This article reveals that adolescents with severe obesity exhibit distinct serum metabolomic and gut microbiome profiles – including elevated branched-chain amino acids, altered microbial composition, and age- and sex-specific metabolic adaptations – that differ from…
The lab of John Rawls at Duke University is happy and grateful to have received a new R21 grant to develop new tools to identify and study zebrafish enteroendocrine peptide hormones to define their cellular…
The labs of John Rawls and Michel Bagnat at Duke University are happy and grateful to have received a new collaborative NICHD R01 grant. Under this award, we will use zebrafish to define the transcriptional,…
The Rawls lab is happy to welcome Lauren Orr, a new Ph.D. student in Duke’s Cell and Molecular Biology Program.
Mechanisms underlying bacterial fitness in the intestine A central challenge in microbiome science is defining how individual bacterial species achieve ecological fitness in the gut and how strain-level variation shapes host physiology. Phocaeicola vulgatus (Pvu)…
Mechanisms of intestinal repair and inflammation The intestine must sustain barrier integrity and immune balance despite constant microbial and chemical stress; failure of these homeostatic mechanisms contributes to sepsis, inflammatory bowel disease, and related disorders.…
Dr. McCann, a senior research associate in the Rawls lab, was recognized with the Keystone Award for her professional initiative, positive attitude, and ability to foster inter-departmental collaboration. She has been integral to the success…
This article identifies intestinal enteroendocrine cell subtypes in zebrafish and provides the first systematic description of the peptide hormones they produce. Published in PLOS Biology.
