The Smith Lab @ Duke MGM investigate the host-pathogen interactions that underlie tuberculosis infection. We leverage genetically diverse mice and macrophages in conjunction with bacterial clinical isolates and mutant libraries to discover the host-bacterial genetic interactions that define distinct tuberculosis disease states. Lab members are trained in high containment BSL3 procedures to safely conduct tuberculosis research within the Duke Regional Biocontainment Laboratory. We collaborate with our friendly hallway neighbors the Tobin Lab to translate our findings across species and clinical samples and share results in joint Tobin-Smith Lab meetings.
Check out our latest papers using diverse Mammalian and Mycobacterial genetics on the Collaborative Cross and BXD mammalian genome panels.
Want to learn more about new bacterial genetic technologies? Oyinda, Erin and Clare wrote a mini-review as part of the IAI special series from early-stage investigators. Check it out here.
Check out new collaborative papers on host susceptibility loci with the Coers Lab and on ancient Mycobacterial effectors with the Tobin lab.
