October 6, 2022


NMR is excellent analytical tools for the identification and characterization of biomolecules, small molecules, polymers, etc. Whether you need standard spectra for publication of a newly synthesized small molecule or you need a suite of experiments to determine your compound’s orientation or stereochemistry, the Duke NMR Center has the instrumentation and expertise to help you acquire the information you need. Through non-invasive and non-destructive measurements, NMR obtains comprehensive information of the substances which are useful to a wide range of applications in analytical chemistry, life sciences, material science, petroleum exploration, environmental researches, medicinal chemistry and drug discovery.

The Duke NMR Center has several state of the art equipment to address most research endeavors. With instruments ranging from 400 to 800 MHz, cryogenic probes, 16 and 24 position sample changers, the ability to detect NMR active nuclei between 15N and 31P, 4-nuclei probes, and variable temperature range between 150oC to -150oC we provide a robust NMR center to address your research.

  • X-Nucleus detection in solution (see below)
  • Full structure elucidation (small molecule): 1D-1H, 1D-13C, 1D-X, HSQC, HMBC, COSY, NOESY, TOCSY, etc
  • Full structure elucidation (biomolecule): full suite of 3D and 4D experiments for structural characterization
  • DOSY: non-invasive analysis of mixtures, catalyst, and nano-material
  • NMR Quantitation
  • Sensitivity booster: Cryoprobe (3X) and iProbe (1X)
  • Variable Temperature Control: 150oC to -150oC
  • 4 channel consoles enable the 3D and 4D detection
  • 16 (2x) and 24 (2x) position auto samplers for large sample submission
  • Temperature calibration:
    100% Methanol-d4, ~180K to 300K.
    100% Methanol-d4, 300K to 380K.
    Shim maps:
    2 mM Sucrose, 0.5 mM DSS, 2 mM NaN3, 10% D2O, 90% H2O.
    Pulse calibrations:
    0.1 M 15N-Urea, 0.1 M 13C- CH3OH in 100% DMSO-d6.
    48.5 mM TPP in 100% Acetone-d6 for 31P – Sensitivity.
    0.05% α, α, α-F3-CC6H5 in 100% C6D6 for 19F – Sensitivity.
    0.8 mM 13C 15N – GB-1n 20 mM PO4, 100 mM NaCl, pH 6.5, 0.01% NaN3, 10% D2O, 90% H2O.
    0.3% CHCl3 in 100% Acetone-d6.
    Signal to Noise:
    0.1% Ethylbenzine in 100% CDCl3.