How do our brains develop-from just a few cells in the embryo to a complex adult organ? We study this fascinating question, focusing on neurogenesis of the cerebral cortex, the process whereby neurons are generated from neural progenitors. Defective neurogenesis impacts the type and number of neurons in the brain, and can cause broad neurodevelopmental disorders such as microcephaly. We have two major research interests in the lab:
- Genetic basis of brain development and evolution
- RNA regulation, cell fate specification and microcephaly
- RNA localization and local translation
We apply multidisciplinary approaches including live imaging of brain slices and neural progenitors, mouse genetics, and functional genomics.
Recent News from our lab:
- Our newest paper is out in Current Biology! Check out live imaging of mRNAs moving in neural stem cells… Dynamic RNA transport and local translation in radial glial progenitors of the developing brain. Learn more about this study in an accompanying review, on the Node, and by Autism focused Simons Foundation!
- Read our recent paper in Neuron! Prolonged mitosis of neural progenitors alters cell fate in the developing brain.
- Learn about our work on RNA binding proteins in cortical development published in PLoS Genetics!
- Learn about our work on evolutionary-important enhancers published in Current Biology, with an interview with Debby on NPR!
WE ARE HIRING Postdoctoral Fellows:
Our lab is accepting applications from highly motivated, hard-working postdoctoral applicants. This application is for a funded position to study how ZIKA virus and RNA binding proteins impair brain development. Previous experience in relevant fields of developmental neurobiology, stem cells, or RNA biology is a huge plus. Must have a strong record of productivity and publications. Please apply directly to Debra Silver (debra.silver@duke.edu)
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