Ying Yin, Seok-Yong Lee. “Current View of Ligand and Lipid Recognition by the Menthol Receptor TRPM8.” Trends in Biochemical Sciences. 2020, June 9.  DOI:10.1016/j.tibs.2020.05.008


Yang Suo, Zilong Wang, Lejla Zubcevic, Allen L. Hsu, Qianru He, Mario J. Borgnia, Ru-Rong Ji, Seok-Yong Lee. “Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.” Neuron, 2019 December.  DOI: 10.1016/j.neuron.2019.11.023



Ying Yin, Mengyu Wu, Allen L. Hsu, William F. Borschel, Mario J. Borgnia, Gabriel C. Lander, Seok-Yong Lee. “Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.” Nat Commun, 2019 August. DOI: 10.1038/s41467-019-11733-5



Lejla Zubcevic, Seok-Yong Lee. “The role of π-helices in TRP channel gating.” Current Opinion in Structural Biology, 2019 August. DOI: 10.1016/



Lejla Zubcevic, Allan H. Hsu, Mario Borgnia,  Seok-Yong Lee. “Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.” eLife, 2019 May. DOI:10.7554/eLife.45779



Lejla Zubcevic, William Borschel, Allan H. Hsu, Mario Borgnia, Seok-Yong Lee. “Regulatory switch at the cytoplasmic interface controls TRPV channel gating.” eLife, 2019 May. DOI: 10.7554/eLife.47746


Ying Yin, Son C. Lee, Allen H. Hsu, Mario J. Borgnia, Huanghe Yang, Seok-Yong Lee. “Structural basis of cooling agent and lipid sensing by the cold activated TRPM8 channel.” Science,2019. First Release 07 Feb DOI:10.1126/science.aav9334


Lejla Zubcevic, Mark A. Herzik Jr, Mengyu Wu, William Borschel, Marscha Hirschi, AlbertSong, Gabriel C. Lander, Seok-Yong Lee. “Conformational ensemble of the human TRPV3 ion channel.” Nat Commun 2018 Nov 14 DOI: 10.1038/s41467-018-07117-w



Jiho Yoo, Mengyu Wu, Ying Yin, Mark A. Herzik Jr, Gabriel C. Lander, Seok-Yong Lee. “Cryo-EM structure of a Mitochondrial Calcium Uniporter.” Science 2018. First Release. 28 June DOI::10.1126/science.aar4056


Lejla Zubcevic, Son Le, Huanghe Yang, and Seok-Yong Lee. “Conformational plasticity in the selectivity filter of the TRPV2 ion channel.”
Nat Struc & Mol Biol 2018 Epub 2018 Apr 30. DOI:10.1038/s41594-018-0059-z


Ying Yin, Mengyu Wu, Lejla Zubcevic, William F. Borschel, Gabriel C. Lander, Seok-Yong Lee. “Structure of the cold- and menthol-sensing ion channel TRPM8.”
Science First Release 07 Dec DOI:10.1126/science.aan4325


Marscha Hirschi, Mark A. Herzik Jr., Jinhong Wie, Yang Suo, William F. Borschel, Dejian Ren, Gabriel C. Lander, and Seok-Yong Lee. “Cryo-EM structure of the lysosomal Ca2+ permeable channel TRPML3.”
Nature 2017. published online 11 Oct. DOI:10.1038/nature24055.



Lejla Zubcevic, Mark A Herzik Jr, Ben C Chung, Zhirui Liu, Gabriel C Lander, Seok-Yong Lee. “Cryo-electron microscopy structure of the TRPV2 ion channel.” Nat Struct & Mol Biol 2016, Jan18. DOI:10.1038/nsmb.3159.



Nicholas J. Wright, Seok-Yong Lee. “Structures of human ENT1 in complex with adenosine reuptake inhibitors.”
Nat Struct & Mol Biol June 2019. DOI:10.1038/s41594-019-0245-7


Marscha Hirschi, Zachary Johnson and Seok-Yong Lee. “
Visualizing multistep elevator-like transitions of a nucleoside transporter.” Nature 545. 66-70. April 2017.


Zachary Johnson and Seok-Yong Lee. “Liposome reconstitution and transport assay for recombinant transporters.” Method Enzymol 2015. DOI:10.1016/bs.mie.2014.11.048


Zachary Johnson, Jun-Ho Lee, Kiyoun Lee, Minhee Lee, Do-Yeon Kwon, Jiyong Hong and Seok-Yong Lee. “Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.” eLife 2014. DOI:10.7554/eLife.03604.


Zachary Johnson, Cheom-Gil Cheong and Seok-Yong Lee. “Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4Å.Nature 483. 489-493. March 2012.



Ellene H Mashalidis, Seok-Yong Lee. “Structures of Bacterial MraY and Human GPT Provide Insights Into Rational Antibiotic Design.” J Mol Biol. 2020, Mar 19. DOI:10.1016/j.jmb.2020.03.017


Ellene H. Mashalidis, Benjamin Kaeser, Yuma Terasawa, Akira Katsuyama, Do-Yeon Kwon, Kiyoun Lee, Jiyong Hong, Satoshi Ichikawa, Seok-Yong Lee. “Chemical logic of MraY inhibition by antibacterial nucleoside natural products.” Nat Commun 2019,  Jul 02. DOI:10.1038/s41467-019-10957-9




Alvin C. Y. Kuk, Aili Hao, Ziqiang Guan, Seok-Yong Lee. “Visualizing conformation transitions of Lipid II flippase MurJ.” Nat Commun 2019, Apr 15. DOI:10.1038/s41467-019-09658-0


Jiho Yoo, Ellene H. Mashalidis, Alvin C. Y. Kuk, Kazuki Yamamoto, Benjamin Kaeser, Satoshi Ichikawa, Seok-Yong Lee. “GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.”
Nat Struct & Mol Biol 2018. Published online 19 Feb DOI:10.1038/s41594-018-0031-y.

Alvin C. Y. Kuk, Ellene H. Mashalidis, Seok-Yong Lee. “Crystal structure of the MOP flippase MurJ in an inward-facing conformation.” Nat Struct & Mol Biol 2016. Published online 24 Dec DOI:10.1038/nsmb.3346.


Ben C. Chung, Ellene H. Mashalidis, Tetsuya Tanino, Mijung Kim, Akira Matsuda, Jiyong Hong, Satoshi Ichikawa, Seok-Yong Lee.”Structural insights into inhibition of lipid I production in bacterial cell wall synthesis.” Nature 2016. DOI:10.1038/nature17636.


Ben C. Chung, Jinshi Zhao, Robert A. Gillepsie, Do-Yeon Kwon, Ziqiang Guan, Jiyong Hong, Pei Zhou, and Seok-Yong Lee. “Crystal structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis.” Science 2013 Aug 30; 341(6149):1012-6. DOI:10.1126/science.123650.