The newly-formed RNA Biology Group in the Duke Cardiovascular Research Center (CVRC) is seeking a talented post-doctoral associate to work on the role of non-coding RNAs (ncRNA) in cardiovascular health and disease. In particular, the initial focus of the project will be on the novel emerging functions of snoRNAs (small nucleolar RNAs) in cardiac biology. This group is led by Dr. Christopher Holley, MD, PhD, whose own work has led to a new appreciation of snoRNA for their role in the generation of reactive oxygen species and oxidative stress. Work in the RNA Biology group will include innovative use of RNA-sequencing methods to study this under-appreciated class of RNA, so prior experience with RNA-seq is a plus, but not required. Other methods in the lab include classical biochemical methods for subcellular fractionation, cell culture/transfection, isolation of primary cardiac cells from animals, transgenic mice, and analysis of human samples.
