PubMed link for Dr. Holley


Marayati BF, Thompson MG, Holley CL, Horner SM, Meyer KD. Programmable protein expression using a genetically encoded m(6)A sensor. Nat Biotechnol. 2024 Jan 2;. doi: 10.1038/s41587-023-01978-3. [Epub ahead of print] PubMed PMID: 38168988.

Zhou KI, Pecot CV, Holley CL. 2′-O-Methylation (Nm) in RNA: Progress, Challenges, and Future Directions. RNA. 2024 Mar 26;. doi: 10.1261/rna.079970.124. [Epub ahead of print] PubMed PMID: 38531653.


Elliott BA, Wu J-H, Zhang L, Yin X, Davis JK, Wu P-C, Freedman NJ*, Holley CL*. Therapeutic Targeting of Rpl13a-Small Nucleolar RNAs Mitigates Atherosclerosis in Apoe-/-Mice. Abstract # 18861 (Rapid Fire Oral Session; “Top Abstract”), American Heart Association Scientific Sessions 2023. 6 Nov 2023. Circulation. 2023;148:A18861.

Dorgham MG, Elliott BA, Holley CL, Mansfield KD. m6A regulates breast cancer proliferation and migration through stage-dependent changes in Epithelial to Mesenchymal Transition gene expression. Front Oncol. 2023;13:1268977. doi: 10.3389/fonc.2023.1268977. eCollection 2023. PubMed PMID: 38023205; PubMed Central PMCID: PMC10661887.

Truby LK, Kwee LC, Bowles DE, Casalinova S, Ilkayeva O, Muehlbauer MJ, Huebner JL, Holley CL, DeVore AD, Patel CB, Kang L, Pla MM, Gross R, McGarrah RW, Schroder JN, Milano CA, Shah SH. Metabolomic profiling during ex situ normothermic perfusion before heart transplantation defines patterns of substrate utilization and correlates with markers of allograft injury. J Heart Lung Transplant. 2023 Dec 7;. doi: 10.1016/j.healun.2023.12.002. [Epub ahead of print] PubMed PMID: 38065238.

Kwee LC, Truby LK, Page S, Bowles DE, Milano CA, Ilkayeva O, Newgard CB, Felker GM, Bristow M, Holley CL, McGarrah RW, Shah SH. Integrative Omics In Failing Myocardium Highlights Metabolic Substrate Utilization Defects In Human Heart Failure. Abstract (2023-SS-A-16786-AHA), American Heart Association Scientific Sessions 2023. Nov 2023. Circulation. 2023;148:A16786.


Zhu Y, Holley CL, Carmichael GG. Transcriptome-Wide Identification of 2′-O-Methylation Sites with RibOxi-Seq. Methods Mol Biol. 2022; 2404:393-407. doi: 10.1007/978-1-0716-1851-6_22. PubMed PMID: 34694622.

Zhu H, Yin X, Holley CL, Meyer KD. Improved Methods for Deamination-Based m6A Detection. Front Cell Dev Biol. 2022;10:888279. doi: 10.3389/fcell.2022.888279. eCollection 2022. PubMed PMID: 35573664; PubMed Central PMCID: PMC9092492.

Choi SH, Flamand MN, Liu B, Zhu H, Hu M, Wang M, Sewell J, Holley CL, Al-Hashimi HM, Meyer KD. RBM45 is an m(6)A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs. Cell Rep. 2022 Aug 30;40(9):111293. doi: 10.1016/j.celrep.2022.111293. PubMed PMID: 36044854; PubMed Central PMCID: PMC9472474.

Truby LK, Casalinova S, Patel CB, Agarwal R, Holley CL, Mentz RJ, Milano C, Bryner B, Schroder JN, Devore AD. Donation After Circulatory Death in Heart Transplantation: History, Outcomes, Clinical Challenges, and Opportunities to Expand the Donor Pool. J Card Fail. 2022 Sep;28(9):1456-1463. doi: 10.1016/j.cardfail.2022.03.353. Epub 2022 Apr 18. Review. PubMed PMID: 35447338.

Coniglio AC, Kittipibul V, Pelligra R, Richardson ES, Holley CL, Fudim M. One Small Step for a Patient, One Giant Leap for Orthostatic Hypotension. Cureus. 2022 Nov;14(11):e31612. doi: 10.7759/cureus.31612. eCollection 2022 Nov. PubMed PMID: 36540476; PubMed Central PMCID: PMC9759206.


Elliott BA, Holley CL. Assessing 2′-O-Methylation of mRNA Using Quantitative PCR. Methods Mol Biol. 2021; 2298:171-184. doi: 10.1007/978-1-0716-1374-0_11. PubMed PMID: 34085245; PubMed Central PMCID: PMC8369392.

Truby LK, Kwee LC, Agarwal R, Grass E, DeVore AD, Patel CB, Chen D, Schroder JN, Bowles D, Milano CA, Shah SH*, Holley CL*. Proteomic profiling identifies CLEC4C expression as a novel biomarker of primary graft dysfunction after heart transplantation. J Heart Lung Transplant. 2021 Dec;40(12):1589-1598. doi: 10.1016/j.healun.2021.07.024. Epub 2021 Aug 11. PubMed PMID: 34511330; PubMed Central PMCID: PMC8670564.

Martinez Campos C, Tsai K, Courtney DG, Bogerd HP, Holley CL, Cullen BR. Mapping of pseudouridine residues on viral and cellular transcripts using a novel antibody-based technique. RNA. 2021 Aug 10;. doi: 10.1261/rna.078940.121. [Epub ahead of print] PubMed PMID: 34376564.


Abou Assi H, Rangadurai AK, Shi H, Liu B, Clay MC, Erharter K, Kreutz C, Holley CL*, Al-Hashimi HM*. 2′-O-Methylation can increase the abundance and lifetime of alternative RNA conformational states. Nucleic Acids Res. 2020 Oct 26:gkaa928. doi: 10.1093/nar/gkaa928. Online ahead of print. PMID: 33104789.

[preprint] Chao YL, Zhu Y, Wiedner HJ, Tsai Y-H, Wilkinson L, Porrello A, Van Swearingen AED, Carey LA, Giudice J, Holley CL, Pecot CV. Snord67 promotes lymph node metastasis and regulates U6-mediated alternative splicing in breast cancer. bioRxiv. 29 August 2020, 10.1101/2020.08.28.272617.

Abdulrahim J, Kwee LC, Alenezi F, Sun A, Baras A, Ajayi T, Henao R, Holley C, McGarrah R, Daubert J, Truby L, Vemulapalli S, Wang A, Khouri M, Shah S. Identification of Undetected Monogenic Cardiovascular Disorders. JACC. 2020 Jul 15.

Das S, Shah R, Dimmeler S, Freedman JE, Holley C, Lee J-M, Moore K, Musunuru K, Wang D-Z, Xiao J, Yin KJ. AHA Scientific Statement on Non-coding RNAs in Cardiovascular Disease: Current knowledge, tools and technologies for investigation, and future directions. Circ Genom Precis Med. 2020;13:e000062.

Gokhale NS, McIntyre ABR, Mattocks MD, Holley CL, Lazear HM, Mason CE, Horner SM. Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection. Mol Cell. 2020 Feb 6;77(3):542-555.e8. doi: 10.1016/j.molcel.2019.11.007. Epub 2019 Dec 3. PubMed PMID: 31810760; PubMed Central PMCID: PMC7007864.


Abdulrahim JW, Kwee LC, Alenezi F, Baras A, Ajayi T, Holley CL, McGarrah RW, Daubert JP, Truby LK, Vemulapalli S, Wang S, Shah SH. Whole Exome Sequencing in a Cardiovascular Cohort Identifies Previously Undiagnosed Monogenic Cardiovascular Diseases. 11 Nov 2019. Circulation. 2019;140:A11932.

Page S, Kwee L, Kraus W, White P, Devore A, Mentz R, Bristow M, Milano C, Bowles D, Ilkayeva O, Felker GM, Christopher B, Holley C, McGarrah R, Shah S. Integrated Omics Analysis of Diabetic Heart Failure in Human Myocardium. Circ Res. 2019 Oct 16;125(Suppl_1):A933-.

Lerman JB, Giamberardino SN, McNulty SE, Kraus WE, Holley CL, Hernandez AF, Shah SH, McGarrah RW. Abstract 452: A Unique Acylcarnitine Profile is Independently Associated with Diabetic Heart Failure and Associates with Adverse Clinical Outcomes: Insights from the FIGHT Trial. Circ Res 2019 Oct 16;125:.

Song W, Chen Q, Holley C, Patel C, Yang Q, Wang L, Hanshew WE, Schroder J, Milano C, Rogers J, Chen DF. Impact of donor specific HLA antibodies on survival of heart transplants. Human Immunology. 2019 Sep 1;80:146.

Courtney DG, Tsai K, Bogerd HP, Kennedy EM, Law BA, Emery A, Swanstrom R, Holley CL, Cullen BR. Epitranscriptomic Addition of m5C to HIV-1 Transcripts Regulates Viral Gene Expression. Cell Host Microbe. 2019 Aug 14;26(2):217-227.e6. doi: 10.1016/j.chom.2019.07.005. PubMed PMID: 31415754; PubMed Central PMCID: PMC6714563.

Elliot BA*, Ho HT*, Ranganathan SV, Vangaveti S, Ilkayeva O, Abou Assi H, Choi AK, Agris PF, Holley CL. Modification of messenger RNA by 2’-O-methylation regulates gene expression in vivo. Nat Comm. 2019 Jul 10:3401.

Patel CB, Holley CL. Cardiac Allograft Vasculopathy: A Formidable Foe. JACC. 2019 July 9; 74(1).

Courtney DG, Chalem A, Bogerd HP, Law BA, Kennedy EM, Holley CL, Cullen BR. Extensive Epitranscriptomic Methylation of A and C Residues on Murine Leukemia Virus Transcripts Enhances Viral Gene Expression. MBio. 2019 Jun 11;10(3). doi: 10.1128/mBio.01209-19. PubMed PMID: 31186331; PubMed Central PMCID: PMC6561033.

Holley C, Elliot B, Ho H-T. Modification of mRNA by snoRNA-guided 2′-O-methylation. The FASEB Journal 2019;33:220.2-220.2.


Rimer JM, Lee J, Holley CL, Crowder RJ, Chen DL, Hanson PI, Ory DS, Schaffer JE. Long-range function of secreted small nucleolar RNAs that direct 2′-O-methylation. J Biol Chem. 2018 Aug 24;293(34):13284-13296. doi: 10.1074/jbc.RA118.003410. Epub 2018 Jul 6. PubMed PMID: 29980600; PubMed Central PMCID: PMC6109910.

Fry NJ, Law BA, Ilkayeva OR, Carraway KR, Holley CL, Mansfield KD. N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression. Oncotarget. 2018 Jul 27;9(58):31231-31243. doi: 10.18632/oncotarget.25782. eCollection 2018 Jul 27. PubMed PMID: 30131850; PubMed Central PMCID: PMC6101291.


Fry NJ, Law BA, Ilkayeva OR, Holley CL, Mansfield KD. N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs. RNA. 2017 Sep;23(9):1444-1455. doi: 10.1261/rna.061044.117. Epub 2017 Jun 13. PubMed PMID: 28611253; PubMed Central PMCID: PMC5558913.

McCommis KS, Hodges WT, Brunt EM, Nalbantoglu I, McDonald WG, Holley C, Fujiwara H, Schaffer JE, Colca JR, Finck BN. Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis. Hepatology. 2017 May;65(5):1543-1556. doi: 10.1002/hep.29025. Epub 2017 Mar 30. PubMed PMID: 28027586; PubMed Central PMCID: PMC5397348.

Holley CL. The Challenges of Bedside-to-Bench Research in Pediatric Cardiology. Journal of Cardiac Failure. 2017 Jan;23(1):81-82. doi: 10.1016/j.cardfail.2016.09.021. Epub 2016 Sep 30. PubMed PMID: 27697503.


Lee J, Harris AN, Holley CL, Mahadevan J, Pyles KD, Lavagnino Z, Scherrer DE, Fujiwara H, Sidhu R, Zhang J, Huang SC, Piston DW, Remedi MS, Urano F, Ory DS, Schaffer JE. Rpl13a small nucleolar RNAs regulate systemic glucose metabolism. J Clin Invest. 2016 Dec 1;126(12):4616-4625. doi: 10.1172/JCI88069. Epub 2016 Nov 7. PubMed PMID: 27820699; PubMed Central PMCID: PMC5127695.

Gokhale NS, McIntyre AB, McFadden MJ, Roder AE, Kennedy EM, Gandara JA, Hopcraft SE, Quicke KM, Vazquez C, Willer J, Ilkayeva OR, Law BA, Holley CL, Garcia-Blanco MA, Evans MJ, Suthar MS, Bradrick SS, Mason CE, Horner SM. N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20. PubMed PMID: 27773535; PubMed Central PMCID: PMC5123813.

Byku M, Piotrowski R, Itoh A, Larue SJ, Vader JM, Holley CL, Ewald GA. Pre-Extra Corporeal Membrane Oxygenation (ECMO) MELD Score May Predict Meaningful Survival. The Journal of Heart and Lung Transplantation. 2016 Apr 1;35(4):S380-1.


Lindman BR, Breyley JG, Schilling JD, Vatterott AM, Zajarias A, Maniar HS, Damiano RJ Jr, Moon MR, Lawton JS, Gage BF, Sintek MA, Aquino A, Holley CL, Patel NM, Lawler C, Lasala JM, Novak E. Prognostic utility of novel biomarkers of cardiovascular stress in patients with aortic stenosis undergoing valve replacement. Heart. 2015 Sep;101(17):1382-8. doi: 10.1136/heartjnl-2015-307742. Epub 2015 Jun 2. PubMed PMID: 26037104; PubMed Central PMCID: PMC4598053.

Holley CL, Li MW, Scruggs BS, Matkovich SJ, Ory DS, Schaffer JE. Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase. J Biol Chem. 2015 May 1;290(18):11741-8. doi: 10.1074/jbc.M115.637413. Epub 2015 Mar 19. PubMed PMID: 25792744; PubMed Central PMCID: PMC4416874.


Michel CI*, Holley CL*, Scruggs BS*, Sidhu R, Brookheart RT, Listenberger LL, Behlke MA, Ory DS, Schaffer JE. Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress. Cell Metab. 2011 Jul 6;14(1):33-44. doi: 10.1016/j.cmet.2011.04.009. PubMed PMID: 21723502; PubMed Central PMCID: PMC3138526.

Holley CL, Topkara VK. An introduction to small non-coding RNAs: miRNA and snoRNA. Cardiovasc Drugs Ther. 2011 Apr;25(2):151-9. doi: 10.1007/s10557-011-6290-z. Review. PubMed PMID: 21573765.

Holley CL, Cooper JA. Macrovolt T-wave alternans and polymorphic ventricular tachycardia. Circulation. 2009 Aug 4;120(5):445-6. doi: 10.1161/CIRCULATIONAHA.109.861633. PubMed PMID: 19652119.

Olson MR, Holley CL, Gan EC, Colón-Ramos DA, Kaplan B, Kornbluth S. A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation. J Biol Chem. 2003 Nov 7;278(45):44758-68. Epub 2003 Aug 13. PubMed PMID: 12917412.

Olson MR*, Holley CL*, Yoo SJ, Huh JR, Hay BA, Kornbluth S. Reaper is regulated by IAP-mediated ubiquitination. J Biol Chem. 2003 Feb 7;278(6):4028-34. Epub 2002 Nov 20. PubMed PMID: 12446669.

Holley CL*, Olson MR*, Colón-Ramos DA, Kornbluth S. Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition. Nat Cell Biol. 2002 Jun;4(6):439-44. PubMed PMID: 12021770; PubMed Central PMCID: PMC2713440.

Noel LS, Champion BR, Holley CL, Simmons CJ, Morris DC, Payne JA, Lean JM, Chambers TJ, Zaman G, Lanyon LE, Suva LJ, Miller LR. RoBo-1, a novel member of the urokinase plasminogen activator receptor/CD59/Ly-6/snake toxin family selectively expressed in rat bone and growth plate cartilage. J Biol Chem. 1998 Feb 13;273(7):3878-83. PubMed PMID: 9461570.