We aim to understand how the embryonic brain develops. We study neurogenesis of the developing cerebral cortex, the process in which neurons are produced from neural progenitors. Defective neurogenesis impacts neuron production, and can result in neurodevelopmental disorders affecting brain size and structure. We have two major research interests in the lab:
- Genetic basis of brain development and evolution
- Progenitor cell fate specification and RNA regulation
We tackle these complex questions using multidisciplinary approaches including live imaging of brain slices and neural progenitors, mouse genetics, and functional genomics.
Recent News from our lab:
- Our newest paper is out in Current Biology! Check out live imaging in embryonic brain tissue… Dynamic RNA transport and local translation in radial glial progenitors of the developing brain.
- Read our recent paper in Neuron! Prolonged mitosis of neural progenitors alters cell fate in the developing brain.
- Learn about our most recent paper on RNA binding proteins in cortical development published in PLOS Genetics!
- Learn about our work on evolutionary-important enhancers published in Current Biology, with an interview with Debby on NPR!
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