
Ming was invited to present at the 2022 Society for Basic Urologic Research (SBUR) Annual Meeting on Nov 12th. The theme of the meeting was “Complex Cells, Systems, and Regulatory Pathways in Urologic Biology”. The title of his talk was “Engineering Large Chromosomal Deletions in Mice to Advance Precision Oncology for Prostate Cancer”.
OCT
Zoe was awarded a Duke University School of Medicine Office of Biomedical and Graduate Education (OBGE) and Precision Genomics Collaboratory (PGC) Pilot Grant. A news report is here. Congratulations, Zoe!
OCT
Ming receives the Duke Pathology Early Career Research Achievement Award.
OCT
Ming was invited to give a virtual talk in the Department of Cell and Cancer Biology at the University of Toledo. The title of his talk was “Targeting Ferroptosis in RB1-Deficient Lethal Prostate Cancer”.
SEP
Zoe and Jinjin are among four Pathology PhD students named Office of Biomedical Graduate Education (OBGE) Student Peer Mentors 2022-23 in the Duke School of Medicine’s OBGE program. Read more here. Congratulations, Zoe and Jinjin!
SEP
Check out this amazing video by Duke Pathology Residency Program, highlighting why applicants choose our residency program, and what about the department and institution makes them want to stay.
AUG
Mu-En receives the DoD Prostate Cancer Research Program Early Investigator Award. A news report is here. Congratulations, Mu-En!
JUL
Alyssa Bawcom joined the lab as a research technician. Welcome, Alyssa!
JUL
Our 3rd NIH RO1 grant, which was reviewed in March, will begin in August. A news report is here. We are so grateful to NIH for supporting our research.
JUL
Dr. Eden Jacob from Toyo University (Japan) joined the lab as a postdoctoral fellow. Welcome, Eden!
MAY
The Chen Lab receives the 2022 Duke Cancer Institute (DCI) Spring Pilot Projects RFA Award. Thanks to DCI for supporting our research.
MAR
Drs. Chen and Davis receive Borden Scholars Award. A news report is here. We are so grateful to Dr. Ernest and Louise Borden for supporting our research.
MAR
Our RO1 grant titled “Developing A Novel Combinatorial Therapy for Lethal Neuroendocrine Prostate Cancer” received an impact score of 30 and was rated in the 9th percentile. It will be the third of the Chen Lab’s RO1 grants that will be funded by NIH this July. Big thank you to reviewers, NIH staff, collaborators, and lab members.
MAR
Our two new NIH RO1 grants, which were reviewed last Fall, will begin in this month and next month, respectively. A news report is here. We are so grateful to NIH for supporting our research.
JAN
We said goodbye to Jiaqi who went back to China continuing his role as a Urologist. Good luck to Jiaqi!
JAN
Congratulations to Jinjin who passed her preliminary exam! She is now officially a PhD candidate.
JAN
Huarui Zhou, CMB PhD Program Student, started his rotation in our lab. Welcome, Huarui!
JAN
Ming joined the Editorial Board of Acta Materia Medica (AMM). AMM is a newly launched international open access and peer review journal, providing rapid publication of the latest findings, approaches, and viewpoints related to all related areas of pharmacy and pharmaceutical sciences.
2021
OCT
Our RO1 grant titled “Targeting Ferroptosis in Lethal RB1 Deficient Prostate Cancer” received an impact score of 20 and was rated in the 2nd percentile. It will be the second of the Chen Lab’s RO1 grants that will be funded by NIH next Spring. Big thank you to reviewers, NIH staff, collaborators, and lab members.
OCT
Our resubmitted RO1 grant titled “Engineering Large Chromosomal Deletions in Mice to Advance Precision Oncology” received an impact score of 20 and was rated in the 4th percentile. It will be the first of the Chen Lab’s RO1 grants that will be funded by NIH next Spring. Big thank you to reviewers, NIH staff, collaborators, and lab members.
AUG
Lucy Driver, Pathology PhD Program Student, started her rotation in our lab. Welcome, Lucy!
JUN
We said goodbye to Blake who joined uniQure Inc. as an Associate Scientist III. Good luck to Blake!
MAY
Dr. Meredith Davis from the University of Newcastle (UK) joined the lab as a postdoctoral fellow. Welcome, Meredith!
APR
Congratulations to Zoe who passed her preliminary exam! She is now officially a PhD candidate.
FEB
Fernando Souza, Cell and Molecular Biology (CMB) PhD Program Student, started his third rotation in our lab. Welcome, Fernando!
2020
DEC
The Chen Lab receives a pilot grant from the Mike Slive Foundation for Prostate Cancer Research. Thank you so much to the Mike Slive Foundation for this generous award!
DEC
Zoe was awarded the Bass Instructor of Record Fellowship from the Duke Graduate School. Congratulations!
NOV
The Chen Lab receives the 2020 Duke Cancer Institute (DCI) Fall Pilot Projects RFA Award. Thanks to DCI for supporting our research.
FEB
The Chen Lab receives the DoD Prostate Cancer Research Program Idea Development Award. We are very grateful to the DoD for supporting our research.
2019
DEC
Jinjin joined the lab as a PhD student in the Pathology Graduate Program.
NOV
Jinjin Wu, Pathology PhD Program Student, started her second rotation in our lab. Welcome, Jinjin!
OCT
Dr. Blake Zhang from the University of Sydney joined the lab as a postdoctoral fellow. Welcome, Blake!
OCT
We said goodbye to Yubin who went back to China continuing his role as an Associate Chief Physician. Good luck to Yubin!
OCT
Our paper reviewing the expanded role of fatty acid metabolism in cancer was accepted by the Precision Clinical Medicine.
SEP
Amelia Schirmer, Pathology PhD Program Student, started her first rotation in our lab. Welcome, Amelia!
AUG
Check out this awesome video by Duke Pathology PhD program, featuring our stellar faculty and students!
JUL
Yueran (Joyce) Yu from the St. John’s University joined the lab as a summer intern. Welcome, Joyce!
JUN
Dr. Mu-En Wang from the National Taiwan University joined the lab as a postdoctoral fellow. Welcome, Mu-En!
MAY
Yu-ru and Ming’s paper studying WWP1 mediating non-degradative K27-linked PTEN poly-ubiquitination and I3C, a compound found in broccoli, reactivating PTEN tumor suppressor through inhibition of a MYC-WWP1 pathway was published by Science. Here are comments and news.
MAY
We are starting to build the Chen Lab’s website. Thanks everyone for your support and contribution!
APR
We said goodbye to Fengqi who went back to China for his PhD defense. Good luck to Fengqi!
APR
Zoe Loh, Pathology PhD Program Student, started her rotation in our lab. Welcome, Zoe!
FEB
Dr. Jiaqi Chen from Xi’an Jiaotong University joined the lab as a visiting scholar. Welcome, Jiaqi!
2018
DEC
Fengqi Yan from the Fourth Military Medical University joined the lab as a visiting scholar. Welcome, Fengqi!
NOV
Ming joined the Editorial Board of Cancer Medicine. Cancer Medicine is a peer-reviewed, interdisciplinary journal, providing rapid publication of cutting-edge research from global biomedical researchers across the cancer sciences.
OCT
Our paper studying the etiology of broad-scale heterozygous chromosome deletions in cancer was accepted by the Journal of Clinical Investigation.
OCT
Dr. Yubin Wang from Shanxi Provincial People’s Hospital joined the lab as a visiting scholar. Meanwhile, Ms. Yi Lu joined the lab as a research associate/lab manager. Welcome you both!
SEP
The Chen Lab opened at Duke South, Davison Bldg, Rm 304M.