Baldwin, K. and Silver, DL, Expanding Gliogenesis, Science, June 11; 372 (6547):1151-1152. Invited Perspective article.

Liu, J and Silver, DL, Founder cells shape brain evolution, Cell,184(8):1965-1967. 2021, Invited Preview article.


Lupan, B and Silver, DL. Evolution: Does more time buy more neurons? Current Biology,  Nov 2. 30 (21): R1316-R1318. 2020 Invited Dispatch.

Hoye, ML and Silver, DL. Decoding mixed messages in the developing cortex: Translational regulation of neural progenitor fate. Current Opinion in Neurobiology. 66: 93-102. 2020 Invited review article.

D’Arcy, B and Silver, DL Local gene regulation in radial glia: Lessons from across the nervous system. Traffic. 21 (12): 737-748.2020 Invited review article.

Pilaz, LJ, Joshi, K, Liu, J, Tsunekawa, Y,  Alsina, FC, Sethi, S, Suzuki, IK, Vanderhaeghen, P, Polleux, F, Silver, DL. Subcellular mRNA localization and local translation of Arhgap11a in radial glial cells regulates cortical development. bioRxiv 07.30.229724 2020

Mitchell-Dick, AM., Chalem, A., Pilaz, LJ., Silver, DL. Acute lengthening of progenitor mitosis influences progeny fate during cortical development in vivo. Developmental Neuroscience. June 15:1-18. 2020

Huang, Q, Cohen, MA, Alsina, FC, Devlin, G, Garrett, A, McKey, J, Havlik, P, Rakhilin, N, Wang, E, Xiang, K, Mathews, P, Wang, L, Bock, C. Ruthig, V, Wang, Y, Negrete, M, Wong, CW, Murthy, PKL, Zhang, S, Daniel, AR, Kirsch, DG, Kang, Y, Capel, C, Asokan, A, Silver, DL, Jaenisch, R, Shen, X. Intravital imaging of mouse embryos. Science April 10; 368:181-186 2020.

Lennox, AL+, Hoye, ML+, Jiang, R, Johnson-Kerner, BL, Suit, L, Venkataramanan, S, Sheehan, CJ, Alsina, FC, Fregeau, B, Aldinger, KA, Moey, C, Lobach, I, Afenjar, A, Babovic-Vuksanovic, D, Bézieau, S, Blackburn, PR, Jens Bunt, J, Lydie Burglen, L, Philippe M. Campeau, PM, Charles, P, Chung, BHY, Benjamin Cogné, B, Curry, C, D’Agostino, MD, Di Donato, N, Faivre, L, Héron, D, Innes, AM, Isidor, B, Keren, B, Kimball, A, Klee, EW, Kuentz, P, Küry, S, Martin-Coignard, D, Mirzaa, G, Mignot, C, Miyake, N, Matsumoto, N, Fujita, A, Nava, C, Nizon, M, Rodriguez, D, Blok, LS, Thauvin-Robinet, C, Thevenon, J, Vincent, M, Ziegler, A, Dobyns, W, Richards, LJ, Barkovich, AJ, Floor, SN, Silver, DL*, and Sherr, EH*. Pathogenic DDX3X mutations impair RNA metabolism and neurogenesis during fetal cortical development Neuron. May 6; 106, 404-420. 2020  

  • + co-first authors (both Silver lab members); * co-corresponding authors.
  • *Featured in same Neuron issue in preview article, “Unwind and relax: DDX3X RNA Helicase as a critical Mediator of Cortical neurogenesis”.

Alsina, F and Silver, DL, “Post-transcriptional and translational control of neurogenesis: roles for RNA binding proteins”, in Patterning and Cell Type Specification in the Developing CNS and PNS (Second Edition). Elsevier. Editors (John Rubenstein and Pasko Rakic). 2020. Book chapter

Sheehan, C, McMahon, JJ, Serdar, L, and Silver, DL. Dosage dependent requirements of Magoh for cortical interneuron generation and survival. Development Jan 13; 147(1) 2020.


Silver, DL, Rakic, P, Grove, EA, Haydar, TF, Hensch, TK, Huttner, WB, Molnár, Z, Rubenstein, JL, Sestan, N, Stryker, MP, Sur, M, Tosches, MA, Walsh, CA. “Evolution and Ontogenetic Development of Cortical Structures” in The Neocortex, ed. W. Singer, T. J. Sejnowski and P. Rakic. Pp. 61-93. Strüngmann Forum Reports, vol. 27, J. R. Lupp, series editor. Cambridge, MA: MIT Press. 2019 . (http://www.esforum.de and https://mitpress.mit.edu/books/emergent-brain-dynamics)

Alsina, F and Silver, DL. “Damage control in the developing brain: tradeoffs and consequences,” Trends in Neurosciences, October. 42 (10): 661-663. 2019 Invited Spotlight. 


Vitali I, Fièvre S, Telley L, Oberst P, Bariselli S, Frangeul L, Baumann N, McMahon JJ, Klingler E, Bocchi R, Kiss JZ, Bellone C, Silver DL, Jabaudon D.   Progenitor Hyperpolarization Regulates the Sequential Generation of Neuronal Subtypes in the Developing Neocortex. Cell.  Jul 19. 2018

Risher WC, Kim N, Koh S, Choi JE, Mitev P, Spence EF, Pilaz LJ, Wang D, Feng G, Silver DL, Soderling SH, Yin HH, Eroglu C.  Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1.J Cell Biol. July 27. 2018

McFadden MJ, Mitchell-Dick A, Vazquez C, Roder AE, Labagnara KF, McMahon JJSilver DL, Horner SM.  A Fluorescent Cell-Based System for Imaging Zika Virus Infection in Real-Time. Viruses.  Feb. 2018



Mitchell C and Silver DL. Enhancing our brains: Genomic mechanisms underlying cortical evolutionSeminars Cell and Developmental Biology.  Aug 31. 2017 Review





Lennox, AL, Mao, H, and Silver DL. RNA on the brain: emerging layers of post-transcriptional regulation in cerebral cortex development. WIRES-Developmental Biology.  Aug 24. 2017 Review




Miller EE, Kobayashi GS, Musso CM, Allen M, Ishiy FA, de Caires Junior LC, Guimarães ES, Griesi-Oliveira K, Zechi-Ceide RM, Richieri-Costa A, Bertola DR, Passos-Bueno MR, Silver DL. EIF4A3 deficient human iPSCs and mouse models demonstrate neural crest defects that underlie Richieri-Costa-Pereira Syndrome. Human Molecular Genetics. Mar 2 2017




Pilaz LJ, Silver DL.Moving messages in the developing brain-emerging roles for mRNA transport and local translation in neural stem cells. FEBS Letters.  Mar 17. 2017 Review






Hanqian Mao, Hannah E. Brown and Debra L. Silver. Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex. RNA. Online Oct 25. Print Jan. 2017





Louis-Jan Pilaz, Ashley Lennox, Jeremy Rouanet, and Debra L. Silver. Dynamic RNA transport and local translation in radial glial progenitors of the developing brain. Current Biology. Dec. 19. 2016. Featured in accompanying preview article in same issue RNA transport: From Head to toe in Radial glia cells.
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Mladen Roko-Rasin and Debra Silver. The crossroads of RNA regulation and function in neurodevelopment. Int J Dev Neurosci. Dec;55:101. 2016Review.

EJC figure vsn 2

John J. McMahon, Emily E. Miller, and Debra L. Silver. The exon junction complex in neural development and neurodevelopmental disease. Int J Dev Neurosci. Apr 9. 2016 Review.





Hanqian Mao, John J. McMahon, Yi-Hsuan Tsai, Zefeng Wang, and Debra L. Silver. Haploinsufficiency for core exon junction complex components disrupts embryonic neurogenesis and causes p53-mediated microcephaly. PLoS Genetics. Sept 12. 2016.



clock with top_new signs_bottom_sky_with RGC2x3_no Apo_neuron_creases_neurons_gold_high res


Louis-Jan Pilaz, John J. McMahon, Emily E. Miller, Ashley L. Lennox, Aussie Suzuki, Edward Salmon, and Debra L. Silver. Prolonged mitosis of neural progenitors alters cell fate in the developing brain. Neuron, online January 6.  2016.
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Singh SK, Stogsdill JA, Pulimood NS, Dingsdale H, Kim YH, Pilaz LJ, Kim IH, Manhaes AC, Rodrigues WS Jr, Pamukcu A, Enustun E, Ertuz Z, Scheiffele P, Soderling SH, Debra L Silver, Ji RR, Medina AE, Eroglu C.  Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. Cell.  Jan 14. 2016



Debra L. Silver. Genomic divergence and brain evolution: How regulatory DNA influences development of the cerebral cortex. Bioessays, online December 7. 2015. PDF Review



Louis-Jan Pilaz Printand Debra L. Silver.Post-transcriptional regulation in corticogenesis: how RNA-binding proteins help build the brain. WIREs RNA, June 18. 2015. PDF. Review



home_cover 2Hanqian Mao, Louis-Jan Pilaz, John J McMahon, Christelle Golzio, Danwei Wu, Lei Shi, Nicholas Katsanis, and Debra L. Silver. Rbm8a haploinsufficiency disrupts embryonic cortical development resulting in Microcephaly. The Journal of Neuroscience, May 6, 2015PDF.  *Featured on Journal cover and News and Views in same issue.




J. Lomax Boyd, Stephanie L. Skove, Jeremy P. Rouanet, Louis-Jan Pilaz, Tristan Bepler, Raluca Gordan, Gregory A. Wray, and Debra L. Silver. Human-Chimpanzee Differences in a FZD8 Enhancer alter cell-cycle dynamics in the developing neocortex. Current Biology, March 16; 2015.PDF.   *Featured in over 75 print and online forums including Science, Science Translational Medicine, Current BiologyNational Geographic. Also featured on NPR!




W Christopher Risher, Sagar Patel, Il Hwan Kim, Akiyoshi Uezu,Srishti Bhagat, Daniel K Wilton, Louis-Jan Pilaz, Jonnathan Singh Alvarado, Osman Y Calhan, Debra L Silver, Beth Stevens, Nicole Calakos, Scott H Soderling, Cagla Eroglu. Astrocytes refine cortical connectivity at dendritic spines. eLife Dec 2014

Steps vers2


Louis-Jan Pilaz and Debra L. Silver Live imaging of mitosis in the developing mouse embryonic cortex. JoVE. June 4; 2014.




John J McMahon, Lei Shi, and Debra L. Silver Generation of a Magoh conditional allele in miceGenesis. April 27; 2014. 



Elizabeth K Ruzzo, José-Mario Capo-Chichi, Bruria Ben-Zeev,David Chitayat, Hanqian Mao, Andrea L Pappas, Yuki Hitomi, Yi-Fan Lu, Xiaodi Yao, Fadi F Hamdan, Yong-Hui Jiang, William C Wetsel, James O McNamara, Guy A Rouleau, Debra L Silver, Doron Lancet, Elon Pras, Grant A Mitchell, Jacques L Michaud,David B Goldstein. Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy. Neuron 80(2):429-41. 2013



Debra L. Silver*, Karen E Leeds, Hun-way W. Hwang, Emily E. Miller, and William J Pavan*. The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes.  Developmental Biology. March 15; 375 (2): 172-181. 2013. *Featured on cover. *co-corresponding authors.




neural stem cells in brainDebra L. Silver, Dawn Watkins-Chow, Karisa Schreck, Tarran Pierfelice, Denise M Larson, Anthony Burnetti, Hunjun Liaw, Kyungjae Myung, Chris A Walsh, Nicholas Gaiano, and William J Pavan.  The exon junction complex component, Magoh, controls brain size by regulating neural stem cell division. Nature NeuroscienceMay; 13(5)551-558  2010.            *Featured in accompanying News and Views,Regulating Brain Size, Nature Neuroscience, May; 13(5)531. 2010.