Christopher R. Mansfield, Baiyi Quan, Michael E. Chirgwin, Benjamin Eduful, Philip F. Hughes,Gaëlle Neveu, Kayla Sylvester, Daniel H. Ryan, Björn F.C. Kafsack, Timothy A.J. Haystead, James W. Leahy, Michael C. Fitzgerald, Emily R. Derbyshire. “Selective targeting of Plasmodium falciparum Hsp90disrupts the 26S proteasomeCell Chemical Biology April. 2024. https://doi.org/10.1016/j.chembiol.2024.02.008 Full Text

Morgan A. Bailey, Justin G. Martyr, Amanda E. Hargrove, and Michael C. Fitzgerald. “Stability-Based Proteomics for Investigation of Structured RNA–Protein InteractionsAnalytical Chemistry Feb. 2024. http://doi.org/10.1021/acs.analchem.3c04978 Full Text
Baiyi Quan, Morgan A. Bailey, John Mantyh, David S. Hsu, and Michael C. Fitzgerald. “Protein Folding Stability Profiling of Colorectal Cancer Chemoresistance Identifies Functionally Relevant Biomarkers“. Journal of Proteome Research, May 2023. https://doi.org/10.1021/acs.jproteome.3c00045. Full Text

Morgan A. Bailey, Yun Tang, Hye-Jin Park, and Michael C. Fitzgerald. “Comparative Analysis of Protein Folding Stability-Based Profiling Methods for Characterization of Biological Phenotypes.”Journal of the American Society for Mass Spectrometry, February, 2023. https://doi.org/10.1021/jasms.2c00248. Full Text

 

Amy T R Robison, Grace R Sturrock, Jacqueline M Zaengle-Barone, Nancy Wiebelhaus, Azim Dharani, Isabella G Williams, Michael C Fitzgerald, Katherine J Franz. “Analysis of copper-induced protein precipitation across the E. coli proteome.” Metallomics, Volume 15, Issue 1, January 2023. https://doi.org/10.1093/mtomcs/mfac098. Full Text

 

Wiebelhaus, Nancy, Niven Singh, Peng Zhang, Stephen L. Craig, David N. Beratan, and Michael C. Fitzgerald. “Discovery of the Xenon–Protein Interactome Using Large-Scale Measurements of Protein Folding and Stability.” Journal of the American Chemical Society, vol. 144, no. 9, Mar. 2022, pp. 3925–38. DOI.org (Crossref), https://doi.org/10.1021/jacs.1c11900. Full Text

Cabrera, Aurora, Alexander C. Y. Foo, Michael C. Fitzgerald, and Geoffrey A. Mueller. “Bet v 1 and other birch allergens are more resistant to proteolysis and more abundant than other birch pollen proteins.” Allergy, January 7, 2022. https://doi.org/10.1111/all.15209. Full Text

Hatstat, A. K., B. Quan, M. A. Bailey, M. C. Fitzgerald, M. C. Reinhart, and D. G. McCafferty. “Chemoproteomic-enabled characterization of small GTPase Rab1a as a target of an: N -arylbenzimidazole ligand’s rescue of Parkinson’s-associated cell toxicity.” RSC Chemical Biology 3, no. 1 (January 1, 2022): 96–111. https://doi.org/10.1039/d1cb00103e. Full Text

Ma, Renze, Julia H. R. Johnson, Yun Tang, and Michael C. Fitzgerald. “Analysis of Brain Protein Stability Changes in Mouse Models of Normal Aging and α-Synucleinopathy Reveals Age- and Disease-Related Differences.” Journal of Proteome Research 20, no. 11 (November 2021): 5156–68. https://doi.org/10.1021/acs.jproteome.1c00653. Full Text

Lu, Kuan-Yi, Christopher R. Mansfield, Michael C. Fitzgerald, and Emily R. Derbyshire. “Chemoproteomics for Plasmodium Parasite Drug Target Discovery.” Chembiochem : A European Journal of Chemical Biology 22, no. 16 (August 2021): 2591–99. https://doi.org/10.1002/cbic.202100155. Full Text

Wiebelhaus, Nancy, Jacqueline M. Zaengle-Barone, Kevin K. Hwang, Katherine J. Franz, and Michael C. Fitzgerald. “Protein Folding Stability Changes Across the Proteome Reveal Targets of Cu Toxicity in E. coli.” ACS Chemical Biology, December 11, 2020. https://doi.org/10.1021/acschembio.0c00900. Full Text

 

Lu, Kuan-Yi, et al. “Plasmodium chaperonin TRiC/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy.” Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 11, Mar. 2020, pp. 5810–17. Epmc, doi:10.1073/pnas.1913525117. Full Text

 
 
 
 
Cabrera, Aurora, Nancy Wiebelhaus, Baiyi Quan, Renze Ma, He Meng, and Michael C. Fitzgerald. “Comparative Analysis of Mass-Spectrometry-Based Proteomic Methods for Protein Target Discovery Using a One-Pot Approach.” Journal of the American Society for Mass Spectrometry 31, no. 2 (February 2020): 217–26. https://doi.org/10.1021/jasms.9b00041. Full Text
 
 
 

Cabrera, Aurora, et al. “Are allergens more abundant and/or more stable than other proteins in pollens and dust?” Allergy, Nov. 2019. Epmc, doi:10.1111/all.14121. Full Text

Ma, Renze, et al. “Chemo-Selection Strategy for Limited Proteolysis Experiments on the Proteomic Scale.” Analytical Chemistry, vol. 90, no. 23, Dec. 2018, pp. 14039–47. Epmc, doi:10.1021/acs.analchem.8b04122. Full Text

Kaur, Upneet, et al. “Proteome-Wide Structural Biology: An Emerging Field for the Structural Analysis of Proteins on the Proteomic Scale.” Journal of Proteome Research, vol. 17, no. 11, Nov. 2018, pp. 3614–27. Epmc, doi:10.1021/acs.jproteome.8b00341. Full Text

Meng, He, et al. “Chemical Denaturation and Protein Precipitation Approach for Discovery and Quantitation of Protein-Drug Interactions.” Analytical Chemistry, vol. 90, no. 15, Aug. 2018, pp. 9249–55. Epmc, doi:10.1021/acs.analchem.8b01772. Full Text

Meng, He, and Michael C. Fitzgerald. “Proteome-Wide Characterization of Phosphorylation-Induced Conformational Changes in Breast Cancer.” Journal of Proteome Research, vol. 17, no. 3, Mar. 2018, pp. 1129–37. Epmc, doi:10.1021/acs.jproteome.7b00795. Full Text

Ogburn, Ryenne N., et al. “Discovery of Tamoxifen and N-Desmethyl Tamoxifen Protein Targets in MCF-7 Cells Using Large-Scale Protein Folding and Stability Measurements.” Journal of Proteome Research, vol. 16, no. 11, Nov. 2017, pp. 4073–85. Epmc, doi:10.1021/acs.jproteome.7b00442. Full Text

Liu, Fang, et al. “Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using SILAC-SPROX.” Journal of Proteome Research, vol. 16, no. 9, Sept. 2017, pp. 3277–86. Epmc, doi:10.1021/acs.jproteome.7b00283. Full Text

Lim, Kwang Hun, et al. “Pathogenic Mutations Induce Partial Structural Changes in the Native β-Sheet Structure of Transthyretin and Accelerate Aggregation.” Biochemistry, vol. 56, no. 36, Sept. 2017, pp. 4808–18. Epmc, doi:10.1021/acs.biochem.7b00658. Full Text

Randall, Thomas A., et al. “Proteases of Dermatophagoides pteronyssinus.” International Journal of Molecular Sciences, vol. 18, no. 6, June 2017. Epmc, doi:10.3390/ijms18061204. Full Text

Ogburn, Ryenne N., et al. “Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins?” The Journal of Allergy and Clinical Immunology, vol. 139, no. 3, Mar. 2017, pp. 1030-1032.e1. Epmc, doi:10.1016/j.jaci.2016.08.016. Full Text

Roberts, Julia H., et al. “Discovery of Age-Related Protein Folding Stability Differences in the Mouse Brain Proteome.” Journal of Proteome Research, vol. 15, no. 12, Dec. 2016, pp. 4731–41. Epmc, doi:10.1021/acs.jproteome.6b00927. Full Text

Liu, Fang, and Michael C. Fitzgerald. “Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using Limited Proteolysis.” Journal of Proteome Research, vol. 15, no. 12, Dec. 2016, pp. 4666–74. Epmc, doi:10.1021/acs.jproteome.6b00755. Full Text

Jin, Lorrain, et al. “Targeted Mass Spectrometry-Based Approach for Protein-Ligand Binding Analyses in Complex Biological Mixtures Using a Phenacyl Bromide Modification Strategy.” Analytical Chemistry, vol. 88, no. 22, Nov. 2016, pp. 10987–93. Epmc, doi:10.1021/acs.analchem.6b02658. Full Text

Xu, Yingrong, et al. “Thermodynamic Analysis of the Geldanamycin-Hsp90 Interaction in a Whole Cell Lysate Using a Mass Spectrometry-Based Proteomics Approach.” Journal of the American Society for Mass Spectrometry, vol. 27, no. 10, Oct. 2016, pp. 1670–76. Epmc, doi:10.1007/s13361-016-1457-2. Full Text

Geer Wallace, M. Ariel, et al. “Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements.” J Proteome Res, vol. 15, no. 8, Aug. 2016, pp. 2688–96. Pubmed, doi:10.1021/acs.jproteome.6b00237. Full Text

Geer, M. Ariel, and Michael C. Fitzgerald. “Characterization of the Saccharomyces cerevisiae ATP-Interactome using the iTRAQ-SPROX Technique.” Journal of the American Society for Mass Spectrometry, vol. 27, no. 2, Feb. 2016, pp. 233–43. Epmc, doi:10.1007/s13361-015-1290-z. Full Text

Kwon, Do-Yeon, et al. “Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition.” J Med Chem, vol. 58, no. 19, Oct. 2015, pp. 7659–71. Pubmed, doi:10.1021/acs.jmedchem.5b01220. Full Text

Adhikari, Jagat, et al. “Global analysis of protein folding thermodynamics for disease state characterization.” Journal of Proteome Research, vol. 14, no. 5, May 2015, pp. 2287–97. Epmc, doi:10.1021/acs.jproteome.5b00057. Full Text

Adhikari, Jagat, and Michael C. Fitzgerald. “SILAC-pulse proteolysis: A mass spectrometry-based method for discovery and cross-validation in proteome-wide studies of ligand binding.” Journal of the American Society for Mass Spectrometry, vol. 25, no. 12, Dec. 2014, pp. 2073–83. Epmc, doi:10.1007/s13361-014-0992-y. Full Text

Tran, Duc T., et al. “StableIsotope Labeling with Amino Acids in Cell Culture (SILAC)-based strategy for proteome-wide thermodynamic analysis of protein-ligand binding interactions.” Molecular & Cellular Proteomics : Mcp, vol. 13, no. 7, July 2014, pp. 1800–13. Epmc, doi:10.1074/mcp.M113.034702. Full Text

Xu, Yingrong, et al. “Thermodynamic analysis of protein folding and stability using a tryptophan modification protocol.” Analytical Chemistry, vol. 86, no. 14, July 2014, pp. 7041–48. Epmc, doi:10.1021/ac501278j. Full Text

Geer, M. Ariel, and Michael C. Fitzgerald. “Energetics-based methods for protein folding and stability measurements.” Annual Review of Analytical Chemistry (Palo Alto, Calif.), vol. 7, Jan. 2014, pp. 209–28. Epmc, doi:10.1146/annurev-anchem-071213-020024. Full Text

Strickland, Erin C., et al. “False-positive rate determination of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform.” Journal of the American Society for Mass Spectrometry, vol. 25, no. 1, Jan. 2014, pp. 132–40. Epmc, doi:10.1007/s13361-013-0754-2. Full Text

Strickland, Erin C., et al. “Thermodynamic analysis of protein-ligand binding interactions in complex biological mixtures using the stability of proteins from rates of oxidation.” Nature Protocols, vol. 8, no. 1, Jan. 2013, pp. 148–61. Epmc, doi:10.1038/nprot.2012.146. Full Text

Banerjee, Sambuddha, et al. “Evidence of Fe3+ interaction with the plug domain of the outer membrane transferrin receptor protein of Neisseria gonorrhoeae: implications for Fe transport.” Metallomics : Integrated Biometal Science, vol. 4, no. 4, Apr. 2012, pp. 361–72. Epmc, doi:10.1039/c2mt20037f. Full Text

Reichmann, Dana, et al. “Order out of disorder: working cycle of an intrinsically unfolded chaperone.” Cell, vol. 148, no. 5, Mar. 2012, pp. 947–57. Epmc, doi:10.1016/j.cell.2012.01.045. Full Text

Tran, Duc T., et al. “Slow histidine H/D exchange protocol for thermodynamic analysis of protein folding and stability using mass spectrometry.” Analytical Chemistry, vol. 84, no. 3, Feb. 2012, pp. 1653–60. Epmc, doi:10.1021/ac202927p. Full Text

Dearmond, Patrick D., et al. “Thermodynamic analysis of protein-ligand interactions in complex biological mixtures using a shotgun proteomics approach.” Journal of Proteome Research, vol. 10, no. 11, Nov. 2011, pp. 4948–58. Epmc, doi:10.1021/pr200403c. Full Text

Xu, Ying, et al. “Mass spectrometry- and lysine amidination-based protocol for thermodynamic analysis of protein folding and ligand binding interactions.” Analytical Chemistry, vol. 83, no. 9, May 2011, pp. 3555–62. Epmc, doi:10.1021/ac2016745. Full Text

DeArmond, Patrick D., et al. “Stable isotope labeling strategy for protein-ligand binding analysis in multi-component protein mixtures.” Journal of the American Society for Mass Spectrometry, vol. 22, no. 3, Mar. 2011, pp. 418–30. Epmc, doi:10.1007/s13361-010-0060-1. Full Text

Xu, Y., et al. “Xu, Y., Falk, I.N., Hallen, M.A., and Fitzgerald, M.C.” Analytical Chemistry, no. 83, 2011, pp. 3555–62.

Dearmond, Patrick D., et al. “Discovery of novel cyclophilin A ligands using an H/D exchange- and mass spectrometry-based strategy.” J Biomol Screen, vol. 15, no. 9, Oct. 2010, pp. 1051–62. Pubmed, doi:10.1177/1087057110382775. Full Text

Kim, Hyoungsu, et al. “Total synthesis, assignment of the absolute stereochemistry, and structure-activity relationship studies of subglutinols A and B.” Chemistry, an Asian Journal, vol. 5, no. 8, Aug. 2010, pp. 1902–10. Epmc, doi:10.1002/asia.201000147. Full Text

West, Graham M., et al. “Mass spectrometry-based thermal shift assay for protein-ligand binding analysis.” Anal Chem, vol. 82, no. 13, July 2010, pp. 5573–81. Pubmed, doi:10.1021/ac100465a. Full Text Open Access Copy

West, Graham M., et al. “Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements.” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 20, May 2010, pp. 9078–82. Epmc, doi:10.1073/pnas.1000148107. Full Text

Xu, Ying, et al. “Thermodynamic analysis of a molecular chaperone binding to unfolded protein substrates.” Biochemistry, vol. 49, no. 6, Feb. 2010, pp. 1346–53. Epmc, doi:10.1021/bi902010t. Full Text Open Access Copy

DeArmond, P. D., et al. “Discovery of Novel Cyclophilin A Ligands Using an H/D Exchange- and Mass Spectrometry-Based Strategy. Journal of Biomolecular Screening.” Journal of Biomolecular Screening, vol. 15, no. 9, 2010, pp. 1051–62.

Hopper, Erin D., et al. “Hydrogen/deuterium exchange- and protease digestion-based screening assay for protein-ligand binding detection.” Anal Chem, vol. 81, no. 16, Aug. 2009, pp. 6860–67. Pubmed, doi:10.1021/ac900854t. Full Text

Fitzgerald, Michael C., and Graham M. West. “Painting proteins with covalent labels: what’s in the picture?” Journal of the American Society for Mass Spectrometry, vol. 20, no. 6, June 2009, pp. 1193–206. Epmc, doi:10.1016/j.jasms.2009.02.006. Full Text

Siburt, Claire J. Parker, et al. “Hijacking transferrin bound iron: protein-receptor interactions involved in iron transport in N. gonorrhoeae.” Metallomics : Integrated Biometal Science, vol. 1, no. 3, Jan. 2009, pp. 249–55. Epmc, doi:10.1039/b902860a. Full Text

Fitzgerald, M. C., et al. “Chapter 6 Thermodynamic Analysis of Protein Folding and Ligand Binding by SUPREX.” Comprehensive Analytical Chemistry, vol. 52, Dec. 2008, pp. 127–49. Scopus, doi:10.1016/S0166-526X(08)00206-7. Full Text

Hopper, Erin D., et al. “In vivo and in vitro examination of stability of primary hyperoxaluria-associated human alanine:glyoxylate aminotransferase.” The Journal of Biological Chemistry, vol. 283, no. 45, Nov. 2008, pp. 30493–502. Epmc, doi:10.1074/jbc.M803525200. Full Text

Hopper, Erin D., et al. “Throughput and efficiency of a mass spectrometry-based screening assay for protein-ligand binding detection.” J Am Soc Mass Spectrom, vol. 19, no. 9, Sept. 2008, pp. 1303–11. Pubmed, doi:10.1016/j.jasms.2008.06.007. Full Text

Weaver, Katherine D., et al. “Ga3+ as a mechanistic probe in Fe3+ transport: characterization of Ga3+ interaction with FbpA.” Journal of Biological Inorganic Chemistry, vol. 13, no. 6, Aug. 2008, pp. 887–98. Epmc, doi:10.1007/s00775-008-0376-5. Full Text

West, Graham M., et al. “Thermodynamic analysis of protein stability and ligand binding using a chemical modification- and mass spectrometry-based strategy.” Analytical Chemistry, vol. 80, no. 11, June 2008, pp. 4175–85. Epmc, doi:10.1021/ac702610a. Full Text

Roulhac, Petra L., et al. “Ex vivo analysis of synergistic anion binding to FbpA in Gram-negative bacteria.” Biochemistry, vol. 47, no. 14, Apr. 2008, pp. 4298–305. Epmc, doi:10.1021/bi701188x. Full Text

Tang, Liangjie, et al. “H/D exchange and mass spectrometry-based method for biophysical analysis of multidomain proteins at the domain level.” Analytical Chemistry, vol. 79, no. 22, Nov. 2007, pp. 8728–39. Epmc, doi:10.1021/ac071380a. Full Text

Tang, Liangjie, et al. “H/D exchange- and mass spectrometry-based strategy for the thermodynamic analysis of protein-ligand binding.” Analytical Chemistry, vol. 79, no. 15, Aug. 2007, pp. 5869–77. Epmc, doi:10.1021/ac0700777. Full Text

Williams, John C., et al. “Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex.” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 24, June 2007, pp. 10028–33. Epmc, doi:10.1073/pnas.0703614104. Full Text

Frankel, Brenda A., et al. “Mutational analysis of active site residues in the Staphylococcus aureus transpeptidase SrtA.” Biochemistry, vol. 46, no. 24, June 2007, pp. 7269–78. Epmc, doi:10.1021/bi700448e. Full Text

Frankel, B. A., et al. “Analysis of Active Site Residues in the Staphylococcus aureus Transpeptidase SrtA Mutational.” Biochemistry, no. 46, 2007, pp. 7269–78.

Dai, Susie Y., and Michael C. Fitzgerald. “Accuracy of SUPREX (stability of unpurified proteins from rates of H/D exchange) and MALDI mass spectrometry-derived protein unfolding free energies determined under non-EX2 exchange conditions.” Journal of the American Society for Mass Spectrometry, vol. 17, no. 11, Nov. 2006, pp. 1535–42. Epmc, doi:10.1016/j.jasms.2006.06.025. Full Text

Yang, Xiaoye, et al. “Direct analysis of backbone-backbone hydrogen bond formation in protein folding transition states.” Journal of Molecular Biology, vol. 363, no. 2, Oct. 2006, pp. 506–19. Epmc, doi:10.1016/j.jmb.2006.07.058. Full Text

Dai, Susie Y., and Michael C. Fitzgerald. “A mass spectrometry-based probe of equilibrium intermediates in protein-folding reactions.” Biochemistry, vol. 45, no. 42, Oct. 2006, pp. 12890–97. Epmc, doi:10.1021/bi061295h. Full Text

Yang, Xiaoye, and Michael C. Fitzgerald. “Total chemical synthesis of the B1 domain of protein L from Peptostreptococcus magnus.” Bioorganic Chemistry, vol. 34, no. 3, June 2006, pp. 131–41. Epmc, doi:10.1016/j.bioorg.2006.02.001. Full Text

Wang, Min, et al. “Conserved thermodynamic contributions of backbone hydrogen bonds in a protein fold.” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 8, Feb. 2006, pp. 2600–04. Epmc, doi:10.1073/pnas.0508121103. Full Text

Cisneros, G. Andrés, et al. “Theoretical and experimental determination on two substrates turned over by 4-oxalocrotonate tautomerase.” The Journal of Physical Chemistry. A, vol. 110, no. 2, Jan. 2006, pp. 700–08. Epmc, doi:10.1021/jp0543328. Full Text

Tong, Yan, et al. “Thermodynamic analysis of subunit interactions in Escherichia coli molybdopterin synthase.” Biochemistry, vol. 44, no. 7, Feb. 2005, pp. 2595–601. Epmc, doi:10.1021/bi047762h. Full Text

Dai, Susie Y., et al. “Protocol for the thermodynamic analysis of some proteins using an H/D exchange- and mass spectrometry-based technique.” Analytical Chemistry, vol. 77, no. 2, Jan. 2005, pp. 693–97. Epmc, doi:10.1021/ac048967z. Full Text

Wang, M., et al. “The Thermodynamics of Backbone-Backbone Hydrogen Bonds are Conserved ina Protein Fold.” Proceedings of the National Academy of Sciences, Usa, 2005.

Lin, Simon M., et al. “Characterising phase variations in MALDI-TOF data and correcting them by peak alignment.” Cancer Inform, vol. 1, 2005, pp. 32–40. Open Access Copy

Yang, Xiaoye, et al. “Analysis of protein folding and function using backbone modified proteins.” Bioorganic Chemistry, vol. 32, no. 5, Oct. 2004, pp. 438–49. Epmc, doi:10.1016/j.bioorg.2004.06.011. Full Text

Wang, Michael Z., et al. “Thermodynamic analysis of cyclosporin a binding to cyclophilin a in a lung tumor tissue lysate.” Anal Chem, vol. 76, no. 15, Aug. 2004, pp. 4343–48. Pubmed, doi:10.1021/ac049536j. Full Text

Wales, Thomas E., et al. “Facile chemical synthesis and equilibrium unfolding properties of CopG.” Protein Sci, vol. 13, no. 7, July 2004, pp. 1918–26. Pubmed, doi:10.1110/ps.04671804. Full Text

Cisneros, G. Andrés, et al. “The protein backbone makes important contributions to 4-oxalocrotonate tautomerase enzyme catalysis: understanding from theory and experiment.” Biochemistry, vol. 43, no. 22, June 2004, pp. 6885–92. Epmc, doi:10.1021/bi049943p. Full Text

Powell, Kendall D., and Michael C. Fitzgerald. “High-throughput screening assay for the tunable selection of protein ligands.” Journal of Combinatorial Chemistry, vol. 6, no. 2, Mar. 2004, pp. 262–69. Epmc, doi:10.1021/cc034051e. Full Text

Ma, L., and M. C. Fitzgerald. “Thermodynamic Analysis of Protein-DNA Interactions using a New H/D Exchange- and Mass Spectrometry-Based Method.” Chemistry & Biology, vol. 10, Dec. 2003.

Ma, Liyuan, and Michael C. Fitzgerald. “A new H/D exchange- and mass spectrometry-based method for thermodynamic analysis of protein-DNA interactions.” Chemistry & Biology, vol. 10, no. 12, Dec. 2003, pp. 1205–13. Epmc, doi:10.1016/j.chembiol.2003.11.017. Full Text

Powell, K. D., et al. “The accuracy and precision of a new H/D exchange- and mass spectrometry-based technique for measuring the thermodynamic stability of proteins.” Analytica Chimica Acta, vol. 496, no. 1–2, Oct. 2003, pp. 225–32. Scopus, doi:10.1016/S0003-2670(03)01002-X. Full Text

Campa, M. J., et al. “Erratum: Exploring the proteome with MALDI-TOF (Editorial) (Proteomics 3: 9 (1659-1660)).” Proteomics, vol. 3, no. 10, Oct. 2003, p. 2067. Scopus, doi:10.1002/pmic.200390099. Full Text

Campa, M. J., et al. “Exploring the proteome with MALDI-TOF.” Proteomics, vol. 3, no. 9, Sept. 2003, pp. 1659–60.

Howard, Brandon A., et al. “Identification and validation of a potential lung cancer serum biomarker detected by matrix-assisted laser desorption/ionization-time of flight spectra analysis.” Proteomics, vol. 3, no. 9, Sept. 2003, pp. 1720–24. Pubmed, doi:10.1002/pmic.200300514. Full Text

Wang, Michael Z., et al. “Analysis of human serum proteins by liquid phase isoelectric focusing and matrix-assisted laser desorption/ionization-mass spectrometry.” Proteomics, vol. 3, no. 9, Sept. 2003, pp. 1661–66. Pubmed, doi:10.1002/pmic.200300513. Full Text

Ercole, F., et al. “A combinatorial approach in designing hydrophilic surfaces for solid-phase peptide synthesis.” Journal of Applied Polymer Science, vol. 89, no. 12, July 2003, pp. 3371–78. Scopus, doi:10.1002/app.12574. Full Text

Silinski, Peter, and Michael C. Fitzgerald. “Comparative analysis of two different amide-to-ester bond mutations in the beta-sheet of 4-oxalocrotonate tautomerase.” Biochemistry, vol. 42, no. 21, June 2003, pp. 6620–30. Epmc, doi:10.1021/bi020700b. Full Text

Powell, Kendall D., and Michael C. Fitzgerald. “Accuracy and precision of a new H/D exchange- and mass spectrometry-based technique for measuring the thermodynamic properties of protein-peptide complexes.” Biochemistry, vol. 42, no. 17, May 2003, pp. 4962–70. Epmc, doi:10.1021/bi034096w. Full Text

Wu, Zemin, et al. “Synthesis of tetrahydro-1,4-benzodiazepine-2-ones on hydrophilic polyamide SynPhase lanterns.” Journal of Combinatorial Chemistry, vol. 5, no. 2, Mar. 2003, pp. 166–71. Epmc, doi:10.1021/cc020057c. Full Text

Campa, M. J., et al. “Protein Expression Profiling Identifies MIF and Cyclophilin A as Potential Molecular Targets in Non-Small Cell Lung Cancer.” Cancer Research, vol. 63, no. 7, 2003, pp. 1652–56.

Wang, M. Z., et al. “A fractionation protocol to reduce signal suppression effects in the MALDI analysis of blood proteins.” Proceedings 50th Asms Conference on Mass Spectrometry and Allied Topics, Dec. 2002, pp. 587–88.

Ma, L., et al. “A new H/D exchange- and MALDI-based assay for the quantitative analysis of protein-DNA interactions in solution.” Proceedings 50th Asms Conference on Mass Spectrometry and Allied Topics, Dec. 2002, pp. 471–72.

Ghaemmaghami, S., et al. “Quantitative protein stability measurement in living bacteria.” Proceedings 50th Asms Conference on Mass Spectrometry and Allied Topics, Dec. 2002, pp. 109–10.

Powell, K. D., and M. C. Fitzgerald. “Quantitative determination of protein-peptide binding constants using a new, MALDI- and H/D-exchange based technique.” Proceedings 50th Asms Conference on Mass Spectrometry and Allied Topics, Dec. 2002, pp. 445–46.

Fitzgerald, M. C., et al. “A general mass spectrometry-based method for the quantitation of protein-ligand binding interactions in solution.” Proceedings 50th Asms Conference on Mass Spectrometry and Allied Topics, Dec. 2002, pp. 395–96.

Powell, Kendall D., et al. “A general mass spectrometry-based assay for the quantitation of protein-ligand binding interactions in solution.” J Am Chem Soc, vol. 124, no. 35, Sept. 2002, pp. 10256–57. Pubmed, doi:10.1021/ja026574g. Full Text

Silinski, Peter, and Michael C. Fitzgerald. “A stable dimer in the pH-induced equilibrium unfolding of the homo-hexameric enzyme 4-oxalocrotonate tautomerase (4-OT).” Biochemistry, vol. 41, no. 13, Apr. 2002, pp. 4480–91. Epmc, doi:10.1021/bi011872w. Full Text

Powell, Kendall D., et al. “Thermodynamic stability measurements on multimeric proteins using a new H/D exchange- and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry-based method.” Protein Science : A Publication of the Protein Society, vol. 11, no. 4, Apr. 2002, pp. 841–51. Epmc, doi:10.1110/ps.3820102. Full Text

Wales, T. E., and M. C. Fitzgerald. “The energetic contribution of backbone–backbone hydrogen bonds to the thermodynamic stability of a hyperstable P22 Arc repressor mutant.” Journal of the American Chemical Society, vol. 123, no. 31, Aug. 2001, pp. 7709–10. Epmc, doi:10.1021/ja010775n. Full Text

Powell, K. D., and M. C. Fitzgerald. “Measurements of protein stability by H/D exchange and matrix-assisted laser desorption/ionization mass spectrometry using picomoles of material.” Analytical Chemistry, vol. 73, no. 14, July 2001, pp. 3300–04. Epmc, doi:10.1021/ac0100805. Full Text

Silinski, P., et al. “Guanidine-induced equilibrium unfolding of a homo-hexameric enzyme 4-oxalocrotonate tautomerase (4-OT).” Biochemistry, vol. 40, no. 14, Apr. 2001, pp. 4493–502. Pubmed, doi:10.1021/bi002752b. Full Text

Wang, M. Z., and M. C. Fitzgerald. “A solid sample preparation method that reduces signal suppression effects in the MALDI analysis of peptides.” Analytical Chemistry, vol. 73, no. 3, Feb. 2001, pp. 625–31. Epmc, doi:10.1021/ac0009090. Full Text

Moss, J. A., et al. “Mapping tertiary interactions in protein folding reactions: a novel mass spectrometry- and chemical synthesis-based approach.” Fresenius’ Journal of Analytical Chemistry, vol. 369, no. 3–4, Feb. 2001, pp. 252–57. Epmc, doi:10.1007/s002160000644. Full Text

Powell, K. D., and M. C. Fitzgerald. “High Sensitivity Measurements of Protein Stability by H/D Exchange and Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass spectrometry.” Analytical Chemistry, vol. 73, no. 14, 2001, pp. 3300–04.

Nakhle, B. M., et al. “Identification of an essential backbone amide bond in the folding and stability of a multimeric enzyme.” Journal of the American Chemical Society, vol. 122, no. 34, Aug. 2000.

Nakhle, B. M., et al. “Identification of an essential backbone amide bond in the folding and stability of a multimeric enzyme.” Journal of the American Chemical Society, vol. 122, no. 34, Aug. 2000, pp. 8105–11. Scopus, doi:10.1021/ja0006090. Full Text

Ghaemmaghami, S., et al. “A quantitative, high-throughput screen for protein stability.” Proc Natl Acad Sci U S A, vol. 97, no. 15, July 2000, pp. 8296–301. Pubmed, doi:10.1073/pnas.140111397. Full Text

Nakhle, B. M., et al. “Identification of an essential backbone amide bond in the folding and stability of a multimeric enzyme.” Journal of the American Chemical Society, vol. 122, no. 34, 2000.

Winston, R. L., and M. C. Fitzgerald. “Concentration and desalting of protein samples for mass spectrometry analysis.” Analytical Biochemistry, vol. 262, no. 1, Aug. 1998, pp. 83–85. Epmc, doi:10.1006/abio.1998.2754. Full Text

Stamps, S. L., et al. “Characterization of the role of the amino-terminal proline in the enzymatic activity catalyzed by macrophage migration inhibitory factor.” Biochemistry, vol. 37, no. 28, July 1998, pp. 10195–202. Epmc, doi:10.1021/bi9806955. Full Text

Johnson, W. H., et al. “Inactivation of 4-oxalocrotonate tautomerase by 2-oxo-3-pentynoate.” Biochemistry, vol. 36, no. 50, Dec. 1997, pp. 15724–32. Epmc, doi:10.1021/bi971608w. Full Text

Fitzgerald, M. C., et al. “A continuous fluorometric assay for the feline immunodeficiency virus protease.” Analytical Biochemistry, vol. 254, no. 2, Dec. 1997, pp. 226–30. Epmc, doi:10.1006/abio.1997.2407. Full Text

Carrasco, M. R., et al. “Direct monitoring of organic reactions on polymeric supports.” Tetrahedron Letters, vol. 38, no. 36, Sept. 1997, pp. 6331–34. Scopus, doi:10.1016/S0040-4039(97)01456-1. Full Text

Dawson, P. E., et al. “Methods for the chemical synthesis and readout of self-encoded arrays of polypeptide analogues.” Journal of the American Chemical Society, vol. 119, no. 34, Aug. 1997, pp. 7917–27. Scopus, doi:10.1021/ja963122t. Full Text

Laco, G. S., et al. “Molecular analysis of the feline immunodeficiency virus protease: generation of a novel form of the protease by autoproteolysis and construction of cleavage-resistant proteases.” Journal of Virology, vol. 71, no. 7, July 1997, pp. 5505–11.

Muir, T. W., et al. “Protein signature analysis: a practical new approach for studying structure-activity relationships in peptides and proteins.” Methods in Enzymology, vol. 289, Jan. 1997, pp. 545–64. Epmc, doi:10.1016/s0076-6879(97)89063-5. Full Text

Fitzgerald, M. C., et al. “A Continuous Fluorometric Assay for the FIV Protease.” Analytical Biochemistry, vol. 254, no. 2, 1997, pp. 226–30.

Qian, X., et al. “C2-symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and HIV/FIV proteases.” Bioorganic & Medicinal Chemistry, vol. 4, no. 12, Dec. 1996, pp. 2055–69. Epmc, doi:10.1016/s0968-0896(96)00218-0. Full Text

Muir, T. W., et al. “Probing the chemical basis of binding activity in an SH3 domain by protein signature analysis.” Chemistry & Biology, vol. 3, no. 10, Oct. 1996, pp. 817–25. Epmc, doi:10.1016/s1074-5521(96)90067-8. Full Text

Fitzgerald, M. C., and G. Siuzdak. “Biochemical mass spectrometry: worth the weight?” Chemistry & Biology, vol. 3, no. 9, Sept. 1996, pp. 707–15. Epmc, doi:10.1016/s1074-5521(96)90245-8. Full Text

Fitzgerald, M. C., et al. “Probing the oligomeric structure of an enzyme by electrospray ionization time-of-flight mass spectrometry.” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 14, July 1996, pp. 6851–56. Epmc, doi:10.1073/pnas.93.14.6851. Full Text

Fitzgerald, M. C., et al. “Direct characterization of solid phase resin-bound molecules by mass spectrometry.” Bioorganic and Medicinal Chemistry Letters, vol. 6, no. 8, Apr. 1996, pp. 979–82. Scopus, doi:10.1016/0960-894X(96)00152-7. Full Text

Qian, X., et al. “C2-Symmetrical Tetrahydroxyazepenes as Inhibitors of Glyosidases and HIV/FIV Proteases.” Bioorganic & Medicinal Chemistry, vol. 4, no. 12, 1996, pp. 2055–69.

Zhu, L., et al. “Oligodeoxynucleotide Fragmentation in MALDI/TOF Mass Spectrometry Using 355-nm Radiation.” Journal of the American Chemical Society, vol. 117, no. 22, Jan. 1995, pp. 6048–56. Scopus, doi:10.1021/ja00127a018. Full Text

Fitzgerald, M. C., et al. “Total Chemical Synthesis and Catalytic Properties of the Enzyme Enantiomers L- and D-4-Oxalocrotonate Tautomerase.” Journal of the American Chemical Society, vol. 117, no. 45, Jan. 1995, pp. 11075–80. Scopus, doi:10.1021/ja00150a006. Full Text

Fitzgerald, M. C., and L. M. Smith. “Mass spectrometry of nucleic acids: the promise of matrix-assisted laser desorption-ionization (MALDI) mass spectrometry.” Annual Review of Biophysics and Biomolecular Structure, vol. 24, Jan. 1995, pp. 117–40. Epmc, doi:10.1146/annurev.bb.24.060195.001001. Full Text

Shen, C. L., et al. “Effect of acid predissolution on fibril size and fibril flexibility of synthetic beta-amyloid peptide.” Biophysical Journal, vol. 67, no. 3, Sept. 1994, pp. 1238–46. Epmc, doi:10.1016/s0006-3495(94)80593-4. Full Text

Fitzgerald, M. C., et al. “Basic matrices for the matrix-assisted laser desorption/ionization mass spectrometry of proteins and oligonucleotides.” Analytical Chemistry, vol. 65, no. 22, Nov. 1993, pp. 3204–11. Epmc, doi:10.1021/ac00070a007. Full Text

Fitzgerald, M. C., et al. “The analysis of mock DNA sequencing reactions using matrix‐assisted laser desorption/ionization mass spectrometry.” Rapid Communications in Mass Spectrometry, vol. 7, no. 10, Jan. 1993, pp. 895–97. Scopus, doi:10.1002/rcm.1290071008. Full Text

Fitzgerald, M. C., et al. “Rapid shotgun cloning utilizing the two base recognition endonuclease CviJI.” Nucleic Acids Research, vol. 20, no. 14, July 1992, pp. 3753–62. Epmc, doi:10.1093/nar/20.14.3753. Full Text

Parr, G. R., et al. “Matrix‐assisted laser desorption/ionization mass spectrometry of synthetic oligodeoxyribonucleotides.” Rapid Communications in Mass Spectrometry, vol. 6, no. 6, Jan. 1992, pp. 369–72. Scopus, doi:10.1002/rcm.1290060603. Full Text

Beeston, R. F., et al. “Ground- and Excited-State Properties of a Photostable Hemicage Ruthenium(II) Polypyridine Complex.” Inorganic Chemistry, vol. 28, no. 23, Nov. 1989, pp. 4187–89. Scopus, doi:10.1021/ic00322a003. Full Tex