Instructor: Ken Schmader, MD
Read: Chapter 7: Therapy
- Describe the basic design of a randomized controlled trial and its advantages and disadvantages for examining the effectiveness of a given therapy.
- Explain the rationale of each of the validity criteria set forth in the Critical Appraisal Worksheet.
- Understand the magnitude and precision of results and be able to describe them to patients with respect to both benefits and risks.
- Logically apply evidence for therapy in clinical practice.
Read the article:
- Baden LR, El Sahly HM, Essink B, et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. N Engl J Med. 2021;384(5):403-416. doi:10.1056/NEJMoa2035389. Also freely available via PubMed Central.
- Use DUMC Library EBM worksheet for appraisal of articles on therapy