The Duke Magnetic Resonance Spectroscopy Center (DMRSC) provides access to high field NMR instrumentation, training in the use of NMR methods, and expert consultation on advanced NMR applications. The Center serves as a research resource and shared instrument facility for research programs at Duke and in the Southeastern region. The Center was established with funding from the National Science Foundation, the Biomedical Research Support Shared Instrumentation Grants Program of the National Institutes of Health, the North Carolina Biotechnology Center of the State of North Carolina, and Duke University. Over the past five years the Center has invested over $3M in the purchase of additional equipment including new 500 MHz and 700 MHz Bruker spectrometers equipped for small molecule elucidation and macromolecular structure and dynamics studies respectively. Additionally, the Center has three cryogenically cooled probes that provide the highest sensitivity for biological research with enhanced 13C detection. These purchases and upgrades ensure the availability of the highest performing NMR instrumentation to all users and keep the resource on the cutting edge of functionality. General guidelines for allocation of time on the NMR spectrometers and the operating policy of the NMR Center are established and periodically reviewed by the DMRSC Steering Committee and by CoreResearch@Duke.
The NMR Spectroscopy Resource is physically located in some 5,000 sq. ft. of modern, custom designed space on the ground floor of the B-wing of the Levine Science Research Center and is operated as a shared resource that has some 29 currently active user groups. In addition to environmentally controlled instrument rooms, there are offices for the professional staff, a shared wet laboratory, and a conference room. The design of the resource is intended to provide maximum opportunity for investigators to communicate with one another and to share experiences and knowledge of value in studying the, often complex, systems associated with the projects being pursued. Having had the opportunity to design this suite specifically for the equipment and support personnel housed there, we were able to create an integrated shared resource environment that encourages maximum productivity.
Additionally, a Bruker Avance III 700MHz instrument, along with a Bruker NEO 500 MHz and an Agilent 400 MHz instrument are located in a specially designed 850 sq. ft. facility in the new French Science Building adjacent to Levine Science Research Center. This location is particularly useful to users pursuing projects in Chemical Biology who are in the Chemistry Department that is located in the same building.