Publications/Presentations

Publications

2022

• JR Cranfill, DM Tuccero, S Watkins, SK Murphy, ED Levin, JT Mitchell, & AN Tran. (2022). CIPHERS: Effects of male marijuana use on sperm health and potential risks to future children. Science Talks, 100047, ISSN 2772-5693, https://doi.org/10.1016/j.sctalk.2022.100047.

2021

• Schrott R, SK Murphy, JL Modliszewski, DE King, Hill B, N Itchon-Ramos, D Raburn, T Price, ED Levin, R Vandrey, DL Corcoran, SH Collins & JT Mitchell. (2021). Refraining from use diminishes cannabis-associated epigenetic changes in human sperm. Environmental Epigenetics, 7(1). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455898/
• Slotkin A, ED Levin, FJ Seidler. (2021). Paternal Cannabis Exposure Prior to Mating, but Not D9-Tetrahydrocannabinol, Elicits Deficits in Dopaminergic Synaptic Activity in the Offspring. Toxicological Sciences, 184(2). https://academic.oup.com/toxsci/article/184/2/252/6378255

2020

• Holloway ZR, Hawkey AB, Torres AK, Evans J, Pippen E, White H, Katragadda V, Kenou B, Wells C, Murphy SK, Rezvani AH. (2020). Paternal Cannabis Extract Exposure in Rats: Preconception Timing Effects on Neurodevelopmental Behavior in Offspring. NeuroToxicology, 81, 180-188. Oct 19. https://pubmed.ncbi.nlm.nih.gov/33091435/
• Schrott R, M Rajavel, K Acharya, Z Huang, C Acharya, A Hawkey, E Pippen, HK Lyerly, ED Levin & SK Murphy. (2020). Sperm DNA methylation altered by THC and nicotine: Vulnerability of neurodevelopmental genes with bivalent chromatin. Scientific Reports, 10(16022). https://pubmed.ncbi.nlm.nih.gov/32994467/
• Acharya KS, R Schrott, C Grenier, Z Huang, Z Holloway, A Hawkey, ED Levin & SK Murphy. (2020). Epigenetic alterations in cytochrome P450 oxidoreductase (Por) in sperm of rats exposed to tetrahydrocannabinol (THC). Scientific Reports, 10(12251). https://doi.org/10.1038/s41598-020-69204-7
• Schrott R and SK Murphy. (2020). Cannabis use and the sperm epigenome: a budding concern?. Environmental Epigenetics, 6(1). https://doi.org/10.1093/eep/dvaa002
• Holloway Z, AB Hawkey, E Pippin, H White, C Wells, B Kenou, AH Rezvani, SK Murphy, ED Levin. (2020). Paternal Factors in Neurodevelopmental Toxicology: THC Exposure of Male Rats Causes Long-lasting Neurobehavioral Effects in Their Offspring. NeuroToxicology, 78, 57-63.  https://doi.org/10.1016/j.neuro.2020.01.009
• Slotkin TA, S Skavicus, ED Levin & FJ Seidler. (2020). Paternal Delta-9-Tetrahydrocannabinol Exposure Prior to Mating, Elicits Deficits in Cholinergic Synaptic Function in the Offspring. Toxicological Sciences. https://doi.org/10.1093/toxsci/kfaa004

2019

• Schrott R, K Acharya, N Itchon-Ramos, AB Hawkey, E Pippen, JT Mitchell, SH. Kollins, ED Levin & SK Murphy. (2019). Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm. Epigenetics, DOI: https://doi.org/10.1080/15592294.2019.1656158
• Levin ED, AB Hawkey, BJ Hall, M Cauley, S Slade, E Yazdani E, … & SK Murphy. (2019). Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring. Neurotoxicology and Teratology. https://doi.org/10.1016/j.ntt.2019.04.003

2018

• Murphy SK, N Itchon-Ramos, Z Visco, Z Huang, C Grenier, R Schrott, … & DL Corcoran. (2018). Cannabinoid exposure and altered DNA methylation in rat and human sperm. Epigenetics, 13(12), 1208-1221. https://doi.org/10.1080/15592294.2018.1554521

Presentations/Posters

2020

• Schrott R et al. (February 20, 2020). DNA Methylation at Neurodevelopmentally Active Genes is Altered in Sperm by Exposure to THC & Nicotine: A Role for Bivalent Chromatin? North Carolina State University Center for Human Health and the Environment’s 4th Annual Symposium: Interactions Between Brain and the Environment. Raleigh, NC.

2019

• Murphy SK. (November 13-15, 2019). Paternal Cannabinoid Exposure Alters the Sperm Methylome. World Advanced Genetics Conference. Baltimore, MD.
• Levin ED, Z Holloway, A Hawkey, E Pippen, H White, B Kenou, J Kim, E Greengrove, AH Rezvasni, and SK Murphy. (October 19-23, 2019). Chronic paternal THC in rats prior to mating causes long-lasting behavioral disruption in their offspring. Society for Neurosciences, Annual Meeting. Chicago, IL.
• Levin ED, AB Hawkey, BJ Hall, M Cauley, S Slade, E Yazdani, B Kenou, H White, C Wells, AH Rezvani, and SK Murphy. (July 15-18, 2019). Paternal factors in neurodevelopmental toxicology: THC exposure of male rats causes long-lasting neurobehavioral effects in their offspring. International Union for Toxicology, Annual Meeting. Honolulu HI.
• Holloway Z, AB Hawkey, E Pippen, H White, B Kenou, J Kim, E Greengrove, and ED Levin. (June 22-26, 2019). Chronic paternal THC in rats causes long-lasting behavioral disruption in the offspring. Developmental Neurotoxicology Society, Annual Meeting. San Diego, CA.
• Levin E. (April 17, 2019). THC Exposure in Male Rats: Long-term Behavioral Effects in Their Offspring. Altered States of Cannabis Regulation: Informing Policy with Science Symposium. Duke Institute of Brain Sciences, Center for Addiction and Behavioral Change. Duke University, Durham, NC.
• Murphy SK. (April 17, 2019). Cannabinoids & the Sperm Epigenome. Altered States of Cannabis Regulation: Informing Policy with Science Symposium. Duke Institute of Brain Sciences, Center for Addiction and Behavioral Change. Duke University, Durham, NC.
• Acharya KS, R Schrott, ED Levin, and SK Murphy. (March 15, 2019). Epigenetic Alterations in Cytochrome P450 Oxidoreductase (Por) in Sperm Exposed to Tetrahydrocannabinol (THC). Society for Reproductive Investigation 2019 Meeting. Paris, France.
• Schrott R. (February 9, 2019). Cannabis use is associated with widespread changes in autism candidate gene DLGAP2 methylation in human sperm. At the Triangle Consortium on Reproductive Biology Meeting. National Institute of Environmental Health Sciences, Research Triangle Park, NC

2018

• Levin, ED, BJ Hall, M Cauley, C Wells, AH Rezvani, and SK Murphy. (November 3-7, 2018). Paternal THC exposure in rats and neurobehavioral effects in the offspring. Society for Neurosciences, Annual Meeting. San Diego, CA.
• Levin ED, AB Hawkey, BJ Hall, M Cauley, E Yazdani, B Kenoi, H White, C Wells, AH Rezvani, and SK Murphy. Paternal THC exposure in rats impacts neurobehavioral effects in offspring. (October 1-2, 2-18). US Developmental Origins of Health and Disease Society, Annual Meeting. Chapel Hill, NC.