• Coco Liu starts her rotation. Welcome! 07/24
• Zoe and Trieu’s First Person Interview by J. Cell Sci. is online. Congratulations! 07/24
• Zoe and Trieu’s paper about TMEM16F’s intracellular signaling role in angiogenesis was accepted by J. Cell Sci. Congratulations! 07/24
  
• J. Gen. Physiol. chose our niclosamide paper as the cover of their July issue. Many thanks to Dr. Criss Hartzell! 07/24
• Chris Hahn starts his hematology fellow research in the lab. Welcome! 07/24
• Our discovery of the midline thalamus in absence epilepsy is accepted in PNAS. 06/24
  
• Pengfei won the 2nd place of the best poster prize during the 1st Gateway Ion Channel Symposium. Congratulations! 06/24
• Pengfei’s mechanistic study of niclosamide effect on TMEM16A was published in J. Gen. Physiol. Congratulations! 05/24
• Ryan Chou joined the lab to conduct his undergraduate independent study. Welcome! 05/24
  
• Welcome exchange student Wenxuan Zhen from Zhejiang university! 03/24
• Pengfei won the American Society of Hematology postdoctoral fellowship. Congratulations! 01/24
• Aiza Akhtar joined the lab to conduct her undergraduate independent study. Welcome! 01/24
• Sophia Link starts her rotation in the lab. Welcome! 01/24

• Our first red blood cell manuscript got accepted by Blood. Congratulations Yang, Pengfei and other authors! See commentary. 11/2023
  
• Huanghe won the Duke SPARK Award. 11/2023
• Serena passed prelim. Official PhD candidate. Congratulations! 10/2023
• Gus won the best poster award in our department retreat. Congrats! 10/2023
• Luna Chen, a rising high school junior, starts her summer intern in the lab. Welcome! 07/24
  
• Serena received the American Hematology Society predoctoral fellowship. Congrats! 06/2023

• Zoe was selected into the Duke Scholars in Molecular Medicine (DSMM) Program. Congratulations! 07/22
  
• The work about TRPV4-TMEM16F functional coupling in trophoblast fusion published in eLife. Congrats Yang, Pengfei and Zoe! 07/22
  
• Yang won the best poster in GRC-Cell Fusion conference. Congrats! 07/22
  
• Yang will start his own lab soon. 1st faculty trained in this lab. Congrats Yang! 05/22
• Serena Wan joined the lab. Welcome! 05/22
• Yang won the best poster award during Biochemistry retreat. Congratulations! 04/22
• Gus received the prestigious NSF predoctoral fellowship. Congratulations! 04/22
• Ping’s paper on BK D434G channelopathy is published in PNAS. Congratulations! 03/22

2021

• • Pengfei received AHA postdoc fellowship. Congratulations! 12/21
    
  • Zoe passed her prelim. Congratulations! 12/21
    
  • Serena Wan rotated in the lab. Welcome. 09/21
    
  • Dr. Takafumi Kawai joined the lab as a visiting scholar. Welcome! 06/21
    
  • Gus joined the lab. Welcome! 04/21
  • Son successfully defended his thesis. Congratulations, Dr. Son Le! 03/21
  • Lydia Li rotated in the lab. Welcome! 03/21
  • Trieu successfully defended her thesis. Congratulations, Dr. Trieu Le! 02/21
  • Gus Lowry rotated in the lab. Welcome! 01/21

2020

• • Son identified the third calcium binding site in TMEM16A and demonstrated how calcium binding to this site remotely regulates TMEM16A gating.  This works has been accepted by Cell Reports. Congratulations! 12/20
  • Pengfei discovered the molecular mechanism of intracellular pH regulation of TMEM16 proteins. This works has been accepted by J. Gen. Physiol. Congratulations! 11/20
  • Trieu and her collaborators discovered that tannic acid and EGCG polyphenols are not TMEM16F inhibitors. This work is published in JBC. Congratulations! 08/20
  • Our collaboration with the Mikati lab and the Cui lab demonstrated the pathophysiology of a new BK channel de novo mutation. This work is published in Movement Disorders. 07/20
  • Yang collaborated with the Zhang lab and demonstrated the role of BBOX1 in triple-negative breast cancer. This work is published in Cancer Discov. 07/20
  • Ping received the the American Epilepsy Society postdoctoral fellowship to study a channelopathy in epilepsy and movement disorders. Congratulations! 06/20
  • Zoe joins our lab. Welcome! 03/20
  • Yang’s elegant work on TMEM16F scramblase-mediated trophoblast fusion was accepted in Sci. Adv. Congrats! 02/20
  • Zoe Shan starts her rotation in the lab. Welcome! 01/20

2019

• • Trieu Le received a prestigious American Heart Association Predoctoral Fellowship. Congrats! 12/19
  • Son received the BPS travel award to attend the coming Biophysical Society meeting. Congrats! 12/19
    
  • Uyen Pham and Siyao Wang started rotating in the lab. Welcome! 11/19
  • The Yang lab and the Mikati lab received DIBS Incubator Award. Cheers! 11/19
    
  • All lab members presented their findings in Biochemistry Retreat.10/19.
  • David Zhu started his rotation in the lab. Welcome! 09/19.
  • Dr. Yang Zhang received a travel award from the Layton Holladay Memorial Fund to attend SFN. Congrats! 08/19.
    
  • Son Le and coworkers discovered the structural basis of TMEM16A channel desensitization. Son not only verified PIP2 is the key factor for TMEM16A desensitization, identified a putative PIP2 binding site, but also discovered a modular design of the TMEM16A ion permeation pore, which consists of two relatively independent modules: the Ca2+ binding module is dedicated to Ca2+ activation and the regulatory module is responsible for PIP2 regulation. The work was published in Nat. Commun. Good job. Congrats! 08/2019.
    
  • Dr. Pengfei Liang joined the lab. Welcome! 07/2019
  • Trieu Le and coworkers discovered an activation gate for TMEM16 phospholipid scramblase that controls phospholipid transport. This gate seems to be conserved within the TMEM16 family. Amazingly, a single mutation at the gate can convert a TMEM16A chloride channel to a scramblase. The paper was published in Nat. Commun. Nice job, congrats! 04/19.
    
  • A collaborative work with Dr. Seok-Yong Lee on TRPM8 channel was published in Science. Son made critical contributions. Congrats! 03/19.
  • Dr. Yang Zhang invented a novel method to quantify cell fusion. The paper was published in Placenta. Congrats! 02/19
  • Trieu Le and Son Le discovered a new phospholipid scramblase Subdued. The paper was published in JBC. Congrats! 01/19

2018

• • Son Le received a prestigious 2-year American Heart Association Predoctoral Fellowship, Congrats! 08/18
  • A collaborative work with Dr. Seok-Yong Lee on TRPV2 channel was published in NSMB. Son made critical contributions. Congrats! 04/2018
  • Claudia Lee and Yudong Sun started rotating in our lab. Welcome! 01/18

2017

• • Yang gave a nice oral presentation during sfn. Congrats! 11/17
  • Son and Trieu passed their prelims. Congratulations! 10/17
  • Huanghe was awarded 2018 NIH Director’s New Innovator DP2 Award 08/17.
  • Yang presented his work at 2017 Neuroretreat 08/17.
  • Our first paper was published in Neuron. Congratulations, Yang and Zhushan! 08/17.
  • Yang was awarded the Burroughs Wellcome Fund Collaborative Research Travel Grant. Congrats! 08/17.
  • Welcome Joanna came back for another summer research 07/17.
  • Huanghe was funded by the International Essential Tremor Foundation 07/17. 

2016

• • Yang was awarded the Rockland Joy Cappel Young Investigator Award. Congrats! 04/16.
  • Our lab moved to Nanaline Duke 09/16.
  • Mike Young joined our lab for his first rotation. Welcome! 09/16. 
  • High schooler, Joanna Chu-Jian, joined the lab. Welcome! 07/16.
  • Welcome Dr. Zhushan Zhang who joined the lab 04/16.
  • Welcome Son and Trieu joined the lab 03/16. 
  • Welcome our rotation students Son Le and Trieu Le 01/16!
  • Welcome to the lab, Saikiran Gudla, our 1st undergrad!

2015

• • Welcome Dr. Yang Zhang to the Yang lab! 07/15
  • The Yang Laboratory officially opens 06/15.