Fitzgerald Lab Members
Michael C. Fitzgerald, Professor & Director of Graduate Studies
Department of Chemistry (and Department of Biochemistry – Secondary Appointment)
Education
1989-1994 University of Wisconsin. Madison, Wisconsin, Ph.D.
Ph.D. in Analytical Chemistry. (Thesis Advisor: Prof. Lloyd M. Smith)
1985-1989 Davidson College. Davidson, North Carolina, B.S., Honors in Chemistry
Professional Positions:
2014-Present Professor (Secondary Appointment) Dept. of Biochemistry, Duke University Medical School, Durham, NC
2011-Present Professor, Department of Chemistry, Duke University, Durham, NC
2004-Present Member, Center for Biomolecular and Tissue Engineering, Duke University, Durham, NC
1999-Present Member, Cancer Center, Duke University Medical Center, Durham, NC
2005-2014 Associate Professor (Secondary Appointment) Dept. of Biochemistry
2001-2005 Assistant Professor (Secondary Appointment) Dept. of Biochemistry Duke University Medical Center, Durham, NC
2004-2011 Associate Professor, Department of Chemistry, Duke University, Durham, NC
1998-2004 Assistant Professor, Department of Chemistry, Duke University, Durham, NC
1997-1998 Senior Research Associate, Dept. of Cell Biology, The Scripps Research Institute, La Jolla, CA
1994-1997 Post-Doctoral Research Fellow. The Scripps Research Institute, La Jolla, CA Analytical and Synthetic Protein Chemistry, (Advisor: Dr. Stephen B.H. Kent)
Current Research Group
Morgan Bailey, 5th Year Ph.D. Student, morgan.a.bailey@duke.edu
Morgan uses energetic-based proteomics to characterize different biological phenotypes and disease states. Additional interests include elucidating biomarkers of intrinsic resistance to chemotherapy treatment in patient derived colorectal cancer cell lines using various proteomic and data analysis techniques.
Yun Tang, 5th Year Ph.D. Student, yun.tang@duke.edu
Yun’s work uses mass spectrometry-based proteomics to identify age-related protein hits. She is also interested in post-translational modifications in proteins and their impact on protein function.
Grace (Bertles) Sturrock, 4th Year Ph.D. Student, grace.bertles@duke.edu
Grace's work utilizes mass spectrometry-based proteomics to determine the direct and indirect protein targets of Cu and other metals under conditions of cellular metal stress to further understand and elucidate their antimicrobial capability. Other interests include utilizing histidine hydrogen-deuterium exchange (HDX) mass spectroscopy techniques to evaluate the association constants and binding stoichiometry of metals to proteins on the proteomic scale.
Yueqi Chen, 3rd Year Ph.D. Student, yueqi.chen@duke.edu
Aaron Petty, Undergraduate Student, aaron.petty@duke.edu
Aaron is developing a histidine H/D exchange-mass spectrometry technique to identify protein-copper binding sites in the E. coli proteome.
Alumni
Former Graduate Students
Dr. Baiyi Quan Duke Chemistry PhD (2022)
Dissertation Title: “Development and Application of Complementary Protein Stability Profiling on Target Deconvolution and Biomarker Identification“
Current Position: Staff Scientist at Caltech, Pasadena, CA
Dr. Nancy (Weibelhaus) Corsi Duke Chemistry PhD (2022)
Dissertation Title: “Large-Scale Analysis of Protein-Gas and Protein-Metal Interactions using Mass Spectrometry-Based Proteomic Methods“
Current Position: Researcher at Exela Pharma Sciences, Lenoir, NC
Dr. Aurora Cabrera Duke Chemistry PhD (2021)
Dissertation Title: “Development and Application of Mass Spectrometry-based Strategies for Proteomic Evaluations of the Thermodynamics and Kinetics of Protein Folding“
Current Position: Postdoctoral Researcher at UNC Chapel Hill, Chapel Hill, NC
Dr. Renze (Arthur) Ma Duke Chemistry PhD (2020)
Dissertation Title: “Development and Application of Large-scale Protein Folding Stability Analysis in Drug Target and Disease Biomarker Discovery”
Current Position: Research Scientist at Abbvie, Inc., Chicago, IL
Dr. He Meng Duke Chemistry PhD (2019)
Dissertation Title: “Proteomic Methods and Applications for Protein Folding and Stability Measurements”
Current Position: Investment Analyst, Small Company in China
Dr. Fang Liu Duke Chemistry PhD (2018)
Dissertation Title: “Large-Scale Analysis of Protein Folding and Stability Changes Associated with Breast Cancer”
Current Position: Proteomics Staff Scientist at the Stanford University Mass Spectrometry Facility, Palo Alto, CA
Dr. Lorrain (Xiaopu) Jin Duke Chemistry PhD (2017)
Dissertation Title: “Development and Application of Mass Spectrometry-Based Approaches for Thermodynamic Analysis of Protein-Ligand Binding Interactions”
Current Position: Research Scientist, Biogen Inc., Boston, MA
Dr. Ryenne Ogburn Duke Chemistry PhD (2017)
Dissertation Title: “Development of Data Analysis Methods and Applications for Proteome-Wide SPROX Measurements”
Current Position: Formulations Chemist, Bert’s Bees, Inc., Durham, NC
Dr. Julia Roberts Duke Chemistry PhD (2017)
Dissertation Title: “Application of the Stability of Proteins from Rates of Oxidation Technique to the Analysis of Mouse Models of Aging and Parkinson’s Disease”
Current Position: Assistant Director of Educational Development, The Teaching Center, Washington University, St. Louis, MS
Dr. Yingrong Xu Duke Chemistry PhD (2016)
Dissertation Title: “Development and Application of Covalent-Labeling Strategies for the Large-Scale Thermodynamic Analysis of Protein Folding and Ligand Binding”
Current Position: Research Scientist, Pfizer, Inc., Groton, CT
Dr. Arial Geer Duke Chemistry PhD (2015)
Dissertation Title: “Evaluation of Energetics-based Techniques for Proteome-Wide Studies of Protein-Ligand Binding Interactions”
Current Position: Research Scientist, US Environmental Protection Agency, Research Triangle Park, NC
Dr. Jagat Adhikari Duke Biochemistry PhD (2015)
Dissertation Title: “Global Analysis of Protein Folding Thermodynamics for Disease State Characterization and Biomarker Discovery”
Current Position: Research Scientist, Cedilla Therapeutics, Cambridge, MA
Dr. Duc Tran Duke Chemistry PhD (2013)
Dissertation Title: “Development and Application of a Quantitative Mass Spectrometry-Based Platform for Thermodynamic Analysis of Protein Interaction Networks”
Current Position: Research Scientist, Encodia, Inc., San Diego, CA
Dr. Erin Strickland Duke Chemistry PhD (2013)
Dissertation Title: “Application and Evaluation of a Chemical Modification- and Mass Spectrometry-Based Thermodynamic Assay for the Study of Protein-Ligand Interactions in Complex Mixtures”
Current Position: Toxicologist, Harris County Institute of Forensic Sciences, Houston, TX)
Ms. Dongyu Wang Duke MS (2013)
Thesis Title: “Development and Application of Analytical Strategies to Facilitate Protein-Ligand Binding Analysis on the Proteomic Scale”
Current Position: Research Analyst, Arbor Research Collaborative for Health, Ann Arbor, MI
Dr. Ying Xu Duke Chemistry PhD (2011)
Dissertation Title: “Development and Applications of Chemical Labeling Protocols for Protein-Ligand Binding Analysis Using Bottom-Up Proteomics”
Current Position: Senior Scientist, Sanofi Genzyme, Cambridge, MA
Dr. Patrick DeArmond Duke Chemistry PhD (2011)
Dissertation Title: “Mass Spectrometry-Based Strategies for Multiplexed Analyses of Protein-Ligand Binding Interactions”
Current Position: Senior Research Scientist, Nationwide Children’s Hospital, Columbus, Ohio
Dr. Graham West Duke Chemistry PhD (2009)
Dissertation Title: “A Covalent Modification Technique for Protein-Ligand Binding Analysis Using Mass Spectrometry-Based Proteomics Platforms”
Current Position: Senior Principal Scientist, Pfizer, Mystic, Connecticut
Dr. Erin Hopper Duke Chemistry PhD (2009)
Dissertation Title: “Development and Application of a Mass Spectrometry-Based Assay for the High Throughput Analysis of Protein-Ligand Binding”
Current Position: Innovation Special Projects Lead, Office of Innovate Carolina, University of North Carolina-Chapel Hill, Chapel Hill, NC
Ms. Tabitha George Duke Chemistry MS (2007)
Thesis Title: “Thermodynamic Stability Measurements on Proteins in Complex Mixtures”
Current Position: Research Technician, Enthalpy Analytics, Durham, NC
Dr. Liangjie Tang Duke Chemistry PhD (2007)
Dissertation Title: “Novel Mass Spectrometry-Based Strategies for Biophysical Analysis of Proteins and Protein-Ligand Complexes”
Current Position: Research Scientist, ImClone, Branchburg, NJ
Dr. Petra Roulhac Duke Chemistry PhD (2007)
Dissertation Title: “Protein-Ligand Binding Analysis in Complex Mixtures using Amide Hydrogen Exchange and MALDI Mass Spectrometry”
Current Position: Director of Quality Control, OrganaBio, LLC
Dr. Min Wang Duke Chemistry PhD (2006)
Dissertation Title: “Understanding the Role of Backbone-Backbone Hydrogen Bonding in Protein Folding and Function”
Current Position: Research Scientist, Cytec Industries, Inc.
Dr. Yuan (Susie) Dai Duke Chemistry PhD (2006)
Dissertation Title: “Biophysical Applications of Amide Proton Hydrogen Exchange and MALDI Mass Spectrometry to Protein Folding”
Current Position: Research Assistant Professor, Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas
Dr. Yan Tong Duke Chemistry PhD (2006)
Dissertation Title: “Application and Development of Amide Hydrogen Exchange and MALDI Mass Spectrometry to Protein Folding and Stability”
Current Position: Research Assistant Professor, NanoScience Technology Center, University of Central Florida
Ms. Xiaoye Yang Duke Chemistry MS (2006)
Thesis Title: “Total Chemical Synthesis and Biophysical Characterization of the B1 Domain of Protein L and Its Analogue”
Current Position: Research Technician, Eastman Chemicals, Kingsport, TN
Dr. Liyuan Ma Duke Chemistry PhD (2005)
Dissertation Title: “Development and Application of H/D Exchange and Mass Spectrometry to the Thermodynamic Analysis of DNA Binding Proteins and Their Complexes”
Current Position: Research Scientist, Eastman Kodak, Kingsport, TN
Dr. Kendall Powell Duke Chemistry PhD (2003)
Dissertation Title: “Thermodynamic Analysis of Protein Folding Reactions by H/D Exchange and Matrix -Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry”
Current Position: Senior Director of Bioanalytical Chemistry, MedPharm, Ltd, Durham NC
Dr. Michael Wang Duke Chemistry PhD (2003)
Dissertation Title: “Complex Mixture Analysis by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry”
Current Position: Associate Professor, Department of Pharmaceutical Chemistry, University of KS, Lawrence, KS)
Dr. Thomas Wales Duke Chemistry PhD (2003)
Dissertation Title: “Total Chemical Synthesis and Biophysical Characterization of Backbone-Modified Protein Analogues”
Current Position: Research Associate Professor, Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA)
Dr. Peter Silinski Duke Chemistry PhD. (2003)
Dissertation Title: “Understanding the Role of Backbone-Backbone Hydrogen Bonding in the Folding and Stability of the Hexameric Enzyme 4-Oxalocrotonate Tautomerase (4OT)”
Current Position: Director, Chemistry Department Instrument Facility, Duke University, Durham, NC
Former Undergraduate Students
Ryan Fader (Trinity ’20)
Mac Karnuta (Trinity ’16)
Medical School, Case Western Reserve
Jacob Martin (Trinity ’14)
Osagie Obanor (Trinity ’12)
Hai-Tsang (Hubert) Huang (Trinity ’12)
Graduate School, Harvard University
Irene Falk (Trinity ’11)
Medical School, Medical College of GA
Pim Dangkulwanich (Trinity ’09)
Graduate School, UC-Berkeley
Stephanie Cordato (Trinity ’09)
Graduate School, Cornell University
Vaibhav Upadhyay (Trinity ’07)
Chris Manz (Trinity ’05)
Myles Garner (Trinity ’04)
Graduate School, University of Texas-Austin
Raimy Amasha (Trinity ’03)
Jagat Shetty (Trinity ’03)
Michael Allingham (Trinity ’02)
Medical School, UNC-Chapel Hill
Laura Weeshoff (Trinity ’01)
Jason Moss (Trinity ’00)
Graduate School, Scripps Research Institute
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