CALCIUM PERMEATION IN SOMATOSENSATION
Ying Yin, Cheon-Gyu Park, Shasha Feng, Ziqiang Guan, Hyuk-Joon Lee, Feng Zhang, Kedar Sharma, Mario J. Borgnia, Wonpil Im & Seok-Yong Lee. “Molecular basis of neurosteroid and anticonvulsant regulation of TRPM3.” Nat Struct Mol Biol 2025 Jan. DOI:10.1038/s41594-024-01463-8
Ying Yin, Cheon-Gyu Park, Feng Zhang, Justin G. Fedor, Shasha Feng, Yang Suo, Wonpil Im & Seok-Yong Lee. “Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.” Sci Adv 2024 Aug. DOI:10.1126/sciadv.adp2211
Sarah H Berth, Linh Vo, Do Hoon Kwon, Tiffany Grider, Yasmine S Damayanti, Gage Kosmanopoulos, Andrew Fox, Alexander R Lau, Patrice Carr, Jack K Donohue, Maya Hoke, Simone Thomas, Chafic Karim, Alex J Fay, Ethan Meltzer, Thomas O Crawford, Rachelle Gaudet, Michael E Shy, Ute A Hellmich, Seok-Yong Lee, Charlotte J Sumner & Brett A McCray. “Combined clinical, structural, and cellular studies discriminate pathogenic and benign TRPV4 variants.” Brain 2024 Jul. DOI:10.1093/brain/awae243
Do Hoon Kwon, Feng Zhang, Brett A. McCray, Shasha Feng, Meha Kumar, Jeremy M. Sullivan, Wonpil Im, Charlotte J. Sumner & Seok-Yong Lee. “TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.” Nat Commun 2023 Jun. DOI:10.1038/s41467-023-39345-0
Ying Yin, Feng Zhang, Shasha Feng, Kevin John Butay, Mario J. Borgnia, Wonpil Im & Seok-Yong Lee. “Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP2.” Science 2022 Oct. DOI:10.1126/science.add1268
Do Hoon Kwon, Feng Zhang, Justin G. Fedor, Yang Suo & Seok-Yong Lee. “Vanilloid-Dependent TRPV1 Opening Trajectory From CryoEM Ensemble Analysis.” Nat Commun 2022 May. DOI:10.1038/s41467022-30602-2
Do Hoon Kwon, Feng Zhang, Yang Suo, Jonathan Bouvette, Mario J. Borgia & Seok-Yong Lee. “Heat-Dependent Opening Of TRPV1 in the Presence of Capsaicin.” Nat Struct Mol Biol 2021 Jul. DOI:10.1038/s41594-021-00616-3. Discussed in the 2021 Nobel Prize Medicine website (reference #29)
Yang Suo & Seok-Yong Lee. “Chapter Four – Sample Preparation of the Human TRPA1 Ion Channel for Cryo-Em Studies.” Methods Enzymol 2021 Jan. DOI:10.1016/bs.mie.2020.12.018
Ying Yin & Seok-Yong Lee. “Current View of Ligand and Lipid Recognition by the Menthol Receptor TRPM8.” Trends Biochem Sci 2020 Jun. DOI:10.1016/j.tibs.2020.05.008
Yang Suo, Zilong Wang, Lejla Zubcevic, Allen L. Hsu, Qianru He, Mario J. Borgnia, Ru-Rong Ji & Seok-Yong Lee. “Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.” Neuron 2019 Dec. DOI:10.1016/j.neuron.2019.11.023
Ying Yin, Mengyu Wu, Allen L. Hsu, William F. Borschel, Mario J. Borgnia, Gabriel C. Lander & Seok-Yong Lee. “Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.” Nat Commun 2019 Aug. DOI:10.1038/s41467-019-11733-5
Lejla Zubcevic & Seok-Yong Lee. “The role of π-helices in TRP channel gating.” Curr Opin in Struct Biol 2019 Aug. DOI:10.1016/j.sbi.2019.06.011
Lejla Zubcevic, Allan H. Hsu, Mario Borgnia & Seok-Yong Lee. “Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.” eLife 2019 May. DOI:10.7554/eLife.45779
Lejla Zubcevic, William Borschel, Allan H. Hsu, Mario Borgnia & Seok-Yong Lee. “Regulatory switch at the cytoplasmic interface controls TRPV channel gating.” eLife 2019 May. DOI:10.7554/eLife.47746
Ying Yin, Son C. Lee, Allen H. Hsu, Mario J. Borgnia, Huanghe Yang & Seok-Yong Lee. “Structural basis of cooling agent and lipid sensing by the cold activated TRPM8 channel.” Science, 2019. First Release 07 Feb DOI:10.1126/science.aav9334
Lejla Zubcevic, Mark A. Herzik Jr, Mengyu Wu, William Borschel, Marscha Hirschi, AlbertSong, Gabriel C. Lander & Seok-Yong Lee. “Conformational ensemble of the human TRPV3 ion channel.” Nat Commun 2018 Nov. DOI:10.1038/s41467-018-07117-w
Jiho Yoo, Mengyu Wu, Ying Yin, Mark A. Herzik Jr, Gabriel C. Lander & Seok-Yong Lee. “Cryo-EM structure of a Mitochondrial Calcium Uniporter.” Science 2018. First Release. 28 June DOI:10.1126/science.aar4056
Lejla Zubcevic, Son Le, Huanghe Yang & Seok-Yong Lee. “Conformational plasticity in the selectivity filter of the TRPV2 ion channel.” Nat Struct Mol Biol 2018. Epub 2018 Apr 30. DOI:10.1038/s41594-018-0059-z
Ying Yin, Mengyu Wu, Lejla Zubcevic, William F. Borschel, Gabriel C. Lander & Seok-Yong Lee. “Structure of the cold- and menthol-sensing ion channel TRPM8.” Science 2017. First Release 07 Dec. DOI:10.1126/science.aan4325
Marscha Hirschi, Mark A. Herzik Jr., Jinhong Wie, Yang Suo, William F. Borschel, Dejian Ren, Gabriel C. Lander & Seok-Yong Lee. “Cryo-EM structure of the lysosomal Ca2+ permeable channel TRPML3.” Nature 2017. Published Online 11 Oct. DOI:10.1038/nature24055
Lejla Zubcevic, Mark A Herzik Jr, Ben C Chung, Zhirui Liu, Gabriel C Lander & Seok-Yong Lee. “Cryo-electron microscopy structure of the TRPV2 ion channel.” Nat Struct Mol Biol 2016 Jan. DOI:10.1038/nsmb.3159
DRUG & METABOLITE TRANSPORT
Nicholas J. Wright, Yutaka Matsuoka, Hyeri Park, Wei He, Caroline G. Webster, Kenta Furutani, Justin G. Fedor, Aidan McGinnis, Yiquan Zhao, Ouyang Chen, Sangsu Bang, Ping Fan, Ivan Spasojevic, Jiyong Hong, Ru-Rong Ji & Seok-Yong Lee. “Design of an equilibrative nucleoside transporter subtype 1 inhibitor for pain relief.” Nat Commun 2024 Dec. DOI:10.1038/s41467-024-54914-7
Nicholas J. Wright, Feng Zhang, Yang Suo, Lingyang Kong, Ying Yin, Justin G. Fedor, Kedar Sharma, Mario J. Borgnia, Wonpil Im & Seok-Yong Lee. “Antiviral Drug Recognition and Elevator-Type Transport Motions of CNT3.” Nat Chem Biol 2024 Feb. DOI:10.1038/s41589-024-01559-8
Yang Suo, Nicholas J. Wright, Hugo Guterres, Justin G. Fedor, Kevin John Butay, Mario J. Borgnia, Wonpil Im & Seok-Yong Lee. “Molecular Basis of Polyspecific Drug and Xenobiotic Recognition by OCT1 and OCT2.” Nat Struct Mol Biol 2023 Jun. DOI:10.1038/s41594-023-01017-4
Nicholas J. Wright, Justin G. Fedor, Han Zhang, Pyeonghwa Jeong, Yang Suo, Jiho Yoo, Jiyong Hong, Wonpil Im & Seok-Yong Lee. “Methotrexate recognition by the human reduced folate carrier SLC19A1.” Nature 2022 Sep. DOI:10.1038/s41586-022-05168-0. Featured in Nature Reviews Cancer and Nature.
Nicholas J Wright & Seok-Yong Lee. “Recent Advances on the Inhibition of Human Solute Carriers: Therapeutic Implications and Mechanistic Insights.” Curr Opin Struct Biol 2022 Apr. DOI:10.1016/j.sbi.2022.102378
Nicholas J. Wright & Seok-Yong Lee. “Toward a Molecular Basis of Cellular Nucleoside Transport in Humans.” Chem Rev 2020 Nov. DOI:10.1021/acs.chemrev.0c00644
Nicholas J. Wright & Seok-Yong Lee. “Structures of human ENT1 in complex with adenosine reuptake inhibitors.” Nat Struct Mol Biol 2019 Jun. DOI:10.1038/s41594-019-0245-7
Marscha Hirschi, Zachary Johnson & Seok-Yong Lee. “Visualizing multistep elevator-like transitions of a nucleoside transporter.” Nature 2017 Apr. DOI:10.1038/nature22057
Zachary Johnson & Seok-Yong Lee. “Liposome reconstitution and transport assay for recombinant transporters.” Methods Enzymol 2015 Mar. DOI:10.1016/bs.mie.2014.11.048
Zachary Johnson, Jun-Ho Lee, Kiyoun Lee, Minhee Lee, Do-Yeon Kwon, Jiyong Hong & Seok-Yong Lee. “Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.” eLife 2014 Jul. DOI:10.7554/eLife.03604
Zachary Johnson, Cheom-Gil Cheong & Seok-Yong Lee. “Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 Å.” Nature 2012 Mar. DOI:10.1038/nature10882
POLYSACCHARIDE TRANSPORT IN MICROBIAL CELL WALL SYNTHESIS
Kazuki Yamamoto, Toyotaka Sato, Aili Hao, Kenta Asao, Rintaro Kaguchi, Shintaro Kusaka, Radhakrishnam Raju Ruddarraju, Daichi Kazamori, Kiki Seo, Satoshi Takahashi, Motohiro Horiuchi, Shin-ichi Yokota, Seok-Yong Lee & Satoshi Ichikawa. “Development of a natural product optimization strategy for inhibitors against MraY, a promising antibacterial target.” Nat Commun 2024 Jun. DOI:10.1038/s41467-024-49484-7
Aili Hao, Yang Suo & Seok-Yong Lee. “Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae” Structure 2023 Dec. DOI:10.1016/j.str.2023.11.007
Takeshi Nakaya, Miyuki Yabe, Ellene H. Mashalidis, Toyotaka Sato, Kazuki Yamamoto, Yuta Hikiji, Akira Katsuyama, Motoko Shinohara, Yusuke Minato, Satoshi Takahashi, Motohiro Horiuchi, Shin-ichi Yokota, Seok-Yong Lee & Satoshi Ichikawa. “Synthesis of Macrocyclic Nucleoside Antibacterials and Their Interactions With MraY.” Nat Commun 2022 Dec. DOI:10.1038/s41467-022-35227-z
Zhenning Ren, Abhishek Chhetri, Ziqiang Guan, Yang Suo, Kenichi Yokoyama & Seok-Yong Lee. “Structural basis for inhibition and regulation of a chitin synthase from Candida albicans.” Nat Struct Mol Biol 2022 Jul. DOI:10.1038/s41594-022-00791-x
Alvin C Y Kuk, Aili Hao & Seok-Yong Lee. “Structure and Mechanism of the Lipid Flippase MurJ.” Annu Rev Biochem 2022 Feb. DOI:10.1146/annurev-biochem-040320-105145
Seung-Hwa Kwak, Won Young Lim, Aili Hao, Ellene H. Mashalidisb, Do-Yeon Kwon, Pyeonghwa Jeong, Mi Jung Kim, Seok-Yong Lee & Jiyong Hong. “Synthesis and Evaluation of Cyclopentane-Based Muraymycin Analogs Targeting MraY.” Eur J Med Chem 2021 Apr. DOI:10.1016/j.ejmech.2021.113272
Ellene H Mashalidis & Seok-Yong Lee. “Structures of Bacterial MraY and Human GPT Provide Insights Into Rational Antibiotic Design.” J Mol Biol 2020 Mar. DOI:10.1016/j.jmb.2020.03.017
Ellene H. Mashalidis, Benjamin Kaeser, Yuma Terasawa, Akira Katsuyama, Do-Yeon Kwon, Kiyoun Lee, Jiyong Hong, Satoshi Ichikawa & Seok-Yong Lee. “Chemical logic of MraY inhibition by antibacterial nucleoside natural products.” Nat Commun 2019 Jul. DOI:10.1038/s41467-019-10957-9
Alvin C. Y. Kuk, Aili Hao, Ziqiang Guan & Seok-Yong Lee. “Visualizing conformation transitions of Lipid II flippase MurJ.” Nat Commun 2019 Apr. DOI:10.1038/s41467-019-09658-0
Jiho Yoo, Ellene H. Mashalidis, Alvin C. Y. Kuk, Kazuki Yamamoto, Benjamin Kaeser, Satoshi Ichikawa & Seok-Yong Lee. “GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.” Nat Struct Mol Biol 2018. Published online 19 Feb DOI:10.1038/s41594-018-0031-y
Alvin C. Y. Kuk, Ellene H. Mashalidis & Seok-Yong Lee. “Crystal structure of the MOP flippase MurJ in an inward-facing conformation.” Nat Struct Mol Biol 2016. Published online 24 Dec. DOI:10.1038/nsmb.3346
Ben C. Chung, Ellene H. Mashalidis, Tetsuya Tanino, Mijung Kim, Akira Matsuda, Jiyong Hong, Satoshi Ichikawa & Seok-Yong Lee.”Structural insights into inhibition of lipid I production in bacterial cell wall synthesis.” Nature 2016 Apr. DOI:10.1038/nature17636
Ben C. Chung, Jinshi Zhao, Robert A. Gillepsie, Do-Yeon Kwon, Ziqiang Guan, Jiyong Hong, Pei Zhou & Seok-Yong Lee. “Crystal structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis.” Science 2013 Aug. DOI:10.1126/science.123650
