Do Hoon Kwon, Feng Zhang, Brett A. McCray, Shasha Feng, Meha Kumar, Jeremy M. Sullivan, Wonpil Im, Charlotte J. Sumner, Seok-Yong Lee. “TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.” Nat. Commun. 2023 June. DOI: 10.1038/s41467-023-39345-0



Ying Yin, Feng Zhang, Shasha Feng, Kevin John Butay, Mario J. Borgnia, Wonpil Im, Seok-Yong Lee. “Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP2.” Science. 2022 October. DOI: 10.1126/science.add1268




Do Hoon Kwon, Feng Zhang, Justin G. Fedor, Yang Suo & Seok-Yong Lee. “Vanilloid-Dependent TRPV1 Opening Trajectory From CryoEM Ensemble Analysis.” Nat Commun. 2022 May. DOI:10.1038/s41467022-30602-2




Do Hoon Kwon, Feng Zhang, Yang Suo, Jonathan Bouvette, Mario J. Borgia, Seok-Yong Lee. “Heat-Dependent Opening Of TRPV1 in the Presence of Capsaicin.” Nat Struc & Mol Biol. 2021 July. DOI:10.1038/s41594-021-00616-3. Discussed in the 2021 Nobel Prize Medicine website (reference #29)



Yang Suo, Seok-Yong Lee. “Chapter Four – Sample Preparation of the Human TRPA1 Ion Channel for Cryo-Em Studies.” Meth in Enzymol. DOI:10.1016/bs.mie.2020.12.018


Ying Yin, Seok-Yong Lee. “Current View of Ligand and Lipid Recognition by the Menthol Receptor TRPM8.” Trends Biochem Sci. 2020 June.  DOI:10.1016/j.tibs.2020.05.008



Yang Suo, Zilong Wang, Lejla Zubcevic, Allen L. Hsu, Qianru He, Mario J. Borgnia, Ru-Rong Ji, Seok-Yong Lee. “Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.” Neuron, 2019 December. DOI:10.1016/j.neuron.2019.11.023



Ying Yin, Mengyu Wu, Allen L. Hsu, William F. Borschel, Mario J. Borgnia, Gabriel C. Lander, Seok-Yong Lee. “Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.” Nat Commun, 2019 August. DOI:10.1038/s41467-019-11733-5



Lejla Zubcevic, Seok-Yong Lee. “The role of π-helices in TRP channel gating.” Curr Opin in Struct Biol. 2019 August. DOI:10.1016/



Lejla Zubcevic, Allan H. Hsu, Mario Borgnia,  Seok-Yong Lee. “Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.” eLife, 2019 May. DOI:10.7554/eLife.45779



Lejla Zubcevic, William Borschel, Allan H. Hsu, Mario Borgnia, Seok-Yong Lee. “Regulatory switch at the cytoplasmic interface controls TRPV channel gating.” eLife, 2019 May. DOI:10.7554/eLife.47746


Ying Yin, Son C. Lee, Allen H. Hsu, Mario J. Borgnia, Huanghe Yang, Seok-Yong Lee. “Structural basis of cooling agent and lipid sensing by the cold activated TRPM8 channel.” Science, 2019. First Release 07 Feb DOI:10.1126/science.aav9334


Lejla Zubcevic, Mark A. Herzik Jr, Mengyu Wu, William Borschel, Marscha Hirschi, AlbertSong, Gabriel C. Lander, Seok-Yong Lee. “Conformational ensemble of the human TRPV3 ion channel.” Nat Commun. 2018 Nov. DOI:10.1038/s41467-018-07117-w



Jiho Yoo, Mengyu Wu, Ying Yin, Mark A. Herzik Jr, Gabriel C. Lander, Seok-Yong Lee. “Cryo-EM structure of a Mitochondrial Calcium Uniporter.” Science 2018. First Release. 28 June DOI:10.1126/science.aar4056



Lejla Zubcevic, Son Le, Huanghe Yang, and Seok-Yong Lee. “Conformational plasticity in the selectivity filter of the TRPV2 ion channel.” Nat Struc & Mol Biol.  2018. Epub 2018 Apr 30. DOI:10.1038/s41594-018-0059-z


Ying Yin, Mengyu Wu, Lejla Zubcevic, William F. Borschel, Gabriel C. Lander, Seok-Yong Lee. “Structure of the cold- and menthol-sensing ion channel TRPM8.”
Science. First Release 07 Dec DOI:10.1126/science.aan4325


Marscha Hirschi, Mark A. Herzik Jr., Jinhong Wie, Yang Suo, William F. Borschel, Dejian Ren, Gabriel C. Lander, and Seok-Yong Lee. “Cryo-EM structure of the lysosomal Ca2+ permeable channel TRPML3.”
Nature. 2017. published online 11 Oct. DOI:10.1038/nature24055.


Lejla Zubcevic, Mark A Herzik Jr, Ben C Chung, Zhirui Liu, Gabriel C Lander, Seok-Yong Lee. “Cryo-electron microscopy structure of the TRPV2 ion channel.”
Nat Struct & Mol Biol. 2016 Jan. DOI:10.1038/nsmb.3159.




Nicholas J. Wright, Feng Zhang, Yang Suo, Lingyang Kong, Ying Yin, Justin G. Fedor, Kedar Sharma, Mario J. Borgnia, Wonpil Im & Seok-Yong Lee. “Antiviral Drug Recognition and Elevator-Type Transport Motions of CNT3.” Nature Chemical Biology. 2024 Feb.



Yang Suo, Nicholas J. Wright, Hugo Guterres, Justin G. Fedor, Kevin John Butay, Mario J. Borgnia, Wonpil Im & Seok-Yong Lee. “Molecular Basis of Polyspecific Drug and Xenobiotic Recognition by OCT1 and OCT2.” Nat Struct & Mol Biol. 2023 June.


Nicholas J. Wright, Justin G. Fedor, Han Zhang, Pyeonghwa Jeong, Yang Suo, Jiho Yoo, Jiyong Hong, Wonpil Im & Seok-Yong Lee. “
Methotrexate recognition by the human reduced folate carrier SLC19A1.” Nature. 2022 Sept. DOI:10.1038/s41586-022-05168-0. Featured in Nature Reviews Cancer and Nature.



Nicholas J Wright, Seok-Yong Lee. “Recent Advances on the Inhibition of Human Solute Carriers: Therapeutic Implications and Mechanistic Insights.” Curr Opin Struct Biol. 2022 April. DOI:10.1016/



Nicholas J. Wright, Seok-Yong Lee. “Toward a Molecular Basis of Cellular Nucleoside Transport in Humans.” Chem Rev. 2020 Nov. DOI:10.1021/acs.chemrev.0c00644


Nicholas J. Wright, Seok-Yong Lee. “Structures of human ENT1 in complex with adenosine reuptake inhibitors.”
Nat Struct & Mol Biol. 2019 June. DOI:10.1038/s41594-019-0245-7


Marscha Hirschi, Zachary Johnson and Seok-Yong Lee. “
Visualizing multistep elevator-like transitions of a nucleoside transporter.” Nature 545. 66-70. 2017 April.


Zachary Johnson and Seok-Yong Lee. “Liposome reconstitution and transport assay for recombinant transporters.” Method Enzymol 2015. DOI:10.1016/bs.mie.2014.11.048


Zachary Johnson, Jun-Ho Lee, Kiyoun Lee, Minhee Lee, Do-Yeon Kwon, Jiyong Hong and Seok-Yong Lee. “Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.” eLife 2014. DOI:10.7554/eLife.03604.


Zachary Johnson, Cheom-Gil Cheong and Seok-Yong Lee. “Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4Å.Nature 483. 489-493. 2012 March.



Aili Hao, Yang Suo, Seok-Yong Lee. “Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae” Structure 2023 Dec 6:S0969-2126(23)00409-4. DOI: 10.1016/j.str.2023.11.007


Takeshi Nakaya, Miyuki Yabe, Ellene H. Mashalidis, Toyotaka Sato, Kazuki Yamamoto, Yuta Hikiji, Akira Katsuyama, Motoko Shinohara, Yusuke Minato, Satoshi Takahashi, Motohiro Horiuchi, Shin-ichi Yokota, Seok-Yong Lee & Satoshi Ichikawa. “Synthesis of Macrocyclic Nucleoside Antibacterials and Their Interactions With MraY.”  Nature Communications. 2022 December. DOI:10.1038/s41467-022-35227-z

Zhenning Ren, Abhishek Chhetri, Ziqiang Guan, Yang Suo, Kenichi Yokoyama & Seok-Yong Lee. “Structural basis for inhibition and regulation of a chitin synthase from Candida albicans.” Nature Structural & Molecular Biology. 2022 July. DOI:10.1038/s41594-022-00791-x


Alvin C Y Kuk, Aili Hao, Seok-Yong Lee. “Structure and Mechanism of the Lipid Flippase MurJ.” Annu Rev Biochem. 2022 Feb. DOI:10.1146/annurev-biochem-040320-105145.


Seung-Hwa Kwak, Won Young Lim, Aili Hao, Ellene H.Mashalidisb, Do-YeonKwon, Pyeonghwa Jeong, Mi Jung Kim, Seok-YongLee, JiyongHong. “Synthesis and Evaluation of Cyclopentane-Based Muraymycin Analogs Targeting MraY.” Eur J Med Chem 2021 Apr. DOI:10.1016/j.ejmech.2021.113272

Ellene H Mashalidis, Seok-Yong Lee. “Structures of Bacterial MraY and Human GPT Provide Insights Into Rational Antibiotic Design.” J Mol Biol. 2020 Mar. DOI:10.1016/j.jmb.2020.03.017


Ellene H. Mashalidis, Benjamin Kaeser, Yuma Terasawa, Akira Katsuyama, Do-Yeon Kwon, Kiyoun Lee, Jiyong Hong, Satoshi Ichikawa, Seok-Yong Lee. “Chemical logic of MraY inhibition by antibacterial nucleoside natural products.” Nat Commun 2019 Jul. DOI:10.1038/s41467-019-10957-9




Alvin C. Y. Kuk, Aili Hao, Ziqiang Guan, Seok-Yong Lee. “Visualizing conformation transitions of Lipid II flippase MurJ.” Nat Commun 2019 Apr. DOI:10.1038/s41467-019-09658-0


Jiho Yoo, Ellene H. Mashalidis, Alvin C. Y. Kuk, Kazuki Yamamoto, Benjamin Kaeser, Satoshi Ichikawa, Seok-Yong Lee. “GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.”
Nat Struct & Mol Biol.  2018. Published online 19 Feb DOI:10.1038/s41594-018-0031-y.

Alvin C. Y. Kuk, Ellene H. Mashalidis, Seok-Yong Lee. “Crystal structure of the MOP flippase MurJ in an inward-facing conformation.” Nat Struct & Mol Biol 2016. Published online 24 Dec. DOI:10.1038/nsmb.3346.


Ben C. Chung, Ellene H. Mashalidis, Tetsuya Tanino, Mijung Kim, Akira Matsuda, Jiyong Hong, Satoshi Ichikawa, Seok-Yong Lee.”Structural insights into inhibition of lipid I production in bacterial cell wall synthesis.” Nature 2016. DOI:10.1038/nature17636.


Ben C. Chung, Jinshi Zhao, Robert A. Gillepsie, Do-Yeon Kwon, Ziqiang Guan, Jiyong Hong, Pei Zhou, and Seok-Yong Lee. “Crystal structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis.” Science 2013 Aug 30; 341(6149):1012-6. DOI:10.1126/science.123650.