Further information regarding the new standardized system of kinesin nomenclature (Lawrence et al., 2004) is shown below. Original protein names are retained but new names have been given to the kinesin groups or families. New and former names of the kinesin families with examples of the proteins they include are shown in the table below.
Archived Web Discussion Problems with Previous Nomenclature Systems
Table 1. Standardized names for each kinesin family (from the JCB manuscript).
| Standardized
Name |
Example
Sequences a |
Other Names for this Group of Sequencesb |
|||
| Endow et al. c | HirokawaIdIII |
Lawrence et al. e |
Other NamesI |
||
| Kinesin-1 | KHC (J05258)
KIF5A (AF067179) KHC (L47106) K7 (U41289) |
KHC | N-I | Kinesin-I | Conventional |
| Kinesin-2 | KRP85 (L16993)
KRP95 (U00996) KIF3A (D12645) KIF3B (D26077) FLA10 (L33697) |
KRP85/95 | N-IV | Kinesin-II | Heterotrimeric |
| Kinesin-3 | KIF1A (D29951)
UNC104 (M58582) KIN (L07879) Unc104 (AF245277) |
Unc-104/Kif1 | N-III | Unc104 | Monomeric |
| Kinesin-4 | KIF4 (D12646)
CHRKIN (U18309) XKLP1 (X82012) F11C1.80 (AB061676) AY224568 (AY224568) K8 (U69985) |
Chromokinesin/Kif4 | N-V | Chromokinesin (upper clade) | |
| Kinesin-5 | KIF11 (AB001427)
EG5 (X54002) BIMC (M32075) KRP125 (AC005896) |
BimC | N-II | BIMC | Eg5
Bipolar Tetrameric |
| Kinesin-6 | MKLP1 (X67155)
KIF20A (NM_009004) K12 (AY484465) |
MKLP1 | N-VI | MKLP
(lower clade) |
Cho1 |
| Kinesin-7 | CENP-E (Z15005)
KIF10 (AB001426) KIP2p (Z11963) AB028470 (AB028470) |
CENP-E
|
N-VII | CENP-E | |
| Kinesin-8 | KIF19A (AB054026)
KIP3p (Z72739) T9C5.240 (NM_114825) |
Kip3 | N-IIX | Kip3 | |
| Kinesin-9 | KIF9 (AJ132889)
KLP1 (X78589) |
MKLP
(middle clade) |
|||
| Kinesin-10 | Nod (M36195)f
KID (AB017430) KIF22(NM_145588) T1E22.130 (NM_120315) |
||||
| Kinesin-11 | VAB-8 (NM_073662)
KIF26A (XM_138275) SMY1p (M69021)f |
Divergent
Kinesin-I |
|||
| Kinesin-12 | KIF15 (AJ560623)
Xklp2 (X94082) PaKRP1 (NM_117492) 3g23670 (NM_113271) JGI_3356g |
MKLP
(upper clade) |
|||
| Kinesin-13
|
MCAK (U11790)
KIF2 (D12644) 3g16060 (NM_112476) DSK1 (U51680) |
MmKif2,
MCAK/Kif2 |
M | I-Type | KinI |
| Kinesin-14 | NCD (X52814)
KIFC1 (D49544) KAR3p (M31719) KATA (D11371) KCBP (L40358) |
C-Terminal Motor | C | C-Type | |
| Orphan Kinesinsh |
|
Orphans | Orphans | Ungrouped | |
a Sequences are listed by common name followed by their GenBank ID in parentheses and are color-coded by kingdom: protist sequences are purple, plant sequences are green, animal sequences are red, and those from fungi are blue.
b A list of kinesin sequences and their respective family classification (if known) is actively maintained and exists online at http://www.proweb.org/kinesin//MotorSeqTable.html.
c Dagenbach and Endow, 2004; Goodson et al., 1994; Kim and Endow, 2000; Moore and Endow, 1996
d Hirokawa, 1998
e Lawrence et al., 2002
f Drosophila melanogaster Nod and Saccharomyces cerevisiae SMY1p do not always group with their respective families. The placement of these two sequences is difficult to attain without carrying out in-depth, careful phylogenetic analyses, and their family placement should be considered tenuous.
g Chlamydomonas reinhardtii sequence from the DOE Joint Genome Institute (http://www.jgi.doe.gov/genomes/). JGI_3356 is a locus on scaffold 135 at positions 184041-190631.
h Goldstein 1993
